SABIIA - Sistema Aberto e Integrado de Informação em Agricultura (Sabiia)

Codes,Liana; Matos,Ludmilla; Paraná,Raymundo.

The main injury caused by hepatitis C virus is the hepatic fibrosis, as a result of a chronic inflammatory process in the liver characterized by the deposit of components from the extracellular matrix. The fibrosis development leads to the modification of the hepatic architecture, of the hepatocellular function and to irregularities in the microcirculation. The tissue remodeling process observed in fibrosis has stellate cells, located at the space of Disse, as main acting agents. These cells, in response to a harmful stimulus, undergo phenotypic changes from non-proliferating cells to proliferating cells that express a- smooth-muscle actin (a-SMA), a process called as transdifferentiation. There are evidences that the oxidative stress is involved in the...

Congenital toxoplasmosis transmitted by human immunodeficiency-virus infected women

Palavras-chave: Hepatitis C; Fibrosis; Estrogen; Benefits.

Ano: 2007

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000300014

Azevedo,Kátia Martins Lopes de; Setúbal,Sérgio; Lopes,Vania Gloria Silami; Camacho,Luiz Antônio Bastos; Oliveira,Solange Artimos de.

We report the occurrence of congenital toxoplasmosis in three infants born to HIV infected women who had high anti-toxoplasma IgG and negative IgM during pregnancy. We briefly reviewed available literature and discussed the possible transmission mechanisms of congenital toxoplasmosis among HIV infected pregnant women. Serum samples were tested for Toxoplasma gondii IgM and IgG antibodies using commercial enzyme immunoassay and IgG-avidity tests. In the first case, fetal death occurred at 28th week of gestation. In the second case, congenital toxoplasmosis was diagnosis at 6th month of life; and in the third case, an HIV-infected newborn, congenital toxoplasmosis was asymptomatic. These cases point out to the possibility of enhanced maternal-fetal...

Autoimmune features caused by dengue fever: a case report

Palavras-chave: Congenital toxoplasmosis; Human immunodeficiency-virus; Prevention; AIDS.

Ano: 2010

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200014

Jardim,Denis Leonardo Fontes; Tsukumo,Daniela Miti Lemos; Angerami,Rodrigo N.; Carvalho Filho,Marco Antonio de; Saad,Mário José Abdalla.

Dengue virus is the most important mosquito-borne viral disease in the world. Co-circulation of the four types of dengue viruses and expansion of dengue epidemic gave rise to infection enhancement and a big expansion of clinical aspects of the disease. Herein we report a case of a 25-year-old white woman with dengue fever and numerous associated autoimmune features. Our patient had proteinuria, an extensive right pleural effusion, a thin pericardial effusion and ascites. She had a low C3 level and positive antinuclear antibody; cryoglobulins were also positive. The numerous autoimmune features of this patient were a diagnostic challenge, since she was a young woman and could be easily mistaken for a rheumatologic patient in a newly open disease. Dengue...

Comparison of multiplex PCR with serogrouping and PCR-RFLP of fliC gene for the detection of enteropathogenic Escherichia coli (EPEC)

Palavras-chave: Dengue; Autoimmunity; Hematologic diseases.

Ano: 2012

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100018

Bouzari,Saeid; Aslani,Mohammad M; Oloomi,Mana; Jafari,Anis; Dashti,Amir.

Enteropathogenic Escherichia coli (EPEC) comprise one of the six categories of diarrhoeagenic E. coli (DEC). EPEC is subgrouped into typical (tEPEC) and atypical (aEPEC). The identification of DEC cannot be based only on cultural and biochemical criteria, since they are indistinguishable from the non-pathogenic E. coli commonly found in human feces. Several PCR methods, with both single and multiple target genes, have been reported for detecting the different DEC pathotypes. In the present study five hundred E. coli isolates from children with diarrhea were subjected into multiplex PCR. Furthermore the strains were typed serologically with O antisera and their fliC gene was characterized by PCR-RFLP. The results obtained revealed that overall 41 (8.2%)...

A case of myopericarditis associated to Campylobacter jejuni infection in the southern hemisphere

Palavras-chave: Diarrhea; Enteropathogenic Escherichia coli; Polymerase chain reaction.

Ano: 2011

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400011

Fica,Alberto; Seelmann,Daniela; Porte,Lorena; Eugenin,Daniela; Gallardo,Ricardo.

