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| Registros recuperados: 193 | |
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| Rodrick Wallace; Deborah Wallace. |
| We apply Tlusty's information-theoretic index theorem analysis of the genetic code to the glycome, using a cognitive paradigm by which external information sources constrain and tune the glycan code error network, in the context of available metabolic energy. The model suggests spontaneous symmetry breaking of the glycan code as a function of metabolic energy intensity, an effect that may be currently present, or embedded in evolutionary trajectory, recording large-scale ecosystem resilience shifts in energy availability such as the aerobic transition. Once focused on a subset of the glycan error code network however, the glycan production machinery must then be regulated by an elaborate cognitive process to ensure that what is produced matches... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Developmental Biology; Ecology; Molecular Cell Biology; Pharmacology; Evolutionary Biology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5932/version/2 |
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| Ravi Bhushan Sinha; Anil Kumar Debnath; Bishwa Mohan Kumar Singh; Bhagwan Chandra Prasad. |
| _Aeolesthes holosericea_, a polyphagous stem borer has been reported to damage up to 40% of tropical tasar silkworm host-plants wherever infestation is high. Known control measures are not very effective as information on its life cycle and susceptible stages against insecticides and bio-agents are insufficient. Laboratory culture of the insect is inevitable for developing control measures as the insect passes most of its life within stem tissues. Culture method of other borer species was not applied to it due to sophistication of process. A convenient laboratory culture method has been developed for the insect. The culture includes complete larval rearing; preservation of pupa; rearing and mating of adults followed by oviposition, incubation and hatching.... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5640/version/1 |
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| Michael E. Baker. |
| Although, as their names imply, vertebrate and invertebrate estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. We searched recently sequenced genome of _Trichoplax_, the simplest known animal, and genomes from three lophotrochozoans: _Capitella_, a worm, _Helobdella robusta_, a leech, and _Lottia gigantea_, a snail, to elucidate the origins and evolution of ERs and ERRs. BLAST found an ERR in _Trichoplax_, but no ER. BLAST searches of the lophotrochozaons found ERRs in all three and invertebrate ERs in _Capitella_ and _Lottia_, but not in _Helobdella_. These database searches and a phylogenetic analyses indicate that invertebrate ERs... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Ecology; Evolutionary Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1863/version/1 |
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| Dominika Borek; Zbyszek Otwinowski. |
| Chromatin structure undergoes many changes during the cell cycle and in response to regulatory events. A basic unit of chromatin organization is the nucleosome core particle. However, very little is known about how nucleosomes are arranged into higher-order structures in vivo, even though the efficiency and precision of cell division imply high levels of structural organization. We propose abandoning the current paradigm of chromatin organization based on thermodynamics of the lowest energy state and replace it with the idea of a topologically restrained, high-energy structure. We propose that DNA is subject to a recursive topological restraint, and is anchored by hemicatenates that are part of the chromosomal scaffold. Long-distance _cis_-regulation of... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Genetics & Genomics; Molecular Cell Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2672/version/1 |
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| John R. Skoyles. |
| 1.	After weaning, human hunter-gatherer juveniles receive substantial (≈3.5-7 MJ day^-1^), extended (≈15 years) and reliable (kin and nonkin food pooling) energy provision.
2.	The childhood (pediatric) and the adult human brain takes a very high share of both basal metabolic rate (BMR) (child: 50-70%; adult: ≈20%) and total energy expenditure (TEE) (child: 30-50%; adult: ≈10%).
3.	The pediatric brain for an extended period (≈4-9 years-of-age) consumes roughly 50% more energy than the adult one, and after this, continues during adolescence, at a high but declining rate. Within the brain, childhood cerebral gray matter has an even higher 1.9 to... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Ecology; Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1856/version/1 |
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| Perumal P. |
| Endoscopy is a minimally invasive diagnostic medical procedure that is used to assess the interior surfaces of an organ by inserting a tube into the body. The instrument may have a rigid or flexible tube and not only provide an image for visual inspection and photography, but also enable taking biopsies and retrieval of foreign objects. Endoscopy is the vehicle for minimally invasive surgery and patients may receive conscious sedation so they do not have to be consciously aware of the discomfort. Many endoscopic procedures are considered to be relatively painless and, at worst, associated with moderate discomfort. |
| Tipo: Presentation |
Palavras-chave: Developmental Biology; Microbiology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7064/version/1 |
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| Michael E. Baker. |
| Although, as their names imply, estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood. To elucidate the origins and evolution of ERs and ERRs, we searched for their orthologs in the recently sequenced genome of _Trichoplax_, the simplest known animal, and in the genomes of three lophotrochozoans: _Capitella_, an annelid worm, _Helobdella robusta_, a leech, and _Lottia gigantea_, a snail. BLAST searches found an ERR in _Trichoplax_, but no ER. BLAST searches also found ERRs in all three lophotrochozoans and invertebrate-like ERs in _Capitella_ and _Lottia_, but not in _Helobdella_. Unexpectedly we find that the _Capitella_ ER sequence is... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Ecology; Evolutionary Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2170/version/1 |
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| Ruud F. R. van der Weel; Audrey van der Meer. |
| A fundamental property of most animals is the ability to see whether an object is approaching on a direct collision course and, if so, when it will collide. Using high-density electroencephalography in 5- to 11-month-old infants and a looming stimulus approaching under three different accelerations, we investigated how the young human nervous system extracts and processes information for impending collision. Here we show that infants' looming related brain activity is characterized by theta oscillations. Source analyses reveal clear localised activity in the visual cortex. Analysing the temporal dynamics of the source waveform, we provide evidence that the temporal structure of different looming stimuli is sustained during processing in the more... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Neuroscience. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2917/version/1 |
