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| Registros recuperados: 39 | |
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| García,Liseth; Bulnes,C; Melchor,G; Hidalgo,L; Figueredo,J; Vega,E; Marrero,E. |
| To obtain safe quality criteria for biological control agents, many tests have been developed. The aim of these studies was to determine the potentiality of Pochonia chlamydosporia var. catenulata to produce toxicity, infectivity or other organ/tissue damage in quails. Acute and toxicity/pathogenicity studies were performed by oral route. A maximum dose level of 6x10(6) units of the microbial pest control agent per bird treated was used. Mortality or clinical signs were not observed and no effects on body weight, haematology, microbiology and gross or microscopic pathology were detected. Thus clinical, microbiological and pathological results provided evidence for the safety properties of this fungus in quails. |
| Tipo: Journal article |
Palavras-chave: Pochonia chlamydosporia var. catenulata; Toxicity/pathogenicity; Safety; Quails. |
| Ano: 2009 |
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0253-570X2009000100008 |
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| Oliveira-Filho, Eduardo Cyrino; Embrapa Cerrados; Ramos, Marianni Gonçalves; Centro Universitário de Brasília - UniCEUB; Freire, Ingrid Souza; Centro Universitário de Brasília - UniCEUB; Muniz, Daphne Heloisa de Freitas; Embrapa Cerrados. |
| This study evaluated the efficiency of two bioindicators, fecal coliforms and ecotoxicity tests, set out in CONAMA Resolution 274/00 and CONAMA Resolution 357/05, in assessment of water quality. For this study, Lake Paranoá, Federal District of Brazil, was chosen, since it is a water body directly contaminated by effluents from a sewage treatment plant. Four sampling points were chosen in accordance with the map of recreational water quality published weekly by CAESB/DF, after analysis of fecal coliforms. Samples from these points were collected for 6 months and tested on Danio rerio fish (acute toxicity) and on the microcrustacean Ceriodaphnia dubia (acute and chronic toxicity), besides measuring chemical and physico-chemical parameters. The data obtained... |
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Palavras-chave: 2.00.00.00-6 water quality; Ecotoxicity tests; Fecal coliforms; Paranoá lake; Recreational water; Safety 2.00.00.00-6 water quality; Ecotoxicity tests; Fecal coliforms; Paranoá lake; Recreational water; Safety. |
| Ano: 2011 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/7725 |
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| BARBOSA,HUMBERTO M.; NASCIMENTO,JAILSON N. DO; ARAÚJO,THIAGO A.S.; DUARTE,FILIPE S.; ALBUQUERQUE,ULYSSES P.; VIEIRA,JEYMESSON R.C.; SANTANA,EDSON R.B. DE; YARA,RICARDO; LIMA,CLÁUDIA S.A.; GOMES,DAYANE A.; LIRA,EDUARDO C.. |
| ABSTRACT Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Female Wistar rats were divided into: control (C) and animal treated single doses of 300mg/Kg (EEStb300) or 2.000mg/kg body weight (ESStb2.000) of the EEStb. After 24 hours and 14 days from gavage, the behavior, hematological, biochemical and histopathological parameters were assayed. Cytotoxicity effect was evaluated on HEp-2 cell lines. Neither EEStb300 nor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute toxicity; Cytotoxicity; Phytomedicine; Safety; Spondias tuberosa Arruda; Toxicology. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501993 |
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| Qu,Xiao-Yu; Hu,Ting-Ting; Zhou,Wei. |
| Objective: The aim of this article is to compare the efficacy and safety of doripenem for bacterial infections. Methods: We included six randomized clinical trials identified from PubMed and Embase up to July 31, 2014. The included trials compared efficacy and safety of doripenem for complicated intra-abdominal infections, complicated urinary tract infection, nosocomial pneumonia, and acute biliary tract infection. The meta-analysis was carried on by the statistical software of Review Manager, version 5.2. Results: Compared with empirical antimicrobial agents on overall treatment efficacy, doripenem was associated with similar clinical and microbiological treatment success rates (for the clinical evaluable population, odds ratio [OR] = 1.26, 95% confidence... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Doripenem Meta-analysis Efficacy; Safety; Infection. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200156 |
