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| Registros recuperados: 413 | |
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| Damian,B.B.; Bonetti,T.C.S.; Horovitz,D.D.G.. |
| Preimplantation genetic diagnosis (PGD) was originally developed to diagnose embryo-related genetic abnormalities for couples who present a high risk of a specific inherited disorder. Because this technology involves embryo selection, the medical, bioethical, and legal implications of the technique have been debated, particularly when it is used to select features that are not related to serious diseases. Although several initiatives have attempted to achieve regulatory harmonization, the diversity of healthcare services available and the presence of cultural differences have hampered attempts to achieve this goal. Thus, in different countries, the provision of PGD and regulatory frameworks reflect the perceptions of scientific groups, legislators, and... |
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Palavras-chave: Preimplantation genetic diagnosis; Public policy; Regulation; Ethics; Brazil. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000100025 |
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| Superoxide (O2-) is the compound obtained when oxygen is reduced by one electron. For a molecule with an unpaired electron, O2- is surprisingly inert, its chief reaction being a dismutation in which it reacts with itself to form H2O2 and oxygen. The involvement of O2- in biological systems was first revealed by the discovery in 1969 of superoxide dismutase, an enzyme that catalyzes the dismutation of O2-. Since then it has been found that biological systems produce a bewildering variety of reactive oxidants, all but a few arising ultimately from O2-. These oxidants include O2- itself, H2O2 and alkyl peroxides, hydroxyl radical and other reactive oxidizing radicals, oxidized halogens and halamines, singlet oxygen, and peroxynitrite. These various oxidants... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: NADPH oxidase; Superoxide; Oxidative stress; Antioxidant; Regulation; Host defense. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000200001 |
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| MALULY,Hellen Dea Barros; JOHNSTON,Craig; GIGLIO,Norberto Damián; SCHREINER,Ligia Lindner; ROBERTS,Ashley; ABEGAZ,Eyassu Getachew. |
| Abstract The increase of the prevalence of type-2 diabetes as a consequence of overweight and obesity has stimulated public health authorities worldwide to develop strategies for its risk management and prevention. Among them, a reduction on the content of sugar in sugar-sweetened foods and beverages has been suggested, which led the food industry to replace partially sucrose with food additives, such as low- and no-calorie sweeteners (LNCS). As a consequence, there has been an increase of their consumption, which has made regulatory agencies to evaluate their exposure and possible consequences. At the same time, speculations about adverse effects, such as carcinogenicity, preterm delivery and metabolic changes involving appetite, weight increase and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sweeteners; Safety; Regulation; Metabolism; Cancer. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020000100001 |
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| Cheong, So-Min; University of Kansas, Department of Geography; somin@ku.edu. |
| The issue of whether adaptations to past disasters can impede adaptation to new disasters of a different type or intensity will be analyzed by examining the transition from frequent hurricanes to the Deepwater Horizon oil spill in coastal Louisiana. In particular, the effects of changed regulatory structures from the Stafford Act to the Oil Pollution Act of 1990 in response to the Deepwater Horizon oil spill are investigated. The article describes how the federal, state, and local governments adjust. In addition, it illustrates the shifting focus on the environment with the activation of the Oil Pollution Act and the Clean Water Act. It wraps up with a discussion of the uncertainty that is pervasive in the case of the oil spill derived from changed... |
| Tipo: Peer-Reviewed Reports |
Palavras-chave: Disaster response; Government; Hurricanes; Oil spill; Regulation. |
| Ano: 2014 |
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| Peterson, Garry D; McGill University; garry.peterson@mcgill.ca; Cunningham, Saul; CSIRO Entomology; saul.cunningham@ento.csiro.au; Deutsch, Lisa; Department of Systems Ecology, Stockholm University; lisad@system.ecology.su.se; Erickson, Jon; Rensselaer Polytechnic Institute; erickj@rpi.edu; Quinlan, Allyson; Conservation Ecology; aquinlan@resalliance.org; Tinch, Robert; School of Environmental Sciences, University of East Anglia; R.Tinch@uea.ac.uk; Troell, Max; Beijer Institute, Royal Swedish Academy of Sciences; max@system.ecology.su.se; Woodbury, Peter; Boyce Thompson Institute for Plant Research; pbw1@cornell.edu; Zens, Scot; Department of Biology, Dartmouth College; zens@dartmouth.edu. |
| The benefits and risks of any particular GM crop depend on the interactions of its ecological functions and natural history with the agroecosystem and ecosystems within which it is embedded. These evolutionary and ecological factors must be considered when assessing GM crops. We argue that the assessment of GM crops should be broadened to include alternative agricultural practices, ecosystem management, and agricultural policy. Such an assessment would be facilitated by a clearer understanding of the indirect costs of agriculture and the ecological services that support it. The benefits of GM crops should be compared to those of other means of agricultural intensification such as organic farming, integrated pest management, and agricultural policy reform.... |
| Tipo: Peer-Reviewed Reports |
Palavras-chave: Agriculture; Biotechnology; Genetically modified crops (GM); Interdisciplinary; Public dialogue; Regulation; Risk assessment. |
