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Changes health-related quality of life in HIV-infected patients following initiation of antiretroviral therapy: a longitudinal study BJID
Dutra,Brenda Soares; Lédo,Ana Paula; Lins-Kusterer,Liliane; Luz,Estela; Prieto,Indira Rodriguez; Brites,Carlos.
Abstract Background: Several tools have been developed to evaluate HIV health-related quality of life (HRQoL) during and after antiretroviral therapy (ART). Few longitudinal studies evaluated the effect of ART on the quality of life of HIV patients. Objective: To evaluate changes in HRQoL in HIV-infected individuals one year after initiating ART. Methods: A prospective study was conducted from May 2016 to July 2018. Data on clinical and sociodemographic characteristics of 91 HIV-infected patients were collected prior to initiation of ART and one year thereafter. Demographic and clinical data were collected and the questionnaires 36-item Short Form Health Survey (SF-36) and HIV/AIDS-targeted quality of life (HAT-QoL) were administered in both periods....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Health-related quality of life; Antiretroviral Therapy; HIV; Patient Reported Outcome Measures.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400211
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Impact of macrolide therapy on mortality of HIV-infected patients with community-acquired pneumonia in a tertiary teaching hospital BJID
Mello,Claudia Figueiredo; Negra,Marinella Della.
BACKGROUND: Bacterial pneumonia is one of the main causes of morbidity and mortality in patients infected by the human immunodeficiency virus (HIV). The main objective of this study was to evaluate the effect of macrolide therapy in combination with a beta-lactam based empiric regimen for inpatients with community-acquired pneumonia and HIV. METHODS: This is a retrospective cohort study of hospitalized patients. Adult patients who had received treatment with ceftriaxone or ceftriaxone plus clarithromycin were included. RESULTS: 76 patients met the inclusion criteria. Among baseline characteristics analyzed, only respiratory rate showed significant difference: patients who had received clarithromycin were more likely to have a respiratory rate > 30/min...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Pneumonia; Macrolides; Mortality.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300014
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Vasculitis: an unusual manifestation in an HIV-infected patient BJID
Manuel,Ana; Victório,Tânia; Gomes,Constança; Martins,Telmo; Dias Neto,António.
Human immunodeficiency virus (HIV) positive patients may develop vasculitis, either mediated by immunological factors or by direct vascular injury. We describe a patient who developed manifestations suggestive of extremities vasculitis with no identifiable risk factors other than HIV, Epstein Barr and Herpes Simplex Virus (HSV) type 1 co-infection. Physicians should be aware that vasculitis may have a heterogeneous presentation and occur associated with HIV infection. Although unusual, this association should be recognized for early proper treatment and prevention of ischemia.
Tipo: Info:eu-repo/semantics/report Palavras-chave: Vasculitis; HIV; Epstein Barr virus; Herpes Simplex Virus.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400439
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Detection of mycobacteria in the bloodstream of patients with Acquired Immunodeficiency Syndrome in a University Hospital in Brazil BJID
Oplustil,Carmen Paz; Leite,Olavo H.M.; Oliveira,Marilia S.; Sinto,Sumiko I.; Uip,David E.; Boulos,Marcos; Mendes,Caio F..
This study was done to determine the occurrence of mycobacteria in the bloodstreams of patients with fever and advanced AIDS in a Brazilian hospital. We also verified the capability of an automated method for recovering these bacteria. During a period of 19 months, 254 patients with AIDS were evaluated. Blood cultures were generally submitted in pairs and drawn separately. Blood cultures were processed by the BACTEC 460TB System (Becton Dickinson Microbiology Systems, Sparks, MD), using the Bactec 13A media (Becton Dickinson Microbiology Systems, Sparks, MD). Of the 530 vials submitted, 77 (14.5%) from 41 (16%) patients were positive. Mycobacterium avium complex was recovered from 45 (58.4%) of the 77 positive vials, corresponding to 22 (53.6%) patients...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mycobacterial infection; HIV; Automated diagnosis; AIDS.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500003
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Transfusion risk for hepatitis B, hepatitis C and HIV in the state of Santa Catarina, Brazil, 1991-2001 BJID
Kupek,Emil.
