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Biological taxonomy and ontology development: scope and limitations Nature Precedings
Nico M. Franz; David M. Thau.
The prospects of integrating full-blown biological taxonomies into an ontological reasoning framework are reviewed. We contrast the common usage of a static 'snapshot' hierarchy in ontological representations of taxonomy with a more realistic situation that involves dynamic, piece-meal revisions of particular taxonomic groups and requires alignment with relevant preceding perspectives. Taxonomic practice is characterized by a range of phenomena that are orthogonal to the logical semantic background from which ontological entities and relationships originate, and therefore pose special challenges to ontological representation and reasoning. Among these phenomena are: (1) the notion that there is a single phylogenetic hierarchy in nature...
Tipo: Manuscript Palavras-chave: Bioinformatics; Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4593/version/1
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GMOD for Evolutionary Biology Nature Precedings
Robert Buels; Dave Clements.
The Generic Model Organism Database (GMOD, "http://gmod.org":http://gmod.org) project provides interoperable, open source software tools for managing, visualizing and annotating biological data. GMOD is also a community of people addressing common challenges with biological data. Some well known software in GMOD includes GBrowse and JBrowse for genome browsing, Apollo for genome annotation, Chado for managing data, CMap for comparative map viewing, Galaxy for workflow creation and persistence, and BioMart for warehousing biological data.

This talk will focus on three areas of particular interest to iEvoBio participants. 
1) GBrowse_syn comparative genomics viewer
2)...
Tipo: Manuscript Palavras-chave: Bioinformatics; Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4611/version/1
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Human metabolic adaptations and prolonged expensive neurodevelopment: A review Nature Precedings
John R. Skoyles.
1.	After weaning, human hunter-gatherer juveniles receive substantial (≈3.5-7 MJ day^-1^), extended (≈15 years) and reliable (kin and nonkin food pooling) energy provision.
2.	The childhood (pediatric) and the adult human brain takes a very high share of both basal metabolic rate (BMR) (child: 50-70%; adult: ≈20%) and total energy expenditure (TEE) (child: 30-50%; adult: ≈10%).
3.	The pediatric brain for an extended period (≈4-9 years-of-age) consumes roughly 50% more energy than the adult one, and after this, continues during adolescence, at a high but declining rate. Within the brain, childhood cerebral gray matter has an even higher 1.9 to...
Tipo: Manuscript Palavras-chave: Developmental Biology; Neuroscience; Evolutionary Biology.
Ano: 2008 URL: http://precedings.nature.com/documents/1856/version/2
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The Teleost Taxonomy Ontology Nature Precedings
Peter E. Midford; James P. Balhoff; Wasila Dahdul; Cartik R. Kothari; Hilmar Lapp; John Lundberg; Paula Mabee; Todd J. Vision; Monte Westerfield.
The Teleost Taxonomy Ontology (TTO) is an ontology of taxonomic groups and associated names for fish (not just teleosts). This ontology has served as a source of names and taxonomic structure within the Phenoscape project since early 2008. Although the TTO is based on Eschmeyer's Catalog of Fishes (CoF) and incorporates all valid species and genus names, it is also extended by the curation needs of the Phenoscape project. Names of fossil taxa not included in the CoF as well as references to specimens identied only to genus (e.g., _Eigenmannia sp._ (Fink and Fink 1981)) are incorporated into the TTO as required by the curation needs of the Phenoscape project. As Phenoscape receives updates to the CoF, a tool called TTOUpdate merges the...
Tipo: Manuscript Palavras-chave: Bioinformatics; Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4629/version/1
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Reply to “Limusaurus and bird digit identity” Nature Precedings
Xing Xu; James Clark; Jonah Choiniere; David Hone; Corwin Sullivan.
Vargas et al. agree with us that a lateral shift in theropod dinosaur digits occurred prior to the origin of birds, but contend that it occurred as a single “frameshift” with little outward change to the three main digits involved^1^. We consider the digital morphology of Limusaurus, other ceratosaurs, and non-avian tetanurans to provide evidence that the shift was stepwise, and that a stepwise shift better explains theropod manual morphology than a hidden frameshift.
Tipo: Manuscript Palavras-chave: Evolutionary Biology.
Ano: 2011 URL: http://precedings.nature.com/documents/6375/version/1
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The Earliest Perfect Flower Nature Precedings
Xin Wang; Shaolin Zheng.
