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Antioxidant flavonols from fruits, vegetables and beverages: measurements and bioavailability Biol. Res.
CROZIER,ALAN; BURNS,JENNIFER; AZIZ,AZLINA A; STEWART,AMANDA J; RABIASZ,HELENA S; JENKINS,GARETH I; EDWARDS,CHRISTINE A; LEAN,MICHAEL EJ.
Flavonols are polyphenolic secondary plant metabolites that are present in varying levels in commonly consumed fruits, vegetables and beverages. Flavonols have long held an interest for nutritionists, which has increased following a Dutch study in the early 1990’s showing that dietary intake of flavonols was inversely correlated with the incidence of coronary heart disease. The main factors that have hindered workers in the field of flavonol research are (i) the accurate measurement of these compounds in foods and biological samples, and (ii) a dearth of information on their absorption and metabolism. This review aims to highlight the work of the authors in attempting to clarify the situation. The sensitive and selective HPLC procedure to identify and...
Tipo: Journal article Palavras-chave: Bioavailability; Dietary antioxidants; Flavones; Flavonols; HPLC analysis.
Ano: 2000 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200007
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The ingestión of a Nectandra membranácea extract changes the bioavailability of technetium-99m radiobiocomplex in rat organs Biol. Res.
RAMOS FARÍAS MORENO,SILVANA; ARNOBIO,ADRIANO; CARVALH0,JORGE JOSÉ DE; NASCIMENT0,LUCIA; OLIVEIRA TIMOTEO,MARGARETH; OLEJ,BENI; KAZAN ROCHA,EMELY; PEREIRA,MARIO; BERNARDO-FILH0,MARIO; QUERINO DE ARAÚJO CALDAS,LUIZ.
The radiobiocomplexes labeled with technetium-99m (Tc-99m) have been widely used in nuclear medicine in single photon emission computed tomography and in basic research. The aim of this study was to assess the influence of a Nectandra membranácea extract on the bioavailability of the sodium pertechnetate (Na99mTc0(4)) radiobiocomplex in rat organs. The animals were treated with a N. membranácea extract (30 mg/ ml), for 6 days. Na99mTc0(4) was injected, the organs were isolated and weighed, and the radioactivity was determined in each organ (%ATI/organ). The %ATI/organ was divided by the mass of each organ to calculate the %ATI/g. A significant increase of the %ATI/organ of Na99mTc0(4) was observed in muscle and thyroid as well as in the %ATI/g in the...
Tipo: Journal article Palavras-chave: Nectandra membranácea; Bioavailability; Sodium pertechnetate; Radiobiocomplex.
Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200004
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Drug interaction with radiopharmaceuticals: effect on the labeling of red blood cells with technetium-99m and on the bioavailability of radiopharmaceuticals BABT
Gomes,Maria Luisa; Oliveira,Marcia B. Nunes de; Bernardo-Filho,Mario.
The evidence that natural and synthetic drugs can affect radiolabeling or bioavailability of radiopharmaceuticals in setting of nuclear medicine clinic is already known. However, this drug interaction with radiopharmaceuticals (DIR) is not completely understood. Several authors have described the effect of drugs on the labeling of blood elements with technetium-99m (99mTc) and on the biodistribution of radiopharmaceuticals. When the DIR is known, if desirable or undesirable, the natural consequence is a correct diagnosis. However, when it is unknown, it is undesirable and the consequences are the possibility of misdiagnosis and/or the repetition of the examination with an increase of radiation dose to the patient. The possible explanation to the appearance...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug interaction; Blood elements; Radiopharmaceuticals; Bioavailability.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000500020
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Bioavailability of the sodium pertechnetate and morphometry of organs isolated from rats: study of possible pharmacokinetic interactions of a ginkgo biloba extract BABT
Moreno,Silvana Ramos Farias; Carvalho,Jorge José; Nascimento,Ana Lúcia; Pereira,Mário; Rocha,Emely Kazan; Diré,Gláucio; Arnobio,Adriano; Caldas,Luiz Querino de Araújo; Bernardo-Filho,Mario.
