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| Registros recuperados: 51 | |
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| Travassos,Ana Gabriela; Xavier-Souza,Eveline; Netto,Eduardo; Dantas,Eda Vinhaes; Timbó,Maiara; Nóbrega,Isabella; Haguihara,Tatiana; Neumayer,Júlia; Lisboa,Nathalia; Soidan,Maria Angela; Ferreira,Fábio; Brites,Carlos. |
| ABSTRACT Background: Infections caused by Chlamydia trachomatis and Neisseria gonorrhoeae are the most common bacterial sexually transmitted infections throughout the world. These sexually transmitted infections are a growing problem in people living with HIV/AIDS. However, the presence of these agents in extra genital sites, remains poorly studied in our country. The objective of this study was to estimate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae anal and genital infection in people living with HIV/AIDS followed in a reference center in Salvador, Brazil. Methods: Cross-sectional study, from June 2013 to June 2015. Proven HIV-infected people attending this reference center were invited. Clinical and epidemiological data were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Chlamydia trachomatis; Neisseria gonorrhoeae; Sexually transmitted infections; Anogenital infections. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600569 |
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| Torres,Alex José Leite; Brígido,Luis Fernando de Macedo; Abrahão,Marcos Herculano Nunes; Angelo,Ana Luiza Dias; Ferreira,Gilcivaldo de Jesus; Coelho,Luana Portes; Ferreira,João Leandro; Jorge,Célia Regina Mayoral Pedroso; Martins Netto,Eduardo; Brites,Carlos. |
| Use of CCR5 antagonists requires previous viral tropism determination. The available methods have high cost, are time-consuming, or require highly trained personnel, and sophisticated equipment. We compared a flow cytometry-based tropism assay with geno2pheno method to determine HIV-1 tropism in AIDS patients, in Bahia, Brazil. We tested peripheral blood mononuclear cells of 102 AIDS patients under antiretroviral therapy by using a cytometry-based tropism assay and geno2pheno assay. Cellular membrane receptors were identified by using CXCR4, CCR5 and CD4 monoclonal antibodies, while detection of cytoplasmic mRNAs for gag and pol HIV regions was achieved by using a labeled probe. Genotypic identification of X4 and R5 tropic viruses was attempted by geno2pheno... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV-1; Tropism; Flow cytometry; Geno2pheno. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200163 |
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| Gomes Neto,Mansueto; Conceição,Cristiano Sena; Ogalha,Cecília; Brites,Carlos. |
| Abstract Introduction HIV infection and its therapy which can affect their aerobic capacity and health-related quality of life of patients. Objective We conducted a cross-sectional study to determine if aerobic capacity and health related quality of life was decreased in HIV-infected patients receiving highly active antiretroviral therapy and comparing patients with and without lipodystrophy. Research design and methods HIV-infected patients older than 18 years, and in current use of highly active antiretroviral therapy drugs, were evaluated for blood count, fasting total cholesterol, high density lipoprotein, triglycerides, glucose, HIV viral load and CD4/CD8 counts, body composition, peak oxygen consumption (peak VO2) and metabolic equivalent. Health... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antiretroviral therapy; HIV infection; Quality of life; Disability. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100076 |
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| Alves,Crésio; Souza,Thaisa; Meyer,Isadora; Toralles,Maria Betânia P.; Brites,Carlos. |
| Many studies have tried to identify genetic markers for infectious diseases, some of them have focused on human leukocyte antigens (HLA). The products of HLA genes interact with surface-specific receptors of T lymphocytes, resulting in activation of the host's immune response. Association of bacterial, viral, parasitic and fungal infections with the host's HLA has been widely investigated. The type and strength of this association differs among distinct populations, as well as among racial and/or ethnic groups. The new molecular methods for the identification of the HLA alleles, and the resulting new nomenclature, have contributed to a better understanding of this system. Unfortunately, this information has not been adequately transmitted to clinicians,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HLA; Infectious diseases; Major histocompatibility complex. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200010 |
