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Medicinal plants for the "nerves": a review of ethnobotanical studies carried out in South Brazil Acta Botanica
Gross,Andressa Verdum; Stolz,Eveline Dischkaln; Müller,Liz Girardi; Rates,Stela Maris Kuze; Ritter,Mara Rejane.
ABSTRACT Among the medicinal purposes for which plants have been used is the treatment of “nerves". The objective of this study was to search for species of plants used in the state of Rio Grande do Sul (South Brazil) for the relief of symptoms related to central nervous system (CNS) disorders. Twenty-seven ethnobotanical studies were compiled, in which a total of 94 species were cited. The five most cited species were Cymbopogon citratus (81.5 %), Melissa officinalis (77.7 %), Aloysia citriodora (66.6 %), Matricaria chamomilla (62.9 %) and Passiflora edulis (51.8 %). Scientific studies have corroborated the popular use of these plants as sedatives, but most studies are preclinical and very few have been clinical (M. chamomilla and M. officinalis), and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Central nervous system disorders; Ethnobotany; Popular medicine; Sedative; Toxicity.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062019000200269
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Influence of agrochemicals fipronil and imidacloprid on the learning behavior of Apis mellifera L. honeybees - doi: 10.4025/actascianimsci.v35i4.18683 Animal Sciences
Carrillo, Marcela Pedraza; Universidade Estadual Paulista “Júlio de Mesquita Filho”; Bovi, Thaís de Souza; Universidade Estadual Paulista “Júlio de Mesquita Filho”; Negrão, Adriana Fava; Universidade Estadual Paulista “Júlio de Mesquita Filho”; Orsi, Ricardo de Oliveira; Universidade Estadual Paulista “Júlio de Mesquita Filho”.
Agrochemicals on crop cultivated areas is a source of contamination for bees and may cause physiological and behavioral disorders and mortality. The LD50 of the pesticides fipronil and imidacloprid was determined and their effect on the learning behavior of Apis mellifera L. honeybee evaluated. LD50 was determined by the ingestion of contaminated food with different concentrations of insecticide concentrations: Fipronil (0, 0.8, 0.4, 0.2, 0.1 and 0.05 µg bee-1) and imidacloprid (0, 0.4, 0.2, 0.1, 0.05 and 0.025 µg bee-1). The method of proboscis extension reflection (PER) and learning through citral odor evaluated their responses to food stimulation. LD50 obtained were 0.28 ± 0.11 and 0.10 ± 0.04 µg bee-1 for fipronil and imidacloprid, respectively. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Beekeeping; Toxicity; Lethal dose Agrochemical fipronil; Beekeeping; Toxicity; Lethal dose.
Ano: 2013 URL: http://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/18683
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Folk medicine in Mandaguaçu municipality, Paraná State: an ethnobotanical approach - doi: 10.4025/actascibiolsci.v34i4.9306 Biological Sciences
Furlanetto, Patrícia de Nazaré Cardoso; Unidade de Ensino Superior Ingá; Novakowski, Gisele Caroline; Universidade Estadual de Maringá/Unidade de Ensino Superior Ingá; Correa, Edmar Antônio; Unidade de Ensino Superior Ingá.
Herein, we present results from an ethnobotanical study (from February to August 2009) aiming the improvement and rationalization of medical practices, based on popular use of plants. We applied semi-structured interviews to 220 families from the urban area of Mandaguaçu municipality, Paraná State. During the interviews we recorded the following information about the used plants: common name; plant part used; method of preparation; collection site; therapeutic indication, and known adverse effects. Additionally, we compared the data obtained in the interviews with the literature in order to identify contradiction in use and application. Among the interviewees, 90% use medicinal plants, obtained especially from the backyards. We recorded 44 ethnobotanical...
Tipo: Etnobotânica Palavras-chave: 2.03.00.00-0 medicinal plants; Folk knowledge; Toxicity; Adverse effects Botânica.
