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| Registros recuperados: 1.312 | |
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| Enrico Glaab; Jonathan M. Garibaldi; Natalio Krasnogor. |
| DNA microarray experiments provide a means to understand cancer and genetic diseases on a molecular level, improve diagnosis and identify new drug targets. However, choosing appropriate data processing methods and parameters is a difficult and time-consuming task, particularly for researchers without prior experience in this field. 
We present *ArrayMining.net*, a free web-service for automatic microarray analysis to address these issues. ArrayMining.net covers several major areas in statistical microarray analysis - Feature Selection, Clustering, Prediction, Gene Set and Network Analysis - providing access to several algorithms for each of these tasks based on a single, easy-to-use interface. |
| Tipo: Poster |
Palavras-chave: Cancer; Genetics & Genomics; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5552/version/1 |
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| Rachael Huntley; Emily Dimmer; Daniel Barrell; David Binns; Rolf Apweiler. |
| The Gene Ontology (GO) is a well-established, structured vocabulary that has been successfully used for 10 years in the annotation of proteins. GO terms, created in consultation with the biology community, are used to replace the multiple nomenclatures used by scientific databases that can hamper data integration. Currently GO consists of more than 26,500 terms distributed over three ontologies that describe the molecular function, biological process and subcellular location of a protein in a generic cell.

The Gene Ontology Annotation (GOA) database ("http://www.ebi.ac.uk/GOA":http://www.ebi.ac.uk/GOA) aims to provide high-quality manual and electronic GO annotations to proteins within the UniProt... |
| Tipo: Poster |
Palavras-chave: Genetics & Genomics; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3154/version/1 |
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| Cynthia Parr; Dana Campbell; John Park. |
| Online resources to aid large-scale ecological and evolutionary biology are beginning to take root, only a decade behind fields such as genomics and molecular biology. One barrier has been a long tradition, in evolutionary biology at least, of work by individuals on the order of a few hundred of species rather than the thousands or hundreds of thousands necessary to understand the general evolutionary or ecological processes that explain species characteristics and distributions. Advances in collaborative and semantic software offer promise – it should be possible to develop high quality online species-level datasets for comparative analyses and even to integrate, via machine reasoning, across highly customized datasets. In this talk we will... |
| Tipo: Presentation |
Palavras-chave: Ecology; Bioinformatics; Evolutionary Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4603/version/1 |
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| Heather A. Piwowar; Wendy W. Chapman. |
| Repurposing research data holds many benefits for the advancement of biomedicine, yet is very difficult to measure and evaluate. We propose a data reuse registry to maintain links between primary research datasets and studies that reuse this data. Such a resource could help recognize investigators whose work is reused, illuminate aspects of reusability, and evaluate policies designed to encourage data sharing and reuse. |
| Tipo: Poster |
Palavras-chave: Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2152/version/1 |
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| Rodrick Wallace. |
| The Stanley Miller experiment suggests that amino acid-based life is ubiquitous in our universe, although its varieties are not likely to have followed the particular, highly contingent and path-dependent, trajectory found on Earth. Are many of these life forms likely to be conscious in ways that we would recognize? Almost certainly. Will many conscious entities develop high order technology? Less likely. If so, will we be able to communicate with them? Only on a basic level, and only with profound difficulty. The argument is straightforward. |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Bioinformatics; Evolutionary Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5286/version/1 |
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| I. C. Baianu. |
| There is an urgent need for the early detection of diseases such as Alzheimer’s (AD) and Cancers in order to enable their successful treatment. Cancer is the second major cause of death after Heart Disease, and AD is the third major cause of death with major, human and financial/economics trillion dollar consequences for the society. Nuclear Medicine is concerned with applications in Medicine of Nuclear Science and Engineering techniques and knowledge. Three major Nuclear Medicine techniques that are established for diagnostic and research purposes are: Positron Emission Tomography (PET) and CAT/CT, Nuclear Magnetic Resonance Imaging (NMRI/MRI). However, these three techniques have also major limitations in terms of either cost or image... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Chemistry; Genetics & Genomics; Molecular Cell Biology; Neuroscience; Pharmacology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6271/version/1 |
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| Sandeep Swargam; K Mahesh; Amineni Umamaheswari. |
| Human myotrophin is the smallest ankyrin repeat protein implicated as a factor to induce cardiac hypertrophy. Activation of myotrophin was observed during acute myocardial infarction (MI). In acute coronary syndrome (ACS) patients, myotrophin acts as a self-governing predictor of major adverse cardiac events (MACE). Therefore, human myotrophin serves as an effective drug target for discovery of new potential drugs. Recent human myotropin inhibitors have poor pharmalogical properties leading to intolerable side effects. Hence, ligand based virtual screening protocol of CADD method was persuaded in the present study to propose new class potential myotrophin inhibitors. Docking was done by using Schrödinger software suite 2010 (maestro v9.1), docked... |
| Tipo: Poster |
Palavras-chave: Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6562/version/1 |
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| Leonardo Varuzza; Arthur Gruber; Carlos A. B. Pereira. |
| Most of the statistical tests currently used to detect differentially expressed genes are based on asymptotic results, and perform poorly for low expression tags. Another problem is the common use of a single canonical cutoff for the significance level (p-value) of all the tags, without taking into consideration the type II error and the highly variable character of the sample size of the tags.

