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| Dotta, Geovana; Laboratório AQUOS-Sanidade de Organismos Aquáticos, Depto. de Aqüicultura, CCA, UFSC - Rod. Admar Gozaga 1346 - 88040-900 - Florianópolis, SC - Brasil; Mouriño, José Luis Pedreira; Laboratório de Camarões Marinhos, Depto. de Aqüicultura, CCA, UFSC, Beco dos Coroas, Barra da Lagoa - Florianópolis, SC - Brasil; Jatobá, Adolfo; Laboratório de Camarões Marinhos, Depto. de Aqüicultura, CCA, UFSC, Beco dos Coroas, Barra da Lagoa - Florianópolis, SC - Brasil; Burgos Morán, Ricardo Ernesto; Universidad Politécnica de Catalunya, Campus del Baix Llobregat, Av. del Canal Olímpic, s/n - 08860 - Castelldefels, Catalunya - España; Pilati, Celso; UFSC; Martins, Maurício Laterça; UFSC. |
| The present study evaluated the acute inflammatory response induced by carrageenin (500 µg) injected in the swim bladder of Nile tilapia, after fed or not probiotic supplemented diet. Fifty four fish were distributed in six treatments and three replicates: Group A: Fish fed unsupplemented diet: 0.5 mL saline-injected fish; fish injected with 500 µg carrageenin diluted in 0.5 mL saline; Non-injected. Group B: Fish fed probiotic supplemented diet: saline-injected fish; carrageenin-injected fish; Non-injected. Fifteen days after feeding the fish were injected with carrageenin or saline. After six hours, inflammatory exudate was collected, as well as the blood for hematocrit, red blood cell (RBC) and white blood cell (WBC) counts,... |
| Tipo: Composição bioquímica |
Palavras-chave: 2.00.00.00-6 Ciencias Biologicas Tilapia; Probiotic; Lactobacillus plantarum; Inflammation; Haematology; Phagocytosis 2.00.00.00-6 Ciencias Biologicas Tilapia; Probiotic; Lactobacillus plantarum; Inflammation; Haematology; Phagocytosis. |
| Ano: 2011 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/8011 |
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| LIMA,JOSÉLIA A.; COSTA,THIAGO W.R.; SILVA,LEANDRO L.; MIRANDA,ANA LUÍSA P.; PINTO,ANGELO C.. |
| ABSTRACT Geissospermum vellosii (Pao pereira) is a Brazilian tree whose stem barks are rich in indole alkaloids that present intense anticholinesterase activity. The present study evaluated the effects of a stem bark fraction (PPAC fraction) and ethanolic extract (EE) of Pao pereira in classic murine models of inflammation and pain. The EE and PPAC fraction, both at a dose of 30 mg/kg, significantly reduced mice abdominal constriction induced by acetic acid by 34.8% and 47.5%, respectively. In the formalin test, EE (30 mg/kg) and PPAC fraction (30 and 60 mg/kg) inhibited only the second phase, by 82.8%, 84.9% and 100%, respectively. Compared with indomethacin, similar doses of EE or PPAC fraction were approximately twice as effective in causing... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Geissospermum vellosii; Pao pereira; Antinociception; Inflammation; Cholinergic anti-inflammatory pathway. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100237 |
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| SGROTT,SANDRO M.; NEVES,RODRIGO D.; D’ACAMPORA,ARMANDO J.; BERNARDES,GERALDO J.S.; BELMONTE,LUIZ; MARTINS,THIAGO C.; BOBINSKI,FRANCIANE; CARGNIN-FERREIRA,EDUARDO; HOEPERS,ANDREZA; COMIM,CLARISSA M.; MARTINS,DANIEL F.; PIOVEZAN,ANNA P.. |
| Abstract Silicone breast implant is associated with complications inherent to the surgical procedure. Prosthesis coating with polyurethane, however, commonly reduces the incidence of such complications. In this paper, the authors evaluated the inflammatory histomorphometric profile and oxidative damage associated to the implant of polyester urethane sheets. Forty-eight Wistar rats were divided into Sham or polyester urethane groups (n = 8/group) and underwent a polyester urethane implant in the dorsal skinfold. Tissue samples were collected on days seven, 30, and 90 after surgery and subjected to histomorphometric analysis and biochemical tests. Results were analyzed by one-way ANOVA (p ≤ 0.05). Peri-implant tissue samples exhibited characteristic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polyurethane; Inflammation; Cytokines; Oxidative stress; Wistar rats. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502211 |
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| KWON,DA HYE; JEONG,JIN WOO; CHOI,EUN OK; LEE,HYE WON; LEE,KI WON; KIM,KI YOUNG; KIM,SUNG GOO; HONG,SU HYUN; KIM,GI-YOUNG; PARK,CHEOL; HWANG,HYE-JIN; SON,CHANG-GUE; CHOI,YUNG HYUN. |
| ABSTRACT Mori folium, the leaf of Morus alba L. (Moraceae), has been traditionally used for various medicinal purposes from ancient times to the present. In this study, we examined the effects of water extract of Mori folium (WEMF) on the production of inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2), and reactive oxygen species (ROS) in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophages. Our data indicated that WEMF significantly suppressed the secretion of NO and PGE2 in RAW 264.7 macrophages without any significant cytotoxicity. The protective effects were accompanied by a marked reduction in their regulatory gene expression at the transcription level. WEMF attenuated LPS-induced intracellular ROS production in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mori folium; Inflammation; ROS; Macrophage; Zebrafish. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200661 |