Many compounds affect the bioavailability of radiobiocomplexes as radiopharmaceuticals. Ginkgo Biloba extract (EGb) has several effects. The influence of an EGb on the bioavailability of the radiobiocomplex sodium pertechnetate (Na99mTcO4) and on the morphometry of the organs was evaluated. Rats were treated with EGb and Na99mTcO4 was injected. The animals were sacrificed; the radioactivity in the organs was counted. The results showed that EGb altered the Na99mTcO4 bioavailability in the kidneys, liver and duodenum. Morphometric analysis of the organs showed significant alterations (P<0.05), probably caused by metabolites generated by EGb and capable of altering the bioavailability of the Na99mTcO4.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ginkgo biloba extract; Bioavailability; Radiobiocomplex; Sodium pertechnetate; Morphometry.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700011
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Pharmacodynamic and Pharmacokinetic Studies of β-Cyclodextrin:Dexamethasone Acetate Complexes in Mice BABT
Rodrigues,Patrik Oening; Becker,Ana Cláudia; Dellagnelo,Viviane Aparecida; Benetti,Cibele Nabhan; Pereira,Eduardo Manoel; Wagner,Theodoro Marcel; Silva,Marcos Antonio Segatto.
The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β-cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evaluated in pharmacodynamics and pharmacokinetics studies. The pharmacodynamic effect was investigated although the capacity of the inhibited the inflammation. Models of abdominal constriction, carrageenan-induced paw oedema and formalin induced licking were used. The study of the pharmacodynamic comparison of free DMA and products of β-CD:DMA demonstrated no significant difference in the majority of the tests performed. Plasma concentrations of DMA and DMA:β-CD...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Solubility; Dexamethasone acetate; Β-cyclodextrin; Bioavailability; Anti-inflammatory activity.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000600887
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Drug interaction with radiopharmaceuticals: a review BABT
Bernardo-Filho,Mario; Santos-Filho,Sebastião David; Moura,Egberto Gaspar de; Maiworm,Adalgisa Ieda; Orlando,Margarida Maria de Camões; Penas,Maria Expósito; Cardoso,Valbert Nascimento; Bernardo,Luciana Camargo; Brito,Lavínia de Carvalho.
Clinical images are worthwhile in Health Sciences and their analysis and correct interpretation aid the professionals,such as physicians, physiotherapists and occupational therapists, to make decisions and take subsequent therapeutic and/or rehabilitation measures. Other factors, besides the state of the disease, may interfere and affect the bioavailability of the radiopharmaceuticals (radiobiocomplexes) and the quality of the SPECT and PET images. Furthermore, the labeling of some of these radiobiocomplexes, such as plasma proteins, white blood cells and red blood cells, with 99mT, can also be modified. These factors include drugs (synthetic and natural) and dietary conditions, as well as some medical procedures (invasive or non-invasive), such as...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Drug interaction; Blood constituents; Radiobiocomplexes; Bioavailability.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700003
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Combined application of bio-organic phosphate and phosphorus solubilizing bacteria (Bacillus strain MWT 14) improve the performance of bread wheat with low fertilizer input under an arid climate BJM
Tahir,Muhammad; Khalid,Umaira; Ijaz,Muhammad; Shah,Ghulam Mustafa; Naeem,Muhammad Asif; Shahid,Muhammad; Mahmood,Khalid; Ahmad,Naveed; Kareem,Fazal.
Abstract This study was aimed to investigate the effect of bio-organic phosphate either alone or in combination with phosphorus solubilizing bacteria strain (Bacillus MWT-14) on the growth and productivity of two wheat cultivars (Galaxy-2013 and Punjab-2011) along with recommended (150–100 NP kg ha−1) and half dose (75–50 NP kg ha−1) of fertilizers. The combined application of bio-organic phosphate and the phosphorous solubilizing bacteria strain at either fertilizer level significantly improved the growth, yield parameters and productivity of both wheat cultivars compared to non-inoculated control treatments. The cultivar Punjab-2011 produced the higher chlorophyll contents, crop growth rate, and the straw yield at half dose of NP fertilizer; while...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phosphorous; Phosphorous solubilizing bacteria; Bioavailability; Rhizosphere; Low fertilizer input.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000500015
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Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline BJPS
Rahman,Mohammad Akhlaquer; Mujahid,Mohammad.
Abstract The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral bioavailability of sertraline. Aqueous titration method was used to prepare the liquid SNEDDS; ternary phase diagrams were constructed and based on smaller droplet size (24.8 nm), minimum viscosity (153.63 cP) and polydispersity index (0.182), higher percentage transmittance (95%) and in vitro drug release (97%), an optimum system was designated. Liquid SNEDDS was transformed into free-flowing powder by solid adsorption technique followed by compression into tablets. In vitro release of sertraline from...
Tipo: Info:eu-repo/semantics/article Palavras-chave: SNEDDS; Phase diagrams; Solubility; Thermodynamic stability; Oral delivery; Bioavailability.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100620
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A nanoemulsion-based delivery system for imatinib and in vitro anticancer efficacy BJPS
Karimi,Maryam; Karimian,Khashayar; Heli,Hossein.
A self-nanoemulsifying drug delivery system (SNEDDS) composed of ethyl oleate, Tween 80 and polyethylene glycol 600 was prepared as a new route to improve the efficacy of imatinib. The drug-loaded SNEDDS formed nanodroplets of ethyl oleate stabilized by Tween 80 and polyethylene glycol 600 with a diameter of 81.0±9.5 nm. The nanoemulsion-based delivery system was stable for at least two months, with entrapment efficiency and loading capacity of 16.4±0.1 and 48.3±0.2%, respectively. Imatinib-loaded SNEDDS was evaluated for the drug release profiles, and its effectiveness against MCF-7 cell line was investigated. IC50 values for the imatinib-loaded SNEDDS and an imatinib aqueous solution were 3.1 and 6.5 µg mL-1, respectively.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Glivec; Nanoemulsion; Anticancer drug; Bioavailability; Breast cancer cell.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100640
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The Liquisolid technique: an overview BJPS
Burra,Shashidher; Yamsani,Madhusudhanrao; Vobalaboina,Venkateswarlu.
A novel "Powder Solution Technology" involves absorption and adsorption efficiency which makes use of liquid medications, drug suspensions admixed with suitable carriers, coating materials and formulated into free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of Avicel ® PH 200 and Aerosil ® PH 200 from 50:1 ratio to 5:1 and in which the drug is dispersed in an almost molecularly state. Due to their significantly improved wetting properties a greater drug surface area is exposed to the dissolution media, resulting in an increased dissolution rate and bio availability. By using the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Liquisolid; Solubility; Bioavailability; Flow properties; Load factor; Powder solution technology.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300005
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Dietary intake and health effects of selected toxic elements Braz. J. Plant Physiol.
Silva,André Luiz Oliveira da; Barrocas,Paulo R.G.; Jacob,Silvana do Couto; Moreira,Josino Costa.
Anthropogenic activities have being contributing to the spread of toxic chemicals into the environment, including several toxic metals and metalloids, increasing the levels of human exposure to many of them. Contaminated food is an important route of human exposure and may represent a serious threat to human health. This mini review covers the health effects caused by toxic metals, especially Cd, Hg, Pb and As, the most relevant toxic elements from a human health point of view.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bioavailability; Contamination; Heavy metals; Metal toxicity.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-04202005000100007
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Nickel adsorption and desorption in an acric oxisol as a function of pH, ionic strength and incubation time Ciência e Agrotecnologia
Mellis,Estêvão Vicari; Casagrande,José Carlos; Soares,Marcio Roberto.
ABSTRACT Although nickel (Ni) has both important potential benefits and toxic effects in the environment, its behavior in tropical soils has not been well studied. Nickel adsorption-desorption in topsoil and subsoil samples of an acric Oxisol was studied at three pH values (from 3.0 to 8.0). Adsorption-desorption isotherms were elaborated from experiments with increasing Ni concentration (5 to 100 mg L-1), during 0, 4, and 12 weeks, using CaCl2 0.01 and 0.1 M as electrolytic support in order to also verify the effect of Ni-soil time contact and of ionic strength on the reaction. Experimental results of Ni adsorption fitted Langmuir model, which indicated that maximum Ni adsorption (71,440 mg kg-1) occurred at subsoil, after 12 weeks. Nickel affinity (KL)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sorption; Bioavailability; Soil pollution; Heavy metal..
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-70542017000100032
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Evaluation of iron bioavailability in a mixture of cereals, seeds, and grains ("Human Ration") Ciênc. Tecnol. Aliment.
Enes,Bárbara Nery; Alves,Natália Elizabeth Galdino; Valdés,Samanta Thomas; Silveira,Carlos Mário Martins; Costa,Neuza Maria Brunoro; Ribeiro,Sônia Machado Rocha; Pires,Shaila Turbay; Martino,Hércia Stampini Duarte.