 This work reports the development of two significance tests for the comparison of digital expression profiles, based on frequentist and Bayesian points of view, respectively. Both tests are exact, and do not use any asymptotic considerations, thus producing more correct results for low frequency tags than the chi-square test. The... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2002/version/3 |
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| Nicolas Le Novère; Stuart Moodie; Anatoly Sorokin; Falk Schreiber; Huaiyu Mi. |
| Standard graphical representations have played a crucial role in science and engineering throughout the last century. Without electrical symbolism, it is very likely that our industrial society would not have evolved at the same pace. Similarly, specialised notations such as the Feynmann notation or the process flow diagrams did a lot for the adoption of concepts in their own fields. With the advent of Systems Biology, and more recently of Synthetic Biology, the need for precise and unambiguous descriptions of biochemical interactions has become more pressing. While some ideas have been advanced over the last decade, with a few detailed proposals, no actual community standard has emerged. The Systems Biology Graphical Notation (SBGN) is a graphical... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3719/version/1 |
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| Rodrick Wallace. |
| Intrinsically disordered proteins (IDP) appear far more likely to engage in functional moonlighting than well-structured proteins. The recent use of nonrigid molecule theory to address IDP structure and dynamics produces this result directly: Mirror image subgroup or subgroupoid tiling matching of the molecular fuzzy lock-and-key can be much richer for IDPs since the number of possible group or groupoid symmetries can grow exponentially with molecule length, while tiling matching for 3D structured proteins is relatively limited. A simple information catalysis model suggests how this mechanism can produce a vast spectrum of biological 'logic gates' having subtle properties far beyond familiar AND, OR, XOR, etc. behaviors. Inferring the... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Cancer; Chemistry; Developmental Biology; Molecular Cell Biology; Pharmacology; Bioinformatics; Evolutionary Biology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6413/version/1 |
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| Min Yue; Weicheng Bei; Huanchun Chen. |
| Upper respiratory tract (URT) infection caused the leading and devastating diseases in pigs. It was believed that the normal microbiome of URT plays a vital role in health and disease development. As the entry point of the URT, little knowledge of bacterial microbiome in porcine nasal was known. A cultivation-independent approach directly to 16s ribosomal RNA genes enabled us to reveal the nasal bacterial community, structure and diversity. Here, we found that an unprecedented 207 phylotypes were characterized from 933 qualified clones, indicating the variable, species richness but particularly dominant bacterial microbiome. The dominant species were from genus Comamonas and Acinetobacter, which constitute core normal bacterial microbiome in porcine nasal.... |
| Tipo: Manuscript |
Palavras-chave: Microbiology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6699/version/1 |
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| Qi Wang. |
| 3DScape is the first plug-in which enables three-
dimensional network visualization in Cytoscape. The extra dimension is useful in accommodating, visualizing, and distinguishing larger networks with multiple crossing connections.
Special features in 3DScape include 3D layout algorithms, mapping onto 3D models and animation effects on a series of expression data. 3DScape is available at http://www.rendware.com |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/6094/version/1 |
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| Wei Zhang. |
| Understanding of the mechanism of DNA mutation process is critical for studying the functional consequences of genetic variation in clinical medicine (eg. drug response) as well as other complex traits (eg. gene expression and cause of common diseases). During the last several decades, many probabilistic models of DNA nucleotide substitution have been proposed for studying this process. A common feature of these mutation models is that they assume the nucleotides evolve independently at each site. In other words, they are sequence context-independent models. However, based on various biochemical studies, it is now recognized that the DNA mutation process resulting in substitutions in both coding and non-coding regions may depend on sequence context. We... |
| Tipo: Presentation |
Palavras-chave: Ecology; Bioinformatics; Evolutionary Biology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1243/version/1 |
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| Jeremy I. Posner; Seth Berger; Avi M. Ma'ayan. |
| In recent years, in-silico literature-based mammalian protein-protein interaction network datasets have been developed. These datasets contain binary interactions extracted manually from legacy experimental biomedical research literature. Placing lists of genes or proteins identified as significantly changing in multivariate experiments, in the context of background knowledge about binary interactions, can be used to place these genes or proteins in the context of pathways and protein complexes.
Genes2Networks is a software system that integrates the content of ten mammalian literature-based interaction network datasets. Filtering to prune low-confidence interactions was implemented. Genes2Networks is delivered as a web-based service using... |
| Tipo: Manuscript |
Palavras-chave: Biotechnology; Molecular Cell Biology; Bioinformatics. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/35/version/2 |
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| Camille Laibe. |
| This presentation gives a short introduction of MIRIAM Resources ("http://www.ebi.ac.uk/miriam/":http://www.ebi.ac.uk/miriam/), a robust annotation and cross referencing framework, based on URNs.

The presentation also explains some potential issues with the current system and presents a possible solution.

Finally, the presentation introduces some forthcoming and suggested updates and extensions to the current infrastructure. |
| Tipo: Presentation |
Palavras-chave: Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5130/version/1 |
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| Registros recuperados: 1.312 | |
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