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	Provedor de dados ArchiMer (1) Autor Bozec, Ym (1) Kulbicki, M (1) Labrosse, Pierre (1) Letourneur, Y (1) Mou-tham, G (1) Wantiez, L (1) Mais... Palavra-chave Coral reefs (1) Fish diet (1) Indian ocean (1) Trophic level (1) Tipo do documento Text (1) Ano 2005 (1) País France (1) Idioma Francês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 38 Primeira ... 1 2 ... Última Role of hyaluronic acid and laminin as serum markers for predicting significant fibrosis in patients with chronic hepatitis B BJID Li,Feng; Zhu,Chang-Lai; Zhang,Hong; Huang,Hua; Wei,Qun; Zhu,Xiang; Cheng,Xiao-Yang. OBJECTIVES: The aim of this study was to evaluate the diagnostic performance of serum HA and LN as serum markers for predicting significant fibrosis in CHB patients. METHODS: Serum HA and LN levels of 87 patients with chronic hepatitis B and 19 blood donors were assayed by RIA. Liver fibrosis stages were determined according to the Metavir scoring-system. The diagnostic performances of all indexes were evaluated by the receiver operating characteristic (ROC) curves. RESULTS: Serum HA and LN concentrations increased significantly with the stage of hepatic fibrosis, which showed positive correlation with the stages of liver fibrosis (HA: r = 0.875, p < 0.001; LN: r = 0.610, p < 0.001). There were significant differences of serum HA and LN levels... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B; Chronic Hyaluronic acid Laminin Liver Cirrhosis ROC curve. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100002 Human immunodeficiency virus and hepatitis C virus/hepatitis B virus co-infection in Southern Brazil: clinical and epidemiological evaluation BJID Raboni,Sonia Mara; Tuon,Felipe Francisco; Beloto,Nayara Carvalho Polido; Demeneck,Henrique; Oliveira,Andre; Largura,Denis; Sagrado,Andressa Gervasoni; Lima,Bárbara Perdonsini; Franzoni,João Paulo; Pedroso,Maria Lucia. Hepatitis B virus, hepatitis C virus and human immunodeficiency virus share a similar transmission pathway and are often diagnosed in the same patient. These patients tend to have a faster progression of hepatic fibrosis. This cross-sectional study describes the demographic features and clinical profile of human immunodeficiency virus/hepatitis co-infected patients in Parana, Southern Brazil. A total of 93 human immunodeficiency virus-infected patients attending a tertiary care academic hospital in Southern Brazil were included. Clinical, demographic and epidemiological data were evaluated. Hepatitis B virus and/or hepatitis C virus positive serology was found in 6.6% of patients. The anti-hepatitis C virus serum test was positive in 85% (79/93) of... Tipo: Info:eu-repo/semantics/report Palavras-chave: Human immunodeficiency virus; Hepatitis B; Hepatitis C; Co-infection. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600664 Serological markers of hepatitis A, B and C viruses in rural communities of the semiarid Brazilian Northeast BJID Almeida,Delvone; Tavares-Neto,José; Vitvitski,Ludmila; Almeida,Alessandro; Mello,Caroline; Santana,Diana; Tatsch,Fernando; Paraná,Raymundo. In the village of Cavunge, located in a dry tropical, semiarid rural region of the state of Bahia, Brazil, a sentinel study on viral hepatitis is underway. We report on the first part of the study. The objective of this study was to determine the prevalence of serological markers for hepatitis A, B and C in the village. Cross sectional study. Blood samples were tested for serological markers of hepatitis A (HAV), B (HBV) and C (HCV) through ELISA-III assay. In HBsAg and anti-HCV carriers, HCV-RNA and HBV-DNA were checked by PCR. The prevalence of anti-HAV IgG was 83.3% (1,210/1,452), being higher among residents from the village (87.4%) than in residents from the rural area (79.5%); it also higher among individuals older than 10 years of age. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis A; Hepatitis B; Hepatitis C; Epidemiology; Brazil. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000500003 Simultaneous detection of hepatitis B virus genotypes and mutations associated with resistance to lamivudine, adefovir, and telbivudine by the polymerase chain reaction-ligase detection reaction BJID Wang,Yong-Zhong; Xiao,Jun-Hua; Liu,Long-Gen; Ye,Chun-Yan; Shen,Hong-Yu; Xu,Tian-Min; Zhu,Ke-Zhuan. OBJECTIVES: Detection of mutations associated to nucleos(t)ide analogs and hepatitis B virus (HBV) genotyping are essential for monitoring treatment of HBV infection. We developed a multiplex polymerase chain reaction-ligase detection reaction (PCR-LDR) assay for the rapid detection of HBV genotypes and mutations associated with lamivudine, adefovir, and telbivudine resistance in HBV-infected patients. METHODS: HBV templates were amplified by PCR, followed by LDR and electrophoresis on a sequencer. The assay was evaluated using plasmids that contained wild-type or mutant HBV sequences and 216 clinical samples. RESULTS: The PCR-LDR assay and sequencing gave comparable results for 158 of the 216 samples (73.1%) with respect to mutation detection and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B; Drug resistance; Mutation; Genotype. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600010 Hepatitis B virus genotyping in chronic hepatitis B patients in southwestern Saudi Arabia BJID Asaad,Ahmed Morad; Al-Ayed,Mohamed Saeed Zayed; Aleraky,Mohamed; Qureshi,Mohamed Ansar. ABSTRACTThe distribution of hepatitis B virus genotypes in Saudi Arabia is largely unknown. To the best of our knowledge there are no data available about HBV genotypes in southwestern region of the country. This study aimed to determine the epidemiologic distribution of hepatitis B virus genotypes in chronic hepatitis B patients in southwestern region, and to verify possible correlations between these genotypes and the clinical symptoms. A total of 160 patients with chronic hepatitis B infection were enrolled in this study. Sera were tested for liver function tests, hepatitis B virus markers and DNA load by standard procedures. HBV genotyping was performed by 2-tube nested PCR for determination of six genotypes (A-F). Genotype D was the most common, found... Tipo: Info:eu-repo/semantics/other Palavras-chave: Hepatitis B; HBV genotypes; Genotype D; Najran. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500525 The effectiveness of the national hepatitis B vaccination program 25 years after its introduction in Iran: a historical cohort study BJID Moghadami,Mohsen; Dadashpour,Nazanin; Mokhtari,Ali Mohammad; Ebrahimi,Mostafa; Mirahmadizadeh,Alireza. ABSTRACT Introduction: Hepatitis B virus (HBV) is responsible for one of the most common human viral infections. An estimated 257 million people are living with chronic HBV infection worldwide, and mortality has reached 900,000 deaths in recent years. In 2001, the World Health Organization reported a prevalence of chronic hepatitis B infection in Iran between 2-7%. Objective: To assess the effect of the national HBV mass vaccination program after 25 years. Methods: A retrospective cohort study was conducted in vaccinated and unvaccinated people according to the year of birth. Blood samples were obtained from each enrolled person and data about demographic variables, and medical and vaccination history were collected using a standardized questionnaire.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B; Vaccination; Effectiveness research. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600419 Prevalence of hepatitis B among pregnant women assisted at the public maternity hospitals of São Luís, Maranhão, Brazil BJID Souza,Marinilde Teles; Pinho,Tainá Lima Reis de; Santos,Max Diego Cruz; Santos,Alexsandro dos; Monteiro,Vera Lúcia; Fonsêca,Lena Maria Barros; Ferreira,Pedro Antônio Muniz; Ferreira,Adalgisa de Souza Paiva. INTRODUCTION: Hepatitis B virus (HBV) infection is an important worldwide public health problem. In Brazil, the Ministry of Health estimates that 15% of the population has had contact with HBV, and that the mean rate of chronic carriers in Northeastern Brazil is around 0.5%. OBJECTIVE: The aim of this study was to assess the prevalence of HBV markers in pregnant women receiving prenatal care at the public maternity hospitals of São Luís. Methods: Demographical and epidemiological data were collected from 541 pregnant women according to the research protocol. Blood samples were collected, and the anti-HBc test was performed first. If positive, the sample was subsequently tested for HBsAg and anti-HBs. All HBsAg and/or anti-HBc positive samples were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pregnant; Hepatitis B; HBV-DNA. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600003 Response predictors to treatment with pegylated interferon in chronic hepatitis B BJID Ferreira,Paulo Roberto Abrão; Tenore,Simone de Barros. The clinical and epidemiological importance of chronic B hepatitis is currently unquestionable as a cause of end-stage liver disease and hepatocellular carcinoma. Recently, predictors of treatment response of this disease have been studied, both before and during the course of medication. Therapy stopping rules have been proposed, which may be useful in patients presenting poor treatment tolerance. This review discusses the treatment response predictors usefulness, with emphasis on ALT, quantitative HBsAg and HBeAg, quantitative HBV-DNA and HBV genotype Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B; HBsAg; HBeAg; HBV-DNA; Pegylated interferon. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500017 Hepatitis B virus genotype E detected in Brazil in an African patient who is a frequent traveler BJMBR Sitnik,R; Sette Jr,H; Santana,R.A.F; Menezes,L.C; Graça,C.H.N; Dastoli,G.T.F; Silbert,S; Pinho,J.R.R. Genotype E of hepatitis B virus (HBV) has not been described in Brazil and is found mainly in Africa. Genotype A is the most prevalent in Brazil, and genotypes B, C, D, and F have already been reported. We report here an HBV genotype E-infected patient and some characterization of surface (S) protein, DNA polymerase (P) and precore/core (preC/C) coding regions based on the viral genome. The patient is a 31-year-old black man with chronic hepatitis B who was born and raised in Angola. He has been followed by a hepatologist in São Paulo, Brazil, since November 2003, and he is a frequent traveler to Latin America, Africa, and Europe. In 2003, he was diagnosed with HBV infection and started treatment with lamivudine with the later addition of adefovir... Tipo: Info:eu-repo/semantics/other Palavras-chave: Hepatitis B; HBV genotype E; Precore mutation; Brazil; Africa; African traveler. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001200013 A prospective study of hepatitis B virus markers in patients with chronic HBV infection from Brazilian families of Western and Asian origin BJMBR Carrilho,F.J.; Ono-Nita,S.K.; Cardoso,R.A.; Cancado,E.L.R.; Pinho,J.R.R.; Alves,V.A.F.; Da Silva,L.C.. The purpose of the present study was to determine the frequency of hepatitis B virus (HBV) markers in families of HBsAg-positive patients with chronic liver disease. Serum anti-HBc, HBsAg and anti-HBs were determined by enzyme immunoassay and four subpopulations were considered: genetically related (consanguineous) and non-genetically related (non-consanguineous) Asian subjects and genetically related and non-genetically related Western subjects. A total of 165 and 186 relatives of Asian and Western origin were enrolled, respectively. The occurrence of HBsAg and anti-HBs antibodies was significantly higher (P < 0.0001) in family members of Asian origin (81.8%) than in family members of Western origin (36.5%). HBsAg was also more frequent among brothers... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B; Familial clustering; HBsAg; Vertical transmission; Anti-HBc; Anti-HBs. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900015 The emergence of YMDD mutants precedes biochemical flare by 19 weeks in lamivudine-treated chronic hepatitis B patients: an opportunity for therapy reevaluation BJMBR França,P.H.C.; Coelho,H.S.M.; Brandão,C.E.; Segadas,J.A.; Quintaes,R.F.; Carrilho,F.J.; Ono-Nita,S.; Mattos,A.A.; Tovo,C.; Gouvea,V.S.; Sablon,E.; Vanderborght,B.O.M.. Given the loss of therapeutic efficacy associated with the development of resistance to lamivudine (LMV) and the availability of new alternative treatments for chronic hepatitis B patients, early detection of viral genotypic resistance could allow the clinician to consider therapy modification before viral breakthrough and biochemical relapse occur. To this end, 28 LMV-treated patients (44 ± 12 years; 24 men), on their first therapy schedule, were monitored monthly at four Brazilian centers for the emergence of drug resistance using the reverse hybridization-based INNO-LiPA HBV DR assay and occasionally sequencing (two cases). Positive viral responses (HBV DNA clearance) after 6, 12, and 18 months of therapy were achieved by 57, 68, and 53% of patients,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B; Antiviral therapy; Lamivudine; Drug resistance; YMDD variants; Hepatitis B virus. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001200003 Role of p53 codon 72 polymorphism in chromosomal aberrations and mitotic index in patients with chronic hepatitis B BJMBR Akbaş,H.; Yalcin,K.; Isi,H.; Tekes,S.; Atay,A.E.; Akkus,Z.; Budak,T.. Polymorphisms of the p53 gene, which participates in DNA repair, can affect the functioning of the p53 protein. The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberrations in chronic hepatitis B patients. The present study aimed to examine the frequency of chromosomal aberrations and the mitotic index in patients with chronic hepatitis B and their possible association with p53 gene exon 4 codon 72 Arg72Pro (Ex4+119 G>C; rs1042522) polymorphism. Fifty-eight patients with chronic hepatitis B and 30 healthy individuals were genotyped in terms of the p53 gene codon 72 Arg72Pro polymorphism by PCR-RFLP. A 72-h cell culture was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B; Chromosomal aberrations; Mitotic index; P53 gene codon 72 polymorphism. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100003 Risk of hepatitis B virus transmission by diagnostic hysteroscopy BJMBR Santos,N.C.; Pinho,J.R.R.; Lemos,M.F.; Moreira,R.C.; Lopes,C.M.C.; Sacilotto,M.T.J.; Tacla,M.; Pinheiro,W.S.; Ramos,L.O.. Few data are available in the literature concerning the efficacy of standard hysteroscope disinfection procedures to prevent hepatitis B transmission. The aim of the present study was to determine the risk of hepatitis B virus (HBV) transmission during hysteroscopy among anti-HBc-seropositive women. Serum and hysteroscopic samples were collected from 62 women after diagnostic hysteroscopy. All samples were tested for serologic HBV markers. Polymerase chain reactions (PCR) were carried out to amplify regions C and S of the viral genome and only samples amplified by both pairs of primers were considered to be positive. Anti-HBc was repeatedly reactive in 48 (77%) of 62 serum samples, and HBsAg was detected in 8 (13%). At least one HBV serologic marker was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B; Hysteroscopy; Disinfection; Polymerase chain reaction. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500009 Lamivudine therapy for hepatitis B in renal transplantation BJMBR Santos,F.R.L.; Haiashi,A.R.; Araújo,M.R.T.; Abensur,H.; Romão Junior,J.E.; Noronha,I.L.. Antiviral therapies are associated with an increased risk of acute rejection in transplant patients. The aim of the present study was to evaluate the efficacy and safety of lamivudine therapy for hepatitis B virus (HBV) infection in renal transplant patients. Six patients were included in this study. They received 150 mg/day of lamivudine during a follow-up period of 24 months. The laboratory tests monitored were HBV DNA, HBsAg, HBeAg, ALT, gamma-GT, serum creatinine and blood cyclosporine levels. The HBV DNA became undetectable in four patients as early as in the third month of treatment. After six months, the viral load was also negative in the other two patients, and remained so until 18 months of follow-up. The medication was well tolerated with no... Tipo: Info:eu-repo/semantics/other Palavras-chave: Lamivudine; Kidney transplantation; Hepatitis B. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200008 Serological markers and risk factors related to hepatitis B virus in dentists in the Central West region of Brazil BJM Paiva,Enilza Maria Mendonça de; Tiplle,Anaclara Ferreira Veiga; Silva,Eliane de Paiva e; Cardoso,Divina das Dores de Paula. The hepatitis B virus (HBV) has been considered the major occupational risk agent for dentists. The Central West region of Brazil is considered an intermediate endemic pattern area, but currently there is no information about the HBV prevalence in dentists of Goiânia, Goiás. This study aimed at the detection of the HBV infection rate and risk factors for dentists of Goiânia and the comparison of the obtained data with the general population and other groups. A randomized sample of 680 professionals participated in this study. All dentists gave written consent for the procedure and filled out a questionnaire about risk factors. The HBV serological markers were analyzed using ELISA test and the presence of anti-HBc was observed in 41 (6.0%) of the dentists.... Tipo: Info:eu-repo/semantics/article Palavras-chave: HBV; Dentists; Hepatitis B. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000200010 In-house quantitative real-time PCR for the diagnosis of hepatitis B virus and hepatitis C virus infections BJM Zauli,Danielle Alves Gomes; Menezes,Carla Lisandre Paula de; Oliveira,Cristiane Lommez de; Mateo,Elvis Cristian Cueva; Ferreira,Alessandro Clayton de Souza. Abstract The quantification of viral nucleic acids in serum by real-time PCR plays an important role in diagnosing hepatitis B virus and hepatitis C virus infection. In this study, we developed an assay using specific primers and probes to quantify hepatitis B virus DNA or hepatitis C virus RNA in serum from infected patients. For standardization and validation of the assay, an international panel of hepatitis B virus/hepatitis C virus and standard plasmids was used. A correlation coefficient of 0.983 and 0.963 for hepatitis B virus and hepatitis C virus, respectively, was obtained based on cycle threshold values and concentrations of DNA or RNA. The standard curve showed a linear relationship from 19 IU/mL to 1.9 × 109 IU/mL of serum, with a coefficient... Tipo: Info:eu-repo/semantics/article Palavras-chave: QPCR; Hepatitis B; Hepatitis C. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400987 Aflatoxin M1 in the urine of non-carriers and chronic carriers of hepatitis B virus in Maringa, Brazil BJPS Giolo,Marcel Padovani; Oliveira,Christiane Minervino de; Bertolini,Dennis Armando; Lonardoni,Maria Valdrinez Campana; Gouveia,Matheus Sampaio; Netto,Daisy Pontes; Nixdorf,Suzana Lucy; Machinski Junior,Miguel. Exposure to aflatoxins (AFs) in the diet may favour the development of hepatocellular carcinoma (HCC) and the acute exacerbation of hepatitis in chronic hepatitis B virus (HBV) carriers. Measurement of biomarkers such as aflatoxin M1 (AFM1), a metabolite of aflatoxin B1 (AFB1), in urine allows for the assessment of populations exposed to aflatoxins. The aim of this study was to investigate the occurrence of aflatoxin M1 in the urine of HBV carrier and non-carrier patients. One group included 43 randomly selected HBV carriers treated at two hospitals in the city of Maringa, Brazil, from March to June 2008. Control group consisted of 29 healthy adult volunteers with anti-HBs positive and HBsAg negative test results. Detection of AFM1 was performed by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aflatoxins; Biomarkers; Hepatitis B; Hepatocellular carcinoma; Urina/análise toxicológica; Epidemiology. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300011 Seroprevalence of HBV and HCV markers among young adult males in the Air Force in Florianópolis, South Brazil BJPS Passos,Ana Maria; Strazer Neto,Miguel; Treitinger,Aricio; Spada,Celso. We investigated the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) serological markers of infection in young adults from the metropolitan region of Florianópolis who were conscripts of the Air Base of Florianópolis in the state of Santa Catarina, Brazil. A population-based cross-sectional seroprevalence study was conducted with 371 young males during a one year period starting in June 2009. Demographic characteristics, socio-economic characteristics and possible risk factors to HBV and HCV were assessed. Blood samples were analyzed for HBsAg, anti-HBc, anti-HCV and anti-HBs through automated microparticle enzymatic immunoassays (Abbott®, AxSYM System, Wiesbaden, Germany). None of the participants showed positivity to HBsAg or anti-HCV.... Tipo: Info:eu-repo/semantics/article Palavras-chave: HBV; HCV; Hepatitis B; Hepatitis C; Seroprevalence. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200009 Registros recuperados: 38 Primeira ... 1 2 ... Última

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