| Registro completo |
| Provedor de dados: |
Rev. Bras. Frutic.
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| País: |
Brazil
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| Título: |
Chemical composition, anti-Trypanosoma cruzi and cytotoxic activities of the essential oil from green fruits of Protium ovatum (BURSERACEAE)
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| Autores: |
Estevam,Elisângela Barbosa Borges
Alves,Cássia Cristina Fernandes
Esperandim,Viviane Rodrigues
Cazal,Cristiane de Melo
Souza,Alex Fonseca
Miranda,Mayker Lazaro Dantas
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| Data: |
2018-01-01
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| Ano: |
2018
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| Palavras-chave: |
Protium ovatum
SS-myrcene
Fruits
Essential oil
Trypanosoma cruzi
Cytotoxic analysis
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| Resumo: |
Abstract Chagas disease is a major neglected tropical disease caused by Trypanosoma cruzi. It has been treated with the antiparasitic drugs nifurtimox and benzonidazole, which cause several side effects. The market for natural products has considerably grown lately and the use of plants has become an alternative to the development of novel drugs to cure the disease. Therefore, this study aimed at describing the chemical analysis of the essential oil from green fruits of Protium ovatum and evaluating their trypanocidal and cytotoxic potential. The essential oil was obtained by Clevenger hydrodistillation whereas its chemical composition was determined by gas chromatography coupled to mass spectrometry (GC-MS). The major compounds found in the essential oil from green fruits of P. ovatum were ß-myrcene (62.0 %), a-pinene (11.3 %) and limonene (7.3 %). To the best of our knowledge, this was the first time that the chemical composition of the essential oil from green fruits of P. ovatum was described. Results showed that the essential oil had strong trypanocidal activity against trypomastigote forms of theY strain of Trypanosoma cruzi (IC50 = 1.2 µg/mL). In addition, the essential oil from green fruits of P. ovatum did not display cytotoxicity against LLCMK2 adherent epithelial cell at the concentration range under analysis (CC50 = 550.3 µg/mL). As a result, it is an excellent option for the development of novel antiparasitic drugs.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-29452018000106001
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| Editor: |
Sociedade Brasileira de Fruticultura
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| Relação: |
10.1590/0100-29452018794
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| Formato: |
text/html
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| Fonte: |
Revista Brasileira de Fruticultura v.40 n.1 2018
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| Direitos: |
info:eu-repo/semantics/openAccess
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