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| Yeturu Kalidas; Nagasuma Chandra. |
| Background: Recognizing similarities and deriving relationships among protein molecules is a fundamental
requirement in present-day biology. Similarities can be present at various levels which can be detected through comparison of protein sequences or their structural folds. In some cases similarities obscure at these levels could be present merely in the substructures at their binding sites. Inferring functional similarities between protein molecules by comparing their binding sites is still largely exploratory and not as yet a routine protocol. One of
the main reasons for this is the limitation in the choice of appropriate analytical tools that can compare binding sites with high sensitivity. To benefit from the... |
| Tipo: Manuscript |
Palavras-chave: Bioinformatics. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2142/version/1 |
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| Nick Lee; Michael J. R. Butler; Carl Senior. |
| The application of cognitive neuroscientific techniques to understanding social behaviour has resulted in many discoveries. Yet advocates of the ‘social cognitive neuroscience’ approach maintain that it suffers from a number of limitations. The most notable of these is its distance from any form of real-world applicability. One solution to this limitation is ‘Organisational Cognitive Neuroscience’ – the study of the cognitive neuroscience of human behaviour in, and in response to, organizations. Given that all of us will spend most of our lives in some sort of work related organisation, organisational cognitive neuroscience allows us to examine the cognitive underpinnings of social behaviour that... |
| Tipo: Manuscript |
Palavras-chave: Ecology; Neuroscience. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2159/version/1 |
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| Yaroslav Strokovskyy. |
| We propose a hypothetic mechanism of ordering and shaping cells during _C. elegans_ embryogenesis. The mechanism is based on the assumption that during each round of division of cells, daughter cells acquire electric charges from its mother cells (charge conservation law is taken into account). Between the acts of division, the total electric field, generated by a system of charged cells, change relative positions of the charged cells within the region. In one’s turn, the positions of the charged cells determine the pattern of the electrostatic field. A mathematical model of such self-consistent mechanism is developed. The process of developing the sixteen-cell structure starting with one cell is simulated. The results correspond to the known... |
| Tipo: Manuscript |
Palavras-chave: Developmental Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4277/version/1 |
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| Octavio Martinez; Araceli Fernandez-Cortes. |
| When assembling a large quantity of reads in a genomic shotgun project a serious limitation is the amount of random access memory (RAM) of the computers used in the project. This arises because all assembling programs must look at all the overlaps between reads at the same time, using RAM in order to construct contigs, and the memory of the computer can be filled up during this step, causing the abortion of the assembling process.
Here we propose an algorithm that is capable of overcoming any memory limitation by using redundancy of processing and thus producing an increase in computing time but overcoming the memory limitation.
The proposed algorithm consists in dividing the reads in a set of groups which size is half the... |
| Tipo: Manuscript |
Palavras-chave: Genetics & Genomics; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3712/version/1 |
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| Pundarikakshudu Tetali; Shrikant Sutar; Sujata Tetali. |
| Carnivorous plants comprise roughly 0.24 percent of the flowering plants, or 640 species represented in 12 families. Yet they are regarded as _miracula naturae_. Over fifty percent of these taxa are represented in a single family, namely Lentibulariaceae. Carnivorous plants are generally insectivorous, and carnivory in flowering plants is generally found in taxa that are adapted to nutrient-deficient habitats. The extra nutrients such plants acquire by special ways serve merely as supplements. The origin and evolution of carnivorous plants is a mystery in the phylogenetic tree of angiosperms, they often appear without a clear linkage. Here, we report that _Nymphaea nouchali_ Burm. f. (a cultivar of var. cernua), a large aquatic member of the family... |
| Tipo: Manuscript |
Palavras-chave: Ecology; Earth & Environment; Plant Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1817/version/1 |
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| Larry Weiseenthal; Summer Williamson; Cindy Brunschwiler; Constance Rueff-Weisenthal. |
| Bähr and colleagues reported that 22 of 36 glioblastoma patients treated with bevacizumab showed tumor calcifications on 8 week post therapy follow up with MRI. Early tumor calcification strongly predicted for response, time to progression, and overall survival. The authors didn’t understand the mechanism, but speculated that it was vascular in nature. At the 13th International Anti-Angiogenic Symposium (2011), we presented our discovery of the phenomenon of massive calcium accumulation death, wherein MCAD occurred in endothelial cells (tumor, circulating, and HUVEC), in response to VEGF depletion by bevacizumab and other putative anti-angiogenic agents, but not in response to non-specific cytotoxins. In subsequent work, we have... |
| Tipo: Poster |
Palavras-chave: Cancer. |
| Ano: 2012 |
URL: http://precedings.nature.com/documents/7069/version/1 |
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| Lopamudra Das Roy; Latha Pathangey; Teresa Tinder; Pinku Mukherjee. |
| Chronic inflammation is known to play a role in cancer initiation, promotion,and metastasis. However, the mechanism by which inflammation promotes metastasis is still unclear. We evaluated if chronic inflammation induced by autoimmune arthritis may contribute to increased breast cancer-associated metastasis. We report a three-fold increase in lung metastasis and a significant increase in the incidence of bone metastasis in the pro-arthritic mice compared to control mice. The metastatic breast tumors in turn augment the severity of arthritis resulting in a vicious cycle that increases both bone destruction and metastasis. Enhanced neutrophilic and granulocytic infiltration in lungs and bone of the pro-arthritic mice and subsequent increase in circulating... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Immunology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2632/version/1 |
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| Anthony Johnson; Alberto Pimpinelli. |
