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| Petr Lokhov. |
| Immunization with cancer cells is of great demand in anti-cancer therapy. However, current cellular vaccines are inefficient and there are questions regarding their overall safety. We report a simple and straightforward approach for improving of cellular cancer vaccines. Through treatment of cancer cell cultures with purified protease, it is possible to make preparations of cell-surface antigens that are free of intracellular content and contain two orders-of-magnitude less protein than the whole lysate of an equivalent number of cancer cells. Despite this difference in total protein content, protease-generated preparations stimulate anti-cancer responses from immune cells better those stimulated with cancer cells themselves. The composition of collected... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Pharmacology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4356/version/1 |
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| Piacentini Lucia; Laura Fanti; Rodolfo Negri; Valerio Del Vescovo; Alessandro Fatica; Sergio Pimpinelli. |
| HP1 is a well known conserved protein involved in heterochromatin formation and gene silencing in different species including humans1-4. A general model has been proposed for heterochromatin formation and epigenetic gene silencing in different species that implies an essential role for HP1. According to the model, histone methyltransferase enzymes (HMTases) methylate the histone H3 at lysine 9 (H3-MeK9), creating selective binding sites for itself and the chromodomain of HP15. This complex is thought to form a higher order chromatin state that represses gene activity. It has also been found that HP1 plays a role in telomere capping6. Surprisingly, recent data have suggested an association of HP1 in gene activity7-10 but the nature of this interaction is... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Molecular Cell Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2687/version/1 |
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| Dong Xiao; Enyuan Wang. |
| Microbially Enhance Coalbed Methane technology is used to improve methane content in coalbeds. The methanogen consortium metabolism process is the basic avenue for MECoM to yield methane with some organic compounds in coal. Detailed information about the metabolism process is needed in studying the microbial consortium mechanism. Traditional gas analysis is limited by gas source and test complexity. The real time monitor with Infrared gas sensor breaks the gas analysis limitation. It shows much more detailed information than the traditional analysis method including information about microbial growth factor changes, reaction speeds for environmental changes, the detailed relationship between CH4 and CO2, methane yield and the consumption factor by real... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Microbiology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5426/version/1 |
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| Sierra Rayne; Kaya Forest. |
| Perfluoroalkyl aldehydes (PFAlds) and n:2 fluorotelomer aldehydes (FTAlds) are degradation products of precursor compounds that include fluorotelomer alcohols, iodides, acrylates, phosphate esters, and other derivatives, as well as hydrofluorocarbons and hydrochlorofluorocarbons. The SPARC software program and comparative density functional theory (DFT) calculations were used to investigate the aqueous phase hydration equilibrium constants (K~hyd~) of PFAlds and FTAlds. DFT studies suggest that all PFAlds will be dominantly present as the hydrated form in aqueous solution. While SPARC correctly estimates the K~hyd~ for the C~1~ PFAld, it appears to incorrectly predict a large decline in K~hyd~ (particularly between C~1~ and C~2~) with increasing... |
| Tipo: Manuscript |
Palavras-chave: Chemistry; Earth & Environment. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4520/version/1 |
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| Vivek Bajpai; Yamini Singh Sisodia; Pallavi Sharma; Pankaj Jain. |
| Sewage is waste suspended in water that is intended to flow away from a community. Sewage effluent contains a wide range of pathogenic microorganisms which may pose health hazards to the human population when they are discharged into the environment. This study is carried out to systematically examine the pathogenic microorganisms in sewage samples isolated from the Shekhawati region of Rajasthan. For this purpose a survey was carried out at the Sewage Treatment plant of the Mody Institute of Technology & Science, Laxmangarh, Sikar. In this survey we isolated 26 bacterial strains and identified them using biochemical and molecular methods. Different biochemical tests were performed during the study and in molecular identification by DNA isolation,... |
| Tipo: Poster |
Palavras-chave: Microbiology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6677/version/1 |
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| Octavio Martinez; Humberto Reyes-Valdés. |
| The transcriptome is a set of genes transcribed in a given tissue under specific conditions and can be characterized by a list of genes with their corresponding frequencies of transcription. Transcriptome changes can be measured by counting gene tags from mRNA libraries or by measuring light signals in DNA microarrays. Recently we proposed an approach to define and estimate the diversity and specialization of transcriptomes and gene specificity. This approach can be useful for the determination and measure of transcriptional networks. We defined transcriptome diversity as the Shannon entropy of its frequency distribution. Gene specificity is defined as the mutual information between the tissues and the corresponding transcript, allowing detection of either... |
| Tipo: Poster |
Palavras-chave: Genetics & Genomics; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3012/version/1 |
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| Ricardo Franco-Duarte; Lan Umek; Blaz Zupan; Dorit Schuller. |
| The objective of the present study was to compare genetic and phenotypic variation of 103 Saccharomyces cerevisiae strains isolated from winemaking environments. We used bioinformatics approaches to identify genetically similary strains with specific phenotypes and to estimate a strain's biotechnological potential. 
A S. cerevisiae collection, comprising 440 strains that were obtained from winemaking environments in Portugal has been constituted during the last years. All strains were genetically characterized by a set of eleven highly polymorphic microsatellites and showed unique allelic combinations. Using neural networks, a subset of 103 genetically most diverse strains was chosen for phenotypic analysis, that included growth... |
| Tipo: Poster |
Palavras-chave: Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2288/version/1 |
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| Gabriel Leitner; Ana-Maria Anug; Uzi Merin; Nissim Silanikove. |
| *Background*
Repeated research findings over the last 4 decades show that involution of mammary glands in dairy cows did not regress to same extend as that noticed in other mammalian species.

