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| Registros recuperados: 49 | |
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| Gaydou,Luisa; Bertuzzi,Romina; Moretti,Edgardo. |
| El estrés tiene alta prevalencia en el mundo; una de sus causas es la sepsis. Durante la misma, se liberan citoquinas que activan el eje hipotálamo-hipofiso suprarrenal (HHS) elevándose el cortisol y proteínas de fase aguda. El objetivo de este trabajo fue analizar el efecto de la sepsis sobre el eje HHS a través del cortisol, y asociarlo con interleuquina 1 beta (IL1-beta) y proteína C reactiva (PCR). Se dosó cortisol por electroquimioluminscencia, PCR por inmunoturbidimetría e IL1-beta por ELISA en sueros de pacientes sépticos (S, n=40) y no sépticos (NS, n=21). El cortisol fue significativamente mayor al valor de corte (VC), establecido mediante curva ROC, en el 63% de pacientes S, y sólo en el 14% de NS (OR: 10,0; IC: 2,5 - 39,7; p<0,05). La PCR... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Estrés; Sepsis; Cortisol; Interleuquina 1beta; Proteína C reactiva. |
| Ano: 2009 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-29572009000300002 |
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| Colombo,Arnaldo L.; Janini,Mario; Salomão,Reinaldo; Medeiros,Eduardo A. S.; Wey,Sergio B.; Pignatari,Antonio C. C.. |
| Several epidemiological changes have occurred in the pattern of nosocomial and community acquired infectious diseases during the past 25 years. Social and demographic changes possibly related to this phenomenon include a rapid population growth, the increase in urban migration and movement across international borders by tourists and immigrants, alterations in the habitats of animals and arthropods that transmit disease, as well as the raise of patients with impaired host defense abilities. Continuous surveillance programs of emergent pathogens and antimicrobial resistance are warranted for detecting in real time new pathogens, as well as to characterize molecular mechanisms of resistance. In order to become more effective, surveillance programs of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Emerging infectious diseases; HIV; AIDS; Candidemia; Antimicrobial resistance; Bacteremia; Sepsis; Nosocomial infectious. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300020 |
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| GIUSTINA,AMANDA D.; DANIELSKI,LUCINÉIA G.; NOVOCHADLO,MICHELE M.; GOLDIM,MARIANA P.S.; JOAQUIM,LARISSA; METZKER,KIUANNE L.L.; CARLI,RAQUEL JACONI DE; DENICOL,TAIS; CIDREIRA,THAINA; VIEIRA,THAYNAN; PETRONILHO,FABRICIA. |
| Abstract Abstract: Sepsis is a life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Inflammation and oxidative stress are intrinsically related to sepsis progression and organ failure. Vitamin B6 is an important cellular cofactor for metabolic processes and has anti-inflammatory and antioxidant properties. We aimed at evaluating the effect of vit B6 on inflammation and oxidative stress markers in the liver and lung of rats subjected to a relevant animal model of polymicrobial sepsis. Adult male Wistar rats were submitted to cecal ligation and perforation model and immediately after sepsis induction, vit B6 was administered as a single dose (600 mg/kg, subcutaneous). Twenty-four hours later, the lung and liver... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis; Vitamin B6; Oxidative stress; Antioxidant. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700627 |
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| Costa,Ramon Teixeira; Araújo,Orlei Ribeiro de; Brunialti,Milena Karina Coló; Assunção,Murilo Santucci Cesar; Azevedo,Luciano César Pontes; Freitas,Flávio; Salomão,Reinaldo. |
| ABSTRACT Objective: We evaluated the kinetics of cytokines belonging to the T helper1 (Th1), Th2, and Th17 profiles in septic patients, and their correlations with organ dysfunction and hospital mortality. Methods: This was a prospective observational study in a cohort of septic patients admitted to the intensive care units (ICU) of three Brazilian general hospitals. A total of 104 septic patients and 53 health volunteers (controls) were included. Plasma samples were collected within the first 48 h of organ dysfunction or septic shock (0D), after seven (D7) and 14 days (D14) of follow-up. The following cytokines were measured by flow cytometry: Interleukin-1β (IL-1β), IL-2, IL-6, IL-8, IL-10, IL-12/23p40, IL-17, IL-21, tumor necrosis factor-α (TNF-α),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis; Cytokines; Th response; Organ dysfunction; SOFA. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200079 |