Myopericarditis is an infrequent complication of acute diarrheal illness due to Campylobacter jejuni, and it has been mainly reported in developed nations. The first case detected in Chile - an upper-middle income country -, that is coincidental with the increasing importance of acute gastroenteritis associated to this pathogen, is described. Recognition of this agent in stools requires special laboratory techniques not widely available, and it was suspected when a young patient presented with acute diarrhea, fever, and chest pain combined with electrocardiogram (EKG) abnormalities and elevated myocardial enzymes. C. jejuni myopericarditis can easily be suspected but its detection requires dedicated laboratory techniques.

Current status and recommendations on methicillin-resistant Staphylococcus aureus infection in Latin America

Palavras-chave: Campylobacter jejuni; Myocarditis; Infectious diarrheal disease.

Ano: 2012

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300014

Gotuzzo,Eduardo.

Seronegative cat-scratch disease diagnosed by PCR detection of Bartonella henselae DNA in lymph node samples

Ano: 2010

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000800002

Chondrogiannis,Konstantinos; Vezakis,Antonios; Derpapas,Michael; Melemeni,Aikaterini; Fragulidis,Georgios.

Cat scratch disease (CSD), the typical clinical manifestation of Bartonella infections usually follows a typical benign self-limited course. Nevertheless, a variety of unusual clinical manifestations and confusing imaging features can lead to misinterpretations and render the disease a diagnostic dispute. Routine laboratory tests exhibit varying reported sensitivity and are usually unhelpful in diagnosis, as serology fails in terms of specificity and/or sensitivity. Herein we report a case of seronegative Bartonella infection presenting as symptomatic suppurative lymphadenitis with abscess formation, which was surgically drained. Diagnosis was established by PCR analysis from lymph nodes samples obtained during the procedure. PCR detection of specific DNA...

An adherence trilogy is essential for long-term HAART success

Palavras-chave: Polymerase chain reaction; Cat-scratch disease; Bartonella henselae.

Ano: 2012

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100019

Garcia,Rosa; Schooley,Robert T.; Badaró,Roberto.

Adherence is the milestone of a successful therapy. Over the last decade several authors have addressed the importance of adherence for optimal results of antiretroviral (ARV) therapy. Many health care systems are investing substantial resources to make available contemporary antiretroviral therapy. Despite the large investment in medications, insufficient investments have been made into an integrated adherence component to maximize the impact of these medications. Adherence, unlike drug therapy, cannot be defined as a single method with a defined prescription or formula. Instead, it is the result of a complex interaction between the patient, a prescribed medication and the health system. Many reports are available analyzing each of these components. We...

Risk of coronary artery disease in individuals infected with human immunodeficiency virus

Palavras-chave: Adherence; Compliance; Antiretroviral therapy.

Ano: 2003

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500005

Vilela,Felippe Dantas; Lorenzo,Andrea Rocha de; Tura,Bernardo Rangel; Ferraiuoli,Giovanna Ianini; Hadlich,Marcelo; Barros,Marcelo Viana de Lima; Lima,Ana Beatriz Ribeiro; Meirelles,Vanderson.

Current treatment for human immunodeficiency virus (HIV) infection has improved survival and allowed infected patients to develop atherosclerotic coronary artery disease (CAD). Specific strategies to reduce cardiovascular risk in the infected population have not been developed. It is necessary to know the magnitude of cardiovascular risk in this population. OBJECTIVES: This study aimed to assess cardiovascular risk using a well-known clinical score and to investigate coronary artery calcium scoring (CACS) in this population. METHODS: This was a cross-sectional study. Adults with HIV infection were studied. Demographic, clinical and anthropometric data, serum glucose and lipids were obtained. Cardiovascular risk was calculated through Framingham risk score...

Malaria in Southern Brazil: a potential threat for a non-endemic region

Palavras-chave: Coronary artery disease; HIV; Cardiovascular diseases; HIV protease inhibitors.

Ano: 2011

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600004

Moreira,Daisson L.; Cardoso,Jader C.; Deboni,Sandra C.; Falci,Diego R..

Tipo: Info:eu-repo/semantics/other

Ano: 2017

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600678

Adherence to guidelines for surgical antibiotic prophylaxis: a review

Gouvêa,Marise; Novaes,Cristiane de Oliveira; Pereira,Daniele Masterson Tavares; Iglesias,Antonio Carlos.

ABSTRACTCONTEXT AND OBJECTIVES: The appropriate use of antibiotic prophylaxis in the perioperative period may reduce the rate of infection in the surgical site. The purpose of this review was to evaluate adherence to guidelines for surgical antibiotic prophylaxis.METHODS:The present systematic review was performed according to the Cochrane Collaboration methodology. The databases selected for this review were: Medline (via PubMed), Scopus and Portal (BVS) with selection of articles published in the 2004-2014 period from the Lilacs and Cochrane databases.RESULTS:The search recovered 859 articles at the databases, with a total of 18 studies selected for synthesis. The outcomes of interest analyzed in the articles were as follows: appropriate indication of...