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| Augusto,Ohara; Trindade,Daniel F.; Linares,Edlaine; Vaz,Sandra M.. |
| The substantial therapeutic potential of tempol (4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy) and related cyclic nitroxides as antioxidants has stimulated innumerous studies of their reactions with reactive oxygen species. In comparison, reactions of nitroxides with nitric oxide-derived oxidants have been less frequently investigated. Nevertheless, this is relevant because tempol has also been shown to protect animals from injuries associated with inflammatory conditions, which are characterized by the increased production of nitric oxide and its derived oxidants. Here, we review recent studies addressing the mechanisms by which cyclic nitroxides attenuate the toxicity of nitric oxidederived oxidants. As an example, we present data showing that tempol... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cyclic nitroxides; Tempol; Antioxidants; Nitric oxide-derived oxidants; Inflammation; Acetaminopheninduced hepatotoxicity. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100013 |
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| Lopes,José Daniel; Mariano,Mario. |
| Characterization of the origin, properties, functions and fate of cells is a fundamental task for the understanding of physiological and pathological phenomena. Despite the bulk of knowledge concerning the diverse characteristics of mammalian cells, some of them, such as B-1 cells, are still poorly understood. Here we report the results obtained in our laboratory on these cells in the last 10 years. After showing that B-1 cells could be cultured and amplified in vitro, a series of experiments were performed with these cells. They showed that B1 cells reside mostly in the peritoneal and pleural cavities, migrate to distant inflammatory foci, coalesce to form giant cells and participate in granuloma formation, both in vitro and in vivo. They are also able to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: B-1 cells; IL-10; Inflammation; Infection; Neoplasia; BALB/Xid mice. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300013 |
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| LACERDA-SANTOS,ROGÉRIO; LIMA,ANTONIA BÁRBARA L.; PENHA,ELIZANDRA S. DA; SANTOS,ANTONIELSON DOS; CARVALHO,FABÍOLA G.; PITHON,MATHEUS M.; DANTAS,ANTÔNIO FLÁVIO M.. |
| Abstract the focus ofthis study was to testthe hypothesisthatthere would be no difference betweenthe biocompatibility of silicon dioxide nanofilms used as antimicrobial agents. Sixty male Wistar rats were divided into 4 groups (n=15): Group C (Control,Polyethylene), Group AR (Acrylic Resin), Group NP (Acrylic Resin coated with NP-Liquid), Group BG (Acrylic Resin coated with Bacterlon).the animals were sacrificed with 7,15 and 30 days and tissues analyzed as regardsthe events of inflammatory infiltrate, edema, necrosis, granulation tissue, mutinucleated giant cells, fibroblasts and collagen. Kruskal-Wallis and Dunn tests was used (P<0.05). Intense inflammatory infiltrate was shown mainly in Groups BG and AR, with significant difference from Control Group... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biomaterials; Biocompatibility; Dentistry; Inflammation. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100910 |
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| SILVA,GABRIELA L. DA; LUFT,CAROLINA; LUNARDELLI,ADROALDO; AMARAL,ROBSON H.; MELO,DENIZAR A. DA SILVA; DONADIO,MÁRCIO V.F.; NUNES,FERNANDA B.; AZAMBUJA,MARCOS S. DE; SANTANA,JOÃO C.; MORAES,CRISTINA M.B.; MELLO,RICARDO O.; CASSEL,EDUARDO; PEREIRA,MARCOS AURÉLIO DE ALMEIDA; OLIVEIRA,JARBAS R. DE. |
| Several studies have investigated the antinociceptive, immunomodulatory and anti-inflammatory properties of compounds found in the lavender essential oil (LEO), however to date, there is still lack of substantial data. The objective of this study was to assess the antioxidant, anti-inflammatory and antinociceptive effects of lavender essential oil. The 1,1-diphenyl-2-picrylhydrazyl radical decolorization assay was used for antioxidant activity evaluation. The anti-inflammatory activity was tested using two models of acute inflammation: carrageenan-induced pleurisy and croton oil-induced ear edema. The antinociceptive activity was tested using the pain model induced by formalin. LEO has antioxidant activity, which is dose-dependent response. The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antioxidants; Inflammation; Lavender; Nociception. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301397 |
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| HILEL,ALEXANDRE S.; GYSEMANS,BRUNA; LISBÔA,MARIA E.M.; HEYMANNS,ANA C.; FREIBERGER,VIVIANE; VENTURA,LETÍCIA; MAGNAGO,RACHEL F.; COMIM,CLARISSA M.; HOREWICS,VERÔNICA; MARTINS,DANIEL F.; BOBINSKI,FRANCIANE; PIOVEZAN,ANNA P.. |