We examined the time trend of residual risk of transfusing blood contaminated with HIV, hepatitis B and hepatitis C, in the largest blood bank of the state of Santa Catarina, Brazil, 1991-2001. The HIV risk was reduced approximately 10 times during the decade of 1990, to 1:48777, but then increased significantly by the end of 2001. A similar time trend was observed for hepatitis B and hepatitis C, although the increase was not significant in this case. Even during the period of lowest risk, the estimates were considerably higher than in developed countries.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Blood transfusion; HIV; Hepatitis B; Hepatitis C.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300007
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Anti-glomerular basement membrane glomerulonephritis in an HIV positive patient: case report BJID
Monteiro,Eduardo José Bellotto; Caron,Daiane; Balda,Carlos Alberto; Franco,Marcello; Pereira,Aparecido Bernardo; Kirsztajn,Gianna Mastroianni.
We report on a case of a patient with HIV infection, diagnosed 18 months prior to the development of an anti-glomerular basement membrane (anti-GBM) rapidly progressive glomerulonephritis; this is probably the first report of such an association. A 30-year-old white man presented with elevation of serum creatinine (1.3 - 13.5 mg/dL within one month). At admission, the urinalysis showed proteinuria of 7.2 g/L and 8,000,000 erythrocytes/mL. Renal biopsy corresponded to a crescentic diffuse proliferative glomerulonephritis mediated by anti-GBM, and serum testing for anti-GBM antibodies was positive; antinuclear antibodies (ANA) and anti-neutrophilic cytoplasmic antibodies (ANCA) were also positive. The patient underwent hemodyalisis and was treated with...
Tipo: Info:eu-repo/semantics/report Palavras-chave: Anti-GBM glomerulonephritis; HIV; Urinary abnormalities.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100011
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Clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV BJID
Eduardo Lorens,Braga; André Castro,Lyra; Fabrizio,Ney-Oliveira; Lourianne,Nascimento; Adriano,Silva; Carlos,Brites; Rosicreuza,Marbak; Luiz Guilherme Costa,Lyra; Manuel L.,Ribeiro Neto; Koonj Asvin,Shah.
Co-infection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is increasingly common and affects the clinical course of chronic hepatitis C. Highly active antiretroviral therapy has improved the life expectancy of HIV infected patients, but, by extending survival, it permits the development of HCV cirrhosis. This study tried to evaluate clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV. We evaluated 134 HCV-infected patients: i) group A - 65 co-infected HCV/HIV patients, ii) group B - 69 mono-infected HCV patients. The impact of HIV infection on HCV liver disease was analyzed using Child's score, ultrasound findings and liver histology. Patients were subjected to HCV genotyping and anti-HBs...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C; HIV; Co-infection; Clinical course; HCV genotype.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100004
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HLA-B*5701 frequency in Chilean HIV-infected patients and in general population BJID
Poggi,Helena; Vera,Alejandra; Lagos,Marcela; Solari,Sandra; Rodríguez P,Luis; Pérez,Carlos M.
It has been demonstrated that HLA-B*5701 screening reduces the risk for hypersensitivity reaction to abacavir in HIV-infected patients. Since B*5701 prevalence varies among different populations, it is important to determine the carrier frequency prior to its use for the screening of HIV-infected patients.The aim of this study was to determine HLA-B*5701 carrier frequency in Chilean general population and HIV-infected patients referred for B*5701 typing. For that purpose 300 blood bank donors and 492 abacavir-naïve HIV-infected patients from Chile were screened for B*5701 by a sequence specific primer PCR.We detected 14/300 (4.7%) B*57-positive individuals in the Chilean general population, 11 (3.7%) were B*5701 positive, and 3 (1%) had another subtype.All...
Tipo: Info:eu-repo/semantics/other Palavras-chave: HLA-B*5701; HIV; Abacavir; Chile; Pharmacogenetics.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500015
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Dyslipidemia in AIDS patients on highly active antiretroviral therapy BJID
Nery,Max Weyler; Martelli,Celina Maria Turchi; Turchi,Marília Dalva.