Local circulating clones of Staphylococcus aureus in Ecuador

Palavras-chave: Antibiotic prophylaxis; Antimicrobial prophylaxis; Guideline adherence; Surgical patient.

Ano: 2015

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500517

Zurita,Jeannete; Barba,Pedro; Ortega-Paredes,David; Mora,Marcelo; Rivadeneira,Sebastián.

ABSTRACT The spread of pandemic Staphylococcus aureus clones, mainly methicillin-resistant S. aureus (MRSA), must be kept under surveillance to assemble an accurate, local epidemiological analysis. In Ecuador, the prevalence of the USA300 Latin American variant clone (USA300-LV) is well known; however, there is little information about other circulating clones. The aim of this work was to identify the sequence types (ST) using a Multiple-Locus Variable number tandem repeat Analysis 14-locus genotyping approach. We analyzed 132 S. aureus strains that were recovered from 2005 to 2013 and isolated in several clinical settings in Quito, Ecuador. MRSA isolates composed 46.97% (62/132) of the study population. Within MRSA, 37 isolates were related to the...

Assessing new strategies for TB diagnosis in low- and middle-income countries

Palavras-chave: MRSA; MSSA; Epidemic clones; MLVA typing.

Ano: 2016

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600525

Kritski,Afrânio; Fujiwara,Paula I.; Vieira,Maria Armanda; Netto,Antonio Ruffino; Oliveira,Martha Maria; Huf,Gisele; Squire,S. Bertel.

In this manuscript, we report the current situation of tuberculosis globally and in Brazil, the need for new strategies toward tuberculosis control, focusing on new diagnostic technologies. Critical comments are given on the state of the art regarding the evaluation of new health technologies, degree of scientific evidence needed, evaluation of clinical impact, cost-effectiveness of incorporation into the health system and the social impact.

Emerging and reemerging diseases in Brazil: data of a recent history of risks and uncertainties

Palavras-chave: Tuberculosis; Diagnostics; Impact; Evidence; Policy; Innovation; Regulatory agency.

Ano: 2013

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200015

Cardoso,Telma Abdalla de Oliveira; Navarro,Marli B.M. de Albuquerque.

This article discusses the emergence and reemergence of infectious diseases on the basis of a review of the literature. It shows the critical situations faced worldwide and in special Brazil's susceptible position due to its complexity, mostly represented by the mega-biodiversity of the country and its socio-economic problems directly affecting public health. It approaches the discussions around the issue with emphasis to the recommended investments in the health sector, directed to surveillance and to strengthening the epidemiological, laboratorial and clinical bases and centered on preventive and control measures in the affected areas including Biosafety.

Description of a widespread outbreak of aseptic meningitis due to echovirus 30 in Rio de Janeiro state, Brazil

Palavras-chave: Emerging and reemerging infectious diseases; Epidemiology; Public health; Biosafety.

Ano: 2007

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400013

Pinto Junior,Vitor Laerte; Rebelo,Maria Cristina; Costa,Eliane Veiga da; Silva,Edson Elias da; Bóia,Márcio Neves.

Echovirus 30 belongs to the genus Enterovirus and is widely associated with aseptic meningitis (AM) outbreaks. In Brazil epidemics due to this serotype were reported in several states but in Rio de Janeiro, before this study, it was only involved in sporadic episodes. We retrospectively collected data from AM notifications charts and enterovirus isolation database from Rio de Janeiro State Health Department (RJSHD) and Enterovirus Reference Laboratory in the year of 2005. An outbreak of AM was detected during March, April and May associated with a high cell culture isolation rate for echovirus 30 (17.4%). Male children with ages varying from 1 to 9 years were more affected. Of the 22 patients with confirmed echovirus 30 disease, clinical information was...

Bezafibrate for the treatment of hypertriglyceridemia in HIV1-infected patients on highly active antiretroviral therapy

Palavras-chave: Aseptic meningitis; Enterovirus; Echoviruses; Cerebrospinal fluid.

Ano: 2009

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500011

Geraix,Juliana; Souza,Micheli Evangelista de; Delatim,Francieli Cristina; Pereira,Paulo Câmara Marques.