Ano: 2012 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/9306
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Ecotoxicity of glyphosate and aterbane® br surfactant on guaru (Phalloceros caudimaculatus) - doi: 10.4025/actascibiolsci.v32i3.6795 Biological Sciences
Shiogiri, Natália Sayuri; UNESP; Carraschi, Silvia Patrícia; Unesp; Cubo, Patrícia; Unesp; Schiavetti, Bárbara Lopes; Unesp; Cruz, Claudinei da; Unesp; Pitelli, Robinson Antonio; Unesp.
Aquatic macrophytes are important components of aquatic ecosystems, but these plants have become a problem due to their occurrence in different regions. Some studies aimed to demonstrate the effectiveness of herbicides to control these macrophytes; however, few studies report the possible ecotoxicological effects. The objective of this study was to estimate the acute toxicity (LC (I)50;96h) and assess water quality variables for glyphosate in the Rodeo® formulation, Aterbane® BR surfactant and mixtures of glyphosate + 0.5% and 1.0% of surfactant, for the guaru fish (Phallocerus caudimaculatus). The guaru was exposed to increasing concentrations of glyphosate and a mixture of glyphosate + 0.5 and 1.0% of surfactant. The mixture of glyphosate...
Palavras-chave: Tropical fish; Toxicity; Herbicide tropical fish; Toxicity; Herbicide.
Ano: 2010 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/6795
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Acute Toxicity Of Euphorbia Royleana Boiss (Euphorbiaceae) latex on freshwater catfish, Heteropneustes Fossilis (Siluriformes, Heteropneustidae) Acta Toxicol. Argent.
ManiRam,Prasad; Abhishek,Kumar; Diwakar,Mishra; Sunil K,Srivastav; Ajai K,Srivastav.
An acute toxicity test was performed by using a four-day static renewal test to determine the LC50 value of aqueous extract of Euphorbia royleana latex for the freshwater fsh, Heteropneustes fossilis. The LC50 values, their upper and lower confdence limits and slope functions were calculated. The LC50 values for aqueous extract of Euphorbia royleana latex at various exposure periods were 7.758 mg/L for 24 h, 5.847 mg/L for 48 h, 4.474 mg/L for 72 h and 3.090 mg/L for 96 h. The regression coeffcient showed that there was signifcant negative correlation between exposure time and different LC values. Hence, it is concluded that the concentration to produce toxicity of latex of Euphorbia royleana is comparable and close to the concentration to produce toxicity...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fish; Euphorbia royleana; Toxicity; LC50.
Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-37432010000100001
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Quinolizidine alkaloids in Calia secundiflora (FABACEAE) Agrociencia
García-Mateos,Rosario; Soto-Hernández,Marcos; Zavala-Chávez,Fernando; Kite,Geofrey.
Abstract The purpose of this study was to compare the alkaloid profile in different tissues analyzed by GC/MS and to contribute to the ecological knowledge of Calia secundiflora (patol). Samples of leaves, root and seeds of patol (mescal bean) were collected and field information was recorded in the States of Hidalgo and Querétaro, México, using the point-centered quarted method. Species dominance was calculated (value of importance) and the two locations were compared in species richness, similarity index, and soil data. Seventeen species of plants were found in Hidalgo and 21 in Querétaro; Flourensia resinosa and patol dominated the vegetation in Hidalgo, while patol and Dodonaea viscosa dominated in Querétaro. The profile of the quinolizidine alkaloids...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dodonaea viscosa; Flourensia resinosa; Ecology; Fabaceae; Habitat; Toxicity.
Ano: 2007 URL: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1405-31952007000200161
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Larvicidal activity of the water extract of Moringa oleifera seeds against Aedes aegypti and its toxicity upon laboratory animals Anais da ABC (AABC)
Ferreira,Paulo M.P.; Carvalho,Ana F.U.; Farias,Davi F.; Cariolano,Nara G.; Melo,Vânia M.M.; Queiroz,Maria G.R.; Martins,Alice M.C.; Machado-Neto,Joaquim G..
