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| Registros recuperados: 283 | |
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| PEREIRA,Débora Linsbinski; CUNHA,Ana Paula Simões DA; CARDOSO,Cássia Regina Primila; ROCHA,Cláudia Quintino DA; VILEGAS,Wagner; SINHORIN,Adilson Paulo; SINHORIN,Valéria Dornelles Gindri. |
| ABSTRACT The properties of oil-resin of copaiba, Copaifera multijuga are commonly mentioned in the literature, but there are few studies on extracts from its stem bark. We evaluated the antioxidant effects of ethanolic (EE) and ethyl acetate (EA) crude stem bark extracts from copaiba and compared them to rutin in a paracetamol (PCM)-induced oxidative stress model in mice. All test comparisons differed significantly. Hepatic catalase (CAT) and glutathione-S-transferase (GST) activity decreased in the PCM group, and there was an increase of protein carbonyls in the liver, kidney and brain. However, the protein carbonyls decreased in the liver for the PCM + EE group, in the kidneys for the PCM + EA and PCM + Rutin groups, and in the brain for all treatments.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oxidative stress; Acute intoxication; Acetaminophen; Copaiba. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672018000400347 |
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| BARBOSA,Fernando Gomes; SUGUI,Marina Mariko; SINHORIN,Valéria Dornelles Gindri; BICUDO,Rogério de Campos; MOURA,Fernando Rafael de; SINHORIN,Adilson Paulo. |
| ABSTRACT Capirona decorticans (Rubiaceae) is popularly used to treat warts, wounds, mycoses and scabies, and is also a component of the Ayahuasca tea. Despite its popular use, the phytochemical and pharmacological research on this species is limited. Therefore, this work quantified phenolic compounds in the ethanolic extract (EE) and hydromethanolic fraction (FM) (406, 293 mgEAG g-1, respectively) from leaves of C. decorticans. We identified flavonoids by LC-MS/MS-MMR-ESI (apigenin, rutin, luteolin, miricetin, quercetin, quercetin-3-β-D-glucoside, quercetrin), and evaluated oxidative stress and mutagenic/antimutagenic effect of EE and FM through an in vivo experiment using Swiss mice and cyclophosphamide (CP) as an inducer of DNA damage and oxidative... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oxidative stress; Cyclophosphamide; Genotoxicity; Phenolic compounds. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672018000400338 |
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| CUNHA,Ana Paula Simões da; BALDISSERA,Luana; PEREIRA,Débora Linsbinski; ALBIERO,Lucineia Reuse; CASTOLDI,Lindsey; SINHORIN,Adilson Paulo; SINHORIN,Valéria Dornelles Gindri. |
| ABSTRACT Copaifera multijuga, commonly known as copaiba, is popularly used in the form of tea for various conditions due to the presence of antioxidant substances in its composition, which protect cells against damage caused by free radicals. Its oleoresin is also used as an anti-inflammatory and antitumoral agent. The present study investigated the antioxidant effect of the ethanolic extract of copaiba stem bark on Swiss mice inoculated with solid Ehrlich tumors. Mice were inoculated subcutaneously with 1x106 Ehrlich’s tumor cells and treated via gavage with ethanolic extract of copaiba for thirty days, with doses varying between 100 and 200 mg kg-1. Biochemical analyses of enzymatic antioxidants [superoxide dismutase (SOD), catalase (CAT),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Solid tumor; Oxidative stress; Free radicals; Copaiba; Antineoplasic. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672019000100041 |
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| CAVALCANTE GRANJA,Manuela Maria; LACERDA E MEDEIROS,Maria Jaislanny; MEDEIROS DE ANDRADE SILVA,Marina; CAMARA,Terezinha; WILLADINO,Lilia; ULISSES,Claudia. |
| ABSTRACT Salinity is one of the major environmental stress factors that affect crop productivity, as well as interfering with plant growth and development, resulting in reduced production quality. Given this, we highlight the importance of research in response to plants subjected to salt stress in order to assess the physiological and biochemical behavior of genotypes, with the objective of selecting the more tolerant. One way to ensure the uniformity of the response of the plants is through in vitro cultivation, which allows control of the cultivation conditions. Therefore, the objective of this work was to evaluate the response of two commercial varieties of sugar cane exposed to saline stress in different conditions (gradual and abrupt). Two varieties... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidant enzymes; In vitro culture; Oxidative stress; Salinity. |
