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| Diaz,Ricardo Sobhie; Sucupira,Maria Cecilia A; Vergara,Tania RC; Brites,Carlos; Bianco,Rosana Del; Bonasser Filho,Francisco; Colares,Geova Keny B; Portela,Estevão; Cherman,Lia Adler; Barcelos,Nemora Tregnago; Tupinambas,Unai; Turcato Jr,Gilberto; Allamasey,Lisa; Bacheler,Lee; Tuohy,Martin. |
| OBJECTIVE: To investigates how the use of HIV-1 resistance tests influences physician decision-making. METHODS: Ten experienced reference physicians from the Brazilian Network for Drug Resistance each received ten patients' case histories. The selected patients had experienced at least two virological failures. First, reference physicians were asked to empirically select a new regimen for each patient. Second, after genotype report (ViroSeq 2.6) was provided, and physicians were again asked to select a new regimen considering this additional information. Finally, they were asked to select a regimen after receiving a virtual phenotype result (vircoTYPE 3.9.00). RESULTS: In 79% of the cases, physicians changed their empirical choice of regimen after... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genotype; Virtual phenotype; Antiretroviral resistance; Brazil. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500011 |
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| Grinberg,Gorki; Giron,Leila Bertoni; Knoll,Rosalie Kupka; Galinskas,Juliana; Camargo,Michelle; Arif,Muhammad Shoaib; Samer,Sadia; Janini,Luiz Mario Ramos; Sucupira,Maria Cecilia Araripe; Diaz,Ricardo Sobhie. |
| ABSTRACT Itajaí is a port city in southern Brazil with one of the highest incidence and mortality rates from AIDS in the country. The prevalence and incidence of HIV infection were investigated in 1085 of 3196 new HIV-1 infection cases evaluated in the counseling and testing center of Itajaí from January 2002 to August 2008. Recent infections were assessed using the BED(tm), and polregion sequencing was performed in 76 samples. The prevalence ranged from 3.08% to 6.17% among women and from 10.26% to 17.36% among men. A total of 17% of infections were classified as recent, with annual incidence varying from 1.6% to 4.8 per 100 patient/year among women and from 2.05% to 8.5 per 100 patient/year among men. Pol sequences were obtained from 38 randomly recent... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Recent HIV infection; HIV subtype; Brazil; Transmitted drug resistance. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600631 |
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| Angelis,Daniela Souza Araújo de; Tateno,Adriana Fumie; Diaz,Ricardo Sobhie; Succi,Regina Célia de Menezes; Pannuti,Claudio Sergio; Gouvea,Aida de Fátima Barbosa; Machado,Daisy Maria. |
| Treatment of HIV-1 infection with highly active antiretroviral therapy has led to sustained viral suppression in the plasma in a large number of children. However, studies have suggested that the integrated provirus in resting CD4+ T lymphocytes could be a source of reactivatable virus and maintain drug-resistant virus. We evaluated the resistance-related mutations in children receiving antiretroviral therapy with prolonged viral suppression. Thirty-two peripheral blood mononuclear cell samples from 16 children with viral loads that had been below detection limits for at least 12 months were obtained at two different time points and the DNAs sequenced. The median CD4 cell count was 1,016 cells/mm³ (347-2,588) and 938 cells/mm³ (440-3,038) at the first and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Children; HIV-1; Prolonged viral suppression; Antiretroviral therapy; Antiretroviral resistance. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100011 |
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| Caseiro,Marcos M.; Golegã,Alcino A.C.; Etzel,Arnaldo; Diaz,Ricardo Sobhie. |
| We characterized the virologic failure after an initially successful 48-week course of antiretroviral therapy among HIV/AIDS patients in a retrospective cohort study involving patients from Santos, Brazil. Patients with plasma HIV RNA below 500 copies/mL for 48 weeks were included. Variables analyzed included gender, age, level of education, marital status, mode of HIV acquisition, viral load, and CD4 cell count upon admission. There were 4,909 patients registered with the clinic, of which 669 patients met all the inclusion criteria (41.6% female and 58.4% male). Only 27.5% of the patients maintained undetectable viral loads during up to one year of follow-up. After 48 weeks, virologic failure occurred earlier in females and in patients first treated with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antiretroviral therapy; Virologic failure; HIV; Brazil. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300001 |
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| Munerato,Patrícia; Azevedo,Maria Lúcia; Sucupira,Maria Cecília Araripe; Pardini,Regina; Pinto,Gedson Humberto Novaes; Catroxo,Márcia; Souza,Inara Espinelli; Diaz,Ricardo Sobhie. |
| Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD4and one of the chemokine receptors. Viruses predominantly use one, or occasionally both, of the major co-receptors CCR5 and CXCR4, although other receptors, including CCR2B and CCR3, function as minor co-receptors. A 32-nucleotide deletion (delta32) within the beta-chemokine receptor 5 gene (CCR5) has been described in subjects who remain uninfected despite extensive exposition to HIV-1. The heterozygous genotype delays disease progression. This allele is common among Caucasians, but has not been found in people of African or Asian ancestry. A more common transition involving a valine to isoleucine switch in transmembrane domain I of CCR2B (64I), with unknown functional... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: CCR5; CCR2B; HIV-1 infection; Polymorphisms. |
| Ano: 2003 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400002 |
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