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Pereira,F.Q.; Santos,B.; Carboni,T.; Bender,M.; Driemeier,D.; Cunha,A.C.B.; Biajoli,M.G.; Mello,F.B.; Silva,P.R.; Pigatto,J.A.T.; Mello,J.R.B.. |
ABSTRACT The effect of the systemic absorption of 0.1% diclofenac sodium (DS) eyedrop was compared to that of 0.5% ketorolac tromethamine (KT) in female New Zealand white rabbits treated on both eyes three times a day for 90 days. The rabbits were divided in three groups of six animals (n= 18): KT group, DS group, and control (Co) group, in which saline (0.9% NaCl) solution was instilled. Water and food consumption were measured daily, clinical examination was performed weekly, and blood samples were collected every 30 days for laboratory examination. The plasma was analyzed for the presence of KT and DS by solid-phase extraction (SPE) associated with mass spectrometry (MS). Systemic absorption of these drugs was confirmed by SPE-MS, allowing their... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rabbits; Eyedrops; NSAID; Systemic absorption. |
Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000601865 |
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Perlmann,E.; Rodarte-Almeida,A.C.V.; Albuquerque,L.; Safatle,A.M.V.; Pigatto,J.A.T.; Barros,P.S.M.. |
Two cases of feline intraocular sarcoma were reported in stray cats that presented blindness and hypotonia of the affected eye for years before the tumor development. Phthisis bulbi, a final stage of a severe inflammation of the eye, is frequently unmonitored because eyes are blind, small, opaque, and not painful. Yet, this report shows that monitoring and early enucleation of eyes of cats with phthisis bulbi are important and should be considered as a treatment option, because feline intraocular sarcoma is an aggressive tumor that significantly decreases live expectancy. |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Feline; Phthisis bulbi; Intraocular; Sarcoma; Metastasis. |
Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352011000300009 |
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