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| Romanelli,Roberta Maia de Castro; Anchieta,Lêni Márcia; Fernandes,Juliana Chaves Abreu; Lima,Mariana Antunes Faria; Souza,Taís Marina de; Rosado,Viviane; Clemente,Wanessa Trindade; Camargos,Paulo Augusto Moreira. |
| Abstract Coagulase-negative Staphylococcus has been identified as the main nosocomial agent of neonatal late-onset sepsis. However, based on the pharmacokinetics and erratic distribution of vancomycin, recommended empirical dose is not ideal, due to the inappropriate serum levels that have been measured in neonates. The aim of this study was to evaluate serum levels of vancomycin used in newborns and compare the prediction of adequate serum levels based on doses calculated according to mg/kg/day and m2/day. This is an observational reprospective cohort at a referral neonatal unit, from 2011 to 2013. Newborns treated with vancomycin for the first episode of late-onset sepsis were included. Total dose in mg/kg/day, dose/m2/day, age, weight, body surface and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Vancomycin; Drug dosage calculations; Pharmacokinetics; Infant; Newborn; Sepsis. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500451 |
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| Diament,Décio; Colombari,Fernando; Cypriano,Adriana Serra; Lisboa,Luis Fernando; dos Santos,Bento Fortunato Cardoso; Cendoroglo Neto,Miguel; Serpa Neto,Ary; Silva,Eliezer. |
| Abstract Objective The aim of the present study was to obtain information about deaths due to sepsis in São Paulo from 2004 to 2009 and their relationship with geographical distribution. Methods Causes of death, both main and secondary, were defined according to the codes of the International Classification of Disease version 10 (ICD-10) contained in the database. Sepsis, septic shock, multiple organ failure, pneumonia, urinary tract infection, peritonitis and other intraabdominal infections, skin and soft tissue infections (including surgical wound infection) and meningitis were considered as immediate cause of death or as the condition leading to the immediate cause of death related or associated to sepsis. Results In the analyzed period, there was a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis; Mortality; Infection; Georeferencing. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200149 |
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| Bilevicius,Elizabeth; Dragosavac,Desanka; Dragosavac,Sanja; Araújo,Sebastião; Falcão,Antonio L.E.; Terzi,Renato G.G.. |
| Multiple organ failure (MOF) is the main cause of death in ICUs, especially affecting septic patients. It is strongly related to number of systems with failure, type of system involved, risk factors such as age, previous chronic diseases, delayed or inadequate resuscitation, persistent infection, immune suppression, and others. The prognoses is worse for patients rather than in elective or emergency surgical patients. The objective of this article is to provide data from our university teaching hospital ICU related to the incidence of septic patients, the distribution of MOF, and distribution of failure among each of the organs. The mortality rate, relationship between mortality and age, and mortality and types of organs affected were evaluated. The main... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: APACHE II; Sepsis; Multiple organ failure. |
| Ano: 2001 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000300001 |
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| Silva,Luzia Poliana Anjos da; Cavalheiro,Laura Giotto; Queirós,Fernanda; Nova,Camila Vila; Lucena,Rita. |
| Bacterial meningitis is still a major public health threat inside developing countries. In Brazil, the Department of Public Health estimates that the prevalence of bacterial meningitis is 22 cases per 100,000 persons. During the neonatal period, the bacterial meningitis develops special characteristics that can result in hearing problems and movement loss due to neurological and psychological damages. This study had the aim to analyze the prevalence of bacterial meningitis and sepsis in newborns during the pregnancy period for those using the public health care system in Salvador-Bahia. One of the goal was to describe the risk factors of bacterial meningitis and sepsis in newborns. A second goal was to identify, based on newborn health records, the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Newborn meningitis; Sepsis; Prevalence; Prediction; Complications. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200021 |