*Methodology/Principal Findings*
We took an advantage of a rare event in the normal modern dairy farming: A cow that was false-positively identified as being pregnant was "dried up" (i.e., induced into involution) conventionally about 60 before her expected parturition. This cow was culled, and samples of her mammary gland tissue were examined for gross histology. In this study we demonstrate for the first time that modern dairy cow may undergo extensive obliteration of the... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Developmental Biology; Immunology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/846/version/2 |
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| Malay Bhattacharyya; Sanghamitra Bandyopadhyay. |
| Simultaneous overexpression or underexpression of multiple genes, used in various forms as probes in the high-throughput microarray experiments, facilitates the identification of their underlying functional proximity. This kind of functional associativity (or conversely the separability) between the genes can be represented proficiently using co-expression networks. The extensive repository of diversified microarray data encounters a recent problem of multi-experimental data integration for the aforesaid purpose. This paper highlights a novel integration method of gene co-expression networks, based on the search for their consensus network, derived from diverse microarray experimental data for the purpose of clustering. The proposed methodology avoids the... |
| Tipo: Presentation |
Palavras-chave: Bioinformatics. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7126/version/1 |
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| Jorge Serrador; F. Owen Black; Todd Schlegel; Scott Wood. |
| Humans demonstrate a number of unique adaptations that allow the maintenance of blood pressure and brain blood flow after transition to the upright position. While these adaptations maintain heart-level mean arterial pressure similar to supine values, the brain remains ~30 cm above the heart, resulting in a ~25% decrease in perfusion pressure. To maintain brain blood flow, the cerebral vessels must dilate in response to this change in position. While several physiological systems are involved in adaptation to the upright posture, including cerebral autoregulation, the unique role that the vestibular system plays in helping to maintain brain blood flow is just beginning to be elucidated. Since the vestibular system not only assists in balance control and... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2413/version/1 |
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| Somnath Jha; Vinay Kumar Sehgal; Ramesh Raghava. |
| The Northeast monsoon (NEM) precipitation has undergone a significant change in pattern over the last half century. The changing pattern of climatic variables over the moisture source (i.e. west Pacific High) and the heat sink (Siberian High) of the winter monsoon dynamics over time has caused a shift in the pattern of NEM precipitation over the southern peninsular region of India. There is no significant trend in NEM precipitation in the Indian region whereas the surface temperature has a significantly increasing trend over India during the NEM season. There is no significant trend in outgoing long wave radiation (OLR) of Siberian High (SH) while the west Pacific High (WPH) has a significantly increasing trend in OLR. Surface pressure of both the SH... |
| Tipo: Presentation |
Palavras-chave: Earth & Environment. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5899/version/1 |
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| Robert Buels; Dave Clements. |
| The Generic Model Organism Database (GMOD, "http://gmod.org":http://gmod.org) project provides interoperable, open source software tools for managing, visualizing and annotating biological data. GMOD is also a community of people addressing common challenges with biological data. Some well known software in GMOD includes GBrowse and JBrowse for genome browsing, Apollo for genome annotation, Chado for managing data, CMap for comparative map viewing, Galaxy for workflow creation and persistence, and BioMart for warehousing biological data.

This talk will focus on three areas of particular interest to iEvoBio participants. 
1) GBrowse_syn comparative genomics viewer
2)... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics; Evolutionary Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4611/version/1 |
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| John R. Skoyles. |
| 1.	After weaning, human hunter-gatherer juveniles receive substantial (≈3.5-7 MJ day^-1^), extended (≈15 years) and reliable (kin and nonkin food pooling) energy provision.
2.	The childhood (pediatric) and the adult human brain takes a very high share of both basal metabolic rate (BMR) (child: 50-70%; adult: ≈20%) and total energy expenditure (TEE) (child: 30-50%; adult: ≈10%).
3.	The pediatric brain for an extended period (≈4-9 years-of-age) consumes roughly 50% more energy than the adult one, and after this, continues during adolescence, at a high but declining rate. Within the brain, childhood cerebral gray matter has an even higher 1.9 to... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Neuroscience; Evolutionary Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1856/version/2 |
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| Gustavo Rohenkohl; Anna Dal Molin; Anna C. Nobre. |
| Time is an essential dimension of our experience, framing human behaviour at scales ranging from the millisecond organization of motor actions to circadian rhythms cycle, and beyond. Nevertheless, the mechanisms by which the brain keeps time and uses temporal information to organise behaviour remain unknown. Whereas the principles of the organisation of spatial cognition in the human brain are emerging, the same is not true for temporal cognition. The current study tested the influence of temporal expectations on attentional orienting to moving targets. In this task, a ball appeared at the left side of a screen and moved across the screen in steps following either a regular or irregular rhythm. After reaching an occluding band, the ball was temporarily... |
| Tipo: Poster |
Palavras-chave: Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2956/version/1 |
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| John Wilbanks. |
| Openness at the layer of cultural works and data is the key to the data infrastructure we need to accelerate science. This article lays out three key elements of data infrastructure - collaboration, classification, and openness - which draw us inevitably towards the long-claimed, but rarely-achieved, goal of the scientific method: to make claims that are reproducible under similar circumstances by someone other than the claimant, to be reproducible. |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics; Data Standards. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6032/version/1 |
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| Registros recuperados: 3.453 | |
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