| Registro completo |
| Provedor de dados: |
J. Venom. Anim. Toxins incl. Trop. Dis.
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| País: |
Brazil
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| Título: |
Experimental Tityus serrulatus scorpion envenomation: age- and sex-related differences in symptoms and mortality in mice
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| Autores: |
MB,Pucca
EC,Roncolato
LB,Campos
FS,Fernandes
GR,Mendes
TB,Bertolini
FA,Cerni
JE,Barbosa
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| Data: |
2011-01-01
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| Ano: |
2011
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| Palavras-chave: |
Scorpions
LD50
Stings
Age factors
Gender
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| Resumo: |
Among the various methods for evaluating animal venom toxicity, the calculation of the median lethal dose (LD50) is the most widely used. Although different protocols can be used to calculate the LD50, the source of the venom and the method of extraction, as well as the strain, age, and sex of the animal model employed, should be taken into consideration. The objective of the present study was to evaluate the influence of sex and age on the toxicity of Tityus serrulatus scorpion venom in Swiss mice. Although the symptoms of envenomation were similar in male and female animals, female mice proved to be more resistant to the venom. In females, age had no impact on the susceptibility to scorpion envenomation. Male mice were more sensitive to T. serrulatus venom. Moreover, in males, age was an important parameter since sensitivity to the venom increased with age.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000300013
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| Editor: |
Centro de Estudos de Venenos e Animais Peçonhentos
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| Relação: |
10.1590/S1678-91992011000300013
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| Formato: |
text/html
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| Fonte: |
Journal of Venomous Animals and Toxins including Tropical Diseases v.17 n.3 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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