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| Tonet,A.C; Karnikowski,M; Moraes,C.F; Gomes,L; Karnikowski,M.G.O; Córdova,C; Nóbrega,O.T. |
| In worldwide studies, interleukin-6 (IL-6) is implicated in age-related disturbances. The aim of the present report was to determine the possible association of IL-6 -174 C/G promoter polymorphism with the cytokine profile as well as with the presence of selected cardiovascular risk features. This was a cross-sectional study on Brazilian women aged 60 years or older. A sample of 193 subjects was investigated for impaired glucose regulation, diabetes, hypertension, and dyslipidemia. Genotyping was done by direct sequencing of PCR products. IL-6 and C-reactive protein were quantified by high-sensitivity assays. General linear regression models or the Student t-test were used to compare continuous variables among genotypes, followed by adjustments for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cytokine; Interleukin-6; Genetics; Elderly; Cardiovascular disease; Brazil. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100008 |
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