| Abstract Citrus species are widely related to antihyperalgesic and anti-inflammatory effects. The aim of this study was to investigate if treatment with ethanolic extract from peels of mature Citrus reticulata Blanco causes antihyperalgesic effects on the referred mechanical hyperalgesia in a model of dextran sulphate of sodium (DSS)-induced colitis in mice, as well as the possible oxidative damage in different regions of the brain induced by its inflammatory reaction. Antihyperalgesia (30 to 300 mg/kg) was investigated by behavioral response (frequency of response to von Frey filament stimulation) in Swiss mice, while damage to central nervous system was investigated through techniques that evaluated oxidative stress using male black C57 BL6 mice (n=8).... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Citrus reticulate; Medicinal plants; Inflammation; Oxidative stress; Central nervous system. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000603139 |
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| Todendi,Pâmela F.; Klinger,Elisa I.; Ferreira,Michele B.; Reuter,Cézane P.; Burgos,Miria S.; Possuelo,Lia G.; Valim,Andréia R.M.. |
| Activation of adipose tissue inflammation is associated with obesity caused by lipid accumulation in adipocytes. Through this activation, proinflammatory cytokines, such as Interleukin-6 (IL-6) and C-reactive protein (CRP) seem to influence metabolic disorders. The present study evaluated whether polymorphisms in the CRP (rs1205) and IL-6 (rs1800795, rs2069845) genes are associated with the development of metabolic disorders in children and adolescents. A cross-sectional study was performed, consisting of 470 students from the municipality of Santa Cruz do Sul, Brazil, aged 7-17 years. Body mass index (BMI) was classified according to overweight and obesity. Genotyping was performed by real-time Polymerase Chain Reaction(PCR). Anthropometric... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Inflammation; Obesity; Polymorphisms; Risk; Schoolchildren. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200915 |
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| YU,YING; JIANG,HAIFENG; NIU,YANGYANG; ZHANG,XIAOQIN; ZHANG,YINGYING; LIU,XI; QI,TAO; YU,CHEN. |
| Abstract: Besides stimulating vasoconstriction, Angiotensin II is also well known in inducing reactive oxygen species and promoting inflammatory phenotype switch via its type 1 receptor. In clinic, Angiotensin II type 1 (AT1) receptor blocker like candesartan has been widely applied as an antihypertensive medication. We previous have demonstrated that a higher dose of candesartan plays a protective role after kidney injury. However, whether candesartan could exhibit anti-inflammatory effects remains unclear. Here, by stimulating isolated human embryonic kidney epithelial cells with tumor necrosis factor-α (TNF-α), we observed the anti-inflammation capacity of candesartan ex vivo. It was found that pre-treat with candesartan significantly suppressed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Angiotensin II type 1 receptor blockers; Candesartan; Inflammation; Reactive oxygen species. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300701 |
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| Castro,Jenny P; Ocampo,Yanet C; Franco,Luis A. |
| BACKGROUND: Despite Cryptostegia grandiflora Roxb. ex R. Br. (Apocynaceae) leaves are widely used in folk Caribbean Colombian medicine for their anti-inflammatory effects, there are no studies that support this traditional use. Therefore, this work aimed to evaluate the effect of the total extract and primary fractions obtained from Cryptostegia grandiflora leaves, using in vivo and in vitromodels of inflammation, and further get new insights on the mechanisms involved in this activity. RESULTS: Ethanolic extract of Cryptostegia grandiflora leaves, and its corresponding ether and dichloromethane fractions, significantly reduced inflammation and myeloperoxidase activity (MPO) in ear tissue of mice treated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA).... |
| Tipo: Journal article |
Palavras-chave: Ear edema; Free radicals; Inflammation; MPO; PGE2; RAW 264; 7 macrophages. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100032 |
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| ROJO,DANIEL; SUETOMI,KATSUTOSHI; NAVARRO,JAVIER. |
| Chemokine receptors are G protein-coupled receptors that mediate migration and activation of leukocytes as an important part of a protective immune response to injury and infection. In addition, chemokine receptors are used by HIV-1 to infect CD4 positive cells. The structural bases of chemokine receptor recognition and signal transduction are currently being investigated. High-resolution X-ray diffraction and NMR spectroscopy of chemokines indicate that all these peptides exhibit a common folding pattern, in spite of its low degree of primary-sequence homology. Chemokines' functional motifs have been identified by mutagenesis studies, and a possible mechanism for receptor recognition and activation is proposed, but high-resolution structure data of... |
| Tipo: Journal article |
Palavras-chave: Chemokines; G-protein coupled receptors; Inflammation; HIV-1. |
| Ano: 1999 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97601999000400006 |
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| Registros recuperados: 156 | |
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