Highly active antiretroviral therapy (HAART) reduces AIDS-related morbidity and mortality, however it has been associated with metabolic abnormalities. This study estimated the prevalence of lipid abnormalities and related factors among patients on HAART. A cross-sectional study was conducted on adult patients, in central Brazil. Patients were interviewed, and blood obtained for lipids measurement. Dyslipidemia was defined as total cholesterol (TC) &gt; 240 mg/dL, low-density lipoprotein (LDL) &gt; 160 mg/dL, triglycerides (TG) &gt; 200 and/or high-density lipoprotein (HDL) < 40 mg/dL. Multiple logistic regression analyses were performed (SPSS 13.0). One hundred and thirteen patients were recruited. Mean age was 39.3 years; 68.1% were males;...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Prevalence; Dyslipidemia; HIV; AIDS; HAART.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200010
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Clinical and epidemiological characteristics associated with unfavorable tuberculosis treatment outcomes in TB-HIV co-infected patients in Brazil: a hierarchical polytomous analysis BJID
Prado,Thiago Nascimento do; Rajan,Jayant V.; Miranda,Angélica Espinosa; Dias,Elias dos Santos; Cosme,Lorrayne Beliqui; Possuelo,Lia Gonçalves; Sanchez,Mauro N.; Golub,Jonathan E.; Riley,Lee W.; Maciel,Ethel Leonor.
Abstract Background: TB patients co-infected with HIV have worse treatment outcomes than non-coinfected patients. How clinical characteristics of TB and socioeconomic characteristics influence these outcomes is poorly understood. Here, we use polytomous regression analysis to identify clinical and epidemiological characteristics associated with unfavorable treatment outcomes among TB-HIV co-infected patients in Brazil. Methods: TB-HIV cases reported in the Brazilian information system (SINAN) between January 1, 2001 and December 31, 2011 were identified and categorized by TB treatment outcome (cure, default, death, and development of MDR TB). We modeled treatment outcome as a function of clinical characteristics of TB and patient socioeconomic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis; HIV; Coinfection; Logistic regression.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200162
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Disseminated tuberculosis presenting as mesenteric and cerebral abscess in HIV infection: case report BJID
Pandit,Vinay; Valsalan,Rohith; Seshadri,Shubha; Bahuleyan,Shibu.
Disseminated tuberculosis in HIV infection involves multiple organs. Pulmonary and lymph node involvement are the commonest form of tuberculosis in HIV infection [1, 2]. Other forms of tuberculosis in the absence of lung and lymph node involvement are rare. Various forms of abdominal [3, 4] and neurological [5, 6] tubercular involvement in HIV infection have been reported. But tuberculosis presenting simultaneously with mesenteric and brain abscess has not been reported yet. We report a case of disseminated tuberculosis presenting as mesenteric and cerebral abscess in a HIV case without involving lung and lymph nodes. Bone marrow smears and fine needle aspiration cytology (FNAC) from mesenteric lesion were positive for acid fast bacilli (AFB) and the...
Tipo: Info:eu-repo/semantics/report Palavras-chave: HIV; Tuberculosis; Abscess.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500014
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Cascade of access to interventions to prevent HIV mother to child transmission in the metropolitan area of Rio de Janeiro, Brazil BJID
Araujo,Elaine S. Pires; Friedman,Ruth Khalili; Camacho,Luis Antonio Bastos; Derrico,Monica; Moreira,Ronaldo Ismério; Calvet,Guilherme Amaral; Oliveira,Marília Santini de; Veloso,Valdilea Gonçalves; Pilotto,José Henrique; Grinsztejn,Beatriz.
OBJECTIVES: To describe the access to the interventions for the prevention of Human Immunodeficiency Virus (HIV) mother to child transmission and mother to child transmission rates in the outskirts of Rio de Janeiro, from 1999 to 2009.METHODS: This is a retrospective cohort study. Prevention of HIV mother to child transmission interventions were accessed and mother to child transmission rates were calculated.RESULTS: The study population is young (median: 26 years; interquartile range: 22.0-31.0), with low monthly family income (40.4% up to one Brazilian minimum wage) and schooling (62.1% less than 8 years). Only 47.1% (n = 469) knew the HIV status of their partner; of these women, 39.9% had an HIV-seronegative partner. Among the 1259 newborns evaluated,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; HIV vertical transmission; Antiretroviral chemoprophylaxis; Cohort studies; Brazil.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300252
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Prevalence of lipodystrophy and risk factors for dyslipidemia in HIV-infected children in Brazil BJID
Papi,Luanda; Menezes,Ana Carolina G.B.; Rocha,Hélio; Abreu,Thalita F.; Oliveira,Ricardo Hugo de; Frota,Ana Cristina C.; Evangelista,Lucia de A.; Hofer,Cristina B..
