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| Registros recuperados: 176 | |
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| Xia,H.; Ye,J.; Wang,L.; Zhu,J.; He,Z.. |
| Glutathione synthetase deficiency (GSSD) is a rare inborn error of glutathione metabolism with autosomal recessive inheritance. The severe form of the disease is characterized by acute metabolic acidosis, usually present in the neonatal period with hemolytic anemia and progressive encephalopathy. A case of a male newborn infant who had severe metabolic acidosis with high anion gap, hemolytic anemia, and hyperbilirubinemia is reported. A high level of 5-oxoproline was detected in his urine and a diagnosis of generalized GSSD was made. DNA sequence analysis revealed the infant to be compound heterozygous with two mutations, c.738dupG in exon 8 of GSS gene resulting in p.S247fs and a repetitive sequence in exon 3 of GSS gene. Treatment after diagnosis of GSSD... |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Glutathione synthetase; 5-oxoprolinuria; Newborn; Metabolism; Mutation. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300501 |
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| Newsholme,P.; Lima,M.M.R.; Procopio,J.; Pithon-Curi,T.C.; Doi,S.Q.; Bazotte,R.B.; Curi,R.. |
| Glucose is widely accepted as the primary nutrient for the maintenance and promotion of cell function. This metabolite leads to production of ATP, NADPH and precursors for the synthesis of macromolecules such as nucleic acids and phospholipids. We propose that, in addition to glucose, the 5-carbon amino acids glutamine and glutamate should be considered to be equally important for maintenance and promotion of cell function. The functions of glutamine/glutamate are many, i.e., they are substrates for protein synthesis, anabolic precursors for muscle growth, they regulate acid-base balance in the kidney, they are substrates for ureagenesis in the liver and for hepatic and renal gluconeogenesis, they act as an oxidative fuel for the intestine and cells of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Glutamine; Glutamate; Glucose; Metabolism; Cell function. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000200002 |
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| Faria,A.V.; Macedo Jr.,F.C.; Marsaioli,A.J.; Ferreira,M.M.C.; Cendes,F.. |
| High resolution proton nuclear magnetic resonance spectroscopy (¹H MRS) can be used to detect biochemical changes in vitro caused by distinct pathologies. It can reveal distinct metabolic profiles of brain tumors although the accurate analysis and classification of different spectra remains a challenge. In this study, the pattern recognition method partial least squares discriminant analysis (PLS-DA) was used to classify 11.7 T ¹H MRS spectra of brain tissue extracts from patients with brain tumors into four classes (high-grade neuroglial, low-grade neuroglial, non-neuroglial, and metastasis) and a group of control brain tissue. PLS-DA revealed 9 metabolites as the most important in group differentiation: γ-aminobutyric acid, acetoacetate, alanine,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brain; Tumor; Magnetic resonance spectroscopy; Spectroscopy; Metabolism. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200009 |
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| Hudson,A.S.R.; Kunstetter,A.C.; Damasceno,W.C.; Wanner,S.P.. |
| Physical exercise triggers coordinated physiological responses to meet the augmented metabolic demand of contracting muscles. To provide adequate responses, the brain must receive sensory information about the physiological status of peripheral tissues and organs, such as changes in osmolality, temperature and pH. Most of the receptors involved in these afferent pathways express ion channels, including transient receptor potential (TRP) channels, which are usually activated by more than one type of stimulus and are therefore considered polymodal receptors. Among these TRP channels, the TRPV1 channel (transient receptor potential vanilloid type 1 or capsaicin receptor) has well-documented functions in the modulation of pain sensation and thermoregulatory... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Afferent; Capsaicin; Hyperthermia; Metabolism; Physical activity; Thermoregulation. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000600301 |
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| Teixeira-Coelho,F.; Santos,D.F.C.; Santos,G.A.; Sousa,T.F.; Moreira,S.R.; Souza,M.V.C.; Wanner,S.P.. |
| The consumption of alcoholic beverages influences carbohydrate and lipid metabolism, although it is not yet clear whether metabolism during physical exercise at different intensities is also affected. This was the objective of the present study. Eight young and healthy volunteers performed a treadmill test to identify the running speed corresponding to a lactate concentration of 4 mM (S4mM). At least 48 h later, they were subjected to two experimental trials (non-alcohol or alcohol) in which they performed two 1-km running sessions at the following intensities: 1) S4mM; 2) 15% above S4mM. In both trials, blood lactate, triglycerides, and glucose concentrations were measured before and after exercise. The acute alcohol intake increased triglycerides, but... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Endurance; Ethanol; Glucose; Lactate; Metabolism; Treadmill running. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000400601 |