In this work, biological effects of the water extract of Moringa oleifera seeds (WEMOS) were assessed on eggs and 3rd instar larvae of Aedes aegypti and on its toxicity upon laboratory animals (Daphnia magna, mice and rats). Crude WEMOS showed a LC50 value of 1260µg/mL, causing 99.2 ± 2.9% larvae mortality within 24 h at 5200µg/mL, though this larvicidal activity has been lost completely at 80ºC/10 min. WEMOS did not demonstrate capacity to prevent egg hatching. After extensive dialyses of the crude WEMOS into watersoluble dialyzable (DF) and nondyalizable (NDF) fractions, only DF maintained its efficacy to kill larvae. Acute toxicity evaluations on daphnids (EC50 of 188.7µg/mL) and mice (LD50 of 446.5 mg/kg body weight) pointed out to low toxicity....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aedes aegypti; Daphnia magna; Larvicidal activity; Moringa oleifera seeds; Toxicity.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000200007
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Are salty liquid food flavorings in vitro antitumor substances? Anais da ABC (AABC)
CARVALHO,FRANCISCO R.S.; MOURA,ANTONIO G.; RODRIGUES,GARDENIA F.; NUNES,NARCIA M.F.; LIMA,DAISY J.B.; PESSOA,CLAUDIA; COSTA,MARCILIA P.; FERREIRA,PAULO M.P.; PERON,ANA PAULA.
ABSTRACT The objective of this study was to evaluate the antiproliferative, cytotoxic and genotoxic potential of salty liquid synthetic flavorings of Butter, Cheddar Cheese and Onion. The antiproliferative potential (2.9-1500 µg/mL) was assessed by MTT assay after 72h using the human tumor lines SF-295 (glioblastoma), OVCAR-8 (ovarian), HCT-116 (colon) and HL-60 (promyelocytic leukemia) and primary cultures of murine Sarcoma 180 (S180) and peripheral blood mononuclear cells (PBMC). Allium cepa bulbs were exposed to growing respective doses (1 mL and 2 mL). Only Butter and Cheddar flavorings revealed cytotoxic activity on cancer cells, with IC50 values ranging from 125.4 µg/mL (Cheddar - HCT-116) to 402.6 µg/mL (Butter - OVCAR-8). Butter flavoring was the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Food additives; Allium cepa; Antiproliferative action; Neoplasic cells; Toxicity.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401419
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Evaluation of antibiotics as a methodological procedure to inhibit free-living and biofilm bacteria in marine zooplankton culture Anais da ABC (AABC)
Agostini,Vanessa O.; Macedo,Alexandre J.; Muxagata,Erik.
There is a problem with keeping culture medium completely or partially free from bacteria. The use of prokaryotic metabolic inhibitors, such as antibiotics, is suggested as an alternative solution, although such substances should not harm non-target organisms. Thus, the aim of this study was to assess the effectiveness of antibiotic treatments in inhibiting free-living and biofilm bacteria and their half-life in artificial marine environment using the copepod Acartia tonsa as bioindicador of non-harmful antibiotic combinations. Regarding to results, the application of 0.025 g L-1 penicillin G potassium + 0.08 g L-1 streptomycin sulphate + 0.04 g L-1 neomycin sulphate showed great potential for use in marine cultures and scientific experiments without...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acartia tonsa; Antimicrobials; Experiment; Marine culture; Toxicity.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000200733
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Counteracting effects on free radicals and histological alterations induced by a fraction with casearins Anais da ABC (AABC)
ARAÚJO,ÉVERTON JOSÉ FERREIRA DE; OLIVEIRA,GUILHERME ANTÔNIO LOPES DE; SOUSA,LÍVIA QUEIROZ DE; BOLZANI,VANDERLAN DA SILVA; CAVALHEIRO,ALBERTO JOSÉ; TOME,ADRIANA DA ROCHA; PERON,ANA PAULA; SANTOS,ANDRÉ GONZAGA DOS; CITÓ,ANTONIA MARIA DAS GRAÇAS LOPES; PESSOA,CLÁUDIA; FREITAS,RIVELILSON MENDES DE; FERREIRA,PAULO MICHEL PINHEIRO.