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| Rodrick Wallace. |
| For a broad spectrum of low level cognitive regulatory and other biological phenomena, isolation from signal crosstalk between them requires more metabolic free energy than permitting correlation. This allows an evolutionary exaptation leading to dynamic global broadcasts of interacting physiological processes at multiple scales. The argument is similar to the well-studied exaptation of noise to trigger stochastic resonance amplification in physiological subsystems. Not only is the living state characterized by cognition at every scale and level of organization, but by multiple, shifting, tunable, cooperative larger scale broadcasts that link selected subsets of functional modules to address problems. This multilevel dynamical viewpoint has implications... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Developmental Biology; Immunology; Molecular Cell Biology; Pharmacology. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/6973/version/1 |
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| Qin Zhu; Geoffrey Bingham. |
| Heaviness perception involves a misperception of weight known, since the 19th century, as the Size-Weight Illusion ^1^. The larger of two objects of equal mass is reported to be lighter than the smaller when they are lifted. The illusion has been found to be reliable and robust. It persists even when people know that the masses are equal and handle objects properly ^2^. It has been exhibited by children of only 2 years of age ^3,4^. All this suggests that the effect might be intrinsic to humans. Although different hypotheses have been advanced to account for the illusion over the 100+ years it has been studied ^5-11^, its origin remains unknown. More recently, people's perception of optimal objects for long distance throwing was found to exhibit a... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Ecology; Evolutionary Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4584/version/1 |
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| Gizachew Tiruneh. |
| *Objective*: To investigate the best statistical models that describe the effect of physical activity on BMI.
*Design*: Cross-sectional analyses of physical activity and BMI data. 
*Subjects*: 107 obese, overweight, and healthy college students (mean duration of physical activity for the normal, overweight, and obese students: 89, 59, and 24 months, respectively; mean BMI for the normal, overweight, and obese students: 21.61, 27.07, and 35.54 kg/m2, respectively).
*Measurements*: Inverse linear, inverse logarithmic, and inverse logistics models were used to analyze survey data for physical activity (measured by both frequency and duration of exercise) and BMI. Gender, age, and physical intensity variables... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2758/version/4 |
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| Leonid A. Mirny. |
| Cooperative binding of transcription factors (TFs) to cis-regulatory regions (CRRs) is essential for precision of gene expression in development and other processes. The classical model of cooperativity requires direct interactions between TFs, thus constraining the arrangement of TFs sites in a CRR. On the contrary, genomic and functional studies demonstrate a great deal of flexibility in such arrangements with variable distances, numbers of sites, and identities of the involved TFs. Such flexibility is inconsistent with the cooperativity by direct interactions between TFs. Here we demonstrate that strong cooperativity among non-interacting TFs can be achieved by their competition with nucleosomes. We find that the mechanism of nucleosome-mediated... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology; Genetics & Genomics; Molecular Cell Biology; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/2796/version/1 |
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| Rodrick Wallace. |
| Protein folding disorders of aging like Alzheimer's and Parkinson's diseases currently present intractable medical challenges. 'Small molecule' interventions - drug treatments - often have, at best, palliative impact, failing to alter disease course. The design of individual or population level interventions will likely require a deeper understanding of protein folding and its regulation than currently provided by contemporary 'physics' or culture-bound medical magic bullet models. Here, a topological rate distortion analysis is applied to the problem of protein folding and regulation that is similar in spirit to Tlusty's (2010a) elegant exploration of the genetic code. The formalism produces... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Developmental Biology; Molecular Cell Biology; Neuroscience; Pharmacology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4847/version/2 |
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| Roxana Moslehi; Caroline Signore; James Troendle; Amiran Dzutsev; James L. Mills. |
| The effects of DNA repair and transcription genes in human prenatal life have never been studied. Trichothiodystrophy (TTD) is a rare (affected frequency of 10^-6^) recessive disorder caused by mutations in genes involved in the nucleotide excision repair (NER) pathway and in transcription. Based on our clinical observations, we conducted a genetic epidemiologic study to investigate gestational outcomes associated with TTD. We compared pregnancies resulting in TTD-affected offspring (N=24) with respect to abnormalities in their antenatal and neonatal periods to pregnancies resulting in their unaffected siblings (N=18), accounting for correlation, and to population reference values. Significantly higher incidence of several severe gestational complications... |
| Tipo: Poster |
Palavras-chave: Developmental Biology; Genetics & Genomics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3582/version/1 |
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| Doina M. Costescu; I. C. Baianu. |
| NMR, NIR and EM techniques are suitable methods of measuring protein and oil content in soybeans. After completion of a measurement with NMR or NIR, a soybean sample could be either replanted or consummated. NMR techniques involved in the present work are based on the response of nuclei, as nuclear spin flips, when set in a 7.05T magnetic field and excited with rf pulses of 300 MHz. NIR spectroscopy is based on outer electron molecular vibrations, when excited with radiation of frequency 1012 -4×1014Hz, and =2.5Om-750 nm. 
TEM and ESEM techniques are bulk and surface analysis techniques, respectively, working with electron beams of 15KV, and image resolution in the range of nm’s. ESEM is based on the... |
| Tipo: Presentation |
Palavras-chave: Biotechnology; Chemistry; Developmental Biology; Genetics & Genomics; Molecular Cell Biology; Plant Biology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6192/version/1 |
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| Registros recuperados: 193 | |
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