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| We have studied the metabolism of diglycine and triglycine in the isolated non-filtering rat kidney. Kidneys from adult male Wistar Kyoto rats weighing 250-350 g were perfused with Krebs-Henseleit solution containing either 1 mM diglycine or triglycine. The analysis of the peptide residues and their components was performed using an amino acid microanalyzer utilizing ion exchange chromatography. Diglycine was degraded to a final concentration of 0.09 mM after 120 min (91%); this degradation occurred predominantly during the first hour, with a 56% reduction of the initial concentration. The metabolism of triglycine occurred similarly, with a final concentration of 0.18 mM (82%); during the first hour there was a 67% reduction of the initial concentration of... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Non-filtering kidney; Dipeptide; Tripeptide; Metabolism; Peptidases. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000200005 |
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| Paes,L.S.; Borges,J.P.; Cunha,F.A.; Souza,M.G.C.; Cyrino,F.Z.G.A.; Bottino,D.A.; Bouskela,E.; Farinatti,P.. |
| This study compared strategies to equalize the volume of aerobic exercise performed with different intensities by Wistar rats, based on the distance covered during exercise bouts and energy expenditure (EE, isocaloric sessions) obtained from oxygen uptake (V̇O2) or respiratory exchange ratio (RER). Thirty-three male rats (270.5±12.8 g) underwent maximal exercise tests to determine V̇O2 reserve (V̇O2R), being randomly assigned to three groups: moderate-intensity continuous exercise at speed corresponding to 50% V̇O2R (MIC; n=11); high-intensity continuous exercise at 80% V̇O2R (HIC; n=11); and high-intensity intermittent exercise (HII; n=11) at 60% V̇O2R (3 min) and 80% V̇O2R (4 min). Exercise duration was calculated individually to elicit EE of 5 kcal in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Energy expenditure; Aerobic exercise; Exercise testing; Metabolism; Fitness. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000800607 |
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| Bazotte,R.B.; Batista,M.R.; Curi,R.. |
| Naomi Shinomiya Hell was the first researcher to investigate the physiological adaptations to a meal-feeding scheme (MFS) in Brazil. Over a period of 20 years, from 1979 to 1999, Naomi's group determined the physiological and metabolic adaptations induced by this feeding scheme in rats. The group showed the persistence of such adaptations even when MFS is associated with moderate exercise training and the performance to a session of intense physical effort. The metabolic changes induced by the feeding training were discriminated from those caused by the effective fasting period. Naomi made an important contribution to the understanding of the MFS but a lot still has to be done. One crucial question still remains to be satisfactorily answered: what is the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Meal-feeding scheme; Metabolism; Exercise; Fasting; Liver. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900001 |
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| Dube,Aman K.; Kumar,Maushmi S.. |
| Abstract Fungi is a well-known model used to study drug metabolism and its production in in vitro condition. We aim to screen the most efficient strain of Cunninghamella sp. among C. elegans, C. echinulata and C. blakesleeana for bromhexine metabolites production. We characterized the metabolites produced using various analytical tools and compared them with mammalian metabolites in Rat liver microsomes (RLM). The metabolites were collected by two-stage fermentation of bromhexine with different strains of Cunninghamella sp. followed by extraction. Analysis was done by thin layer chromatography, high performance thin layer chromatography, Fourier transform infrared spectroscopy, high performance liquid chromatography and Liquid chromatography–mass... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cunninghamella sp.; Bromhexine; RLM; CYP3A4; Inhibitor; Metabolism. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000200259 |
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| Fornazier,Ricardo Francisco; Azevedo,Ricardo Antunes; Ferreira,Renato Rodrigues; Varisi,Vanderlei Aparecido. |
| Lysine is an essential amino acid, synthesized in plants in the aspartic acid pathway. The lysine catabolism is performed by the action of two consecutive enzymes, lysine 2-oxoglutarate reductase (LOR) and saccharopine dehydrogenase (SDH). The steady state of lysine is controlled by both, synthesis and catabolism rates, with the final soluble lysine concentration in cereal seeds a direct result of these processes. In the last 40 years, the enzymes involved in lysine biosynthesis have been purified and characterized from some plant species such as carrot, maize, barley, rice, and coix. Recent reports have revealed that lysine degradation might be related to various physiological processes, for instance growth, development and response to environmental... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amino acids; Lysine; Metabolism; Mutants. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-04202003000100002 |
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| Naves,Luciana de Paula; Rodrigues,Paulo Borges; Teixeira,Levy do Vale; Bertechini,Antônio Gilberto; Alvarenga,Renata Ribeiro; Bernardino,Verônica Maria Pereira; Santos,Luziane Moreira dos; Natividade,Yuri Pereira Efrem. |