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| Pasqualotto,Alessandro C.; Almeida,Camila S.; Kliemann,Dimas A.; Barcellos,Guilherme B.; Queiroz-Telles,Flávio; Abdala,Edson; Resende,Mariangela; Batista,Filipe P.; Vidal,José E.; Rocha,Jaime; Raboni,Sonia M.; Cimerman,Sergio; Gales,Ana C.. |
| ABSTRACT The Choosing Wisely Initiative aims to collect statements from medical societies all over the world on medical interventions that result in no benefit to patients, with the potential to cause harm. In this article we present the views of the Diagnostic Laboratory Group at the Brazilian Society of Infectious Diseases (SBI). Ten experts from SBI were asked to list 10 diagnostic tests that were perceived as unnecessary in the field of infectious diseases. After voting for the more relevant topics, a questionnaire was sent to all SBI members, in order to select for the most important items. A total of 482 votes were obtained, and the top 10 results are shown in this manuscript. The Choosing Wisely statements of SBI should facilitate clinical practice... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Choosing wisely; Quality; Safety; Infectious diseases; Microbiology; Diagnostic tests; Healthcare administration. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500331 |
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| Zerbini,Cristiano A.F.; Ribeiro dos Santos,Rodrigo; Jose Nunes,Maria; Soni,Jyoti; Li,Ping; Jain,Varsha K.; Ofori-Anyinam,Opokua. |
| Abstract The World Health Organization influenza forecast now includes an influenza B strain from each of the influenza B lineages (B/Yamagata and B/Victoria) for inclusion in seasonal influenza vaccines. Traditional trivalent influenza vaccines include an influenza B strain from one lineage, but because two influenza B lineages frequently co-circulate, the effectiveness of trivalent vaccines may be reduced in seasons of influenza B vaccine-mismatch. Thus, quadrivalent vaccines may potentially reduce the burden of influenza compared with trivalent vaccines.In this Phase III, open-label study, we assessed the immunogenicity and safety of Southern Hemisphere inactivated quadrivalent influenza vaccine (Fluarix™ Tetra) in Brazilian adults (NCT02369341). The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Quadrivalent; Influenza; Vaccine; Immunogenicity; Safety; Brazil; Adults. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100063 |
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| Parise,E.; Cheinquer,H.; Crespo,D.; Meirelles,A.; Martinelli,A.; Sette,H.; Gallizi,J.; Silva,R.; Lacet,C.; Correa,E.; Cotrim,H.; Fonseca,J.; Paraná,R.; Spinelli,V.; Amorim,W.; Tatsch,F.; Pessoa,M.. |
| Peginterferon alfa plus ribavirin is currently the treatment of choice for chronic hepatitis C. Peginterferon alfa-2a (40KD) plus ribavirin has given an overall sustained virological response of 18% in F3/F4 previous nonresponder US patients. We evaluated the effectiveness of peginterferon alfa-2a (40KD) plus ribavirin in Brazilian patients who were relapsers or nonresponders to previous interferon-based therapy. One-hundred-thirty-four patients with biopsy-proven chronic hepatitis C, HCV RNA positive, elevated ALT and who were either relapsers (n=37) or nonresponders (n=97) to at least 24 weeks of conventional interferon/ribavirin therapy were retreated with peginterferon alfa-2a (40KD) 180mg/qw and ribavirin 800mg bid for 48 weeks. Efficacy was assessed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Peginterferon alfa; Ribavirin; Hepatitis C; Safety; Efficacy. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100003 |
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| Nascimento,I.P.; Leite,L.C.C.. |
| Vaccines were initially developed on an empirical basis, relying mostly on attenuation or inactivation of pathogens. Advances in immunology, molecular biology, biochemistry, genomics, and proteomics have added new perspectives to the vaccinology field. The use of recombinant proteins allows the targeting of immune responses focused against few protective antigens. There are a variety of expression systems with different advantages, allowing the production of large quantities of proteins depending on the required characteristics. Live recombinant bacteria or viral vectors effectively stimulate the immune system as in natural infections and have intrinsic adjuvant properties. DNA vaccines, which consist of non-replicating plasmids, can induce strong... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Human vaccines; Vectors for immunization; Safety; Recombinant vaccines. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200001 |
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| Noël,F.; Nascimento-Viana,J.B.; Romeiro,L.A.S.; Silva,R.O.; Lemes,L.F.N.; Oliveira,A.S.; Giorno,T.B.S.; Fernandes,P.D.; Silva,C.L.M.. |
| This study aimed to estimate the absorption, distribution, metabolism and excretion (ADME) properties and safety of LDT5, a lead compound for oral treatment of benign prostatic hyperplasia that has previously been characterized as a multi-target antagonist of α1A-, α1D-adrenoceptors and 5-HT1A receptors. The preclinical characterization of this compound comprised the evaluation of its in vitro properties, including plasma, microsomal and hepatocytes stability, cytochrome P450 metabolism and inhibition, plasma protein binding, and permeability using MDCK-MDR1 cells. De-risking and preliminary safety pharmacology assays were performed through screening of 44 off-target receptors and in vivo tests in mice (rota-rod and single dose toxicity). LDT5 is stable in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Benign prostatic hyperplasia; ADME; Safety; Permeability; CYP; Preclinical development. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001200603 |
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| Nardi,A.E.; Valença,A.M.; Freire,R.C.; Mochcovitch,M.D.; Amrein,R.; Sardinha,A.; Levitan,M.N.; Nascimento,I.; de-Melo-Neto,V.L.; King,A.L.; de O. e Silva,A.C.; Veras,A.B.; Dias,G.P.; Soares-Filho,G.L.; da Costa,R.T.; Mezzasalma,M.A.; de Carvalho,M.R.; de Cerqueira,A.C.; Hallak,J.E.; Crippa,J.A.; Versiani,M.. |
| The objective of the present randomized, open-label, naturalistic 8-week study was to compare the efficacy and safety of treatment with clonazepam (N = 63) and paroxetine (N = 57) in patients with panic disorder with or without agoraphobia. Efficacy assessment included number of panic attacks and clinician ratings of the global severity of panic disorders with the clinical global impression (CGI) improvement (CGI-I) and CGI severity (CGI-S) scales. Most patients were females (69.8 and 68.4% in the clonazepam and paroxetine groups, respectively) and age (mean ± SD) was 35.9 ± 9.6 years for the clonazepam group and 33.7 ± 8.8 years for the paroxetine group. Treatment with clonazepam versus paroxetine resulted in fewer weekly panic attacks at week 4 (0.1 vs... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Paroxetine; Clonazepam; Panic disorder; Efficacy; Safety. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400015 |
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| Calixto,J.B.. |
| This review highlights the current advances in knowledge about the safety, efficacy, quality control, marketing and regulatory aspects of botanical medicines. Phytotherapeutic agents are standardized herbal preparations consisting of complex mixtures of one or more plants which contain as active ingredients plant parts or plant material in the crude or processed state. A marked growth in the worldwide phytotherapeutic market has occurred over the last 15 years. For the European and USA markets alone, this will reach about $7 billion and $5 billion per annum, respectively, in 1999, and has thus attracted the interest of most large pharmaceutical companies. Insufficient data exist for most plants to guarantee their quality, efficacy and safety. The idea that... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Herbal medicine; Efficacy; Safety; Quality control; Market; Regulatory guidelines. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200004 |
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| Andrade,E.L.; Bento,A.F.; Cavalli,J.; Oliveira,S.K.; Schwanke,R.C.; Siqueira,J.M.; Freitas,C.S.; Marcon,R.; Calixto,J.B.. |
| The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through several steps, such as determination of drug availability (studies on pharmacokinetics), absorption, distribution, metabolism and elimination (ADME) and preliminary studies that aim to investigate the candidate safety including genotoxicity, mutagenicity, safety pharmacology and general toxicology. These preliminary studies generally do not need to comply with GLP regulations. These studies aim at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Non-clinical studies; GLP studies; Safety; Pharmacokinetics; Toxicology. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001200301 |
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| Malheiros,Camila Krüger Cardoso; Silva,Joyce Sayonara Barbosa; Hofmann,Tânia Cristiane; Messina,Thiane Martins; Manfredini,Vanusa; Piccoli,Jacqueline da Costa Escobar; Faoro,Débora; Oliveira,Luís Flávio Souza; Machado,Michel Mansur; Farias,Fabiane Moreira. |
