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| Registros recuperados: 31 | |
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| Poletto,Edina; Pasqualim,Gabriela; Giugliani,Roberto; Matte,Ursula; Baldo,Guilherme. |
| Abstract Lysosomal storage diseases (LSDs) are inherited conditions caused by impaired lysosomal function and consequent substrate storage, leading to a range of clinical manifestations, including cardiovascular disease. This may lead to significant symptoms and even cardiac failure, which is an important cause of death among patients. Currently available treatments do not completely correct cardiac involvement in the LSDs. Gene therapy has been tested as a therapeutic alternative with promising results for the heart disease. In this review, we present the results of different approaches of gene therapy for LSDs, mainly in animal models, and its effects in the heart, focusing on protocols with cardiac functional analysis. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lysosomal storage disease; Gene therapy; Cardiovascular disease; Animal models; Heart. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200261 |
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| Ozolina, Karlina; Shiels, Holly A.; Ollivier, Helene; Claireaux, Guy. |
| The European sea bass (Dicentrarchus labrax) is an economically important fish native to the Mediterranean and Northern Atlantic. Its complex life cycle involves many migrations through temperature gradients that affect the energetic demands of swimming. Previous studies have shown large intraspecific variation in swimming performance and temperature tolerance, which could include deleterious and advantageous traits under the evolutionary pressure of climate change. However, little is known of the underlying determinants of this individual variation. We investigated individual variation in temperature tolerance in 30 sea bass by exposing them to a warm temperature challenge test. The eight most temperature-tolerant and eight most temperature-sensitive fish... |
| Tipo: Text |
Palavras-chave: Aerobic scope; Climate change; Fish; Heart; Individual variability; Swimming. |
| Ano: 2016 |
URL: https://archimer.ifremer.fr/doc/00337/44827/44369.pdf |
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| Bezerra,Frank Silva; Nagato,Akinori Cardoso; Vieira,Carolina Lourdes Julião; Reis,Liana Antonicci; Novais,Luciene; Valença,Samuel Santos. |
| Thirty hearts from adult individuals, 15 from male individuals and 15 female individuals, from the Anatomy Institute of Severino Sombra University were used. After a paramedian incision in the sternocostal joint, a careful dissection was performed in order to expose and identify the sinoatrial nodal artery (SAN), a right or left coronary artery branch. The domain was registered as right, if the right coronary branch irrigated the SAN. The same was listed for the left coronary artery. In addition, cases were both arteries irrigated SAN also were listed. All data, including hearts mass according to gender definition, were compared with previous reports through the variance analysis test (One-way ANOVA) and the post-hoc test of Newman-Keuls with p 0.05.... |
| Tipo: Journal article |
Palavras-chave: Heart; Sinoatrial nodal artery; Arterial dominance. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100008 |
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| De Carvalho,C. A. M; Thomazini,J. A. |
| The rat is probably the most commonly used animal in scientific research. There are many benefits to its use such as: ability to work a large number of animals allowing greater statistical validity, the relatively short life cycles. However, the scant literature regarding the anatomy and morphology of these animals is also old and not very descriptive. The objective of this research is to study the macroscopic morphometric aspects of several parameters that have not been described yet regarding the heart of Wistar rats in different phases of their lives. Thirty-six adult male and female rats (Rattus norvegicus) weighting 150-770 g were randomly divided into 6 experimental groups. The heart was then carefully dissected and removed from the chest. After this... |
| Tipo: Journal article |
Palavras-chave: Weight; Measures; Heart; Rats. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000200039 |
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| de Carvalho,C. A. M; Thomazini,J. A. |
| The use of animals in scientific research is not recent. The rat has been used in experiments since before Christ and, in the XIX century, with the intensification of the research reports, the use of this species increased considerably. Although this fact happens, the literature regarding the heart of these animals is not very detailed and descriptive. The objective of this research is to study the macroscopic morphometric of several parameters that have not been described yet regarding the hearth of Wistar rats in different phases of their lives. Thirty-six adult male and female rats (Rattus norvegicus) weighing 150-770 g were randomly divided into 6 experimental groups: 6 animals of the group I male-weighting 150-249g (I-M); 6 animals of the group I... |
| Tipo: Journal article |
Palavras-chave: Heart; Ventricle; Atrium; Rats. |
| Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000200061 |
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| Ferreira-Machado,Samara C.; Salata,Camila; Rocha,Nazareth N.; Corrêa,Alexandre F.S.; Côrte-Real,Suzana; Peregrino,Antônio A.F.; Campos,Vera M.A. de; Andrade,Cherley B.V.; Bernardo-Filho,Mario; Cabral-Neto,Januário B.; Dealmeida,Carlos E.. |
| The caspase-3-cleaved presence was evaluated in this study in the heart of irradiated rats, during the decline of ventricular function. Female Wistar rats were irradiated with a single dose of radiation (15 Gy) delivered directly to the heart and the molecular, histological and physiological evaluations were performed at thirteen months post-irradiation. The expressions of procollagen type I, TGF-ß1 and caspase-3-cleaved were analyzed using Western blotting. Cardiac structural and functional alterations were investigated by echocardiography and electron microscopy. In the irradiated group, the levels of procollagen type I, TGF-ß1 and caspase-3-cleaved are increased. Significant histological changes (degeneration of heart tissue and collagen deposition) and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Apoptosis; Caspase-3; Fibrosis; Heart; Ionizing radiation; TGF-β1. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000100215 |
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| Samuels,Richard I.. |
| Destruxin A, a toxic cyclodepsipeptide, was purified from culture filtrates of the entomopathogenic fungus Metarhizium anisopliae (Metsch.) Sorok. by Reverse-Phase HPLC, and assayed for its effects on a larval Manduca sexta (L.) (Lepidoptera: Sphingidae) heart preparation. Destruxin A was found to cause reversible and dose-dependent acceleration of the heart beat. The heart bioassay was highly sensitive to pulse applications of destruxin A at concentrations as low as 35 pmol. Because of its high level of sensitivity, the M. sexta heart bioassay could be used to detect and quantify destruxins in tissue extracts from mycosed insects or to confirm bioactivity of HPLC fractions. The site of action of Destruxin A was not determined. However, this toxin did not... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Insecta; Manduca sexta; Heart; Toxin; Peptide; Destruxin. |
| Ano: 1998 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0301-80591998000200009 |
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| Cruvinel,C.A.T.; Cruvinel,T.M.A.; Aires,L.P.N.; Rodrigues,R.F.; Melo,A.P.F.. |
| ABSTRACT Were used twelve (12) adult anteaters (Myrmecophaga tridactyla), adults, 6 (six) males and 6 (six) females, weighing from 20 to 27.32kg from free life. The thoracic cavity was opened until visualization of the whole heart and lungs and later injection of the coronary vessels. The right coronary artery emerged through a single coronary ostium of the aorta, 50%, emitting the intermediate branch and the subsinuous interventricular branch, had a path directed to the subsurface interventricular groove. In the other 50%, the right coronary artery was not present, showing only its branches, intermediate branch and subsurface interventricular branch with emergence of the aorta. Left coronary artery presented, in 83.33%, origin from the aorta in single... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Heart; Coronary artery; Wild animals; Giant anteaters. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000200545 |
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| Moura,L.S.; Rodrigues,R.P.S.; Silva,A.B.S.; Pessoa,G.T.; Sousa,F.C.A.; Barbosa,M.A.P.S.; Souza,A.B.; Alves,J.J.R.P.; Macedo,K.V.; Diniz,A.N.; Silva,E.G.; Araújo,J.R.; Marques,D.C.; Cavalcante-Filho,M.F.; Alves,F.R.. |
| ABSTRACT Peccaries are wild mammals belonging to the Tayassu genus that are found almost everywhere in the Americas and have demonstrated great potential as an experimental model for scientific investigations. Twelve healthy adult animals were sedated to perform echocardiographic examinations in B, M and Doppler mode. The variables that exhibited statistically significant correlation coefficients with weight were LVFWd, LVIDd, LVIDs, E wave, A’RV, MAM, and TAPSE. The HR exhibited a negative relationship with the IVRT. The LA variable showed a positive correlation with the AO. The MAM exhibited correlations with the LVIDd and LVIDs. The TAPSE showed positive correlations with the E’RV and A’RV. The present study provides the first reference values for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cardiology; Wild animals; Diagnostic imaging; Heart; Hemodynamics. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000100068 |
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| BURNEIKO,REGINA COELI; DINIZ,YEDA SANT'ANA; FAINE,LUCIANE APARECIDA; MACHADO GALHARDI,CRISTIANO; PADOVANI,CARLOS ROBERTO; NOVELLI,ETHEL LOURENZI B.; CICOGNA,ANTONIO CARLOS. |
| The aim of this study was to investigate the effects of training programs on serum lipid profile and myocardial oxidative stress. Male Wistar rats (2 mo-old) were divided into three groups (n=8): sedentary (S), loadless trained (T) and trained-overload 2% body weight (TL). T and TL were trained through swimming for 9 weeks. T and TL rats had increased myocardial lipoperoxide (TBA) and lipid hydroperoxide (HP), whereas HP was higher in TL than in T animals. Superoxide dismutase (SOD) activities were lowest in TL. Myocardial glutathione peroxidase (GSH-Px) was lower in TL than in T and S rats. TL decreased HDL-cholesterol and increased LDL-cholesterol. The serum lactate dehydrogenase and TBA were increased, while SOD and GSH-Px activities were decreased in... |
| Tipo: Journal article |
Palavras-chave: Training; Lipid profile; Oxidative stress; Heart; Serum. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000100006 |
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| Alihemmati,Alireza; Yousefi,Hadi; Ahmadiasl,Naser; Habibi,Parisa. |
| ABSTRACT Ischemia-reperfusion injury was seen in strokes, myocardial infarctions, acute kidney injury, mesenteric ischemia, liver and systemic shock. Renal ischemia-reperfusion is more importance in the setting of kidney transplantation that affects distant organs. In this study forty Male Albino Wistar rats (200-250g) were randomly divided in four group (n=10) including control, sham operation group, nephrectomy and IRI group. All rats anesthetized with intraperitoneal injection of ketamine (50 mg/kg) and xylazine (10 mg/kg) and maintained the core body temperature at approximately 37°C. For inducing IRI group, it was performed right nephrectomy, and in continuing, the left kidney pedicle occluded to 45 min via nontraumatic microvascular clamp for making... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Renal Ischemia-reperfusion injury; Glycogen accumulation; Apoptosis; Heart; Rat. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100443 |
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| Mota,A.; Silva,P.; Neves,D.; Lemos,C.; Calhau,C.; Torres,D.; Martel,F.; Fraga,H.; Ribeiro,L.; Alçada,M.N.M.P.; Pinho,M.J.; Negrão,M.R.; Pedrosa,R.; Guerreiro,S.; Guimarães,J.T.; Azevedo,I.; Martins,M.J.. |
| Alkaline phosphatase (ALP) is important in calcification and its expression seems to be associated with the inflammatory process. We investigated the in vitro acute effects of compounds used for the prevention or treatment of cardiovascular diseases on total ALP activity from male Wistar rat heart homogenate. ALP activity was determined by quantifying, at 410 nm, the p-nitrophenol released from p-nitrophenylphosphate (substrate in Tris buffer, pH 10.4). Using specific inhibitors of ALP activity and the reverse transcription-polymerase chain reaction, we showed that the rat heart had high ALP activity (31.73 ± 3.43 nmol p-nitrophenol·mg protein-1·min-1): mainly tissue-nonspecific ALP but also tissue-specific intestinal ALP type II. Both ALP isoenzymes... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Heart; Alkaline phosphatase; Polyphenol-rich beverages; Steroid hormones; Methylxanthines. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000700009 |
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| Gutkowska,J.; Jankowski,M.; Mukaddam-Daher,S.; McCann,S.M.. |
| Oxytocin (OT), a nonapeptide, was the first hormone to have its biological activities established and chemical structure determined. It was believed that OT is released from hypothalamic nerve terminals of the posterior hypophysis into the circulation where it stimulates uterine contractions during parturition, and milk ejection during lactation. However, equivalent concentrations of OT were found in the male hypophysis, and similar stimuli of OT release were determined for both sexes, suggesting other physiological functions. Indeed, recent studies indicate that OT is involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of cardiovascular functions. It has long been known that OT induces... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oxytocin; Natriuretic peptides; Heart. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600003 |
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| Registros recuperados: 31 | |
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