|
|
|
| Registros recuperados: 49 | |
|
|
| COMANDOLLI-WYREPKOWSKI,Claudia Dantas; JENSEN,Bruno Bezerra; GRAFOVA,Iryna; SANTOS,Pierre Alexandre dos; BARROS,Angela Maria Comapa; SOARES,Fabiane Veloso; BARCELLOS,José Fernando Marques; SILVA,Aline Fagundes da; GRAFOV,Andriy; FRANCO,Antonia Maria Ramos. |
| ABSTRACT Treatment of cutaneous leishmaniasis (CL) is difficult due to the scarce number of drugs able to eliminate completely the intracellular form of the parasite. In the present study, the aim was to evaluate: i) phytochemical properties of extracts from Libidibia ferrea; ii) antileishmanial activity of extracts from L. ferrea against promastigotes and amastigotes of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) guyanensis; iii) the effects of topical treatment using hydrogel containing active extract of L. ferrea on golden hamsters infected with L. (L.) amazonensis. Extracts from leaves, branches and fruits of L. ferrea were obtained with hexane and methanol and were tested by in vitro assays in promastigotes and murine macrophages J774... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cutaneous leishmaniasis; Natural products; Topical formulations; Experimental treatment. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672017000400331 |
| |
|
|
| Cruz,Carolinie Batista Nobre da; Pieri,Fabio Alessandro; Carvalho-Zilse,Gislene Almeida; Orlandi,Patrícia Puccinelli; Nunes-Silva,Carlos Gustavo; Leomil,Luciana. |
| Honeys are described possessing different properties including antimicrobial. Many studies have presented this activity of honeys produced by Apis mellifera bees, however studies including activities of stingless bees honeys are scarce. The aim of this study was to compare the antimicrobial activity of honeys collected in the Amazonas State from Melipona compressipes, Melipona seminigra and Apis mellifera against Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Chromobacterium violaceum, and Candida albicans. Minimum inhibitory concentrations were determined using the agar dilution method with Müller-Hinton agar (for bacteria) or Saboraud agar (for yeast). Staphylococcus aureus and E. faecalis were inhibited by all honeys at concentrations... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Melipona; Antibacterial; Antifungal; Natural products; Functional food. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672014000200015 |
| |
|
| |
|
| |
|
|
| Nascimento, Luciana Cordeiro do; Universidade Federal da Paraíba; Nery, Aparecida Rodrigues; UFP; Rodrigues, Luís Nery; UFCG. |
| O presente trabalho teve como objetivo avaliar o controle de doenças do mamoeiro, utilizando extratos vegetais (alho, angico e manjericão), óleos naturais (urucum e algodão), indutores de resistência (Bion®, Ecolife® e Agro-mos®) e fungicida Mancozeb/Dithane. O Experimento I consistiu-se da avaliação dos tratamentos sobre o crescimento micelial de Colletotrichum gloeosporioides, in vitro; no Experimento II, efetuou-se a inoculação artificial do fungo sobre frutos sadios de mamão e avaliou-se a severidade da podridão peduncular, por meio de escala de notas e, no Experimento III, aplicaram-se os tratamentos em mudas de mamoeiro, inoculadas artificialmente com C. gloeosporioides, avaliando-se a antracnose com escala de notas. Os resultados obtidos... |
|
Palavras-chave: 5.01.00.00-9 Agronomia Carica papaya L.; Antracnose; Produtos naturais; Pós-colheita Fitossanidade Carica papaya L.; Anthracnose; Natural products; Postharvest. |
| Ano: 2008 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciAgron/article/view/3500 |
| |
|
| |
|
| |
|
| |
|
|
| WISINTAINER,GABRIELLE G.N.S.; SIMÕES,EVELYNE R.B.; LEMOS,TELMA L.G.; MOURA,SIDNEI; SOUZA,LUCIANA G.S.; FONSECA,ALUISIO M.; MORAES,MANOEL ODORICO; PESSOA,CLAUDIA; ROESCH-ELY,MARIANA; HENRIQUES,JOÃO A.P.. |
| Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflorin is an isolated compound taken from the roots of the plantCapraria biflora L. (Schrophulariaceae), indigenous of the West Indies and South America, which is located in temperate or tropical areas. This compound has shown to be strongly active against grampositive and alcohol-acid-resistant bacteria. It has been efficient in inhibiting the proliferation tumor cell lines CEM, HL-60, B16, HCT-8 and MCF-7. Recently, SK-Br3 cell line was treated with biflorin showing important cytotoxic effects. In this article, information related to the first structural characterization studies are presented, as well as the latest... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biological activity; Biflorin; Capraria biflora; Natural products. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401907 |
| |
|
| |
|
|