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| Diaz,Ricardo Sobhie; Sucupira,Maria Cecilia A; Vergara,Tania RC; Brites,Carlos; Bianco,Rosana Del; Bonasser Filho,Francisco; Colares,Geova Keny B; Portela,Estevão; Cherman,Lia Adler; Barcelos,Nemora Tregnago; Tupinambas,Unai; Turcato Jr,Gilberto; Allamasey,Lisa; Bacheler,Lee; Tuohy,Martin. |
| OBJECTIVE: To investigates how the use of HIV-1 resistance tests influences physician decision-making. METHODS: Ten experienced reference physicians from the Brazilian Network for Drug Resistance each received ten patients' case histories. The selected patients had experienced at least two virological failures. First, reference physicians were asked to empirically select a new regimen for each patient. Second, after genotype report (ViroSeq 2.6) was provided, and physicians were again asked to select a new regimen considering this additional information. Finally, they were asked to select a regimen after receiving a virtual phenotype result (vircoTYPE 3.9.00). RESULTS: In 79% of the cases, physicians changed their empirical choice of regimen after... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genotype; Virtual phenotype; Antiretroviral resistance; Brazil. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500011 |
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| Brites,Carlos; Pinto-Neto,Lauro; Medeiros,Melissa; Nunes,Estevão; Sprinz,Eduardo; Carvalho,Mariana. |
| Abstract Background Development of drug-resistance mutations is the main cause of failure in antiretroviral therapy. In Brazil, there is scarce information on resistance pattern for patients failing antiretroviral therapy. Objectives To define the HIV mutational profile associated with drug resistance in Brazilian patients from 5 large cities, after first, second or further failures to antiretroviral therapy. Methods We reviewed genotyping results of 1520 patients failing therapy in five Brazilian cities. Frequency of mutations, mean number of active drugs, viral susceptibility to each antiretrovirals drug, and regional differences were assessed. Results Mean time of antiretrovirals use was 22.7 ± 41.1 months. Mean pre-genotyping viral load was 4.2 ±... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Resistance; Brazil; Mutations. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400323 |
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| Nóbrega,Isabella; Dantas,Paula; Rocha,Priscila; Rios,Isabela; Abraão,Marcos; M. Netto,Eduardo; Brites,Carlos. |
| BACKGROUND: The occurrence of syphilis and HIV-1 infections during pregnancy are major risks to the fetus due to mother-to-child transmission (MTCT). OBJECTIVES: To determine peripartum seroprevalence and risk factors of syphilis and HIV-1 infection among pregnant women in Salvador, Brazil, and the rate of HIV-1 MTCT. METHODS:Cross-sectional study of pregnant women who were admitted for delivery in a reference maternity hospital between May 2008 and March 2009 was conducted. Women were screened for HIV-1 infection and syphilis, and interviewed regarding demographic, behavioral and obstetric data. Newborns to HIV-infected mothers were tested by b-DNA and DNA-PCR to detect HIV-1. RESULTS: A total 3300/8516 women were evaluated. Mean age was 25.8 ± 7.3 years.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Human immunodeficiency virus; Syphilis; Seroprevalence; Risk factors; Parturient; Pregnant; Mother-to-child transmission; Brazil. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200012 |
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| Timerman,Artur; Brites,Carlos; Bicudo,Eliana; Grinbaum,Renato S.; Costa Filho,Rubens; Carrilho,Claudia D.M.; Bichels,Andre; Barreto,Tânia. |
| OBJECTIVES: To collect data about non-controlled prescribing use of daptomycin and its impact among Brazilian patients with serious Gram positive bacterial infection, as well as the efficacy and safety outcomes. MATERIALS AND METHODS: This is a multi-center, retrospective, non-interventional registry (August 01, 2009 to June 30, 2011) to collect data on 120 patients (44 patients in the first year and 76 patients in the second year) who had received at least one dose of commercial daptomycin in Brazil for the treatment of serious Gram-positive bacterial infection. RESULTS: Right-sided endocarditis (15.8%), complicated skin and soft tissue infections (cSSTI)wound (15.0%) and bacteremia-catheter-related (14.2%) were the most frequent primary infections; lung... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Daptomycin; Methicillin-resistant; Staphylococcus aureus; Bacteremia; Endocarditis; Skin diseases; Infectious. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600004 |
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| Registros recuperados: 51 | |
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