The use of highly active antiretroviral therapy (HAART) in HIV-infected patients has been associated with the development of risk factors for cardiovascular diseases (CD) including dyslipidemia and insulin resistance, hypertriglyceridemia being the most frequent metabolic disturbance in these patients. Fibrates are indicated when hypertriglyceridemia is accentuated and persists for over six months. We evaluated the efficacy and safety of bezafibrate for the treatment of hypertriglyceridemia in HIV-infected individuals on HAART. All patients received 400mg/day of bezafibrate and were evaluated three times: Mo (pre-treatment), M1 (one month after treatment), and M2 (six months after treatment). Fifteen adult individuals, eight males and seven females with...

Xerostomy, dental caries and periodontal disease in HIV+ patients

Palavras-chave: HIV; HAART; Hypertriglyceridemia; Bezafibrate.

Ano: 2006

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300001

Cavasin Filho,Julio César; Giovani,Élcio Magdalena.

We studied xerostomy and its correlation with periodontal and dental cavity diseases in HIV patients, through measurement of salivary flow and through variables such as saliva buffer capacity, salivary pH, periodontal index, MDF index, dental carie risk and risk of periodontal disease. One hundred patients were analyzed. They were distributed into two groups: Group I (test) - 50 patients evidently HIV+, from whom information was collected and analyzed regarding age, gender, skin color, habits, general and oral diseases, levels of T-CD4 lymphocytes, viral load and highly active antiretroviral therapy (HAART); and Group II - (control) 50 HIV- patients, from whom information was collected and analyzed regarding age, gender, skin color, habits, general and...

Successful treatment of vancomycin-resistant enterococcus ventriculitis in a child

Palavras-chave: Acquired Immune Deficiency Syndrome; HIV; Salivary flow; Xerostomy; Dental cavity; Periodontal disease.

Ano: 2009

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100005

Silva,Paulo Sérgio Lucas da; Monteiro Neto,Henrique; Sejas,Lílian Márcia.

Enterococci are an uncommon cause of CNS infection. A 20 month-old boy, diagnosed with hydrocephalus with ventriculoperitoneal shunt and history of lengthy hospitalization and use of wide spectrum antibiotics, was admitted to the pediatric intensive care unit diagnosed with ventriculitis. On the 14th day of empirical antibiotic therapy (vancomycin and meropenem) the child presented fever while the CSF sample culture evidenced vancomycin-resistant Enterococcus faecium. The patient received intravenous linezolid achieving cerebrospinal fluid sterilization. Conclusion: Intravenous linezolid appears to be a safe and effective therapy for vancomycin-resistant enterococcus ventriculoperitoneal shunt infection.

HIV subtype, epidemiological and mutational correlations in patients from Paraná, Brazil

Palavras-chave: Vancomycin; Resistance; Treatment.

Ano: 2007

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200027

Silva,Monica Maria Gomes da; Telles,Flavio Queiroz; Cunha,Clovis Arns da; Rhame,Frank S.

OBJECTIVE: Analyze patients with HIV infection from Curitiba, Paraná, their epidemiological characteristics and HIV RAM. METHODS: Patients regularly followed in an ID Clinic had their medical data evaluated and cases of virological failure were analyzed with genotypic report. RESULTS: Patients with complete medical charts were selected (n = 191). Demographic and clinical characteristics were compared. One hundred thirty two patients presented with subtype B infection (69.1%), 41 subtype C (21.5%), 10 subtype F (5.2%), 7 BF (3.7%) and 1 CF (0.5%). Patients with subtype B infection had been diagnosed earlier than patients with subtype non-B. Also, subtype B infection was more frequent in men who have sex with men, while non-B subtypes occurred more...

Characterization of the Brazilian endemic clone of methicillin-resistant Staphylococcus aureus (MRSA) from hospitals throughout Brazil

Palavras-chave: HIV; Aids; Subtypes; Subtype B; Subtype non-B; Genetic diversity; Antiretroviral; Brazil.

Ano: 2010

URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500012

Oliveira,Geraldo A.; Faria,Juarez B.; Levyand,Carlos E.; Mamizuka,Elsa M..

The objective of this study was to characterize patterns of the Brazilian endemic clone of methicillin-resistant Staphylococcus aureus (MRSA) from hospitals throughout Brazil. We studied 83 MRSA strains isolated from patients hospitalized in 27 public and private hospitals in 19 cities located in 14 Brazilian states from September, 1995, to June, 1997. The MRSA strains were typed using antibiograms, bacteriophage typing and pulsed field gel electrophoresis (PFGE). The analysis of genomic DNA by PFGE showed that 65 isolates presented the same PFGE pattern. This pattern was present in all of the hospitals studied indicating the presence of an endemic MRSA clone widely disseminated throughout Brazilian hospitals (BEC). All isolates belonging to the BEC proved...