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Palavra-chave Leishmania (41) Leishmaniasis (5) Trypanosoma cruzi (4) Cão (3) Nitric oxide (3) Apoptosis (2) Cytokines (2) Dog (2) Dogs (2) Infection (2) Macrophages (2) Trypanosoma (2) Visceral leishmaniasis (2) Actin-interacting proteins (AIPs) (1) Adjuvant (1) Agglutination tests (1) Amiodarone (1) Amphibians (1) Anaplasma (1) Anergy (1) Mais... Tipo do documento Info:eu-repo/semantics/article (37) Info:eu-repo/semantics/other (1) Journal article (1) Ano 2020 (1) 2018 (3) 2017 (3) 2016 (4) 2014 (2) 2013 (1) 2012 (1) 2011 (2) 2010 (1) 2009 (4) 2008 (1) 2007 (1) 2006 (2) 2005 (6) 2004 (2) 2003 (1) 1999 (1) 1998 (4) 1994 (1) Mais... País Brazil (36) Japan (2) Argentina (1) Colombia (1) Cuba (1) Idioma Inglês (30) Português (7) Espanhol (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 41 Primeira ... 1 2 3 ... Última Current relevance of fungal and trypanosomatid glycolipids and sphingolipids: studies defining structures conspicuously absent in mammals Anais da ABC (AABC) Takahashi,Helio K.; Toledo,Marcos S.; Suzuki,Erika; Tagliari,Loriane; Straus,Anita H.. Recently, glycosphingolipids have been attracting attention due to their role on biological systems as second messengers or modulators of signal transduction, affecting several events, which range from apoptosis to regulation of the cell cycle. In pathogenic fungi, glycolipids are expressed in two classes: neutral monohexosylceramides (glucosyl-or galactosylceramide) and acidic glycosylinositol phosphorylceramides (the latter class carries longer glycan chains). It is worth to mention that monohexosylceramides exhibit significant structural differences in their lipid moieties compared to their mammalian counterparts, whereas the glycosylinositol phosphorylceramides exhibit remarkable structural differences in their carbohydrate moieties in comparison to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Glycosphingolipids; Glycosylinositol phosphorylceramides; Inositol phosphorylceramide; Leishmania; Membrane rafts; Pathogenic fungi. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300012 Detecção de formas amastigotas em exame parasitológico de esfregaço obtido a partir de suabe conjuntival de cães com leishmaniose visceral Arq. Bras. Med. Vet. Zootec. Barbosa,V.T.; Silva,M.A.G.; Sousa,M.G.; Gering,A.P.; Santos,H.D.; Laus,J.L.. Leishmaniose é uma enfermidade multissistêmica cujas manifestações clínicas são extremamente variáveis. Em cães sinais clínicos oftálmicos são relativamente frequentes, ainda que outros sinais sistêmicos não sejam identificados. Atualmente, o diagnóstico da doença baseia-se em métodos parasitológicos, sorológicos e moleculares, mas, até o momento, a identificação de formas amastigotas desse parasito em esfregaços feitos a partir de suabes conjuntivais não é empregada rotineiramente. Valendo-se de cães sorologicamente positivos para leishmaniose, portadores (G1) ou não (G2) de alterações oftálmicas, este estudo avaliou a viabilidade do esfregaço a partir de suabe conjuntival como método de diagnóstico para a enfermidade. O exame suprarreferido foi positivo... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cão; Leishmania; Linfonodo; Conjuntiva. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000600009 Avaliação dos indicadores de lesão miocárdica em cães com leishmaniose visceral Arq. Bras. Med. Vet. Zootec. Godoy,K.C.S.; Braz,P.H.; Assis,A.R.; Antunes,T.R.; Gomes,D.C.; Souza,A.I.. O objetivo deste estudo foi avaliar os indicadores laboratoriais, eletrocardiográficos e histológicos de lesão cardíaca em diferentes grupos clínicos de cães com leishmaniose visceral. Foram analisados marcadores séricos, traçado eletrocardiográfico e fragmentos de tecido cardíaco de 41 cães naturalmente infectados, distribuídos em três grupos: assintomático, oligossintomático e sintomático. Todos os animais apresentaram aumento na atividade sérica da enzima creatina quinase fração MB. No traçado eletrocardiográfico, o complexo de baixa voltagem foi o distúrbio de condução mais frequente (8/10). Na análise histológica, 75,6% dos cães apresentaram reação inflamatória com predomínio de infiltrados linfo-histiocítico (13/31) de intensidade discreta a moderada... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiomiopatia; Enzimas; Leishmania; Marcadores bioquímicos; Miocardite. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000200313 Ceratoconjuntivite nodular em um caso de leishmaniose visceral canina: relato de caso Arq. Bras. Med. Vet. Zootec. Eguchi,G.U.; Oliveira,G.G.; Babo-Terra,V.J.; Souza,A.I.; Barros,R.; Palumbo,M.I.P.. RESUMO Relata-se um caso de leishmaniose visceral canina com ceratoconjuntivite nodular como queixa exclusiva do proprietário. O diagnóstico se deu pela observação de formas amastigotas de Leishmania sp. no exame parasitológico direto de citologia aspirativa conjuntival. Lesões oculares raramente são queixas principais únicas de cães com leishmaniose, como o caso em questão, o que demonstra a variabilidade de apresentação clínica da doença e a importância da realização de testes laboratoriais diagnósticos para leishmaniose como triagem para pacientes de áreas endêmicas. Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania; Neoplasias; Oftalmopatias. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000601480 Técnicas de citologia aspirativa, biópsia e citobloco de medula óssea para identificação e determinação de intensidade parasitária na leishmaniose visceral canina Arq. Bras. Med. Vet. Zootec. Antunes,T.R.; Godoy,K.C.S.; Oliveira,G.G.; Silveira,A.W.; Ramos,C.A.N.R.; Souza,A.I.. RESUMO O objetivo com este estudo foi comparar as técnicas de citologia aspirativa, biópsia e citobloco para identificação e quantificação parasitológica de Leishmania (Leishmania) infantum chagasi em medula óssea de cães. Amostras de tecido medular de 26 animais, em diferentes estágios clínico-laboratoriais da doença, foram estudadas obedecendo-se os mesmos critérios de investigação nas técnicas de citologia aspirativa, biópsia e citobloco. O menor número de campos para a confirmação parasitológica foi constatado no esfregaço direto obtido por citologia aspirativa. O estágio clínico-laboratorial não influenciou no número de campos necessários para a primeira visualização do agente em nenhuma das técnicas (p>0,05), e menor intensidade parasitária foi... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cão; Diagnóstico parasitológico; Leishmania. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000501362 Renal involvement in canine leishmaniasis: a morphological and immunohistochemical study Arq. Bras. Med. Vet. Zootec. Soares,M.J.V.; Moraes,J.R.E.; Moraes,F.R.. IgG and IgM deposits in kidneys of dogs with visceral leishmaniasis (VL) were studied in 25 symptomatic dogs (case) and 15 asymptomatic dogs (control) by an immunohistochemical method. All tested dogs were positive for VL by polymerase chain reaction, enzyme-linked immunosorbent assay, and indirect immunofluorescence test. Kidney fragments were submitted to immunohistochemical reaction. Many morphological patterns of distribution of subendothelial granules were identified for IgG and IgM in glomerular capillaries: global, segmental, diffuse, or focal. Intensity of immunohistochemical reaction to IgG was not significantly different when comparing the symptomatic and the asymptomatic animal groups by Fisher's exact test. IgM reactions were significantly... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dog; Leishmania; Kidneys; Glomerulonephritis; Immunoglobulins. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352009000400004 Abortion and fetal death in bitches due anemia caused by vector-borne diseases Arq. Bras. Med. Vet. Zootec. Freire,D.A.C.; Oliveira,I.V.P.M.; Ferreira,H.I.P.; Andrade,V.C.P.; Silva,C.R.F.; Kurissio,J.K.; Ullmann,L.S.; Malossi,C.D.; Joaquim,S.F.; Araújo Júnior,J.P.; Langoni,H.; Calabuig,C.; Megid,J.; Antunes,J.M.A.P.. RESUMO Doenças infecciosas são as maiores responsáveis por falhas reprodutivas (FR) em cadelas, causando aborto, morte fetal e natimortalidade. Este estudo teve como objetivo investigar a associação entre agentes infecciosos, FR inexplicáveis e anemia em cadelas. Todas as amostras maternas e fetais foram negativas para a presença dos principais agentes infecciosos causadores de FR: herpes vírus canino 1, Neospora caninum, Brucella spp. e B. canis, enquanto agentes como o de Leishmania spp., parvovírus canino, Ehrlichia canis e Anaplasma platys foram encontrados em sangue materno. Coinfecções de A. platys/E. canis e A. platys/Leishmania spp. foram diagnosticadas. Os resultados indicam que os animais com anemia causadas por doenças transmitidas por vetores... Tipo: Info:eu-repo/semantics/other Palavras-chave: Anaplasma; Ehrlichia; Leishmania; Reproductive failures. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000501326 Primer informe de Lutzomyia yuilli Young &amp; Porter, 1972 y Lutzomyia triramula (Fairchild &amp; Hertig 1952) (Diptera: Psychodidae) en el departamento de Caldas, Colombia Biota Neotropica Vergara,Daniela; Carrillo,Lina María; Bejarano,Eduar Elías; Vélez,Iván Darío. Durante estudios de foco en varios municipios del departamento de Caldas, Colombia, donde se han presentado casos de leishmaniosis cutánea, se recolectaron nueve especies de Lutzomyia: Lutzomyia gomezi (Nitzulescu 1931), Lu. ayrozai (Barreto &amp; Coutinho 1940), Lu. panamensis (Shannon 1926), Lu. bifoliata Osorno, Morales, Osorno &amp; Hoyos, 1970, Lu. trapidoi (Farchild &amp; Hertig 1952), Lu. yuilli Young &amp; Porter, 1952, Lu. triramula (Fairchild &amp; Hertig 1952), Lu. atroclavata (Knab 1913) y Lu. trinidadensis (Newstead 1922). Dos de estos taxones constituyen nuevos registros para el departamento, Lu. yuilli del subgénero Nyssomyia, y Lu. triramula del subgénero Trichopygomyia. Los individuos de Lu. yuilli se obtuvieron... Tipo: Info:eu-repo/semantics/article Palavras-chave: Phlebotominae; Leishmania; Nyssomyia; Trichopygomia; Nuevo registro; Colombia. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032008000300022 Controle de flebotomíneos com DDT, em àrea endêmica de leishmaniose tegumentar no estado do Paraná, sul do Brasil BABT Teodoro,Ueslei; Galati,Eunice A.B.; Kühl,João Balduíno; Lozovei,Ana Leuch; Barbosa,Orlando Carlos. Evaluation of DDT insecticide used to sand flies control in domiciles and domestic animal shelters in an endemic area of cutaneous leishmaniasis. Collections of sand flies were made with Falcão traps in houses, in one pigsty and in one tree in Jussara Farm, municipality of Jussara, State of Paraná, Brazil, between 10 p.m. and 2 a.m. during 7 days from March 24 to April 1, 1992. In May, 1992 DDT insecticide (Dicloro Difenil Tricloro Etano) (1 g/square meter of area) was applied internally and externally on houses and in pigsty. After this, new collections of sand flies were made from July 1992 to February 1993, once a month, with Falcão traps installed in the same hour and conditions mentioned above. Before DDT insecticide application 12,960 sand flies were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania; Leishmaniose; Controle de flebotomíneos; DDT. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89131998000300014 The use of radionuclide DNA probe technology for epidemiological studies of tegumentary leishmaniasis in Mato Grosso state BABT Andrade,Antero Silva Ribeiro de; Fernandes,Octávio; Heub,Marcia; Carvalho,Maria de Lourdes Ribeiro; Fontes,Cor Jesus; Melo,Maria Norma de. DNA hybridisation, using probes labelled with 32P, was used to type Leishmania samples isolated from patients living in endemic areas of Mato Grosso State (Brazil), and clinically diagnosed as having tegumentary leishmaniasis. kDNA cloned mini-circle probes specific for the Leishmania mexicana and Leishmania braziliensis complexes were used. The results showed that L. braziliensis is the predominant group infecting human patients in the state. Sixty-eight samples were typed, 64 samples (94.1%) belonging to the L. braziliensis complex and only four (5.9%) belonging to the L. mexicana complex. Accurate identification of the Leishmania permits better orientation of the medical follow-up, since clinical manifestations may vary depending on the complex to which... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania; Leishmaniasis; DNA hybridisation; Mato Grosso state. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700030 Comparison of different primes for PCR-based diagnosis of cutaneous leishmaniasis BJID Oliveira,Diego Molina de; Lonardoni,Maria Valdrinez Campana; Teodoro,Ueslei; Silveira,Thais Gomes Verzignassi. OBJECTIVE: The objective of this study was to analyze different primers that are commonly used in epidemiological studies for the detection of Leishmania DNA by PCR, and to compare them to the conventional direct parasite search for American cutaneous leishmaniasis (ACL) diagnosis. MATERIAL AND METHODS: Five pairs of primers, four of them derived from Leishmania kDNA sequences (MP3H-MP1L; B1-B2; LBF1-LBR1; 13A-13B), and one derived from the SL RNA (mini-exon) gene repeat (LU5A-LB3C), reported previously, were used. RESULTS: The MP3H-MP1L primers were the best at amplifying the DNA, detecting 2 fg of Leishmania spp. DNA. The 13A-13B primers presented the worst performance, detecting 512 x 10³ fg of DNA. CONCLUSION: The wide variation in the analytical... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmaniasis; Polymerase chain reaction; Leishmania; DNA primers. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300004 Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity BJMBR Romão,P.R.T.; Tovar,J.; Fonseca,S.G.; Moraes,R.H.; Cruz,A.K.; Hothersall,J.S.; Noronha-Dutra,A.A.; Ferreira,S.H.; Cunha,F.Q.. Glutathione is the major intracellular antioxidant thiol protecting mammalian cells against oxidative stress induced by oxygen- and nitrogen-derived reactive species. In trypanosomes and leishmanias, trypanothione plays a central role in parasite protection against mammalian host defence systems by recycling trypanothione disulphide by the enzyme trypanothione reductase. Although Kinetoplastida parasites lack glutathione reductase, they maintain significant levels of glutathione. The aim of this study was to use Leishmania donovani trypanothione reductase gene mutant clones and different Leishmania species to examine the role of these two individual thiol systems in the protection mechanism against S-nitroso-N-acetyl-D,L-penicillamine (SNAP), a... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania; Glutathione; Trypanothione; Trypanothione reductase; Nitric oxide; Free radicals. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000300006 Control of gene expression in Trypanosomatidae BJMBR Teixeira,S.M.R.. The study of mechanisms which control gene expression in trypanosomatids has developed at an increasing rate since 1989 when the first successful DNA transfection experiments were reported. Using primarily Trypanosoma brucei as a model, several groups have begun to elucidate the basic control mechanisms and to define the cellular factors involved in mRNA transcription, processing and translation in these parasites. This review focuses on the most recent studies regarding a subset of genes that are expressed differentially during the life cycle of three groups of parasites. In addition to T. brucei, I will address studies on gene regulation in a few species of Leishmania and the results obtained by a much more limited group of laboratories studying gene... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma; Leishmania; Gene expression; RNA; Antigenic variation; VSG. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200001 What about Th1/Th2 in cutaneous leishmaniasis vaccine discovery? BJMBR Campos-Neto,A.. The T helper cell type 1 (Th1) response is essential to resist leishmaniasis, whereas the Th2 response favors the disease. However, many leishmanial antigens, which stimulate a Th1 immune response during the disease or even after the disease is cured, have been shown to have no protective action. Paradoxically, antigens associated with an early Th2 response have been found to be highly protective if the Th1 response to them is generated before infection. Therefore, finding disease-associated Th2 antigens and inducing a Th1 immune response to them using defined vaccination protocols is an interesting unorthodox alternative approach to the discovery of a leishmania vaccine. Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania; Th1/Th2 paradigm; Infection; Vaccine; Antigen discovery; Adjuvant. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000700001 Apoptotic mimicry: an altruistic behavior in host/Leishmania interplay BJMBR Wanderley,J.L.M.; Benjamin,A.; Real,F.; Bonomo,A.; Moreira,M.E.C.; Barcinski,M.A.. Apoptosis is the most common phenotype observed when cells die through programmed cell death. The morphologic and biochemical changes that characterize apoptotic cells depend on the activation of a diverse set of genes. Apoptosis is essential for multicellular organisms since their development and homeostasis are dependent on extensive cell renewal. In fact, there is strong evidence for the correlation between the emergence of multicellular organisms and apoptosis during evolution. On the other hand, no obvious advantages can be envisaged for unicellular organisms to carry the complex machinery required for programmed cell death. However, accumulating evidence shows that free-living and parasitic protozoa as well as yeasts display apoptotic markers. This... Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Phosphatidylserine; Leishmania; Phagocyte. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600001 Aurapten, a coumarin with growth inhibition against Leishmania major promastigotes BJMBR Napolitano,H.B.; Silva,M.; Ellena,J.; Rodrigues,B.D.G.; Almeida,A.L.C.; Vieira,P.C.; Oliva,G.; Thiemann,O.H.. Several natural compounds have been identified for the treatment of leishmaniasis. Among them are some alkaloids, chalcones, lactones, tetralones, and saponins. The new compound reported here, 7-geranyloxycoumarin, called aurapten, belongs to the chemical class of the coumarins and has a molecular weight of 298.37. The compund was extracted from the Rutaceae species Esenbeckia febrifuga and was purified from a hexane extract starting from 407.7 g of dried leaves and followed by four silica gel chromatographic fractionation steps using different solvents as the mobile phase. The resulting compound (47 mg) of shows significant growth inhibition with an LD50 of 30 µM against the tropical parasite Leishmania major, which causes severe clinical manifestations... Tipo: Info:eu-repo/semantics/article Palavras-chave: Coumarin; Aurapten (7-geranyloxycoumarin); X-rays; Leishmania; Inhibitor. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001200010 Photodynamic antimicrobial chemotherapy (PACT) for the treatment of malaria, leishmaniasis and trypanosomiasis BJMBR Baptista,M.S.; Wainwright,M.. A photodynamic effect occurs when photosensitiser molecules absorb light and dissipate the absorbed energy by transferring it to biological acceptors (usually oxygen), generating an excess of reactive species that are able to force cells into death pathways. Several tropical diseases present physiopathological aspects that are accessible to the application of a photosensitiser and local illumination. In addition, disease may be transmitted through infected blood donations, and many of the aetiological agents associated with tropical diseases have been shown to be susceptible to the photodynamic approach. However, there has been no systematic investigation of the application of photoantimicrobial agents in the various presentations, whether to human disease... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tropical diseases; Photodynamic therapy; Singlet oxygen; Photosensitisers; Leishmania; Chagas’ disease. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000100001 Parasitic infections in germfree animals BJMBR Vieira,L.Q.; Oliveira,M.R.; Neumann,E.; Nicoli,J.R.. The association of vertebrate hosts with the indigenous microbiota and its effect on the response to infections has long been a subject of scientific curiosity. From the first theory supported by Louis Pasteur that life would be impossible in the absence of associated microorganisms to the development of germfree mammals for research, a lot was learned about how the normal microbiota influences the environment in which pathogens may find themselves. In the present review, we attempt to summarize the more recent results from our group and others on the influence of the normal microbiota on the outcome of parasitic infections. Our results and those of others point to a complex relationship between the mammalian system and its indigenous microbiota, leading... Tipo: Info:eu-repo/semantics/article Palavras-chave: Germfree; Microbiota; Gnotobiotic; Infection; Leishmania; Trypanosoma. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100013 Induction of cell-mediated immunity during early stages of infection with intracellular protozoa BJMBR Gazzinelli,R.T.; Talvani,A.; Camargo,M.M.; Santiago,H.C.; Oliveira,M.A.P.; Vieira,L.Q.; Martins,G.A.; Aliberti,J.C.S.; Silva,J.S.. Toxoplasma gondii and Trypanosoma cruzi are intracellular parasites which, as part of their life cycle, induce a potent cell-mediated immunity (CMI) maintained by Th1 lymphocytes and IFN-<FONT FACE="Symbol">g</font>. In both cases, induction of a strong CMI is thought to protect the host against rapid parasite multiplication and consequent pathology and lethality during the acute phase of infection. However, the parasitic infection is not eliminated by the immune system and the vertebrate host serves as a parasite reservoir. In contrast, Leishmania sp, which is a slow growing parasite, appears to evade induction of CMI during early stages of infection as a strategy for surviving in a hostile environment (i.e., inside the macrophages which are... Tipo: Info:eu-repo/semantics/article Palavras-chave: Leishmania; Toxoplasma gondii; Trypanosoma cruzi; Macrophages; Cytokines; Nitric oxide. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100012 Leishmanicidal, trypanocidal, and cytotoxic activities of endophytic fungi associated with bioactive plants in Brazil BJM Rosa,Luiz H.; Gonçalves,Vívian N.; Caligiorne,Rachel B.; Alves,Tânia M. A.; Rabello,Ana; Sales,Policarbo A.; Romanha,Alvaro J.; Sobral,Marcos E. G.; Rosa,Carlos A.; Zani,Carlos L.. One hundred and twenty-one isolates of endophytic fungi were recovered from leaves of the bioactive Brazilian plant species Ageratum myriadenia, Palicourea tetraphylla, Piptadenia adiantoides, and Trixis vauthieri. All fungal isolates were cultivated in liquid media and crude extracts were obtained with ethyl acetate. The crude extracts were tested in bioassay panels using Leishmania amazonensis, Trypanosoma cruzi, the enzyme trypanothione reductase (TryR) from Trypanosoma cruzi, and three human cancer cell lines. Thirty-three extracts (27.2%) exhibited at least one biological activity. Seventeen extracts (14%) were cytotoxic against one or more human cancer cell line with the IC50 values ranged of >0.2 to 25 µg/mL. Twenty-four extracts (19.8%)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Endophytic fungi; Human tumoral cell; Leishmania; Secondary metabolites; Trypanosoma cruzi. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822010000200024 Registros recuperados: 41 Primeira ... 1 2 3 ... Última

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