ABSTRACTCasearia sylvestris Swartz is a medicinal plant widely distributed in Brazil. It has anti-inflammatory, antiulcer and antitumor activities and is popularly used to treat snakebites, wounds, diarrhea, flu and chest colds. Its leaves are rich in oxygenated tricyclic cis-clerodane diterpenes, particulary casearins. Herein, we evaluated the antioxidant activities of a fraction with casearins (FC) isolated from C. sylvestrisand histological changes on the central nervous system and livers of Mus musculus mice. Firstly, in vitro studies (0.9, 1.8, 3.6, 5.4 and 7.2 μg/mL) revealed EC50 values of 3.7, 6.4 and 0.16 µg/mL for nitrite, hydroxyl radical and TBARS levels, respectively. Secondly, FC (2.5, 5, 10 and 25 mg/kg/day) was intraperitoneally...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Clerodane diterpenes; Casearia sylvestris; Antioxidant; Morphological changes; Toxicity.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000401791
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Taxonomic and non-taxonomic responses of benthic macroinvertebrates to metal toxicity in tropical reservoirs. The case of Cantareira Complex, São Paulo, Brazil Anais da ABC (AABC)
BEGHELLI,FREDERICO G.S.; CETRA,MAURÍCIO; MARCHESE,MERCEDES; LÓPEZ-DOVÁL,JÚLIO CÉSAR; ROSA,ANDRÉ H.; POMPÊO,MARCELO L. M.; MOSCHINI-CARLOS,VIVIANE.
Abstract Benthic macroinvertebrates are organisms that are recognized as water quality bio-indicators. A wide variety of indices and metrics have been shown to respond to a variety of anthropogenic impacts, usually under a general condition of environmental impairment. The absence of a clear distinction in the relations between specific pollutants and biotic variables is very common and can lead to biased interpretation of biomonitoring. The aims of this research were to test taxonomic and non-taxonomic responses to specific environmental conditions instead to general conditions. For this purpose, we estimated the theoretical toxicity by comparing toxicity values published by EPA with metal concentrations in water and sediments. Then we tested the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bio-indicator; Biomonitoring; Chironomid; Oligochaetes; Toxicity; Metal.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000300701
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Acute toxicity and histopathology in ornamental fish amazon bluespotted corydora (Corydoras melanistius) exposed to formalin Anais da ABC (AABC)
Santos,Rudã F.B.; Dias,Henrique M.; Fujimoto,Rodrigo Y..
The objective of this work was to evaluate the acute toxicity of formalin and histopathological effects on the Amazon ornamental fish, bluespotted coridora (Corydoras melanistius). A randomized design was used, with ten concentrations of formalin (40%) (0, 3, 6, 12, 25, 50, 100, 150, 200 and 250mg.L-1) with four replicates and five fish per container (3L) in static system for 96 hours. The moribund fish were killed and fixed in 10% formalin to proceed the histopathological analysis of gill, liver and kidney. At the end of this experiment the following mortality rates (%) were obtained in increasing order of exposure: 0, 0, 0, 0, 0, 65, 85, 100, 100 and 100%. The lethal concentration 50% (LC50-96h (I)) estimated was 50.76 mg.L-1 with regression of y =...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lethal concentration; Corydora; Formaldehyde; Toxicity; Histology; Amazon.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400014
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Age and time exposure-related toxicity of fenthion to male and female Anastrepha fraterculus (Wied.) (Diptera: Tephritidae) Anais da SEB
Humeres,Eduardo; Da Cruz,Ivana B.M.; Oliveira,Alice K. de.
