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	Provedor de dados Infoteca-e (3) Autor LACERDA, A. E. B. de (3) NIMMO, E. R. (3) CARVALHO, A. I. de (2) ROSOT, M. A. D. (2) ALBERGONI, L. (1) FARIA, B. S. (1) GARRASTAZU, M. C. (1) GOMES, E. P. (1) GOMES, F. B. (1) GOMES, T. (1) KELLERMANN, B. (1) LAVERDI, R. (1) LUIZ, R. G. (1) MATTOS, P. P. de (1) NOGUEIRA, J. F. M. M. (1) OLIVEIRA, Y. M. M. de (1) Mais... Palavra-chave Agroecologia (2) Erva-mate (2) Ilex Paraguariensis (2) Amazonia. (1) Botânica (1) Espécie nativa (1) Identificação. (1) Manejo florestal. (1) Sustentabilidade (1) Mais... Tipo do documento Livros (2) Documentos (INFOTECA-E) (1) Ano 2022 (2) 2010 (1) País Brazil (3) Idioma Português (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 30 Primeira ... 1 2 ... Última Correlation of cadherin-17 protein expression with clinicopathological features and prognosis of patients with sporadic gastric cancer BJMBR Meng,W.; Gu,T.; Gao,L. M.; Zong,Z. G.; Meng,L.; Fu,Z. Z.; Guo,L.. This study aimed to explore the correlations between cadherin-17 (CDH17) protein expression and the clinicopathological features and prognosis of patients with sporadic gastric cancer (GC). Nine relevant studies of 1,960 patients were identified using electronic database searches supplemented with a manual search in strict accordance with inclusion and exclusion criteria. Statistical analyses were conducted using STATA 12.0 statistical software. Relative risks and 95% confidence intervals were determined, and Z test was used to measure the significance of the overall effect size. A total of nine eligible cohort studies were included in this meta-analysis. The expression of CDH17 in patients with diffuse GC was significantly higher than in those with... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cadherin-17; Gastric cancer; Clinicopathological features; Prognosis; Meta-analysis; Cohort study. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201077 MicroRNA-383-5p inhibits the progression of gastric carcinoma via targeting HDAC9 expression BJMBR Xu,Gang; Li,Na; Zhang,Yan; Zhang,Jinbiao; Xu,Rui; Wu,Yanling. MicroRNAs (miRNAs), as post-transcriptional regulators, have been reported to be involved in the initiation and progression of various types of cancer, including gastric cancer (GC). The present study aimed to investigate the role of miR-383-5p in gastric carcinogenesis. Cell viability was analyzed using CCK-8 kit. Annexin V-fluorescein isothiocyanate/propidium iodide double staining was used to evaluate cell apoptosis. The expression levels of miR-383-5p and histone deacetylase 9 (HDAC9) mRNA in GC tissues and cell lines were analyzed using RT-qPCR. The protein expression of HDAC9 was detected by western blotting. We found that HDAC9 was up-regulated and miR-383-5p was down-regulated in GC tissues and cell lines. High HDAC9 expression or low miR-383-5p... Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNA-383-5p; Gastric cancer; HDAC9; Post-transcriptional regulation. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000800602 MicroRNA-4290 suppresses PDK1-mediated glycolysis to enhance the sensitivity of gastric cancer cell to cisplatin BJMBR Qian,Yan; Wu,Xu; Wang,Haixiao; Hou,Guowei; Han,Xiao; Song,Wei. The development of chemotherapy resistance significantly impairs the efficiency of chemotherapy, but the underlying mechanisms of chemotherapy resistance in gastric cancer (GC) are complicated and still need to be further explored. Here, we aimed to reveal the effects of miR-4290/PDK1 (pyruvate dehydrogenase kinase 1) axis on chemotherapy resistance of GC in vitro. The expression patterns of miR-4290 in GC tissues and cell lines were determined by real-time quantitative PCR. Kaplan-Meier was used to assess the relationship between miR-4290 expression levels and patients' overall survival. CCK-8 and flow cytometry technologies were applied to detect cell proliferation and apoptosis. The luciferase gene reporter assay was used to evaluate the interaction... Tipo: Info:eu-repo/semantics/article Palavras-chave: MiR-4290; PDK1; Cisplatin; Chemoresistance; Gastric cancer. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000500604 Relationship of IL-1 and TNF-α polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population BJMBR Santos,J.C.; Ladeira,M.S.P.; Pedrazzoli Jr,J.; Ribeiro,M.L.. It is well known that the risk of development of gastric cancer (GC) in Helicobacter pylori-infected patients depends on several factors. Thus, the aim of this study was to investigate the effect of proinflammatory cytokine gene polymorphisms for IL-1β, IL-1RN and TNF-α on the development of GC in a Brazilian population. A total of 202 biopsies obtained from Brazilian patients with chronic gastritis and GC were included in the study. Infection with H. pylori cagA+ was determined by the polymerase chain reaction (PCR) as previously described. IL-1β, IL-1RN and TNF-α polymorphism genotyping was performed by restriction fragment length polymorphism PCR. Associations between gene polymorphisms, clinical diseases and virulence markers were evaluated using... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chronic gastritis; Gastric cancer; Polymorphisms; Helicobacter pylori; Interleukins; IL-1β; IL-1RN; TNF-α. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900004 Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function BJMBR Bi,Enxu; Liu,Dengqiang; Li,Youxi; Mao,Xuying; Wang,Aihua; Wang,Jingtao. The tumor suppressive role of oridonin, an active compound extracted from Rabdosia rubescens, has been proven in several gastric cancer (GC) cell lines. The present study aimed to evaluate the effect of oridonin on another GC cell line, SNU-216, and explore the potential mechanisms. The viable cell numbers, cell migration, survival fraction, and cell viability were, respectively, evaluated by trypan blue exclusion assay, wound healing assay, clonogenic assay, and CCK-8 assay. Cell apoptosis was determined by flow cytometry assay and western blot. The expression of p53 was inhibited by transient transfection, and the efficiency was verified by western blot. qRT-PCR was performed to measure the mRNA expression of p53. Western blot was used to evaluate the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Oridonin; P53; Gastric cancer; Cell apoptosis; Mdm2. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200608 DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth BJMBR Da,M.X.; Zhang,Y.B.; Yao,J.B.; Duan,Y.X.. DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity, which results in hypermethylation of DNA. The main objectives of this study were to determine whether DNA hypomethylation correlated with vascular endothelial growth factor-C (VEGF-C) expression, and the effect of SAM on VEGF-C methylation and gastric cancer growth inhibition. VEGF-C expression was assayed by Western blotting and RT-qPCR in gastric cancer cells, and by immunohistochemistry in tumor xenografts. VEGF-C methylation was assayed by bisulfite DNA sequencing. The effect of SAM on cell apoptosis was... Tipo: Info:eu-repo/semantics/article Palavras-chave: VEGF-C; Methylation; S-adenosylmethionine; Gastric cancer. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201021 microRNA-3129 promotes cell proliferation in gastric cancer cell line SGC7901 via positive regulation of pRb BJMBR Yang,Shaofeng; Sheng,Nan; Pan,Lili; Cao,Jing; Liu,Jiao; Ma,Ran. Several microRNAs (miRNAs) have been reported as oncogenes or tumor suppressors in many cancers, including gastric cancer (GC). However, the role and molecular mechanism of miR-3129 in GC is largely unknown. We aimed to explore the function and the underlying molecular mechanism of miR-3129 in GC. Cancer tissues and corresponding adjacent tissues were collected from 50 patients with GC, and the expression of miR-3129 was detected by RT-qPCR. The expression of miR-3129 and pRb in human GC cell line SCG7091 was altered by transient transfection. Thereafter, MTT and flow cytometry assays were used to analyze cell viability and cell cycle. The expression of cyclin E, CDK2, CDK2 inhibitors (p16 and 21), and pRb were detected by RT-qPCR and western blot. A... Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNA-3129; Gastric cancer; PRb; Proliferation; Cell cycle. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000600612 Cytogenetic characterization and evaluation of c-MYC gene amplification in PG100, a new Brazilian gastric cancer cell line BJMBR Ribeiro,H.F.; Alcântara,D.F.A.; Matos,L.A.; Sousa,J.M.C.; Leal,M.F.; Smith,M.A.C.; Burbano,R.R.; Bahia,M.O.. Gastric cancer is the fourth most frequent type of cancer and the second cause of cancer mortality worldwide. The genetic alterations described so far for gastric carcinomas include amplifications and mutations of the c-ERBB2, KRAS, MET, TP53, and c-MYC genes. Chromosomal instability described for gastric cancer includes gains and losses of whole chromosomes or parts of them and these events might lead to oncogene overexpression, showing the need for a better understanding of the cytogenetic aspects of this neoplasia. Very few gastric carcinoma cell lines have been isolated. The establishment and characterization of the biological properties of gastric cancer cell lines is a powerful tool to gather information about the evolution of this malignancy, and... Tipo: Info:eu-repo/semantics/other Palavras-chave: Carcinogenesis; Chromosomal abnormalities; Gastric cancer; Oncogenes. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000800004 Knockdown of long non-coding RNA ANRIL inhibits tumorigenesis in human gastric cancer cells via microRNA-99a-mediated down-regulation of BMI1 BJMBR Liu,Pei; Zhang,Mingming; Niu,Qinghui; Zhang,Fengjuan; Yang,Yuling; Jiang,Xiangjun. Long non-coding RNA antisense non-coding RNA in the INK4 locus (ANRIL) has been reported to promote tumorigenesis via regulating microRNA (miR)-99a in gastric cancer cells. However, the role of each component involved in it is still not well understood. This study aimed to verify the role of ANRIL in gastric cancer as well as the underlying mechanisms. ANRIL levels in clinical gastric cancer tissues and cell lines were tested by qPCR. Effects of ANRIL silence on cell viability, migration and invasion, apoptosis, and miR-99a expression in MKN-45 and SGC-7901 cells were measured using CCK-8, Transwell assay, flow cytometry, and qPCR assays, respectively. Then, effects of miR-99a inhibition on ANRIL-silenced cells were evaluated. B-lymphoma Mo-MLV insertion... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gastric cancer; LncRNA ANRIL; MiR-99a; BMI1; Apoptotic pathway; Notch/mTOR pathway. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000609 Paclitaxel and spirulina co-loaded polymeric nanoparticles: in-vitro and in-vivo anticancer study BJPS Ravikumar,Yamuna; Catherine,Dorcas Pinky; Nair,Keerthi G. S; Sekar,Akshya; Velmurugan,Ramaiyan. Paclitaxel spirulina nanoparticles were said to have promising anticancer activity against gastric cancer. Nanoparticles of paclitaxel-spirulina were prepared for treating gastric cancer using precipitation technique. The synergistic anticancer efficiency againstMKN45 cells retains when the paclitaxel and spirulina were encapsulated into nanoparticles. To increase the site specific delivery, intra-tumoral administration was carried in the in vivo evaluation. There was an increase in overall survival in an MKN45-transplanted mice model and notable improvement in anti-tumour efficacy when paclitaxel-spirulina nanoparticles were delivered through intra-tumoral administration. The further investigation of overall anticancer mechanism of these nanoparticles is... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paclitaxel; Spirulina; Nanoparticle; In-vitro; In-vivo; Gastric cancer. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100642 Registros recuperados: 30 Primeira ... 1 2 ... Última

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