| Braga,Virgínia F.; Mendes,Giselle C.; Oliveira,Raphael T.R.; Soares,Carla Q.G.; Resende,Cristiano F.; Pinto,Leandro C.; Santana,Reinaldo de; Viccini,Lyderson F.; Raposo,Nádia R.B.; Peixoto,Paulo H.P.. |
| This work describes an efficient micropropagation protocol for Verbena litoralis and the study of the antinociceptive and antioxidant activities in extracts of this species. For the establishment in vitro, surface-sterilization procedures and PVPP showed high efficiency in fungal-bacterial contamination and phenol oxidation controls. Nodal segments cultivation in MS medium supplemented with 6-benzyladenine (7.5 µM)/α-naphthaleneacetic acid (NAA; 0.005 µM) induced multiple shoots. Elongated shoots were rooted with IAA (0.2 µM). Acclimatization rates were elevated and the plants showed the typical features of this species. The hexanic fraction (HF) of powdered leaves presented a radical scavenging activity with IC50 = 169.3 µg mL-1. HF showed a non-dose... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tissue culture; Biodiversity conservation; Biological effects; Natural products. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000100014 |
| |
|
|
| GÓMEZ-CANSINO,ROCIO; GUZMÁN-GUTIÉRREZ,SILVIA LAURA; CAMPOS-LARA,MARÍA GUADALUPE; ESPITIA-PINZÓN,CLARA INES; REYES-CHILPA,RICARDO. |
| ABSTRACT In Mexican Traditional Medicine 187 plant species are used in the treatment of respiratory conditions that may be associated with tuberculosis. In this contribution, we review the ethnobotany, chemistry and pharmacology of 63 species whose extracts have been assayed for antimycobacterial activity in vitro. Among these, the most potent is Aristolochia brevipes (MIC= 12.5 µg/mL), followed by Aristolochia taliscana, Citrus sinensis, Chrysactinia mexicana, Persea americana, and Olea europaea (MIC<64 µg/mL). Other potent extracts (inhibition > 95%, 50 µg/mL) include: Amphipterygium adstringens, Larrea divaricata, and Phoradendron robinsoni. Several active compounds have been identified, the most potent are: Licarin A (isolated from A. taliscana),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tuberculosis; Medicinal plants; Natural products; Mycobacterium tuberculosis. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100031 |
| |
|
|
| SOUZA,JULIANA M. DE; GALAVERNA,RENAN; SOUZA,ALINE A.N. DE; BROCKSOM,TIMOTHY J.; PASTRE,JULIO C.; SOUZA,RODRIGO O.M.A. DE; OLIVEIRA,KLEBER T. DE. |
| ABSTRACT We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Continuous flow; Natural products; APIs; Synthesis. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301131 |
| |
|
|
| Antinarelli,Luciana M.R.; Pinto,Nícolas C.; Scio,Elita; Coimbra,Elaine S.. |
| Leishmaniasis is a complex of diseases caused by Leishmania protozoa which treatment is restricted to a limited number of drugs that exhibit high toxicity, collateral effects and are often costly. There are a variety of tropical plants distributed in Brazil, and for many poor people the therapy for several diseases is based mainly on the use of traditional herbal remedies. In this work, the cytotoxic activity of 17 plant methanol extracts was evaluated on several Leishmania species and murine macrophages. Among them, the extract of Casearia sylvestris, Piptocarpha macropoda, Trembleya parviflora, Samanea tubulosa and Plectranthus neochilus showed a promissing leishmanicidal activity, exhibiting IC50 values below of 20 µg/mL against at least one species of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brazil; Casearia sylvestris; Leishmanicidal activity; Medicinal plants; Natural products. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000200733 |
| |
|
|
| MERCADANTE-SIMÕES,MARIA OLÍVIA; MAZZOTTINI-DOS-SANTOS,HELLEN C.; NERY,LAYS A.; FERREIRA,PERACIO R.B.; RIBEIRO,LEONARDO M.; ROYO,VANESSA A.; OLIVEIRA,DARIO A. DE. |
| The bark of the underground stem of Tontelea micrantha (Mart. ex. Schult.) A. C. Sm., a native Brazilian Cerrado species, is used in folk medicine for treating kidney ailments. The structures of the underground and the aerial stems were examined and their barks were analyzed for the presence of secondary metabolites. Bark fragments were processed according to conventional techniques in plant anatomy and their chemical compositions examined using histochemical and phytochemical tests, thin layer chromatography, and high-efficiency liquid chromatography. The underground stem is a sobol with unusual cambial activity. Laticifers that secrete terpenoids were present in the cortex and phloem of both organs and can contribute to the identification of the species... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Natural products; Pharmacognosy; Secondary metabolites; Sobol. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301167 |
| |
|
| |
|
| |
|
| |
| Registros recuperados: 49 | |
|
|
|