The aim of present study was to describe the frequency of lipodystrophy syndrome associated with HIV (LSHIV) and factors associated with dyslipidemia in Brazilian HIV infected children. HIV infected children on antiretroviral treatment were evaluated (nutritional assessment, physical examination, and laboratory tests) in this cross-sectional study. Univariate analysis was performed using Mann-Whitney test or Fisher's exact test followed by logistic regression analysis. Presence of dyslipidemia (fasting cholesterol >200 mg/dl or triglycerides >130 mg/dl) was the dependent variable. 90 children were enrolled. The mean age was 10.6 years (3-16 years), and 52 (58%) were female. LSHIV was detected in 46 children (51%). Factors independently associated...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Lipodystrophy; Dyslipidemia; Children.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400394
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Chlamydia trachomatis infection among HIV-infected women attending an AIDS clinic in the city of Manaus, Brazil BJID
Silva,Leila Cristina Ferreira; Miranda,Angélica Espinosa; Batalha,Rosieny Santos; Sabino,Carolina; Dib,Elizabeth Cristina Dantas; Costa,Carolina Marinho da; Ramasawmy,Rajendranath; Talhari,Sinésio.
This was a cross-sectional study aimed to determine the prevalence of and to identify risk factors for Chlamydia trachomatis (CT) among human immunodeficiency virus (HIV)-infected women attending the acquired immunodeficiency syndrome (AIDS) clinic in the city of Manaus, Brazil, in 2009-2010. Participants answered a questionnaire containing demographic, epidemiological, and clinical data. A genital specimen was collected during examination to detect CT-DNA by hybrid capture, and blood samples were taken to determine CD4+T and HIV viral load. There were 329 women included in the study. Median age was 32 years (IQR = 27-38) and median schooling was nine years (IQR = 4-11). The prevalence of CT was 4.3% (95%CI: 2.1-6.5). Logistic regression analysis showed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chlamydia trachomatis; HIV; Women; Amazonas.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400004
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Survival of HIV patients with tuberculosis started on simultaneous or deferred HAART in the THRio cohort, Rio de Janeiro, Brazil BJID
Saraceni,Valeria; Durovni,Betina; Cavalcante,Solange C.; Cohn,Silvia; Pacheco,Antonio Guilherme; Moulton,Lawrence H.; Chaisson,Richard E.; Golub,Jonathan E..
Background:The timing of highly active antiretroviral therapy (HAART) after a tuberculosis diagnosis in HIV-infected patients can affect clinical outcomes and survival. We compared survival after tuberculosis diagnosis in HIV-infected adults who initiated HAART and tuberculosis therapy simultaneously to those who delayed the start of HAART for at least two months.Methods:The THRio cohort includes 17,983 patients receiving HIV care in 29 public clinics in Rio de Janeiro, Brazil. HAART-naïve patients at the time of a new TB diagnosis between September 2003 and June 2008 were included. Survival was measured in days from diagnosis of TB. We compared survival among patients who initiated HAART within 60 days of TB treatment (simultaneous – ST) to those who...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Tuberculosis; Antiretroviral therapy; Survival.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500491
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Aging, neurocognitive impairment and adherence to antiretroviral therapy in human immunodeficiency virus-infected individuals BJID
Pinheiro,Cezar Arthur Tavares; Souza,Luciano Dias de Mattos; Motta,Janaína Vieira dos Santos; Kelbert,Evelin Franco; Martins,Clarissa de Souza Ribeiro; Souza,Marília Silva de; Pinheiro,Karen Amaral Tavares; Coelho,Fábio Monteiro da Cunha; Pinheiro,Ricardo Tavares.