| Ano: 2018 |
URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2018000100030 |
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| L. MEDEIROS,Maria Jaislanny; Medeiros De A. SILVA,Marina; C. GRANJA,Manuela Maria; De SOUZA E SILVA JÚNIOR,Gilberto; CAMARA,Terezinha; WILLADINO,Lilia. |
| Sugarcane (Saccharum officinarum L.) production is influenced by various abiotic stresses, including salt stress. Salinity can induce oxidative stress, which in turn damages biomolecules and cellular structures. However, such damage can be avoided or minimized by the enzymatic and non-enzymatic defense systems of plants. The aim of the study was to determine the effect of exogenous proline on Na+ and K+ content and on the activity of catalase, ascorbate peroxidase and peroxidase in two sugarcane genotypes (RB931011 and RB872552) grown in vitro under salt stress. The plants were grown for 20 days with or without 100 mM NaCl and exposed to 20 mM proline for varying period of time. The data were subjected to ANOVA factorial (two genotypes and five... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidant enzymes; Oxidative stress; Saccharum officinarum L. |
| Ano: 2015 |
URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2015000200006 |
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| Teixeira,Marianne Pinheiro; Cruz,Litiele; Franco,Jeferson Luis; Vieira,Renara Bittencourt; Stefenon,Valdir Marcos. |
| Despite the importance of medicinal plants for the healthcare of local people, the knowledge about medicinal species used in the Pampa biome has been neglected over the years. In this study, an ethnobotanical survey was employed aiming to characterize the species richness and diversity of commercialized medicinal plant species in five cities within the Brazilian Pampa. Additionally, among the listed plants, ten species were selected for in vitro testing of their potential antioxidant activity. A total of 56 plant species belonging to 33 botanical families were listed by the 115 interviewees. No significant difference in commercialized medicinal plant species, and very similar species richness was observed among the cities, indicating that the local... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ethnobiology; Ethnopharmacology; Gaúcho; Oxidative stress; Pampa biome. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062016000100047 |
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| Corrêa,Natália Silveira; Bandeira,Juliana de Magalhães; Marini,Patrícia; Borba,Isabel Cristina Gouvea de; Lopes,Nei Fernandes; Moraes,Dario Munt de. |
| The germination and development of several plant species can be limited when those plants are grown in soils with high salinity, which reduces seedling viability and vigor, as well as activating the antioxidant defense system. The aim of this study was to evaluate germination, initial growth and activity of antioxidant enzymes (superoxide dismutase, catalase and ascorbate peroxidase) in seedlings of three onion cultivars (Madrugada, Fepagro 27 and Petroline) exposed to different concentrations of NaCl (0, 40, 80, 120 and 160 mM). Seedlings were evaluated for viability, vigor and antioxidant enzyme activity. The experimental procedures were completely randomized in 3 × 5 factorial design, with each treatment performed in triplicate, at a significance level... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Allium cepa; Growing; Oxidative stress; Germination; NaCl. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062013000200013 |
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| Silva,Adinan Alves da; Oliveira,Juraci Alves de; Campos,Fernanda Vidal de; Ribeiro,Cleberson; Farnese,Fernanda dos Santos. |
| ABSTRACT In many plant species, tolerance to toxic metals is highly dependent on glutathione, an essential metabolite for cellular detoxification. We evaluated the responses of glutathione metabolism to arsenite (AsIII) in Salvinia molesta, an aquatic fern that has unexplored phytoremediation potential. Plants were exposed to different AsIII concentrations in nutrient solution for 24 h. AsIII caused cell membrane damage to submerged leaves, indicating oxidative stress. There was an increase in the glutathione content and ϒ-glutamylcysteine synthetase enzyme activity in the submerged and floating leaves. The glutathione peroxidase and glutathione sulfotransferase enzymes also showed increased activity in both plant parts, whereas glutathione reductase only... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arsenic; Glutathione; Macrophytes; Oxidative stress; Phytoremediation. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-33062017000400657 |
