Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (62) BJPS (10) Anais da ABC (AABC) (2) Biocell (1) BABT (1) BJID (1) Ciência Rural (1) Genet. Mol. Biol. (1) International Journal of Morphology (1) Mais... Autor Krieger,J.E. (3) Vassallo,D.V. (3) Abreu,G.R. (2) Akamine,E.H. (2) Borgo,M.V. (2) Carneiro-Júnior,M.A. (2) Cazarim,Maurílio de Souza (2) Fazan Jr.,R. (2) Ferreira,S.R.G. (2) Fuchs,F.D. (2) Gerová,M. (2) Irigoyen,M.C. (2) Kristek,F. (2) Mill,J.G. (2) Natali,A.J. (2) Padilha,A.S. (2) Pereira,Leonardo Régis Leira (2) Plavnik,F.L. (2) Prímola-Gomes,T.N. (2) Romero,W.G. (2) Mais... Palavra-chave Hypertension (80) Nitric oxide (5) Renin-angiotensin system (5) Menopause (4) Obesity (4) Vascular reactivity (4) Aldosterone (3) Blood pressure (3) Diabetes mellitus (3) Endothelial dysfunction (3) Heart (3) Left ventricular hypertrophy (3) Ouabain (3) Pharmaceutical care (3) Preeclampsia (3) Pregnancy (3) Angiotensin II (2) Aortic coarctation (2) Cardiovascular disease (2) Cardiovascular risk (2) Mais... Tipo do documento Info:eu-repo/semantics/article (71) Info:eu-repo/semantics/other (7) Info:eu-repo/semantics/report (1) Journal article (1) Ano 2020 (3) 2019 (2) 2018 (4) 2017 (2) 2016 (3) 2015 (4) 2014 (2) 2013 (2) 2012 (3) 2011 (8) 2010 (7) 2009 (4) 2008 (5) 2007 (1) 2006 (2) 2005 (2) 2004 (5) 2003 (1) 2002 (5) 2001 (1) Mais... País Brazil (78) Argentina (1) Chile (1) Idioma Inglês (80)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 80 Primeira ... 1 2 3 4 ... Última Effect of tamoxifen on the coronary vascular reactivity of spontaneously hypertensive female rats BJMBR Borgo,M.V.; Lopes,A.B.; Gouvêa,S.A.; Romero,W.G.; Moyses,M.R.; Bissoli,N.S.; Abreu,G.R.. Tamoxifen has been associated with a reduction in the incidence of myocardial infarction. However, the effects of tamoxifen on coronary reactivity have not been fully elucidated. The objective of this study was to determine the effects of chronic treatment with tamoxifen on coronary vascular reactivity in spontaneously hypertensive rats (SHR). Female SHR were divided into four groups (N = 7 each): sham-operated (SHAM), sham-operated and treated with tamoxifen (10 mg/kg) by gavage for 90 days (TAMOX), ovariectomized (OVX), and ovariectomized and treated with tamoxifen (OVX+TAMOX). Mean arterial pressure (MAP), heart rate (HR), coronary perfusion pressure (CPP), and coronary vascular reactivity were measured. MAP and HR were reduced (9.42 and 11.67%,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tamoxifen; Estrogen; Hypertension; Menopause; Coronary. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000800008 Mechanisms of endothelial dysfunction in obesity-associated hypertension BJMBR Lobato,N.S.; Filgueira,F.P.; Akamine,E.H.; Tostes,R.C.; Carvalho,M.H.C.; Fortes,Z.B.. Obesity is strongly associated with high blood pressure, dyslipidemia, and type 2 diabetes. These conditions synergistically increase the risk of cardiovascular events. A number of central and peripheral abnormalities can explain the development or maintenance of high blood pressure in obesity. Of great interest is endothelial dysfunction, considered to be a primary risk factor in the development of hypertension. Additional mechanisms also related to endothelial dysfunction have been proposed to mediate the development of hypertension in obese individuals. These include: increase in both peripheral vasoconstriction and renal tubular sodium reabsorption, increased sympathetic activity and overactivation of both the renin-angiotensin system and the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Obesity; Endothelial dysfunction; Oxidative stress; Renin-angiotensin system; Nitric oxide. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000500003 Effect of race, genetic population structure, and genetic models in two-locus association studies: clustering of functional renin-angiotensin system gene variants in hypertension association studies BJMBR Pereira,A.C.; Mota,G.A.; Benseñor,I.; Lotufo,P.A.; Krieger,J.E.. Previous genetic association studies have overlooked the potential for biased results when analyzing different population structures in ethnically diverse populations. The purpose of the present study was to quantify this bias in two-locus association studies conducted on an admixtured urban population. We studied the genetic structure distribution of angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensinogen methionine/threonine (M/T) polymorphisms in 382 subjects from three subgroups in a highly admixtured urban population. Group I included 150 white subjects; group II, 142 mulatto subjects, and group III, 90 black subjects. We conducted sample size simulation studies using these data in different genetic models of gene action and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Association study; Genetics; Angiotensin-converting enzyme; ACE; Angiotensinogen. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001100008 Effect of gender on training-induced vascular remodeling in SHR BJMBR Amaral,S.L.; Michelini,L.C.. There is accumulating evidence that physical inactivity, associated with the modern sedentary lifestyle, is a major determinant of hypertension. It represents the most important modifiable risk factor for cardiovascular diseases, which are the leading cause of morbidity and mortality for both men and women. In addition to involving sympathetic overactivity that alters hemodynamic parameters, hypertension is accompanied by several abnormalities in the skeletal muscle circulation including vessel rarefaction and increased arteriole wall-to-lumen ratio, which contribute to increased total peripheral resistance. Low-intensity aerobic training is a promising tool for the prevention, treatment and control of high blood pressure, but its efficacy may differ... Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Hypertension; Microcirculation; Arterioles; Capillaries; Venules. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900001 Prenatally programmed hypertension: role of maternal diabetes BJMBR Gomes,G.N.; Gil,F.Z.. Epidemiological and experimental studies have led to the hypothesis of the fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. Maternal diabetes subjects the fetus to an adverse environment that has been demonstrated to result in metabolic, cardiovascular and renal impairment in the offspring. The growing amount of obesity in young females in developed and some developing countries should contribute to increasing the incidence of diabetes among pregnant women. In this review, we discuss how renal and extrarenal mechanisms participate in the genesis of hypertension induced by a diabetic status during fetal development. Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Maternal diabetes; Renal impairment; Sodium retention. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900011 Vasopressor mechanisms in acute aortic coarctation hypertension BJMBR Angiotensin II (ANG II) and vasopressin (AVP) act together with the mechanical effect of aortic constriction in the onset of acute aortic coarctation hypertension. Blockade of ANG II and AVP V1 receptors demonstrated that ANG II acts on the prompt (5 min) rise in pressure whereas AVP is responsible for the maintenance (30-45 min) of the arterial pressure elevation during aortic coarctation. Hormone assays carried out on blood collected from conscious rats submitted to aortic constriction supported a role for ANG II in the early stage and a combined role for both ANG II and AVP in the maintenance of proximal hypertension. As expected, a role for catecholamines was ruled out in this model of hypertension, presumably due to the inhibitory effect of the... Tipo: Info:eu-repo/semantics/other Palavras-chave: Aortic coarctation; Vasopressin; Angiotensin; Renal afferences; Hypertension. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000400003 Hypertensive effects of the iv administration of picomoles of ouabain BJMBR Padilha,A.S.; Salaices,M.; Vassallo,D.V.; Batista,P.R.; Siman,F.D.M.. Ouabain, an endogenous digitalis compound, has been detected in nanomolar concentrations in the plasma of several mammals and is associated with the development of hypertension. In addition, plasma ouabain is increased in several hypertension models, and the acute or chronic administration of ouabain increases blood pressure in rodents. These results suggest a possible association between ouabain and the genesis or development and maintenance of arterial hypertension. One explanation for this association is that ouabain binds to the α-subunit of the Na+ pump, inhibiting its activity. Inhibition of this pump increases intracellular Na+, which reduces the activity of the sarcolemmal Na+/Ca2+ exchanger and thereby reduces Ca2+ extrusion. Consequently,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ouabain; Hypertension; Vascular reactivity; Renin-angiotensin system. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900015 Familial predisposition to hypertension and the association between urinary sodium excretion and blood pressure in a population-based sample of young adults BJMBR Moraes,R.S.; Fuchs,F.D.; Dalla Costa,F.; Moreira,L.B.. The reasons for the inconsistent association between salt consumption and blood pressure levels observed in within-society surveys are not known. A total of 157 normotensive subjects aged 18 to 35 years, selected at random in a cross-sectional population-based survey, answered a structured questionnaire. They were classified as strongly predisposed to hypertension when two or more first-degree relatives had a diagnosis of hypertension. Anthropometric parameters were obtained and sitting blood pressure was determined with aneroid sphygmomanometers. Sodium and potassium excretion was measured by flame spectrophotometry in an overnight urine sample. A positive correlation between blood pressure and urinary sodium excretion was detected only in the group of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Familial predisposition to hypertension; Urinary sodium excretion; Salt sensitivity. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700010 Endothelial dysfunction in cardiovascular and endocrine-metabolic diseases: an update BJMBR Davel,A.P.; Wenceslau,C.F.; Akamine,E.H.; Xavier,F.E.; Couto,G.K.; Oliveira,H.T.; Rossoni,L.V.. The endothelium plays a vital role in maintaining circulatory homeostasis by the release of relaxing and contracting factors. Any change in this balance may result in a process known as endothelial dysfunction that leads to impaired control of vascular tone and contributes to the pathogenesis of some cardiovascular and endocrine/metabolic diseases. Reduced endothelium-derived nitric oxide (NO) bioavailability and increased production of thromboxane A2, prostaglandin H2 and superoxide anion in conductance and resistance arteries are commonly associated with endothelial dysfunction in hypertensive, diabetic and obese animals, resulting in reduced endothelium-dependent vasodilatation and in increased vasoconstrictor responses. In addition, recent studies have... Tipo: Info:eu-repo/semantics/article Palavras-chave: Endothelial dysfunction; Hypertension; Sympathetic hyperactivity; Diabetes; Obesity. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900014 Dynamic resistance training decreases sympathetic tone in hypertensive ovariectomized rats BJMBR Shimojo,G.L.; Palma,R.K.; Brito,J.O.; Sanches,I.C.; Irigoyen,M.C.; De Angelis,K.. The aim of this study was to investigate the effects of resistance exercise training on hemodynamics and cardiac autonomic control in ovariectomized spontaneously hypertensive rats. Female rats were divided into 4 groups: sedentary control (SC), sedentary hypertensive (SH), sedentary hypertensive ovariectomized (SHO), and resistance-trained hypertensive ovariectomized (RTHO). Resistance exercise training was performed on a vertical ladder (5 days/week, 8 weeks) at 40-60% maximal load. Direct arterial pressure was recorded. Vagal and sympathetic tones were measured by heart rate (HR) responses to methylatropine (3 mg/kg, iv) and propranolol (4 mg/kg, iv). Ovariectomy resulted in additional increases in blood pressure in hypertensive rats and was associated... Tipo: Info:eu-repo/semantics/report Palavras-chave: Resistance exercise training; Menopause; Hypertension; Sympathetic tone; Blood pressure. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000600523 Sodium taste threshold in children and its relationship to blood pressure BJMBR Arguelles,J.; Diaz,J.J.; Malaga,I.; Perillan,C.; Costales,M.; Vijande,M.. Popular science has emphasized the risks of high sodium intake and many studies have confirmed that salt intake is closely related to hypertension. The present mini-review summarizes experiments about salt taste sensitivity and its relationship with blood pressure (BP) and other variables of clinical and familial relevance. Children and adolescents from control parents (N = 72) or with at least one essential hypertensive (EHT) parent (N = 51) were investigated. Maternal questionnaires on eating habits and vomiting episodes were collected. Offspring, anthropometric, BP, and salt taste sensitivity values were recorded and blood samples analyzed. Most mothers declared that they added "little salt" when cooking. Salt taste sensitivity was inversely correlated... Tipo: Info:eu-repo/semantics/article Palavras-chave: Children; Hypertension; Cardiovascular risk factors; Salt taste sensitivity; Pregnancy; Obesity. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500017 Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy BJMBR Yang,Hui-li; Zhang,Hong-zhi; Meng,Fan-rong; Han,Shu-yi; Zhang,Miao. Preeclampsia is a major reason of morbidity and mortality in pregnant women and perinatal fetus. Hence, it is of prime importance that diagnostic markers are defined to predict chances of preeclampsia in pregnant women. It has been previously shown that microRNA (miRNA)-376c expression is decreased in the placenta of preeclampsia patients at term. Even though this decrease was not mimicked in the placenta at the pre-term stage, miR-376c expression was decreased in the plasma of these patients as early as the second trimester. Plasma and placenta specimens were obtained from pregnant women having unifetal gestation undergoing perinatal care between January 2014 and December 2016 (n=49). Early trimester placentas were collected from patients undergoing... Tipo: Info:eu-repo/semantics/article Palavras-chave: Preeclampsia; Pregnancy; Hypertension; MiR-411; MiR-376c. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400607 Percutaneous 17ß-estradiol replacement therapy in hypertensive postmenopausal women BJMBR Osório-Wender,M.C.; Vitola,D.; Spritzer,P.M.. The present study evaluated the short-term effects of percutaneous 17ß-estradiol on blood pressure, metabolic profile and hormonal levels in postmenopausal women with systemic arterial hypertension. After a wash-out period of 15 days, 10 hypertensive patients were treated with guanabenz acetate to control blood pressure, followed by 17ß-estradiol in the form of hydroalcoholic gel administered for 21 of 28 days of each cycle, for 3 cycles. Patients were evaluated before, during and 2 months after estrogen administration. Systolic and diastolic blood pressure or heart rate did not present any significant change in any patient when compared to those periods with the antihypertensive drug only (pretreatment period and 60 days after estrogen therapy was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Menopause; Hormone replacement therapy; Hypertension; 17ß-estradiol; LH; FSH. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900001 Acute lead-induced vasoconstriction in the vascular beds of isolated perfused rat tails is endothelium-dependent BJMBR Silveira,E.A.; Lizardo,J.H.F.; Souza,L.P.; Stefanon,I.; Vassallo,D.V.. Chronic lead exposure induces hypertension in humans and animals, affecting endothelial function. However, studies concerning acute cardiovascular effects are lacking. We investigated the effects of acute administration of a high concentration of lead acetate (100 µΜ) on the pressor response to phenylephrine (PHE) in the tail vascular bed of male Wistar rats. Animals were anesthetized with sodium pentobarbital and heparinized. The tail artery was dissected and cannulated for drug infusion and mean perfusion pressure measurements. Endothelium and vascular smooth muscle relaxation were tested with acetylcholine (5 µg/100 µL) and sodium nitroprusside (0.1 µg/100 µL), respectively, in arteries precontracted with 0.1 µM PHE. Concentration-response curves to PHE... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lead acetate; Vascular reactivity; Endothelium; Hypertension. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500011 Hemodynamic and hormonal actions of adrenomedullin BJMBR Nicholls,M.G.. Adrenomedullin, a 52-amino acid residue peptide, has numerous biological actions which are of potential importance to cardiovascular homeostasis, growth and development of cardiovascular tissues and bone, prevention of infection, and regulation of body fluid and electrolyte balance. Studies in man using intravenous infusion of the peptide have demonstrated that, at plasma levels detected after myocardial infarction or in heart failure, adrenomedullin reduces arterial pressure, increases heart rate and cardiac output, and activates the sympathetic and renin-angiotensin systems but suppresses aldosterone. The thresholds for these responses differ, being lower under some experimental circumstances for arterial pressure than for the other biological effects.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenomedullin; Hypertension; Heart failure; Aldosterone; Renin; Norepinephrine. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800016 Paradoxical sleep deprivation increases plasma endothelin levels BJMBR Palma,B.D.; Gabriel Jr.,A.; Bignotto,M.; Tufik,S.. The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA). OSA patients exhibit repetitive episodes of apnea and hypopnea that result in hypoxia and consecutive arousals. These patients are chronically sleep deprived, which may aggravate the hypertensive features, since literature data show that sleep deprivation results in hypertension both in humans and in animals. Based on the reported relationship between ET-1, hypertension and sleep deprivation consequences, the... Tipo: Info:eu-repo/semantics/other Palavras-chave: Endothelin; Sleep deprivation; Rat; Hypertension. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100011 Hormonal therapy with estradiol and drospirenone improves endothelium-dependent vasodilation in the coronary bed of ovariectomized spontaneously hypertensive rats BJMBR Borgo,M.V.; Claudio,E.R.G.; Silva,F.B.; Romero,W.G.; Gouvea,S.A.; Moysés,M.R.; Santos,R.L.; Almeida,S.A.; Podratz,P.L.; Graceli,J.B.; Abreu,G.R.. Drospirenone (DRSP) is a progestin with anti-aldosterone properties and it reduces blood pressure in hypertensive women. However, the effects of DRSP on endothelium-dependent coronary vasodilation have not been evaluated. This study investigated the effects of combined therapy with estrogen (E2) and DRSP on endothelium-dependent vasodilation of the coronary bed of ovariectomized (OVX) spontaneously hypertensive rats. Female spontaneously hypertensive rats (n=87) at 12 weeks of age were randomly divided into sham operated (Sham), OVX, OVX treated with E2 (E2), and OVX treated with E2 and DRSP (E2+DRSP) groups. Hemodynamic parameters were directly evaluated by catheter insertion into the femoral artery. Endothelium-dependent vasodilation in response to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Menopause; Hypertension; Hormone therapy; Drospirenone; Coronary reactivity. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000100601 Familial hyperaldosteronism BJMBR Torpy,D.J.; Stratakis,C.A.; Chrousos,G.P.. Aldosterone, the major circulating mineralocorticoid, participates in blood volume and serum potassium homeostasis. Primary aldosteronism is a disorder characterised by hypertension and hypokalaemia due to autonomous aldosterone secretion from the adrenocortical zona glomerulosa. Improved screening techniques, particularly application of the plasma aldosterone:plasma renin activity ratio, have led to a suggestion that primary aldosteronism may be more common than previously appreciated among adults with hypertension. Glucocorticoid-remediable aldosteronism (GRA) was the first described familial form of hyperaldosteronism. The disorder is characterised by aldosterone secretory function regulated chronically by ACTH. Hence, aldosterone hypersecretion can be... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aldosterone; Hyperaldosteronism; Genetics; Adrenal tumour; Hypertension. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000004 Aspirin plus calcium supplementation to prevent superimposed preeclampsia: a randomized trial BJMBR Souza,E.V.; Torloni,M.R.; Atallah,A.N.; dos Santos,G.M.S.; Kulay Jr,L.; Sass,N.. Preeclampsia is an important cause of maternal and perinatal morbidity and mortality. Previous studies have tested calcium supplementation and aspirin separately to reduce the incidence of preeclampsia but not the effects of combined supplementation. The objective of this study was to investigate the effectiveness of aspirin combined with calcium supplementation to prevent preeclampsia in women with chronic hypertension. A double-blind, placebo-controlled randomized clinical trial was carried out at the antenatal clinic of a large university hospital in São Paulo, SP, Brazil. A total of 49 women with chronic hypertension and abnormal uterine artery Doppler at 20-27 weeks gestation were randomly assigned to receive placebo (N = 26) or 100 mg aspirin plus 2... Tipo: Info:eu-repo/semantics/article Palavras-chave: Preeclampsia; Hypertension; Ultrasonography; Doppler; Calcium carbonate; Aspirin. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000500419 Calciuria and preeclampsia BJMBR Urinary calcium excretion has been reported to be diminished in preeclampsia. The objective of the present study was to determine urinary calcium excretion in pregnant patients with chronic arterial hypertension (CAH) and preeclampsia (PE), and in normotensive patients (N). Forty-four pregnant patients (gestional age, 20-42 weeks; 18 CAH, 17 PE, 9 N) were evaluated for calciuria, proteinuria, plasma uric acid and blood pressure. Patients with PE (82 ± 15.1 mg/24 h) showed significantly lower calciuria (P<0.05) than the group with CAH (147 ± 24.9 mg/24 h) and the N group (317 ± 86.0 mg/24 h) (P<0.05, Student t-test). Plasma uric acid was significantly higher in the PE group (6.1 ± 0.38 mg/dl) than the CAH group (5.0 ± 0.33 mg/dl;... Tipo: Info:eu-repo/semantics/article Palavras-chave: Preeclampsia; Hypertension; Calciuria; Kidney function; High-risk pregnancy. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400007 Registros recuperados: 80 Primeira ... 1 2 3 4 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco