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| Registros recuperados: 2.719 | |
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| RICHARD,SANDRINE; SELLE,FRÉDÉRIC; LOTZ,JEAN-PIERRE; KHALIL,AHMED; GLIGOROV,JOSEPH; SOARES,DANIELE G.. |
| ABSTRACT It has now been 15 years since the HER2-targeted monoclonal antibody trastuzumab was introduced in clinical and revolutionized the treatment of HER2-positive breast cancer patients. Despite this achievement, most patients with HER2-positive metastatic breast cancer still show progression of their disease, highlighting the need for new therapies. The continuous interest in novel targeted agents led to the development of pertuzumab, the first in a new class of agents, the HER dimerization inhibitors. Pertuzumab is a novel recombinant humanized antibody directed against extracellular domain II of HER2 protein that is required for the heterodimerization of HER2 with other HER receptors, leading to the activation of downstream signalling pathways.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Breast cancer; Dimerization; HER2/3; Monoclonal antibody; Pertuzumab; Trastuzumab. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000200565 |
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| Tudela,Diego R.G.; Tatumi,Sonia H.; Yee,Márcio; Brito,Silvio L.M.; Morais,José L.; Morais,Daisy de; Piedade,Silvia C.; Munita,Casimiro S.P.; Hazenfratz,Roberto. |
| This paper presents the results of TL and OSL dating of soil and fragments of bricks from a grave, which was occupied by two mummified nuns, found at "Luz" Monastery, located in the state of São Paulo, Brazil. The TL and OSL ages were compared to C-14 dating ones obtained from bone collagens of the mummies. The majority of the ages is related to the eighteenth century. The gamma-ray spectroscopy was used to evaluate natural radioisotope concentrations in the samples, and by using these concentrations the annual dose rates, from 3.0 to 5.3 Gy/kyr, were obtained. Neutron activation analysis was performed and the radioisotope contents results are in agreement with those obtained by gamma-ray spectroscopy. The contents of U, Th and Ce elements were higher than... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dating; Thermoluminescence (TL); Optical stimulated Luminescence (OSL); Mummified Nuns; Mosteiro da "Luz". |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000200002 |
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| SOARES,MILENA B. P.; PONTES-DE-CARVALHO,LAIN; RIBEIRO-DOS-SANTOS,RICARDO. |
| Chagas' disease is a major health problem in Latin America, where it constitutes one of the leading causes of heart failure. About one fourth of Trypanosoma cruzi-infected individuals develop chronic chagasic cardiomyopathy (CChC), the most severe form of the disease. CChC is histologically characterized by the presence of multifocal inflammatory infiltrates in the heart, composed mainly by mononuclear cells, usually adhered to myocytes and leading to myocytolysis, and frequently by interstitial fibrosis. The pathogenesis of CChC is still unclear, despite intense investigations both in human beings and in animal models of the disease. Although tissue parasitism is rare in the chronic phase of infection, an immune response targeted to persistent parasites... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chagas' disease; Myocarditis; Autoimmunity; Trypanosoma cruzi; Delayed-type hypersensitivity. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000400008 |
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| SOUZA,GENAINA A. DE; DIAS,DENISE C.F.S.; PIMENTA,THALINE M.; CARDOSO,AMANDA Á.; PIRES,RAQUEL M.O.; ALVARENGA,ANTÔNIO P.; PÍCOLI,EDGARD A.T.. |
| ABSTRACT The physical, physiological and biochemical changes during the development until the dispersal of rubber tree seeds were evaluated with the purpose of estimating the point at physiological maturity. A total of 30 plants were selected at different points in a commercial planting area and had their flowers marked during the anthesis and every 15 days after marking. Fruits and seeds were collected for analysis of moisture content, dry matter, diameter and length. Details of the anatomy ultra-structure of the seeds were evaluated. The seed emergence, emergency speed index, heat resistant proteins and oxidative stress enzymes were examined. It was observed that fruits reached maximum size at 120 days after anthesis and seeds at 150 days. The seeds... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Germination; Oxidative stress enzymes; Physiological maturity; Seeds development. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000401625 |
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| MARINHO,PEDRO R.D.; BOURGUIGNON,MARCELO; SILVA,RODRIGO B.; CORDEIRO,GAUSS M.. |