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| Pizolato Neto, Antonio; Alves, Rita de Cássia; Camargos, Ayza Eugênio Viana; Gratão, Priscila Lupino; Carregari, Sônia Maria Raymundo; Zingaretti, Sonia Marli; Santos, Durvalina Maria Mathias Dos. |
| The present study aims to determine whether exogenous salicylic acid (SA) or spermidine (Spd) has any protective effect against salt stress. Seeds were subjected to 0, 20, 40, and 60 mM NaCl with or without salicylic acid or spermidine (0.5 mM) for 10 days. The evaluated variables were germination rate, shoot and root dry masses, glycine betaine content, lipid peroxidation, and the activities of superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX). The data were subjected to Tukey’s test (p ≤ 0.05). There was a growth increase, especially in plant shoots. The reduction in lipid peroxidation, as indicated by lower malondialdehyde (MDA) levels, can be explained by an increase in antioxidant activity when SA and Spd were added. When... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cajanus cajan; Dolichos lablab; Salt stress; Glycine betaine; Oxidative stress; Growth. Cajanus cajan; Dolichos lablab; Salt stress; Glycine betaine; Oxidative stress; Growth. Fisiologia Vegetal. |
| Ano: 2020 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciAgron/article/view/42809 |
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| Alcântara,Berenice K. de; Pizzaia,Daniel; Piotto,Fernando A.; Borgo,Lucélia; Brondani,Gilvano E.; Azevedo,Ricardo A.. |
| Lipid peroxidation and root elongation of Eucalyptus grandis × Eucalyptus camaldulensis were studied under stress conditions in response to aluminum (Al), a metal known to limit agricultural productivity in acidic soils primarily due to reduced root elongation. In Brazil, the Grancam 1277 hybrid (E. grandis × E. camaldulensis) has been planted in the "Cerrado", a region of the country with a wide occurrence of acidic soils. The present study demonstrated that the hybrid exhibited root growth reduction and increased levels of lipid peroxidation after 24h of treatment with 100 µM of Al, which was followed by a reduction in lipid peroxidation levels and the recovery of root elongation after 48h of Al exposure, suggesting a rapid response to the early... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aluminum; Eucalypt; Lipid peroxidation; Oxidative stress; Root growth. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201063 |
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| BISPO,VANDERSON S.; DANTAS,LUCAS S.; CHAVES FILHO,ADRIANO B.; PINTO,ISABELLA F.D.; SILVA,RAILMARA P. DA; OTSUKA,FELIPE A.M.; SANTOS,RODRIGO B.; SANTOS,ALINE C.; TRINDADE,DANIELLE J.; MATOS,HUMBERTO R.. |
| ABSTRACT Hepatic disorders such as steatosis and alcoholic steatohepatitis are common diseases that affect thousands of people around the globe. This study aims to identify the main phenol compounds using a new HPLC-ESI+-MS/MS method, to evaluate some oxidative stress parameters and the hepatoprotective action of green dwarf coconut water, caffeic and ascorbic acids on the liver and serum of rats treated with ethanol. The results showed five polyphenols in the lyophilized coconut water spiked with standards: chlorogenic acid (0.18 µM), caffeic acid (1.1 µM), methyl caffeate (0.03 µM), quercetin (0.08 µM) and ferulic acid (0.02 µM) isomers. In the animals, the activity of the serum γ-glutamyltranspeptidase (γ-GT) was reduced to 1.8 I.U/L in the coconut... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Coconut water; Ethanol; Oxidative stress; Phenolic compounds. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301095 |
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| FACCIO,LUCIANA; SILVA,ALEKSANDRO S. DA; TONIN,ALEXANDRE A.; OBERHERR,LUCAS; GRESSLER,LUCAS T.; OLIVEIRA,CAMILA B.; OLIVEIRA,DIONATAN T.; SANGOI,MANUELA B.; MORESCO,RAFAEL N.; SAMARA,YASMIN N.; VEIGA,MARCELO; DUARTE,MARTA M.M.F.; MONTEIRO,SILVIA G.. |
| The aim of this study was to evaluate the relationship between testicular lesions and hormone levels in rats experimentally infected with Trypanosoma evansi. For that, the measurement of reproductive hormones, histopathology and biomarkers of cellular injury were carried out in twenty-four animals, which were divided into two groups with 12 animals each. Group A was the negative control, or uninfected, while group B was composed by animals infected with T. evansi. Both groups were divided again into two other subgroups (n=6), from which serum and testicular fragments were collected on days 5 (A1 and B1) and 15 (A2 and B2) post-infection (PI). The morphological analysis showed increased alterations of head and tail of sperm in infected rats when compared... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Protozoa; Wistar rats; Testicular lesion; Reproduction; Oxidative stress. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537 |
