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| Registros recuperados: 128 | |
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| Patel,Satish D.; Sadariya,Kamlesh A.; Gothi,Anil K.; Patel,Urvesh D.; Gohil,Pradhuman A.; Jain,Mukul R.; Bhavsar,Shailesh K.; Thaker,Aswin M.. |
| Pharmacokinetics of tolfenamic acid as a single drug (4 mg/kg, intramuscularly) and its co-administration with moxifloxacin (5 mg/kg, intramuscularly) in wistar rats were studied. The plasma drug concentration of tolfenamic acid was assayed by LC-MS/MS. Following intramuscular administration of tolfenamic acid as single drug and in combination with moxifloxacin in male rats, the mean values of observed peak plasma drug concentration (Cmax), area under plasma drug concentration-time curve (AUC(0-¥) ), volume of distribution (Vz), half-life (t½) and clearance (Cl) were 4111.44 ± 493.15 and 3837.69 ± 351.83 ng/ml, 20280.77 ± 3501.67 and 15229.18 ± 678.80 ng.h/ml, 822.17 ± 115.38 and 1249.64 ± 139.52 ml, 2.59 ± 0.16 and 3.27 ± 0.32 hr, and 218.39 ± 25.47 and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pharmacokinetics; Tolfenamic acid; Anti inflammatory drug; Rats; Interaction; Moxifloxacin. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000400013 |
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| Oliveira,Denise Silva de; Amado,Ciomar Aparecida Bersani; Martini,Mirian Carvalho; Suzuki-Kemmelmeier,Fumie; Bracht,Adelar. |
| Glycogen levels and the energy status of livers from fasting rats with diabetes types 1 and 2 were measured. After a 24 h fast, the hepatic glycogen levels of rats with diabetes1 and diabetes2 were, 18.7 and 2.6 times higher, respectively, than those of livers from the normal rats. In diabetes1 rats, the glycogen levels decreased when the fasting period was extended to 48 and 72 h. The opposite occurred with the control and diabetes2 rats. Consistently, glucose release by the perfused livers from diabetes1 rats was considerably higher during at least 60 minutes after initiating perfusion. The hepatic ATP content of diabetes1 rats was similar to that of the control rats; in diabetes2 rats, the hepatic ATP content was increased. It could be concluded that... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Diabetes type 1; Diabetes type 2; Rats; Hepatic glycogen; Hepatic energy status. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000500006 |
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| Teixeira,Gerlinde Agate Platais Brasil; Antunes,Danielle Mota Fontes; Castro Júnior,Archimedes Barbosa de; Costa,Janilda Pacheco da; Paschoal,Patrícia Olaya; Campos,Sylvia Maria Nicolau; Pedruzzi,Monique de Morais Bitetti; Araújo,Vinicius da Silva; Andrade,Luis Antônio Botelho; Moreno,Silvana Ramos Farias; Nobrega,Alberto Felix Antonio da; Cardoso,Gilberto Perez. |
| Food allergy is an adverse reaction that occurs in susceptible people when they eat sensitizing foods and is one of the causes of Inflammatory Bowel Disease (IBD). The effort to understand the induction process of these diseases is important as IBD is increasing worldwide, including in Brazil. The aim of this study was to develop an experimental antigen specific inflammatory process of the gut of mice and rats, using peanut seeds. Animals were immunized with peanut protein extract before their exposure to the in natura peanut seeds. Results showed that systemic immunization with peanut protein extracts rendered significantly higher antibody titers than control groups and that immunized animals submitted to a challenge diet containing peanuts presented time... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Food allergy; Peanuts; Inflammatory bowel disease; Rats; Mice. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000300012 |
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| Moreira,Lidiane Muniz; Behling,Bruna del Sacramento; Rodrigues,Rosane da Silva; Costa,Jorge Alberto Vieira; Soares,Leonor Almeida de Souza. |
| This study was aimed at evaluating the effects of Spirulina (Arthrospira) as a protein source in the nutritional recovery of rats subjected to protein malnutrition. In order to understand such effects, responses of the developing body, serum biochemical profile, and blood count of animals were analyzed. A total of, 23 Wistar Rattus norvegicus were given a proteic diet (AIN-93G adapted) in malnutrition phase (phase I) for 10 days. After this period, the rats were separated into four groups according to the protein source (recovery phase): Control (C), casein 12%; Spirulina level I (S1), Spirulina 8.8% + casein 5.0%; Spirulina level II (S2), Spirulina 17.6% + casein 0.15%, and Spirulina level III (S3), Spirulina 26.4%. Recovery phase (phase II) lasted 30... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Protein malnutrition; Rats; Nutritional recovery; Rattus norvegicus; Spirulina. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000300013 |
