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Cattle Egrets and dry fish business in coastal areas Nature Precedings
Kotta Seedikkoya; PA Azeezpa.
Cattle Egret is one of the common wetland birds in India known for its efficiency to make use of human interfered habitats. The present study is an attempt to document maggots of houseflies and calliphorids in the coastal sun drying fish yards and the role of the species in containing the vector species. The number of flies and maggots were found related with the visit of cattle egrets, demonstrating the importance of the species in controlling the vectors.
Tipo: Manuscript Palavras-chave: Ecology.
Ano: 2009 URL: http://precedings.nature.com/documents/2752/version/1
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Dys-regulated Gene Expression Networks by Meta-Analysis of Microarray Data on Oral Squamous Cell Carcinoma Nature Precedings
Zhongyu Liu; Yulong Niu; Chao Li; Yang Zhou; Yi Yang; Chunfang Gao.
Background: Oral squamous cell carcinoma (OSCC) is the sixth most common type of carcinoma worldwide. Development of OSCC is a multi-step process involving genes related to cell cycle, growth control, apoptosis, DNA damage response and other cellular regulators. The pathogenic pathways involved in this tumor are mostly unknown and therefore a better characterization of OSCC gene expression profile would represent a considerable advance. The availability of publicly available gene expression datasets has opened up new challenges especially for the integration of data generated by different research groups and different array platforms with the purpose of obtaining new insights on the biological process...
Tipo: Manuscript Palavras-chave: Cancer; Genetics & Genomics; Bioinformatics.
Ano: 2010 URL: http://precedings.nature.com/documents/4269/version/1
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Why overlearned sequences are special: distinct neural networks in the right hemisphere for ordinal sequences Nature Precedings
Vani Pariyadath; Sara J. Churchill; David M. Eagleman.
Written and spoken words activate left hemisphere areas involved in language processing. However, we here show that overlearned sequences (e.g. letters, numbers, weekdays, months) involve an unexpected right hemispheric activation in both the middle temporal gyrus and temporoparietal junction. Our findings offer a framework for understanding neuropsychological patterns seen in conditions such as synesthesia, in which anomalous perceptual experiences are triggered by overlearned sequences, and also in semantic dementia, in which left hemisphere damage disrupts word knowledge even while sequences can be spared.
Tipo: Manuscript Palavras-chave: Neuroscience.
Ano: 2008 URL: http://precedings.nature.com/documents/2452/version/1
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Tracing blastomere fate choices of early embryos in single cell culture Nature Precedings
Yunhan Hong; Haobin Zhao; Ni Hong; Zhendong Li; Meisheng Yi; Rong Liu; Mingyou Li; Yan Yan; Yongming Yuan; Chang Ming Li; Ruowen Ge; Jianxin Song.
Blastomeres of early vertebrate embryos undergo numerous fate choices for division, motility, pluripotency maintenance and restriction culminating in various cell lineages. Tracing blastomere fate choices at the single cell level in vitro has not been possible because of the inability to isolate and cultivate early blastomeres as single cells. Here we report the establishment of single cell culture system in the fish medaka, enabling the isolation and cultivation of individual blastomeres from 16- to 64-cell embryos for fate tracing at the single cell level in vitro. Interestingly, these blastomeres immediately upon isolation exhibit motility, lose synchronous divisions and even stop dividing in ≥50% cases, suggesting that the widely accepted...
Tipo: Manuscript Palavras-chave: Biotechnology; Developmental Biology; Molecular Cell Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4907/version/1
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A sensorimotor area (NIf) is required for the production of learned vocalizations Nature Precedings
Sharon M. H. Gobes; Bence P. Ölveczky.
Sensory feedback is essential for the acquisition of complex motor behaviors, including birdsong. In zebra finches, auditory feedback is relayed to the descending motor pathway primarily through the nucleus interfacialis nidopalii (NIf). NIf projects to HVC - a premotor region essential for song, which projects to RA, a motor cortex analogue brain area that drives muscle activity required for vocalizations. NIf is also essential for ‘sleep replay’, a recapitulation of song-related neural dynamics in the motor pathway during sleep. Despite being one of the major inputs to the song control pathway, there is no known role for NIf in the production of zebra finch song. To address this, we reversibly inactivated NIf using TTX or Muscimol...
Tipo: Poster Palavras-chave: Neuroscience.
Ano: 2011 URL: http://precedings.nature.com/documents/5856/version/1
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Theoretical Investigation on Electronic Properties of Topological Materials: Moebius Nanographite and Conjugated Polymers Nature Precedings
Kikuo Harigaya.