| ABSTRACT The bark tea of Ceiba speciosa, a tropical tree of the Malvaceae family, is used in the Northwestern Region of Rio Grande do Sul state, Brazil, to reduce blood cholesterol levels. However, there are no scientific data on the efficacy and safety of this plant. The aim of the present study was to evaluate the in vitro antioxidant and toxic potential of bark extracts of C. speciosa. We performed a preliminary phytochemical analysis by high-performance liquid chromatography-diode array detection (HPLC-DAD) and evaluated the oxidative damage to proteins and lipids, the radical scavenging effect, and genotoxicity of the lyophilized aqueous extract (LAECs) and the precipitate obtained from the raw ethanol extract (Cs1). The phytochemical profile... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ceiba speciose/phytochemistry; Ceiba speciose/antioxidant activity; Phenolic content; Comet assay; DPPH scavenging capacity; Natural medicine; Safety. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200616 |
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| Zhang,Tan; Zhang,Minjie; Zu,Li’an; Wang,Qian; Wang,Qi; Wang,Wei; Wang,Yitong; Zang,Yannan; Xie,Zhenwei; Chen,Shi; Wang,Mei; Zheng,Qingshan; Li,Zhanguo; Chen,Guihong; Fang,Yi. |
| T0001 is the first mutant of etanercept with a higher affinity to tumor necrosis factor α (TNF-α) than etanercept. In order to investigate the safety and tolerability of T0001, a study was carried out in healthy Chinese subjects. A first-in-human, dose escalation study was conducted in healthy Chinese subjects. Fifty-six subjects were divided into six dose cohorts (10 mg, 20 mg, 35 mg, 50 mg, 65 mg and 75 mg) to receive a single subcutaneous injection of T0001. Safety and tolerability assessment were based on the records of vital signs, physical examinations, clinical laboratory tests, 12-lead electrocardiograms and adverse events (AEs). All subjects were in good compliance and none withdraw due to AEs. No serious AEs occurred. A total of twenty-three AEs... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: T0001; TNF-α; Rheumatoid arthritis; Safety; Tolerability. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100598 |
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| Serna Cock,Liliana; Zetty Arenas,Ana María; Ayala Aponte,Alfredo. |
| Biosensors are an important alternative in the food industry to ensure the quality and safety of products and process controls with effective, fast and economical methods. Their technology is based on a specific biological recognition element in combination with a transducer for signal processing. The use of enzymatic biosensor technology in food processing, quality control and on-line processes is promising compared to conventional analytical techniques, as it offers great advantages due to size, cost, specificity, fast response, precision and sensitivity. This article reviews the development and use of some enzyme biosensors in the food industry, describes the most important application areas and analyzes the current situation and future possibilities.... |
| Tipo: Journal article |
Palavras-chave: Biosensors; Enzymes; Analysis in food; Safety; Quality; Control processes. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-58392009000200017 |
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| Barbieri,Juan Paulo; Schlosser,José Fernando; Farias,Marcelo Silveira de; Negri,Giácomo Müller; Oliveira,Luis Fernando Vargas de. |
| ABSTRACT: This study aimed to develop and validate an ergonomics index for the operator workplace assessment of agricultural tractors sold in the Brazilian market. To develop the ergonomics index, the operator work places were assessed for compliance with current, national and international, safety and ergonomics standards. The following standards were analyzed to develop ergonomics index: ISO 15077 (1996), which regulates the position of operator controls; ABNT NBR ISO 4254-1(2015) and ABNT NBR ISO 4252 (2011), which regulate the access to operator workplaces; and NR 12 (2010), which determines the mandatory items of operator workplaces.Thirty-four operator work places of 152 models of new agricultural tractors sold in the Brazilian market were analyzed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ergonomics; Safety; Operator controls; Access; Standards. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000100352 |
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| Registros recuperados: 39 | |
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