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ABSTRACT: This review covers biological activity of secondary metabolites, coumarin and their derivatives on different organisms (pests, pathogens, weeds), as well as their applications in agriculture as eco-friendly pesticides and weed control agents. Naturally occurring coumarins have shown biological and allelopathic potential on a broad range of organisms. Coumarin inhibits seed germination, root growth, morphology, histology, water uptake, respiration, photosynthesis, cell elongation, cell división and differentiation. Coumarin demonstrate excellent insecticidal potential against eggs, larvae and adult insects. Coumarin showed antifeedent responses in a wide range of memebers from invertebrates to vertebrates. The information provided in this review also shed light on further research and development of coumarin and its derivatives as potential plant protection lead compounds to control weeds and harmful pests.
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