| Registro completo |
| Provedor de dados: |
J. Venom. Anim. Toxins incl. Trop. Dis.
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| País: |
Brazil
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| Título: |
DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status
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| Autores: |
Barbosa,Adriana Sierra Assencio Almeida
Oliveira,Larissa Ragozo Cardoso de
Tavares,Francilene Capel
Lima,Carlos Roberto Gonçalves de
Diório,Suzana Madeira
Calvi,Sueli Aparecida
Vilani-Moreno,Fátima Regina
Pereira,Paulo Câmara Marques
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| Data: |
2015-01-01
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| Ano: |
2015
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| Palavras-chave: |
Jorge Lobo’ disease
Lacazia loboi
Malnutrition
Mice
Genotoxicity
Comet assay
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| Resumo: |
AbstractBackground Jorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.Methods DNA damage was assessed in the peripheral blood by the comet assay (tail intensity).Results The results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.Conclusion These results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100317
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| Editor: |
Centro de Estudos de Venenos e Animais Peçonhentos
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| Relação: |
10.1186/s40409-015-0006-y
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| Formato: |
text/html
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| Fonte: |
Journal of Venomous Animals and Toxins including Tropical Diseases v.21 2015
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| Direitos: |
info:eu-repo/semantics/openAccess
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