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| Amaral,Luane Aparecida do; Souza,Gabriel Henrique Oliveira de; Santos,Mirelly Romeiro; Said,Yasmin Lany Ventura; Souza,Bruna Brandão de; Oliveira,Rodrigo Juliano; Santos,Elisvania Freitas dos. |
| Abstract The Walker-256 tumor is an important experimental model that allow the development of therapies as the biological behavior of this tumor is similar that occur in humans. In front of the above considerations, the aim of this study was to describe the experimental model of Walker-256 tumor, identify the implantations sites as well as define a usual quantity of tumoral cells to induce the ascitic and solid tumor, according to the specialized literature. Were selected 45 articles using the keyword “Walker-256 tumor”, free available. Were possible to observe that 58% (n=26) of the studies inoculate the tumor cells in the animals flank 33% (n = 15) in the tibia bone, 7% (n = 3) in the femur and 2% (n = 1) in the paw. The major quantitates of cells used... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Walker-256 tumor; Cancer; Experimental model; Rats. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100900 |
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| Halfen,Simone; Jacometo,Carolina Bespalhok; Mattei,Patrícia; Fenstenseifer,Samanta Regine; Pfeifer,Luiz Francisco Machado; Pino,Francisco Augusto Burkert Del; Santos,Marco Aurélio Ziemann; Pereira,Cláudio Martin Pereira de; Schmitt,Eduardo; Corrêa,Marcio Nunes. |
| Our study evaluated how the consumption of diets with low (LOW group - 0.4/1) or high (CON group - 13.6/1) omega-6/omega-3 ratio across generations (F1 and F2) can modulate liver fatty acid (FA) profile and blood biomarkers. Liver content of α-linolenic acid was higher in animals always fed with LOW diet than animals that changed from CON to LOW diet, which by your time was higher than animals always fed with CON diet. Liver saturated FA concentration decreased in both groups from F1 to F2. In conclusion, both diets were efficient in decreasing the saturated FA liver content across generations, the LOW ratio diet was more effective in reducing blood triglycerides and non-esterified fatty acids, and there was a multigenerational effect of the LOW ratio... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Alpha-linolenic acid; Essential fatty acid; Lipid; Metabolism; Nutrition; Rats. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100503 |
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| TEIXEIRA,Maria Araújo; CHAGURI,Luziane do Carmo Andrade Guinski; CARISSIMI,André Silva; SOUZA,Nívea Lopes de; MORI,Claudia Madalena Cabrera; GOMES,Valéria Maria Wanderley; POLI NETO,Adelino; NONOYAMA,Kimiyo; MERUSSE,José Luiz Bernardino. |
| Previous studies reported that rats (Rattus norvegicus) kept under microenvironmental ventilation systems (MEV) present better productive and health parameters when compared to animals kept under general diluting ventilation (GDV). The objective of the present research trial was to evaluate hematological and biochemical profiles of rats kept under MVS. In order to achieve this objective, two different trials were designed: Trail 1 (E1), in which it was evaluated the reproductive performance of males and females submitted to two different air speed limits - FV1, from 0.03 to 0.26 m / sec and FV2, from 0.27 to 0.80 m / sec. In Trial 2 (E2) it was evaluated different bed change intervals (3, 5, 7 and 9 days), for males kept under constant air speed (0.5 m /... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Laboratory animals; Rats; Hematology; Biochemistry; Ventilation. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95962000000500001 |
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| Antunes,V.R.; Camargo,G.M.P.A.; Saad,R.; Saad,W.A.; Luiz,A.C.; Camargo,L.A.A.. |
| In this study we investigated the effects of the injection into the supraoptic nucleus (SON) of non-peptide AT1- and AT2-angiotensin II (ANG II) receptor antagonists, DuP753 and PD123319, as well as of the arginine-vasopressin (AVP) receptor antagonist d(CH2)5-Tyr(Me)-AVP, on water and 3% NaCl intake induced by the injection of ANG II into the medial septal area (MSA). The effects on water or 3% NaCl intake were assessed in 30-h water-deprived or in 20-h water-deprived furosemide-treated adult male rats, respectively. The drugs were injected in 0.5 µl over 30-60 s. Controls were injected with a similar volume of 0.15 M NaCl. Antagonists were injected at doses of 20, 80 and 180 nmol. Water and sodium intake was measured over a 2-h period. Previous... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Angiotensin II; AT1 receptors; AT2 receptors; V1 receptors; Water intake; Sodium intake; Medial septal area; Supraoptic nucleus; Rats. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001200013 |