ABSTRACT Background/objective: There is an increasing number of older patients with human immunodeficiency virus infection due to the success of antiretroviral therapy, the improved prognosis and life expectancy of patients, and the higher number of new infections among older individuals. The main objective of the present study was to compare the characteristics of older human immunodeficiency virus patients with those of younger patients. Materials and methods: We conducted a cross-sectional study with human immunodeficiency virus-infected patients who were treated at the Specialized Care Service (Serviço de Assistência Especializada) for human immunodeficiency virus/AIDS in the city of Pelotas, South Brazil. Sociodemographic information as well as data...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Aging; HIV; Neurocognitive impairment; Adherence.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600599
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Factors associated with mortality in HIV patients failing antiretroviral therapy, in Salvador, Brazil BJID
Haguihara,Tatiana; Silva,Márcio da Oliveira; Rebouças,Monaliza Cardozo; Martins Netto,Eduardo; Brites,Carlos.
ABSTRACT Highly active antiretroviral therapy (HAART) has significantly improved survival of people living with HIV/Aids (PLWHA). However, poor treatment adherence to HAART and other problems, still cause therapy failure and contribute to increased morbidity and mortality of PLWHA. In this retrospective cohort study (2013-2015), we sought to evaluate the factors associated with mortality of PLWHA failing HAART in 2013, who were receiving care at a reference center for sexually transmitted diseases (STD) and HIV/AIDS. A total of 165 individuals over 18 years of age who were failing antiretroviral therapy were evaluated. In two-year follow-up, 19 (11.5%) deaths were documented. There were a significant association between mortality and report of illicit drug...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Virologic failure; Mortality; HIV.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300160
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Vascular access-related infections in HIV patients undergoing hemodialysis: case description and literature review BJID
Castro,Carlos E. Figueroa; Madariaga,Miguel G..
Poor immune status, the use of a vascular access different from an AV fistula, and intravenous drug use (IDU) may favor increased rates of vascular access infections among HIV infected patients on hemodialysis. Staphylococcus spp. and Streptococcus spp. are the main cause of these infections, but Gram-negative rods and fungi have been found as well. Using an AV fistula when possible, and eliciting a history of IVDU on every visit may prevent this type of infection. When infections are present, coverage for both Gram-positive and negative organisms is recommended. Additional studies specifically addressing the issue of vascular access infection in HIV infected patients are required.
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Chronic kidney disease; Renal dialysis; Catheter-related infections.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600017
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Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk BJID
Guimarães,Milena Maria Moreira; Greco,Dirceu Bartolomeu; Moreira,Allyson Nogueira; Guimarães,Nathalia Sernizon; Freire,Cláudia Maria Vilas; Rohlfs,Bruna Guimarães; Machado,Lucas José de Campos.
ABSTRACT The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; however, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p <...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Hyperlipidemia; Atherosclerosis; Lipid accumulation product index; Cardiovascular risk; Insulin resistance.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300171
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Magnetic bead technology for viral RNA extraction from serum in blood bank screening BJID
Albertoni,Guilherme Ambrozio; Arnoni,Carine Prisco; Araujo,Patricia Regina Barboza; Andrade,Sheila Siqueira; Carvalho,Fabrício Oliveira; Girão,Manoel João Batista Castello; Schor,Nestor; Barreto,José Augusto.
Nucleic acid amplification testing (NAT) was recently recommended by Brazilian legislation and has been implemented at some blood banks in the city of São Paulo, Brazil, in an attempt to reduce blood-born transmission of human immunodeficiency virus (HIV) and hepatitis C virus. OBJECTIVE: Manual magnetic particle-based extraction methods for HIV and HCV viral nucleic acids were evaluated in combination with detection by reverse transcriptase - polymerase chain reaction (RT-PCR) one-step. METHODS: Blood donor samples were collected from January 2010 to September 2010, and minipools of them were submitted to testing. ELISA was used for the analysis of anti-HCV/HIV antibodies. Detection and amplification of viral RNA was performed using real-time PCR....
Tipo: Info:eu-repo/semantics/article Palavras-chave: HCV; HIV; Infection; Reverse transcriptase polymerase chain reaction; Blood banks.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600008
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