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| Badaró,Roberto; Molinar,Fernando; Seas,Carlos; Stamboulian,Daniel; Mendonça,João; Massud,João; Nascimento,Luiz Olympio. |
| The safety and efficacy of cefepime empiric monotherapy compared with standard broad-spectrum combination therapy for hospitalized adult patients with moderate to severe community-acquired bacterial infections were evaluated. In an open-label, multicenter study, 317 patients with an Acute Physiology and Chronic Health Evaluation (APACHE II) score ranging from >5 to =19 were enrolled with documented pneumonia (n=196), urinary tract infection (n=65), intra-abdominal infection (n=38), or sepsis (n=18). Patients were randomly assigned 1:1 to receive cefepime 1 to 2 g IV twice daily or three times a day or IV ampicillin, cephalothin, or ceftriaxone ± aminoglycoside therapy for 3 to 21 days. For both treatment groups, metronidazole, vancomycin, or macrolide... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cefepime; Ampicillin; Caphalotin; Ceftriaxone; Aminoglycoside; Urinary tract infections; Intra-abdominal infections; Sepsis. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500001 |
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| Barroso,David Eduardo; Carvalho,DM; Casagrande,ST; Rebelo,MC; Soares,V; Zahner,V; Solari,CA; Nogueira,SA. |
| The main objectives of the present study were to investigate the clinical and laboratory features of meningococcal disease in the city of Rio de Janeiro, Brazil, during the overlap of 2 epidemics in the 1990s. We conducted a study of a series of cases of meningococcal disease admitted in a Meningitis Reference Hospital. All clinical isolates available were analyzed by means of microbiological epidemiological markers. In 1990, Neisseria meningitidis serogroup B:4,7:P1.19,15, 1.7,1 sulfadiazine-resistant of the ET-5 complex emerged causing epidemic disease. Despite mass vaccination campaign (VaMengoc B+C®), the ET-5 clone remained hyperendemic after the epidemic peaked. In 1993 to 1995, an epidemic of serogroup C belonged to the cluster A4 overlapped, with a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neisseria meningitidis; Meningococcal disease; Epidemic; Meningitis; Sepsis. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300008 |
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| Kauss,IAM; Grion,Cintia MC; Cardoso,LTQ; Anami,EHT; Nunes,LB; Ferreira,GL; Matsuo,T; Bonametti,AM. |
| OBJECTIVES: The objective of this study was to estimate disease incidence and mortality rate of sepsis in a tertiary public hospital. METHODS: Patients admitted to the Intensive Care Unit (ICU) in 2004 and 2005 were monitored for sepsis using an observational longitudinal study design. Patients were monitored daily for diagnostic criteria of sepsis, according to ACCP/SCCM Consensus Conference criteria, until either death or hospital discharge. RESULTS: During the study, we analyzed 1,179 patients. Systemic Inflammatory Response Syndrome (SIRS) was present in 1,048 (88.9%) patients on admission, and was associated with infection in 554 (47.0%) patients. Of these, sepsis was diagnosed in 30 (2.5%) patients, while severe sepsis was diagnosed in 269 (22.8%)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis; Incidence; Mortality; Epidemiology. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300011 |
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| Romanelli,Roberta Maia de Castro; Anchieta,Lêni Márcia; Carvalho,Elaine Alvarenga de Almeida; Silva,Lorena Ferreira da Glória e; Nunes,Rafael Viana Pessoa; Mourão,Paulo Henrique; Clemente,Wanessa Trindade; Bouzada,Maria Cândida Ferrarez. |
| BACKGROUND: Healthcare Associated Infections constitute an important problem in Neonatal Units and invasive devices are frequently involved. However, studies on risk factors of newborns who undergo surgical procedures are scarce. OBJECTIVE: To identify risk factors for laboratory-confirmed bloodstream infection in neonates undergoing surgical procedures. METHODS: This case-control study was conducted from January 2008 to May 2011, in a referral center. Cases were of 21 newborns who underwent surgery and presented the first episode of laboratory-confirmed bloodstream infection. Control was 42 newborns who underwent surgical procedures without notification of laboratory-confirmed bloodstream infection in the study period. Information was obtained from the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Newborn intensive care units; Infection control; Surgery; Sepsis. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400400 |
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| Registros recuperados: 49 | |
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