1. Topological materials: Moebius nanographite and conjugated polymers
2. Magnetic domain wall states [1] vs. helical magmetic order in nanographite [2]
3. Static polarizability [alpha] and the first hyperpolarizability [beta] are studied, comparing three models: Mobius strip cyclacene, ring cyclacene, and linear strip.
4. Opening the knot of the Mobius to form the ring leads to the increase of [alpha] from 268 to 323 a.u. and [beta] increases about three times from 393 to 1049 a.u.
5. Opening the ring to form the linear strip, [alpha] increases from 323 to 476 a.u. [beta] as well increases about three times from 1049 to 2814 a.u.

[1] K. Wakabayashi and...
Tipo: Presentation Palavras-chave: Chemistry.
Ano: 2009 URL: http://precedings.nature.com/documents/3881/version/1
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Unique for human centromeric regions of interphase chromatin homing (CENTRICH) govern dynamic features of chromatin fractal globules Nature Precedings
Gennadi Glinsky.
We report the results of the genome-wide alignment of inter- and intra-chromosomal chromatin interactions within the context of interphase chromatin binding to nuclear lamina and nucleolus. For all human chromosomes, a significant correlation exists between binding of chromosomal loci to nuclear lamina and segregation into spatially-defined distinct compartments of genome-wide chromatin interactions identified by Hi-C method. We report identification of near-centromeric intergenic regions on human chromosomes (chr2; chr10; chr17; chr1), which are highly enriched for interphase chromatin homing sites and function as attractors of long-range physical interactions (Centromeric Regions of Interphase Chromatin Homing,...
Tipo: Manuscript Palavras-chave: Biotechnology; Cancer; Developmental Biology; Genetics & Genomics; Molecular Cell Biology; Bioinformatics.
Ano: 2012 URL: http://precedings.nature.com/documents/6756/version/1
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A new potential radiosensitizer: ammonium persulfate modified WCNTs Nature Precedings
Jian-She Yang; Bo-Zhang Yu; Wen-Xin Li.
Radiotherapy plays a very important role in cancer treatment. Radiosensitizers have been widely used to enhance the radiosensitivity of cancer cells at given radiations. Here we fabricate multi-walled carbon nanotubes with ammonium persulfate, and get very short samples with 30-50 nanometer length. Cell viability assay show that f-WCNTs induce cell death significantly. We hypothesize that free radicals originated from hydroxyl and carbonyl groups on the surface of f-WCNTs lead cell damage.
Tipo: Manuscript Palavras-chave: Biotechnology; Cancer; Chemistry.
Ano: 2007 URL: http://precedings.nature.com/documents/1421/version/1
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Metastasis as a faulty recapitulation of ontogeny Nature Precedings
Ulf R. Rapp.
RAF oncogenes are involved in a variety of phenotypic switch phenomena. If for example oncogenic RAF is expressed together with Myc in B lineage cells, a lineage switch to macrophages occurs at low frequency in vitro and in vivo. In addition, if RAF is expressed in type II alveolar epithelial cells slow growing lung adenomas are formed and a switch from columnar to cuboidal cells is detected in these mice upon p53 deletion. A similar switch is also seen, if ectopic Myc is present in our lung tumor mouse model. Moreover, in the liver of these mice with both oncogenes metastases are found. If E-cadherin function is impaired in our RAF-dependent lung tumor model, a switch from adenoma to adenocarcinoma occurs and genes characteristic for the early endodermal...
Tipo: Manuscript Palavras-chave: Cancer; Developmental Biology; Genetics & Genomics.
Ano: 2007 URL: http://precedings.nature.com/documents/805/version/1
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Aqueous synthesis of CdTe quantum dot as biological fluorescent probe for monitoring methyl parathion by fluoro-immunosensor Nature Precedings
Raghuraj Chouhan; Aaydha Vinayaka; Munna Thakur.
Bioconjugation of quantum dots (QDs) provide high resolution in biological fluorescent labelling as a result of physical and optical properties of QDs. This intrinsic property of QDs can be made use of for sensitive detection of target analytes including food and environmental monitoring. In this investigation, we report the bioconjugation of thiol stabilized CdTe QD for the sensitive detection of methyl parathion (MP) at picogram level. The specificity in the analysis was attributed by highly specific competitive immunological reactions between free MP and CdTe QD bioconjugated MP (MP-BSA-CdTe) for immobilized anti-MP IgY antibodies in a simple flow injection system. We also report the possible resonance energy transfer phenomenon as a result of...
Tipo: Manuscript Palavras-chave: Biotechnology.