Iron bioavailability was evaluated in three mixtures of cereals, seeds, and grains ("Human Ration"): light, regular, and homemade provided to rats. The animals received an iron depletion diet for 21 days, followed by a repletion diet containing 12 mg·kg-1 of iron for 14 days. The hemoglobin regeneration efficiency and the relative biological value did not differ between the light mixture and control group. The iron bioavailability of the light mixture of cereals, seeds, and grains and the control group were 99.99±27.62 and 80.02±36.63, respectively, while the regular and homemade mixtures of cereals, seeds, and grains showed lower iron bioavailability, 50.12±35.53 and 66.66±15.44, respectively; the iron content of the diet with light cereal mixture light...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dietary fiber; Minerals; Bioavailability; Short chain fatty acids; Condensed tannin.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612014000100003
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Screening of iron-enriched fungus from natural environment and evaluation of organically bound iron bioavailability in rats Ciênc. Tecnol. Aliment.
Zhang,Xin-guo; Peng,Yi-nan; Li,Xiao-ru; Ma,Guo-di; Chen,Xiao-qian.
Iron is an essential element for nearly all living organisms, and its deficiency is the most common form of malnutrition in the world. The organic forms of trace elements are considered more bioavailable than the inorganic forms. Although Saccharomyces cerevisiae can enrich metal elements and convert inorganic iron to organic species, its tolerability and transforming capacity are limited. The aim of this study was to screen higher biomass and other iron-enriched fungi strains besides Saccharomyces cerevisiae from the natural environment. A PDA medium containing 800 μg/mL iron was used for initial screening. Fifty strains that tolerated high iron concentration were isolated from the natural environment, and only one strain, No.BY1109, grew well at Fe (II)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Iron-rich fungus; Screening and isolation; Identification; Cell-iron distribution; Bioavailability.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612015000100058
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Efecto ambiental y económico-social por la aplicación de biosólidos de origen urbano como mejoradores de suelos agrícolas. Colegio de Postgraduados
González Flores, Eduardo.
La generación y disposición final de los biosólidos producidos en las plantas de tratamiento de aguas residuales, es un grave problema ambiental. La aplicación en suelos agrícolas es una opción viable por su contenido de materia orgánica, N, P y micronutrimentos. La principal restricción es su contenido de metales pesados. En la ciudad de Puebla de Zaragoza, México, los biosólidos generados se aplican en suelos agrícolas de comunidades rurales cercanas. Los suelos son delgados y de baja productividad y se cultiva principalmente maíz. El objetivo del presente trabajo fue evaluar los efectos ambientales, económicos y sociales producidos por la aplicación de biosólidos en los agroecosistemas de la comunidad La Paz Tlaxcolpan, Puebla. Se tomaron muestras de...
Palavras-chave: Metabolismo social; Biodisponibilidad; Biosólidos; Metales pesados; Agroecosistema; Social metabolism; Bioavailability; Biosolids; Heavy metals; Agroecosystem; Doctorado; EDAR; Estrategias para el Desarrollo Agrícola Regional.
Ano: 2011 URL: http://hdl.handle.net/10521/531
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Efecto ambiental y económico-social por la aplicación de biosólidos de origen urbano como mejoradores de suelos agrícolas. Colegio de Postgraduados
González Flores, Eduardo.
La generación y disposición final de los biosólidos producidos en las plantas de tratamiento de aguas residuales, es un grave problema ambiental. La aplicación en suelos agrícolas es una opción viable por su contenido de materia orgánica, N, P y micronutrimentos. La principal restricción es su contenido de metales pesados. En la ciudad de Puebla de Zaragoza, México, los biosólidos generados se aplican en suelos agrícolas de comunidades rurales cercanas. Los suelos son delgados y de baja productividad y se cultiva principalmente maíz. El objetivo del presente trabajo fue evaluar los efectos ambientales, económicos y sociales producidos por la aplicación de biosólidos en los agroecosistemas de la comunidad La Paz Tlaxcolpan, Puebla. Se tomaron muestras de...
Palavras-chave: Metabolismo social; Biodisponibilidad; Biosólidos; Metales pesados; Agroecosistema; Social metabolism; Bioavailability; Biosolids; Heavy metals; Agroecosystem; Doctorado; EDAR; Estrategias para el Desarrollo Agrícola Regional.
Ano: 2011 URL: http://hdl.handle.net/10521/531
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The effects of ethylene on the HCl-extractability of trace elements during soybean seed germination Electron. J. Biotechnol.
Liu,Chunming; Zhao,Yixin; Liu,Jianfeng; Gen,Wanting; Cheng,Yunqing.
Background Ethylene is capable of promoting seed germination in some plant species. Mobilization of metals such as Fe, Cu, Mn, and Zn in mature seeds takes place when seeds are germinating. However, whether ethylene is involved in the regulation of soybean seed germination and metal element mobilization during early seed germination stage remains unknown. In the present study, seeds were treated with ethylene synthesis inhibitor aminoethoxyvinylglycine (AVG) and ethylene precursor 1-aminocyclopropane-1-carboxylic acid (ACC), and double distilled H2O (ddH(2)0) treatment was used as control. Ethylene emission, ACC synthase (ACS) expression, ACS enzyme activity and Ca, Zn, Mn, Cu and Fe content in hypocotyls were qualified to analyze the relationship between...
Tipo: Journal article Palavras-chave: ACC synthase; Bioavailability; Ethylene; Metallic elements; Seed germination; Soybean.
Ano: 2015 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000500001
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Cycle du mercure en estuaire, baie de Seine et pays de Caux ArchiMer
Laurier, Fabien.
The Seine estuary and its adjacent region Pays de Caux are two significant sources of mercury for coastal marine environments. It is carried through fluvial means for the Seine bay and through karstic fresh water emergences for Pays de Caux's coastal area. Mercury cycle in the Seine estuary and bay is affected by additional anthropical activities. The estuary's maximal turbidity area acts like a trap and a chemical reactor for fluvial mercury. Within this area, we can confirm: (i) the non conservative behaviour of dissolved mercury; (ii) mercury enrichment of particles when comparing the Seine's and marine environment and we suggest mercury particle redistribution from the organic fraction to the oxyhydroxydes fraction. A large fraction of mercury is...
Tipo: Text Palavras-chave: Bay of Seine; Pays de Caux; Estuary; Coastal zone; Speciation; Bioavailability; Mercury; Pays de Caux; Seine; Estuaire; Emergence; Zone côtière; Spéciation; Biodisponibilité; Mercure.
Ano: 2001 URL: http://archimer.ifremer.fr/doc/2001/these-1842.pdf
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Relationship between sedimentary organic matter and benthic fauna within the Gulf of Lion: synthesis on the identification of new biochemical descriptors of sedimentary organic nutritional value ArchiMer
Gremare, A; Medernach, L; Debovee, F; Amouroux, Jm; Charles, F; Dinet, A; Vetion, G; Albert, P; Colomines, Jc.
The abilities of several biochemical characteristics of sedimentary organic matter to describe quantitative changes in benthic fauna were assessed based on several surveys carried out within the Gulf of Lion during the last decade. Two sets of high frequency samplings were carried out both inshore and offshore, together with an assessment of seasonal variability along a depth gradient, and a synoptic assessment of mesoscale spatial variability. The considered biochemical parameters were: total organic matter, organic carbon, nitrogen, total proteins, available proteins, carbohydrates, lipids, total and available amino acids. The considered faunal parameters were the abundance and the biomass of both meio- and macrofauna. Our results contribute to unravel...
Tipo: Text Palavras-chave: Matière organique sédimentée; Benthos; Golfe du Lion; Acides aminés; Biodisponibilité; Sedimentary organics; Benthos; Gulf of Lion; Amino acids; Bioavailability.
Ano: 2003 URL: http://archimer.ifremer.fr/doc/00321/43264/42995.pdf
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The impact of groundwater discharges on mercury partitioning, speciation and bioavailability to mussels in a coastal zone ArchiMer
Laurier, Fabien; Cossa, Daniel; Beucher, Charlotte; Breviere, Emily.
The Mussel Watch program conducted along the French coasts for the last 20 years indicates that the highest mercury concentrations in the soft tissue of the blue mussel (Mytilus edulis) occur in animals from the eastern part of Seine Bay on the south coast of the English Channel, the "Pays de Caux". This region is characterized by the presence of intertidal and submarine groundwater discharges, and no particular mercury effluent has been reported in its vicinity. Two groundwater emergence systems in the karstic coastal zone of the Pays de Caux (Etretat and Yport with slow and fast water percolation pathways respectively) were seasonally sampled to study mercury distribution, partitioning and speciation in water. Samples were also collected in the...
Tipo: Text Palavras-chave: Mussel; Estuaries; Groundwater seepage; Bioavailability; Speciation; Mercury.
Ano: 2007 URL: https://archimer.ifremer.fr/doc/2007/publication-3113.pdf
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