Despite of angiosperms in the Yixian Formation (>125 Ma, early Cretaceous), there is no perfect flower typical of angiosperms to date. Here we report _Euanthus dilaensis_ gen. et sp. nov as the earliest perfect flower known to date. The flower includes tepals, androecium and gynoecium. The anthers are globose in form, with bristles atop and in situ round-triangular pollen grains. The gynoecium is composed of probably two carpels with plumose stigmas and a carpel-enclosing receptacle. The discovery of _Euanthus_ increases the diversity of early angiosperms, and indicates that perfect flowers occurred as early as 125 Ma ago.

Tipo: Manuscript Palavras-chave: Ecology; Evolutionary Biology.
Ano: 2007 URL: http://precedings.nature.com/documents/1320/version/1
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Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors and amphioxus and human estrogen-related receptors: Towards a better understanding of estrogen receptor evolution Nature Precedings
Michael E. Baker; Charlie Chandsawangbhuwana.
*Background.* The origins of steroid-dependent regulation of the vertebrate estrogen receptor (ER) are poorly understood. Genes with statistically significant sequence similarity to vertebrate ERs have been found in lamprey, a basal vertebrate, and amphioxus, a basal chordate. Motif analysis of these sequences provides an opportunity to investigate early events in the evolution of the ER.
*Results.* We used artificial intelligence-based software to construct twelve motifs specific to the estrogen-binding domain of ER[alpha] and ER[beta] in land vertebrates and teleosts. We mapped these ER-specific motifs onto the sequences of lamprey, amphioxus, invertebrate and selected vertebrate ERs and amphioxus, Ciona and human estrogen-related...
Tipo: Manuscript Palavras-chave: Cancer; Developmental Biology; Ecology; Evolutionary Biology.
Ano: 2008 URL: http://precedings.nature.com/documents/1542/version/2
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Homochirality through Photon-Induced Melting of RNA/DNA: the Thermodynamic Dissipation Theory of the Origin of Life Nature Precedings
Karo Michaelian.
The homochirality of the molecules of life has been a vexing problem with no generally accepted solution to date. Since a racemic mixture of chiral nucleotides frustrates the extension and replication of RNA and DNA, understanding the origin of homochirality has important implications to the investigation of the origin of life. Theories on the origin of life have generally elected to presume an abiotic mechanism giving rise to a large prebiotic enantiomer enrichment. Although a number of such mechanism have been suggested, none has enjoyed sufficient plausibility or relevance to be generally accepted. Here we suggest a novel solution to the homochirality problem based on a recently proposed thermodynamic dissipation theory for the origin of life. The...
Tipo: Manuscript Palavras-chave: Genetics & Genomics; Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/5177/version/1
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Self-organization of intrinsically disordered proteins with folded N-termini Nature Precedings
Philip C. Simister; Fred Schaper; Nicola O'Reilly; Simon McGowan; Stephan M. Feller.
Thousands of human proteins lack recognizable tertiary structure in most of their chains. Here we hypothesize that some use their structured N-terminal domains (SNTDs) to organise the remaining protein chain via intramolecular interactions, generating partially structured proteins. This model has several attractive features: as protein chains emerge, SNTDs form spontaneously and serve as nucleation points, creating more compact shapes. This reduces the risk of protein degradation or aggregation. Moreover, an interspersed pattern of SNTD-docked regions and free loops can coordinate assembly of sub-complexes in defined loop-sections and enables novel regulatory mechanisms, for example through posttranslational modifications of docked regions.
Tipo: Manuscript Palavras-chave: Cancer; Immunology; Molecular Cell Biology; Bioinformatics; Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/5124/version/1
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ABO and Rh Blood Group Distribution Among Kunbis (Maratha) population of Amravati District, Maharashtra Nature Precedings
NANDKISHOR E. WARGHAT; NAVIN R. SHARMA; MUMTAZ M. BAIG; A. R. Yadav; S. H. Sharma; G. S. Pachalore.
The present study reports the distribution of ABO and Rh blood groups among the Kunbis (Maratha) population of Amravati district. The phenotypic frequency of blood group B is observed highest (33.06) percent, O (31.04), A (27.02) and AB is lowest (08.33) percent. The phenotypic frequency of Rh negative is (04.26) percent. TheKunbis (Maratha) population shows close genetic relationship with the Gujratis.
Tipo: Manuscript Palavras-chave: Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4868/version/1
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Words make people think, ... but pictures make people feel: The effect negative vs. positive images on charitable behavior Nature Precedings
Carolina Perez Dueñas; Maria Fernanda Rivas; Olusegun A. Oyediran; Alberto Acosta; Pablo Brañas Garza.
We ran an experiment where the subjects initially played a four-round dictator game, after which each subject was shown either a set of positive images or a set of negative images. Finally the subjects played another four-round dictator game.
The effect of the sign of images shown is clear on the players’ behaviors: positive images have moderate effects on charitable behavior while negative images dramatically increase charity.
We could therefore infer from our experimental results that showing negative images of the Haitian and Chilean catastrophes to the international public would have significant positive impacts on international donations to the victims and the rebuilding programs in both countries.
Tipo: Manuscript Palavras-chave: Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4287/version/1
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Fossil evidence for the origin of spider spinnerets Nature Precedings
Paul A. Selden; William A. Shear.
Silk production from opisthosomal glands is a defining characteristic of spiders (Araneae). Silk emerges from spigots (modified setae) borne on spinnerets (modified appendages). Spigots from _Attercopus fimbriunguis_ (Shear, Selden & Rolfe, 1987^1^), from Middle Devonian (386 Ma) strata of Gilboa, New York were described in 1989^2^ as evidence for the oldest spider and the first use of silk by animals. Slightly younger (374 Ma) material from South Mountain, New York, conspecific with _A. fimbriunguis_, includes spigots and other evidence which elucidate the evolution of early Araneae and the origin of spider silk. No known _Attercopus_ spigots, including the original specimen^2^, occur on true spinnerets but are arranged along the edges of plates....
Tipo: Manuscript Palavras-chave: Genetics & Genomics; Earth & Environment; Evolutionary Biology.
Ano: 2008 URL: http://precedings.nature.com/documents/2088/version/1
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Parameter Estimation for Hidden Markov models with Intractable Likelihoods Nature Precedings
Ajay Jasra; Thomas A. Dean; Sumeetpal S. Simgh; Gareth W. Peters.
In this talk I consider sequential Monte Carlo (SMC) methods for hidden Markov models. In the scenario for which the conditional density of the observations given the latent state is intractable we give a simple ABC approximation of the model along with some basic SMC algorithms for sampling from the associated filtering distribution. Then, we consider the problem of smoothing, given access to a batch data set. We present a simulation technique which combines forward only smoothing (Del Moral et al, 2011) and particle Markov chain Monte Carlo (Andrieu et al 2010), for an algorithm which scales linearly in the number of particles.
Tipo: Presentation Palavras-chave: Evolutionary Biology.
Ano: 2011 URL: http://precedings.nature.com/documents/5957/version/1
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An experimental and modelling exploration of the host-sanction hypothesis in legume-rhizobia mutualism Nature Precedings
Diana Marco; Juan Carbajal; Sergio Cannas; Rebeca Perez-Arnedo; Angeles Hidalgo-Perea; Jose Olivares; Jose Ruiz-Sainz; Juan Sanjuán.
Despite the importance of mutualism as a key ecological process, its persistence in nature is difficult to explain since the existence of exploitative, 'cheating' partners that could erode the interaction is common. By analogy with the proposed policing strategy stabilizing intraspecific cooperation, host sanctions against non N2 fixing, cheating symbionts have been proposed as a force stabilizing mutualism in legume-Rhizobium symbiosis. Following this proposal, penalizations would include decreased nodular rhizobial viability and/or early nodule senescence in nodules occupied by cheating rhizobia. In this work, we analyze the stability of Rhizobium-legume symbiosis when "cheating" strains are present, using an...
Tipo: Manuscript Palavras-chave: Ecology; Microbiology; Evolutionary Biology.
Ano: 2008 URL: http://precedings.nature.com/documents/1964/version/1
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Lengthening of 3'UTR Increases Morphological Complexity in Animal Evolution Nature Precedings
Cho-Yi Chen; Shui-Tein Chen; Hsueh-Fen Juan; Hsuan-Cheng Huang.
By analyzing the structure of mRNA transcripts in multiple metazoan species, we observed a striking exponential correlation between the length of 3' untranslated regions (3'UTR) and morphological complexity as measured by the number of cell types in each organism. Cellular diversity was similarly associated with the accumulation of microRNA genes and their putative targets. We propose that the lengthening of 3'UTRs together with a commensurate expansion in post-transcriptional regulation can contribute to the emergence of new cell types during animal evolution.
Tipo: Manuscript Palavras-chave: Genetics & Genomics; Bioinformatics; Evolutionary Biology.
Ano: 2010 URL: http://precedings.nature.com/documents/4915/version/1
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Third-codon transversion rate-based _Nymphaea_ basal angiosperm phylogeny -- concordance with developmental evidence Nature Precedings
Xiaohan Yang; Gerald A. Tuskan; Timothy J. Tschaplinski; (Max) Zong-Ming Cheng.
Flowering plants (angiosperms) appeared on Earth rather suddenly approximately 130 million years ago and underwent a massive expansion in the subsequent 10-12 million years. Current molecular phylogenies have predominantly identified _Amborella_, followed by _Nymphaea_ (water lilies) or _Amborella_ plus _Nymphaea_, in the ANITA clade (_Amborella_, Nymphaeales, Illiciaceae, Trimeniaceae and Austrobaileyaceae) as the earliest angiosperm. However, developmental studies suggest that the earliest angiosperm had a 4-cell/4-nucleus female gametophyte and a diploid endosperm represented by _Nymphaea_, suggesting that _Amborella_, having an 8-cell/9-nucleus female gametophyte and a triploid endosperm, cannot be representative of the basal angiosperm. This...
Tipo: Manuscript Palavras-chave: Ecology; Plant Biology; Evolutionary Biology.
Ano: 2007 URL: http://precedings.nature.com/documents/320/version/1
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Solubilization of M2 Transmembrane Peptide of Influenza A in Pure Water: Implications for Emergence of Proteins and Protein-embedded Primeval Membranes in Unsalted Oceans Nature Precedings
Jianxing Song; Linlin Miao.
We demonstrated that M2 transmembrane peptide, one of the most hydrophobic sequences in nature, can be solublized to at least ~100 µM in unsalted water without any lipid molecules. Strikingly, the M2 peptide also forms a highly-helical conformation in water which remains almost unchanged even at 95 ºC, as characterized by CD spectroscopy. Our result has critical implications in understanding emergence of proteins and protein-embedded primeval membranes in unsalted oceans.
Tipo: Manuscript Palavras-chave: Chemistry; Molecular Cell Biology; Evolutionary Biology.
Ano: 2012 URL: http://precedings.nature.com/documents/6773/version/1
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A Draft Sequence of the Puerto Rican Parrot Genome (Amazona vittata) – a Genome Project funded by a Local Community Effort Nature Precedings
Taras K. Oleksyk.
The genome of the Puerto Rican parrot (Amazona vittata) has been sequenced and assembled in an international collaboration supported by many individual donations from the people of Puerto Rico. This is a critically endangered endemic bird, the only surviving native parrot species in the territory of the United States, and the first parrot belonging to the large genus Amazona to have its genome sequenced and assembled. A genome of one A. vittata female was sequenced resulting in a total of almost 42.5 billion nucleotide bases equivalent to 26.89X average coverage depth. After filtering out the short fragments (<500bp), the assembly resulted in 259,423 short fragment library contigs, half of them (N50) of at least 6,983 bp in length, with a...
Tipo: Manuscript Palavras-chave: Genetics & Genomics; Bioinformatics; Evolutionary Biology.
Ano: 2011 URL: http://precedings.nature.com/documents/6552/version/1
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Identification of transcription regulation associated proteins in plants and stramenopiles Nature Precedings
Diego Mauricio Riaño Pachón; Silvia Restrepo; Bernd Mueller-Roeber; Francisco Buitrago Florez.
The generation of biodiversity is tied to the evolution and re-wiring of gene regulatory networks (GRNs). One component of these GRN are transcription factors and other transcriptional regulators. We have devised a pipeline for the identification of TFs and TRs, exploiting the domain architecture of these proteins. Currently we have a set of rules, representing 138 proteins families, that we have applied to the identification of ~20 different plant species and several species of Stramenopiles, where important plant pathogens are found. Results for plant species are available at http://plntfdb.uniandes.edu.co/; we are now developing a newer interface for Stramenopiles.
Tipo: Presentation Palavras-chave: Bioinformatics; Evolutionary Biology.
Ano: 2012 URL: http://precedings.nature.com/documents/7000/version/1
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Mega- change gene copies are produced by reverse transcription of precursor RNA with replaced introns. Nature Precedings
Drew Schwartz.
This report describes the presence of copy genes in plants where the sequence similarity to their parental genes is almost completely limited to limited to the exons. Evidence is presented that indicates that they arose via a novel processing of transcribed precursor RNA during which the introns are replaced rather than excised, followed by reverse transcription and incorporation into the chromosomes. Intron replacement may play an important role in evolution as it results in megagene changes.
Tipo: Manuscript Palavras-chave: Genetics & Genomics; Bioinformatics; Plant Biology; Evolutionary Biology.
Ano: 2009 URL: http://precedings.nature.com/documents/3834/version/1
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