| Abstract: In this paper, we introduce a new three-parameter distribution by compounding the Nadarajah-Haghighi and geometric distributions, which can be interpreted as a truncated Marshall-Olkin extended Weibull. The compounding procedure is based on the work by Marshall and Olkin 1997. We prove that the new distribution can be obtained as a compound model with mixing exponential distribution. It can have decreasing, increasing, upside-down bathtub, bathtub-shaped, constant and decreasing-increasing-decreasing failure rate functions depending on the values of the parameters. Some mathematical properties of the new distribution are studied including moments and quantile function. The maximum likelihood estimation procedure is discussed and a particle swarm... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exponential distribution; Failure rate function; Geometric distribution; Maximum likelihood estimation; Nadarajah-Haghighi distribution.. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100202 |
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| Rennó,Magdalena N.; Barbosa,Gleyce M.; Zancan,Patricia; Veiga,Venicio F.; Alviano,Celuta S.; Sola-Penna,Mauro; Menezes,Fábio S.; Holandino,Carla. |
| Plant-derived substances have been considered as important sources of drugs, including antineoplasic agents. Babassu mesocarp is popularly used in Brazil as a food additive, and in popular medicine against several conditions, such as inflammations, menstrual pains and leukaemia. From babassu Orbignya speciosa (Mart.) Barb. Rodr. [Arecaceae (Palmae)] epicarp/mesocarp, an ethanol extract was prepared and named OSEME, which was tested on the viability,morphology and metabolism of several cell lines, such as the leukaemic cell lines, HL-60, K562 and the latter multidrug resistant counterpart K562-Lucena 1, the human breast cancer cell line MCF-7, the mouse fibroblast cell line 3T3-L1 and fresh human lymphocytes. OSEME promoted a dose-dependent decrease on the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antitumoral agents; Ethanol extract; Orbignya speciosa. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000300008 |
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| TRAEBERT,JEFFERSON; LUNARDELLI,SANDRA E.; MARTINS,LUIZ G.T.; SANTOS,KAROLINY DOS; NUNES,RODRIGO D.; LUNARDELLI,ABELARDO N.; TRAEBERT,ELIANE. |
| Abstract The aim of this report is to describe general and methodological characteristics of a cohort study in southern Brazil (Coorte Brasil Sul), aimed at understanding the impact of the first 1,000 days of life on children’s health. It is a cohort study involving all children born in 2009 and their families living in the municipality of Palhoça, State of Santa Catarina, Brazil. Face-to-face interviews with parents at home using a structured questionnaire and children’s physical and clinical examinations at schools have been carried out. Cross-sectional analyzes, longitudinal comparisons and hierarquical regression analysis will allow understanding if the first 1,000 days of life can influence on 6-year-old children’s health. The Coorte Brasil Sul is in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Health surveys; Cohort studies; Social determinants of health; Child health. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000603105 |
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| LIMA,JOSÉLIA A.; COSTA,THIAGO W.R.; SILVA,LEANDRO L.; MIRANDA,ANA LUÍSA P.; PINTO,ANGELO C.. |
| ABSTRACT Geissospermum vellosii (Pao pereira) is a Brazilian tree whose stem barks are rich in indole alkaloids that present intense anticholinesterase activity. The present study evaluated the effects of a stem bark fraction (PPAC fraction) and ethanolic extract (EE) of Pao pereira in classic murine models of inflammation and pain. The EE and PPAC fraction, both at a dose of 30 mg/kg, significantly reduced mice abdominal constriction induced by acetic acid by 34.8% and 47.5%, respectively. In the formalin test, EE (30 mg/kg) and PPAC fraction (30 and 60 mg/kg) inhibited only the second phase, by 82.8%, 84.9% and 100%, respectively. Compared with indomethacin, similar doses of EE or PPAC fraction were approximately twice as effective in causing... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Geissospermum vellosii; Pao pereira; Antinociception; Inflammation; Cholinergic anti-inflammatory pathway. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100237 |
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| Sousa,Saulo M.; Torres,Giovana A.; Viccini,Lyderson F.. |
| The genus Lippia (Verbenaceae) comprise around 160 species spread out mainly in South and Central Americas with few African species, some of them with potential medicinal use. Brazil is one the most important centers of diversity with approximately 75% of the species described so far. Innumerous species are endemic and poorly studied especially at a cytological level. Here, chromosomal length, karyomorphology and chromosome asymmetry of twelve Brazilian species of Lippia were evaluated [L. alba (Miller) N.E.Brown, L. diamantinensis Glaz., L. florida Cham., L. hermanioides Cham., L. lacunosa Mart. & Schauer, L. lupulina Cham., L. pohliana Schauer, L. pseudothea (St. Hil) Schauer, L. rosella Moldenke, L. rotundifolia Cham., L. rubella Moldenke and L.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chromosomes; Cytology; Dysploidy; Karyology; Lippia; Polyploidy. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000400017 |
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| Registros recuperados: 2.719 | |
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