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| GIUSTINA,AMANDA D.; DANIELSKI,LUCINÉIA G.; NOVOCHADLO,MICHELE M.; GOLDIM,MARIANA P.S.; JOAQUIM,LARISSA; METZKER,KIUANNE L.L.; CARLI,RAQUEL JACONI DE; DENICOL,TAIS; CIDREIRA,THAINA; VIEIRA,THAYNAN; PETRONILHO,FABRICIA. |
| Abstract Abstract: Sepsis is a life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Inflammation and oxidative stress are intrinsically related to sepsis progression and organ failure. Vitamin B6 is an important cellular cofactor for metabolic processes and has anti-inflammatory and antioxidant properties. We aimed at evaluating the effect of vit B6 on inflammation and oxidative stress markers in the liver and lung of rats subjected to a relevant animal model of polymicrobial sepsis. Adult male Wistar rats were submitted to cecal ligation and perforation model and immediately after sepsis induction, vit B6 was administered as a single dose (600 mg/kg, subcutaneous). Twenty-four hours later, the lung and liver... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis; Vitamin B6; Oxidative stress; Antioxidant. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700627 |
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| COMIM,CLARISSA M.; MATHIA,GISIANE B.; HOEPERS,ANDREZA; TUON,LISIANE; KAPCZINSKI,FLÁVIO; DAL-PIZZOL,FELIPE; QUEVEDO,JOÃO; ROSA,MARIA I.. |
| We investigated the levels of brain derived-neurotrophic factor (BDNF), cytokines and oxidative parameters in serum and tried to correlate them with the age and functionality of patients with Progressive Muscle Dystrophies (PMD). The patients were separated into six groups (case and controls pared by age and gender), as follows: Duchenne Muscular Dystrophy (DMD); Steinert Myotonic Dystrophy (SMD); and Limb-girdle Muscular Dystrophy type-2A (LGMD2A). DMD patients (±17.9 years old) had a decrease of functionality, an increase in the IL-1β and TNF-α levels and a decrease of IL-10 levels and superoxide dismutase activity in serum. SMD patients (±25.8 years old) had a decrease of BDNF and IL-10 levels and superoxide dismutase activity and an increase of IL-1β... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Progressive Muscular Dystrophies; BNDF; Cytokines; Oxidative stress. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000401809 |
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| ELLWANGER,JOEL H.; FRANKE,SILVIA I.R.; BORDIN,DIANA L.; PRÁ,DANIEL; HENRIQUES,JOÃO A.P.. |
| ABSTRACT Parkinson's disease is characterized by the death of dopaminergic neurons, mainly in the substantia nigra, and causes serious locomotor dysfunctions. It is likely that the oxidative damage to cellular biomolecules is among the leading causes of neurodegeneration that occurs in the disease. Selenium is an essential mineral for proper functioning of the brain, and mainly due to its antioxidant activity, it is possible to exert a special role in the prevention and in the nutritional management of Parkinson's disease. Currently, few researchers have investigated the effects of selenium on Parkinson´s disease. However, it is known that very high or very low body levels of selenium can (possibly) contribute to the pathogenesis of Parkinson's disease,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neurodegeneration; Nutrition; Oxidative stress; Parkinson's disease; Selenium. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501655 |
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| LEAL,DALILA T.; FONTES,GLEIDE G.; VILLA,JULIA K.D.; FREITAS,RODRIGO B.; CAMPOS,MATEUS G.; CARVALHO,CAMILO A.; PIZZIOLO,VIRGINIA R.; DIAZ,MARISA A.N.. |
| Abstract: This study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and three from the shogaol family were identified in the chromatographic analyzes of the extract. The animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. The treatment with ginger improved all these results, highlighting the reduction of 10% of body weight and 66% of the total area of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cafeteria diet; Gingerol; Nonalcoholic fatty liver disease; Oxidative stress; Shogaol; Zingiber officinale. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700801 |
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| Registros recuperados: 283 | |
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