Effect of age, sex and time exposure of Anastrepha fraterculus (Wied.) to toxicity of fenthion was evaluated. The age of the flies was important to the appearance of the first intoxication symptoms; males and females of reproductive ages (30 and 60 days-old, respectively) were less susceptible to insecticide than flies in the remainder ages (four and 120 days-old). The effect of body weight on insect intoxication was not detected. LT 50 biossay with fenthion (varying from 3-7 minutes) showed a lower susceptibility of males than females at all ages. Adults of both sexes and 30 days-old submitted to continuous and discontinuous exposure to fenthion did not show toxic cumulative effect of the insecticide. The statistical analysis suggests a possible general...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Insecta; Fruit-fly; Insecticide; Toxicity.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0301-80591999000200011
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Toxicity of fenthion to Anastrepha fraterculus (Wied.) (Diptera:Tephritidae): dose response analysis Anais da SEB
Da Cruz,Ivana B. M.; Humeres,Eduardo; Oliveira,Alice K..
Three toxicological bioassays were performed in two F1 south Brazilian field populations of Anastrepha fraterculus (Wied.). Lethal doses of fenthion (50% and 90%) were estimated in two bioassays, with oral administration, and with residual contact bioassay. Results of topical bioassays using fenthion diluted in alcohol, acetone or water were inconsistent. Samples treated with acetone or alcohol diluents presented high mortality (>10%), while the samples treated with water diluent showed a non linear response between dose and mortality. The residual contact bioassay was significatively more toxic when compared to a feeding bioassay, occurring equal slopes in males and females in the populations analysed. Additional test showed that insects did not...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Insecta; South American fruit fly; Insecticide; Toxicity.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0301-80591997000300009
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Toxicological evaluation of long-term intravenous administration of amitraz in horses Arq. Bras. Med. Vet. Zootec.
Queiroz-Neto,A.; D'Angelis,F.H.F.; Harkins,J.D.; Tobin,T..
With the aim of determining the possible toxicity of amitraz after its prolonged use in horses, six English Thoroughbred horses received intravenous injections of amitraz (0.05, 0.10 or 0.15 mg/kg) weekly for four months, constituting the experimental group. Eight other animals (control group), via the same route following the same drug administration schedule and period of time, received the vehicle, dimethylformamide. At the end of this period, blood was collected from all the animals, and a comparison was made of the means of the values obtained for the various blood analyses: complete hemogram, alkaline phosphatase, gamma-glutamyltransferase, blood urea nitrogen, lactate dehydrogenase, aspartate aminotransferase, creatine phosphokinase, glucose,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Horse; English Thoroughbred; Amitraz; Toxicity; Blood characteristics; Electrolytes.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352002000400003
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Ultrastructural changes of the olfactory bulb in manganese-treated mice Biocell
Villalobos,Virginia; Bonilla,Ernesto; Castellano,Alan; Novo,Ernesto; Caspersen,Ralph; Giraldoth,Debora; Medina-Leendertz,Shirley.
The effect of manganese toxicity on the ultrastructure of the olfactory bulb was evaluated. Male albino mice were injected intraperitoneally with MnCl2 (5 mg/Kg/day) five days per week during nine weeks. The control group received NaCl (0.9%). The olfactory bulbs of five mice from each group were processed for transmission electron microscopy after 2, 4, 6 and 9 weeks of manganese treatment. On week 2, some disorganization of the myelin sheaths was observed. After 4 weeks, degenerated neurons with dilated cisternae of rough endoplasmic reticulum and swollen mitochondria appeared. A certain degree of gliosis with a predominance of astrocytes with swollen mitochondria, disorganization of the endomembrane system, dilation of the perinuclear cisternae and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Metal toxicity; Toxicity; Neurodegeneration; Electron microscopy.
Ano: 2009 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452009000300007
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Determination of vanadium accumulation in onion root cells (Allium cep a L.) and its correlation with toxicity Biocell
Marcano,Letty; Carruyo,Ingrid; Fernández,Yusmary; Montiel,Xiomara; Torrealba,Zaida.
The vanadium is a metal that presents great interest from the toxicological point of view, because of the numerous alterations that can take place in different biological systems. This work evaluated the capacity of vanadium accumulation and its correlation with genotoxic effects in root cells of Allium cepa L. The bulbs were cultivated in renovated filtered water each 24 h, at a temperature of 25 ± 0.5 ° C, in darkness and constant aeration. Treatments were carried out under the same experimental conditions, using water solutions of vanadium of 25, 50, 75 and 100 µ g/g for 0, 12, 24, 48 and 72 h. A control was carried out where metal solution was substituted by distilled water. After the treatment, the meristems were fixed with alcohol - acetic acid (3:1)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Root cells; Vanadium; Toxicity; Accumulation; GFAAS.
Ano: 2006 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452006000200001
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Preimplantation embryotoxicity after mouse embryo exposition to reactive oxygen species Biocell
Cebral,Elisa; Carrasco,Isabel; Vantman,David; Smith,Rosita.
Exposure of either gametes or embryos to conditions and/or factors that generate oxidative stress has been associated with impaired early embryogenesis. The effects of reactive oxygen species (ROS) on mouse preimplantation development, depending of the ROS-concentration and time of exposition, were studied. Two-cell embryos were incubated with 5, 10, 25 and 50 &#956;M of hydrogen peroxide (H2O2) for 30 and 60 minutes of exposition and allowed to develop for 72 h to study the quality of development. The incubation with 50 &#956;M2HO2 for 30 or 60 minutes, strongly inhibited the 2-cell embryo development as compared to the control (p<0.001). Twenty-five &#956;M2HO2 produced inhibition of blastocyst formation (p<0.001) and 10 &#956;M...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Reactive oxygen species; Preimplantation embryogenesis; Toxicity; Mouse.
Ano: 2007 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452007000100006
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Ethanol in low chronic dose level attenuates major organic effects in malnourished rats Biol. Res.
AGUIAR,ALINE S DE; BOAVENTURA,GILSON T; ABRAHÃO,RAFAEL F; FREITAS,THATIANA L; TAKIYA,CHRISTINA M; FILHO,PORPHIRIO J S; SILVA,VILMA A DA.
The aim of the present study was to evaluate the chronic toxicity of ethanol low blood levels in malnourished rats. Female Wistar rats (220 g) were subjected to either an ad libitum diet (W, well-nourished, n=10) or food restriction (M, malnourished, n=10). Water (WW and MW) or ethanol solution (W5% and M5%) was offered to half of each nutritional group (n=5) as the only fluid source. The treatment was continued for two months. After sacrifice, blood biochemical parameters and macroscopic, histologic and morphometric evaluation of the liver were performed. Results indicated that: Ethanol consumption was higher in malnourished rats and minimized body weight loss in malnourished rats, while it decreased the body weight gain in well-nourished ones. Behavioral...
Tipo: Journal article Palavras-chave: Ethanol; Low dose; Malnutrition; Toxicity.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000100004
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Histidines 13 and 14 in the A&#946; sequence are targets for inhibition of Alzheimer's disease A&#946; ion channel and cytotoxicity Biol. Res.
DÍAZ,JUAN CARLOS; LINNEHAN,JOHN; POLLARD,HARVEY; ARISPE,NELSON.
The fact that Alzheimer's beta amyloid (A&#946;) peptides forms cation channels in lipid bilayers was discovered during the course of our experiments in the laboratory of "Guayo" Rojas at NIH in Bethesda, Maryland (USA). Recently, we found that the A&#946; ion channel could be blocked selectively with small peptides that copy the amino acid sequence of the predicted mouth region of the A&#946; channel pore. We now have searched for the essential amino acid residues required for this blocking effect by mutations. We found that the ability of peptides to block A&#946; channel activity could be lost by replacement of histidines 13 and 14 by alanine or lysine. The amino acid substitution also resulted in the loss of the capacity of the peptides...
Tipo: Journal article Palavras-chave: Alzheimer's disease; Beta amyloid; Ion channel blockers; Peptides; Histidine; Toxicity.
Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300007
Registros recuperados: 225
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