| A recent computer-aided-design investigation of the Neolithic 56 Aubrey Hole circuit at Stonehenge has led to the discovery of an astonishingly simple geometrical construction for drawing an approximately regular 56-sided polygon, feasible with a compass and straightedge. In the present work, we prove analytically that the aforementioned construction yields as a byproduct, an extremely accurate method for approximating a regular heptagon, and we quantify the accuracy that prehistoric surveyors may have ideally attained using simple pegs and ropes. We compare this method with previous approximations, and argue that it is likely to be at the same time the simplest and most accurate. Implications of our findings are discussed. |
| Tipo: Manuscript |
Palavras-chave: Earth & Environment. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2153/version/1 |
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| Pablo Pita; Juan Freire. |
| For years now the estimates of the consequences of overfishing for marine ecosystems have differed greatly within the scientific community^1^. The use of commercial catch statistics to estimate tendencies has been much criticised^2^, but alternative information sources with long time series are rare. Here we employ the historic archive (1953-2007) of the recreational spearfishery in Galicia (NW Spain), which does not have the problems common to other fishery registers, to estimate long-term changes in coastal ecosystems. Using generalized additive regression models (GAM) we estimated decreases of around 83% in the abundances of coastal fish over the last 50 years. In the same period the average body size decreased by 36%. In addition, the relative catch... |
| Tipo: Manuscript |
Palavras-chave: Ecology; Earth & Environment. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4529/version/1 |
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| Steve Kelling; Daniel Fink; Wesley M. Hochachka; Marshall J. Iliff; Brian L. Sullivan; Christopher L. Wood; Arthur Munson; Mirek Riedewald. |
| Increasing public engagement in volunteer science1, either through data collection2 or processing3, is both raising public awareness of science and gathering useful information for scientists. While the payoffs of citizen science4 are potentially large, achieving them requires new approaches to data management and analysis that can only result from strong cross-disciplinary collaborations. This is especially true in ecology and conservation biology, where historically the understanding of species’ responses to environmental change has been constrained by the limited spatial5 or temporal scale6 of available data. Here we describe collaborative research in ecology, computer science, and statistics to generate essential information for... |
| Tipo: Manuscript |
Palavras-chave: Ecology. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3967/version/1 |
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| Wende Li; Farah S. Hosseinian; Arnold W. Hydamaka; Lynda Lowry; Trust Beta. |
| Consumption of fruits and vegetables is shown to be beneficial for protecting health and preventing some chronic diseases such as cancer, cardiovascular disease, and stroke. The positive health effects have been mainly due to the contributions of their natural antioxidant capacity. Chokecherry (Prunus virginiana), a unique fruit, is a member of the Rose family and native to North America. Here we demonstrate that chokecherry fruit with strong antioxidant capacity is available in Manitoba, and that its potent antioxidant potential can be developed for health benefits in value-added applications.These findings are useful for developing novel value-added antioxidant products from chokecherry because of its phytochemical profile associated with health... |
| Tipo: Manuscript |
Palavras-chave: Cancer; Chemistry; Plant Biology. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/1529/version/1 |
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| Zheng Sixiang; Liu Feihu; Zhang Chaojun; Chen Zhilin; Ma Yuhua; Meng Pinghong; Zhao Yan. |
| Mitosis is nuclear division plus cytokinesis,and produces two identical daughter cells during prophase, prometaphase, metaphase, anaphase, and telophase. However, a new nucleus behavior in interspecific hybrid progenies of Lilium was observed in our experiment. Very unusual behaviors of nuclei surprisingly presented during the mitosis, such as sprouting or germination, tube-like elongation, penetrating cell membrane into a neighbor cell, the top of nuclei tube expanding, intruding and splitting of the tube-like nucleus, and micronucleus formation, and so on. Furthermore, the tetrad of meiosis was founded in mitosis of root.

Routine of the unusual nucleus behaviors observed in our experiment may be summarized as nucleus... |
| Tipo: Manuscript |
Palavras-chave: Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4631/version/1 |
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| Diego Mauricio Riaño-Pachón; Luiz Gustavo Guedes Correa; Bernd Mueller-Roeber. |
| PlnTFDB is a publicly available computational resource comprising putative complete sets of transcription factors from plants. The original database listed the putative complete sets of TFs from five different green plant (viridiplantae) species. Up to date, summer 2007, PlnTFDB have had more than one hundred thousand hits from more than one thousand different clients, showing the importance that this resource had acquired for the plant community. In this first major update, we extended the coverage of the database to additional completed viridiplantae genomes, i.e., the moss _Physcomitrella patens_ and the rice _Oryza sativa_ spp _indica_. The scope of PlnTFDB was broadened to encompass other eukaryote photosynthetic organisms, such as the rhodophyte... |
| Tipo: Poster |
Palavras-chave: Ecology; Bioinformatics; Plant Biology. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1094/version/1 |
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| Chien-Hui Liou; Chang-Wei Hsieh; Chao-Hsien Hsieh; Si-Chen Lee; Jyh-Horng Chen; Chi-Hong Wang. |
| The human brain possesses plenty of functions but little is known about its scientific relationship with mind and spirit. Conferences^1,2^ focused on the connection between science and religion were held very recently in which neuroscientists, Buddhist scholars and Dalai Lama discussed attention, mental imagery, emotion, mind, brain functions and meditation, suggesting religious meditation offers an effective means to investigate the mystery of mind and spirit. In the past decade, scientists struggled to obtain brain mappings for various meditation styles using different brain imaging techniques and stimulating results have been observed^3-17^. In this letter we report that, together with other brain regions, pineal body... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience. |
| Ano: 2007 |
URL: http://precedings.nature.com/documents/1328/version/1 |
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| Registros recuperados: 3.453 | |
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