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| De-Castro-e-Silva,E.; Luz,C.P.; Sarmento,C.; Nascimento,T.; Gonzalez,V.; Marinho,C.A.; Castro,L.; Oliveira,P.; Santana Jr.,P.; De-Oliveira,I.R.; De-Paula,S.; Lima,A.K.S.; Fregoneze,J.B.. |
| We have previously demonstrated that acute third ventricle injections of both lead and cadmium prevent the dipsogenic response elicited by dehydration or by central injections of dipsogenic agents such as angiotensin II, carbachol and isoproterenol in rats. We have also shown that the antidipsogenic action of cadmium may be due, at least in part, to activation of thirst-inhibitory central serotonergic pathways. In the present paper we show that in Wistar male rats the antidipsogenic effect of both lead acetate (3.0 nmol/rat) and cadmium chloride (3.0 nmol/rat) may be partially dependent on the activation of brain opiatergic pathways since central injections of naloxone (82.5 nmol/rat), a non-selective opioid antagonist, blunt the thirst-inhibiting effect... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Cadmium; Lead; Water intake; Opioids; Rats. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000600013 |
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| Cendon,S.P.; Battlehner,C.; Lorenzi-Filho,G.; Dohlnikoff,M.; Pereira,P.M.; Conceição,G.M.S.; Beppu,O.S.; Saldiva,P.H.N.. |
| We describe a short time model for inducing experimental emphysema in rats by chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied: controls (N = 8), rats intoxicated for 45 days (s-45, N = 7) or for 90 days (s-90, N = 8). The exposed animals were intoxicated 3 times a day (10 cigarettes per exposure period), 5 days a week. Pulmonary damage was assessed by means of functional tests and quantitative pathological examination of the airways and lung parenchyma. The s-45 and s-90 animals were similar in terms of functional residual capacity (FRC) corrected for body weight (FRC/kg) but both groups of smoking rats exhibited significantly higher FRC/kg values than the controls (s-45 = 6.33; s-90 = 6.46; controls = 3.78;... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Passive smoking; Emphysema; Rats; Pulmonary function; Morphological analysis; Quantification. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000017 |
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| Silva,V.J. Dias da; Ferreira Neto,E.; Salgado,H.C.; Fazan Júnior,R.. |
| The aim of the present study was to investigate the effects of converting enzyme inhibition by captopril on ECG parameters in aged rats. Four-month-old male rats received captopril dissolved in tap water (0.5 mg/l) or tap water for 2 or 20 months. At the end of treatment, under anesthesia, RR and PR interval, P wave and QRS duration, QT and corrected QT interval were measured in all animals. On the following day, chronic ECG (lead II) recordings were performed to quantify supraventricular (SVPB) or ventricular premature beats (VPB). After sacrifice, the hearts were removed and weighed. RR interval was similar in young and untreated aged rats, but significantly larger in aged rats treated with captopril. P wave and QRS length did not differ among groups. PR... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aging; Electrocardiogram; Captopril; Rats. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000900003 |
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| Leopoldo,A.S.; Lima-Leopoldo,A.P.; Nascimento,A.F.; Luvizotto,R.A.M.; Sugizaki,M.M.; Campos,D.H.S.; da Silva,D.C.T.; Padovani,C.R.; Cicogna,A.C.. |
| In experimental studies, several parameters, such as body weight, body mass index, adiposity index, and dual-energy X-ray absorptiometry, have commonly been used to demonstrate increased adiposity and investigate the mechanisms underlying obesity and sedentary lifestyles. However, these investigations have not classified the degree of adiposity nor defined adiposity categories for rats, such as normal, overweight, and obese. The aim of the study was to characterize the degree of adiposity in rats fed a high-fat diet using cluster analysis and to create adiposity intervals in an experimental model of obesity. Thirty-day-old male Wistar rats were fed a normal (n=41) or a high-fat (n=43) diet for 15 weeks. Obesity was defined based on the adiposity index; and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Obesity; Adiposity index; Rats; Cluster analysis. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400601 |
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| Registros recuperados: 128 | |
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