Ano: 2009 URL: http://precedings.nature.com/documents/3451/version/1
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SBML Level 3 Hierarchical Model Composition Nature Precedings
Lucian P. Smith; Michael Hucka.
A new proposal for incorporating modularity (or 'model composition') into SBML Level 3.
Tipo: Presentation Palavras-chave: Biotechnology; Bioinformatics; Data Standards.
Ano: 2010 URL: http://precedings.nature.com/documents/5133/version/1
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BBSRC Data Sharing Policy Nature Precedings
Amanda Collis; David McAllister; Michael Ball.
BBSRC recognizes the importance of contributing to the growing international efforts in data sharing. BBSRC is committed to getting the best value for the funds we invest and believes that making research data more readily available will reinforce open scientific inquiry and stimulate new investigations and analyses. BBSRC supports the view that data sharing should be led by the scientific community and driven by scientific need. It should also be cost effective and the data shared should be of the highest quality. Members of the community are expected and encouraged to practice and promote data sharing, determine standards and best practice, and create a scientific culture in which data sharing is embedded.
Tipo: Manuscript Palavras-chave: Biotechnology; Developmental Biology; Genetics & Genomics; Immunology; Microbiology; Molecular Cell Biology; Neuroscience; Pharmacology; Bioinformatics; Plant Biology; Evolutionary Biology; Data Standards.
Ano: 2011 URL: http://precedings.nature.com/documents/6015/version/1
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A stable backbone for the fungi Nature Precedings
Ingo Ebersberger; Matthias Gube; Sascha Strauss; Anne Kupczok; Martin Eckart; Kerstin Voigt; Erika Kothe; Arndt von Haeseler.
Fungi are abundant in the biosphere. They have fascinated mankind as far as written history goes and have considerably influenced our culture. In biotechnology, cell biology, genetics, and life sciences in general fungi constitute relevant model organisms. Once the phylogenetic relationships of fungi are stably resolved individual results from fungal research can be combined into a holistic picture of biology. However, and despite recent progress, the backbone of the fungal phylogeny is not yet fully resolved. Especially the early evolutionary history of fungi and the order or below-order relationships within the ascomycetes remain uncertain. Here we present the first phylogenomic study for a eukaryotic kingdom that merges all publicly available fungal...
Tipo: Manuscript Palavras-chave: Ecology; Bioinformatics.
Ano: 2009 URL: http://precedings.nature.com/documents/2901/version/1
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MIF-AMPK cascades Nature Precedings
Heng Ma; Jingying Wang; Erin Lane; Lin Leng; Wenkui Wang; Jun Ren; Richard Bucala; Ji Li.
Withdrawn for publication
Tipo: Manuscript Palavras-chave: Molecular Cell Biology; Pharmacology.
Ano: 2009 URL: http://precedings.nature.com/documents/2466/version/2
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Application of a periodic table for the genetic code to influenza A/H3N2 virus Nature Precedings
Susumu Morimoto.
If biologists can utilize a table to have access to biological phenomena in the manner analogous to the periodic table for chemical elements, they may get hold of a directing post in life science. Currently the mutational rule of influenza viruses have remained perplexed and to reveal it should be now desired when avian influenza virus has just then threatened human beings. Here I examine the applicability of a novel periodic table for the genetic code to influenza A/H3N2 virus, while presenting two rules regarding single point mutations of its virus hemagglutinin gene. One rule is that non-synonymous single point mutations are intimately associated with the first or second base replacements between four groups (5, 6, 9, and 10) in the periodic table....
Tipo: Manuscript Palavras-chave: Chemistry; Genetics & Genomics; Evolutionary Biology.
Ano: 2007 URL: http://precedings.nature.com/documents/428/version/1
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Microbial responses to changes in land use Nature Precedings
Rebecca C. Mueller; Klaus Nüsslein; Jorge Rodrigues; James Tiedje; Vivian Pellizari; Brigitte Feigl; Brendan Bohannan.
Background/Question/Methods
Land use change is one of the greatest threats to biodiversity worldwide. This is especially true for land use change that results in the destruction of intact forest, or "deforestation”. Deforestation is causing a loss of biological diversity on an unprecedented scale, especially in the Tropics. It is unclear how the majority of the biodiversity on Earth – microbial biodiversity – is responding to these extraordinary rates of deforestation. I will provide an overview of our current understanding of microbial responses to deforestation. I will focus, as an example, on our current research regarding the effects of deforestation on the diversity of arbuscular mycorrhizal...
Tipo: Poster Palavras-chave: Ecology; Microbiology; Earth & Environment.