| The reduction of the available phosphorus (avP) content in the broiler diet must be followed by the supplementation of adequate phytase. One experiment was conducted with broilers from 15 to 28 days of age to determine the level of necessary phytase when the mashed diet is formulated with 0.213% of avP to enable the results of performance, tibia ash content, and calcium (Ca) utilization similar to those determined for birds fed with diet formulated to meet their nutritional requirements. Thus, 120 broilers were distributed in (4+1) x2 factorial arrangement corresponding to four deficient diets in avP (0.213%) supplemented with phytase (0; 750; 1,500 or 2,250FTU kg-1) plus one positive control diet without phytase (0.426% of avP), supplied to male and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aviculture; Bone ash; Enzyme; Metabolism; Performance; Phytate. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000801479 |
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| Kozloski,Gilberto Vilmar; Rocha,João Batista Teixeira da; Ciocca,Maria de Lourdes Santorio. |
| The visceral system (liver and portal-drained viscera) represents an interface between diet and the animal, and it acts as the main site of regulation of nutrients that are used for maintenance, growth, lactation, reproduction, and physical activities of animals. However the functions carried out by visceral organs have, however, a significant energetic cost and are influenced by a variety of factors, such as the level of feed intake and diet composition, among others. As a result, variable quantities of substances are metabolized by them and, thus, the pattern and the quantity of nutrients available to the peripheral tissues can be quite different from those absorbed at the intestinal lumen. Probably, the major source of variation in the efficiency of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Portal- drained viscera; Liver; Metabolism; Energy; Efficiency. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782001000500030 |
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| Chiaradia,Rafael Coutinho Finamor; Zangeronimo,Márcio Gilberto; Fialho,Elias Tadeu; Lima,José Augusto de Freitas; Rodrigues,Paulo Borges; Sousa,Raimundo Vicente de. |
| An experiment was conducted at the Department of Animal Husbandry of Universidade Federal de Lavras aiming to study the nitrogen and energy balance in diets with reduced crude protein rates (CP) and different levels of energy and lysine for growing pigs. 52 castrated pigs (initial weight = 36.13 ± 2.8 kg) of high genetic potential were used, housed individually in metabolism cages (experimental unit). The treatments consisted of 12 diets with three levels of metabolizable energy (ME) (3060, 3230 and 3400 kcal / kg) and four of true digestible lysine (TDL) (0.7, 0.9, 1.1 and 1, 3%) with 14% CP plus a control diet with 3230 kcal ME / kg, 1.03% TDL and 18% CP. We used a DBC in time 3x4 +1 factorial design with four replications to verify the absorbed nitrogen... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Synthetic amino acids; Nutrition; Metabolism; Ideal protein. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542009000600028 |
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| Gomide,Elisangela Minati; Rodrigues,Paulo Borges; Zangeronimo,Márcio Gilberto; Bertechini,Antônio Gilberto; Santos,Luziane Moreira dos; Alvarenga,Renata Ribeiro. |
| The objective of this study was to evaluate the effect of reduced-crude protein (CP) and available phosphorus (aP) diets, added with phytase and amino acids for broilers in the growing (14 to 21 days old) and retirement (35 to 42 days) phases on nitrogen, potassium and phosphorus balance. Ninety Cobb broilers were distributed in a completely randomized design with three treatments and six replications with five and three birds per experimental unit in the growing and retirement phases, respectively. Diets were elaborated to contain reduced CP and aP levels (19 and 17% CP in the growing phase, with 0.34% aP; and 18 and 16% CP in the retirement phase, with 0.30% aP), supplemented with crystalline amino acids and 500 FTU of phytase/kg diet. These were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Enzyme; Phytate; Environment; Metabolism. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542011000300022 |
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| Gomide,Elisangela Minati; Rodrigues,Paulo Borges; Naves,Luciana de Paula; Bernardino,Verônica Maria Pereira; Santos,Luziane Moreira dos; Garcia,Antonio Amandio Pinto. |
| One performance experiment and another metabolism experiment were conducted simultaneously with broilers from 22 to 35 days of age, evaluating five diets in six replicates. The control diet, without phytase, contained 19% of crude protein (CP); 0.412% of available phosphorus (aP) and 0.824% of calcium (Ca). The other diets were supplemented with phytase and were formulated with 0.262% of aP and 0.524% of Ca, with the CP level ranging from 19 to 16%. In the performance assay, 750 birds were used, in which were evaluated the performance, the tibia ash content and yields of carcass, cuts, and abdominal fat at 35 days of age. The metabolism assay was conducted with 90 birds, evaluating the apparent metabolizable energy corrected by the nitrogen balance; the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tibia ash; Carcass yield; Ideal protein; Metabolism; Performance. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542012000100013 |
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| Registros recuperados: 176 | |
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