| Ano: 2000 |
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| Mendoza-Macedo,Karina; Romero-Díaz,Alexis J; Miranda-Hernández,Mariana P; Campos-García,Víctor R; Ramírez-Ibañez,Nancy D; Juárez-Bayardo,L. Carmina; Moreno-Duran,Karen; Cedillo-Robles,Miriam S; Pérez,Nestor O; Jung-Cook,Helgi; Flores-Ortiz,Luis F; Medina-Rivero,Emilio. |
| Background: Developing countries have an estimate of ten times more approved biosimilars than developed countries. This disparity demands the need of an objective regulation that incorporates health policies according to the technological and economical capabilities of each country. One of the challenges lies on the establishment of comparability principles based on a physicochemical and biological characterization that should determine the extent of additional non-clinical and clinical studies. This is particularly relevant for licensed biosimilars in developing countries, which have an extensive clinical experience since their approval as generics' in some cases more than a decade. To exemplify the current status of biosimilars in Mexico' a... |
| Tipo: Journal article |
Palavras-chave: Bio therapeutic; Comparability; Critical quality attributes; Developing countries; Generics; Health policies; High quality biosimilars; Regulation. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582016000600010 |
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| Antona, Martine; Bailly, Denis; Paquotte, Philippe; Gabott, M; Gibbs, J; Shaw, S; Harmsma, H. |
| This report includes a qualitative and descriptive approach of the oyster and mussel industries in the European Community. This report compares the structure of production, the marketsn the professional organisation, competition for the resource, legislation and support systemat the community levell. Technical and statistical datas are summarized to représent the structure of the industry, the trade flows and the main evolutions of the two industries in the EC. A summary of the county reports gives an overview of the present state of the industry in each country and suggest a first evaluation of constraints and prospects. [NOT CONTROLLDED OCR] |
| Tipo: Text |
Palavras-chave: SEM; Réglementation; Commerce extérieur; Marché; Production; Europe; Conchyliculture; Regulation; External trade; Markets; Production; Europe; Shellfish culture. |
| Ano: 1993 |
URL: http://archimer.ifremer.fr/doc/1993/rapport-4176.pdf |
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| Fabioux, Caroline; Huvet, Arnaud; Le Souchu, Pierrick; Le Pennec, Marcel; Pouvreau, Stephane. |
| This study examined the gametogenic cycle of Crassostrea gigas in controlled conditions over one year, with a focus on the initiation of gametogenesis. This work analysed also the role of temperature and photoperiod in the regulation of oyster reproduction. Broodstock were maintained in natural (NC), accelerated (AC) and perpetual winter (WC) conditions of temperature and photoperiod, with feeding ad libitum. Qualitative and quantitative analyses of the reproductive pattern were performed using biometric measurement approach, sex ratio determination, histology and a gonad filling index. Each experimental treatment led to different strategies for growth and resource allocation. The gametogenic cycle, appeared entirely modulated, accelerated or delayed, by... |
| Tipo: Text |
Palavras-chave: Temperature; Regulation; Gonad filling index; Gonial mitosis; Reproduction; Oyster. |
| Ano: 2005 |
URL: http://archimer.ifremer.fr/doc/2005/publication-826.pdf |
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| Thebaud, Olivier. |
| This report presents, in two parts, the results of a study carried out on the coast of Martinique, during 1993. The first part presents the evolution of perceptions and uses of coastal areas, linked to the socio-economic transformations of the island. Completing this presentation, based on the analysis of management plans from different periods, an overview of the recent state of occupation of coastal areas in Martinique is also given. The second part presents four case studies of conflictual situations concerning access to coastal areas, on l and and at sea, considering differents types of activities and decision-making processes. For each case study, an investigation has been conducted to identify implied actors, their motivations and strategies, as well... |
| Tipo: Text |
Palavras-chave: Regulation; Decision making process; Conflicts; Martinique; Coast; SEM; Réglementation; Processus de décision; Conflits; Martinique; Littoral. |
| Ano: 1994 |
URL: http://archimer.ifremer.fr/doc/1994/rapport-2140.pdf |
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| Bacca, Helene; Huvet, Arnaud; Fabioux, Caroline; Daniel, Jean-yves; Delaporte, Maryse; Pouvreau, Stephane; Van Wormhoudt, A; Moal, Jeanne. |
| To investigate the control at the mRNA level of glycogen metabolism in the cupped oyster Crassostrea gigas, we report in the present paper the cloning and characterization of glycogen phosphorylase and synthase cDNAs (Cg-GPH and Cg-GYS, respectively, transcripts of main enzymes for glycogen use and storage), and their first expression profiles depending on oyster tissues and seasons. A strong expression of both genes was observed in the labial palps and the gonad in accordance with specific cells located in both tissues and ability to store glucose. Cg-GPH expression was also found mainly in muscle suggesting ability to use glycogen as readily available glucose to. supply its activity. For seasonal examinations, expression of Cg-GYS and Cg-GPH genes... |
| Tipo: Text |
Palavras-chave: Reproduction; Regulation; Oyster; Glycogen; Expression; Gene; Energy; Crassostrea gigas; Bivalve. |
| Ano: 2005 |
URL: http://archimer.ifremer.fr/doc/2005/publication-435.pdf |
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| Registros recuperados: 413 | |
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