Ano: 2011 URL: http://precedings.nature.com/documents/5505/version/1
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Lethal and sublethal effects of polybrominated diphenyl ethers (PBDEs) for turbot (_Psetta maxima_) early life stage (ELS) Nature Precedings
Lazhar Mhadhbi; Jose Fumega; Moncef Boumaiza; Ricardo Beiras.
A new toxic menace, polybrominated diphenyl ethers (PBDEs), is being detected in the aquatic environment all over the world. The environmental presence of PBDEs and its entry into the environment as BDE-47 and -99 make quality aquatic toxicity data necessary to assess the aquatic hazard risk of PBDs. This study examines the effects of three PBDE-47 and -99 on embryo and larval stages of the marine flatfish turbot (_Psetta maxima_). The acute toxicity of the three PBDEs was examined and NOEC, LOEC, LC10 and LC50 were calculated. All tested compounds caused lethal as well as nonlethal malformations during embryo development. The effects of PBDEs in the different life stages of turbot were analysed. PBDEs seemed to be teratogenic at concentrations higher than...
Tipo: Manuscript Palavras-chave: Chemistry; Ecology; Earth & Environment.
Ano: 2010 URL: http://precedings.nature.com/documents/4656/version/1
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Coexistence of grazed and grazing excluded patches increases plant and invertebrate diversity in a Mediterranean oak woodland Nature Precedings
Miguel M. N. Bugalho; Lecomte Xavier; Maria Caldeira; Merícia Gonçalves; Manuela Branco.
Grazing is a global, dominant land use affecting biodiversity and ecosystem processes. In Mediterranean ecosystems grazing is a major ecological and evolutionary driver but, surprisingly, there is little information on the use of grazing as a tool to manage biodiversity in these ecosystems. We conducted an experiment to assess if the coexistence of grazing and grazing-excluded patches would increase plant and invertebrate diversity in a Mediterranean evergreen oak woodland. Plant community traits were different between treatments. Plant and litter biomass was higher, and the proportion of bare ground was lower, in grazing-excluded plots. Grazing affected functional diversity with legumes, invertebrate detritivores and sup sucking insects being more...
Tipo: Poster Palavras-chave: Ecology.
Ano: 2010 URL: http://precedings.nature.com/documents/5194/version/1
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LexOWL: A Bridge from LexGrid to OWL Nature Precedings
Cui Tao; Jyotishman Pathak; Harold Solbrig; Christopher Chute.
The Lexical Grid project is an on-going community driven initiative that provides a common terminology model to represent multiple vocabulary and ontology sources as well as a scalable and robust API for accessing such information. In order to add more powerful functionalities to the existing infrastructure and align LexGrid more closely with various Semantic Web technologies, we introduce the LexOWL project for representing the ontologies modeled within the LexGrid environment in OWL (Web Ontology Language). The crux of this effort is to create a “bridge” that functionally connects the LexBIG (a LexGrid API) and the OWL API (an interface that implements OWL) seamlessly. In this paper, we discuss the key aspects of designing and...
Tipo: Presentation Palavras-chave: Bioinformatics.
Ano: 2009 URL: http://precedings.nature.com/documents/3469/version/1
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TMEPAI, a transmembrane TGF-β-inducible protein, sequesters Smad proteins in TGF-β signaling Nature Precedings
Susumu Itoh; Yukihide Watanabe; Kiyotoshi Satoh; Masako Inamitsu; Liang Shi; Naoko Nakano; Aya Tanaka; Eliza Wiercinska; Hiroshi Shibuya; Peter ten Dijke; Mitsuyasu Kato.
Transforming growth factor-[beta] (TGF-[beta]) is a multifunctional cytokine of key importance for controlling embryogenesis and tissue homeostasis. How TGF-[beta] signals are attenuated and terminated is not well understood. Here, we show that TMEPAI, a direct target gene of TGF-[beta] signaling, antagonizes TGF-[beta] signaling by interfering with TGF-[beta] type I receptor (T[beta]RI)-induced R-Smad phosphorylation. TMEPAI can directly interact with R-Smads via a Smad interaction motif (SIM). TMEPAI competes with Smad anchor for receptor activation (SARA) for R-Smad binding, thereby sequestering R-Smads from T[beta]RI kinase activation. In mammalian cells, ectopic expression of TMEPAI inhibited TGF-[beta]-induced PAI-1 production, whereas specific...
Tipo: Manuscript Palavras-chave: Cancer; Molecular Cell Biology.
Ano: 2007 URL: http://precedings.nature.com/documents/1403/version/1
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