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Hippocampal distribution of IL-1β and IL-1RI following lithium-pilocarpine-induced status epilepticus in the developing rat Anais da ABC (AABC)
Álvarez-Croda,Dulce-Mariely; Santiago-García,Juan; Medel-Matus,Jesús S.; Martínez-Quiroz,Joel; Puig-Lagunes,Angel A.; Beltrán-Parrazal,Luis; López-Meraz,María-Leonor.
The contribution of Interleukin-1β (IL-1β) to neuronal injury induced by status epilepticus (SE) in the immature brain remains unclear. The goal of this study was to determine the hippocampal expression of IL-1β and its type 1 receptor (IL-1RI) following SE induced by the lithium-pilocarpine model in fourteen-days-old rat pups; control animals were given an equal volume of saline instead of the convulsant. IL-1β and IL-1RI mRNA hippocampal levels were assessed by qRT-PCR 6 and 24 h after SE or control conditions. IL-1β and IL-1RI expression was detected in the dorsal hippocampus by immunohistochemical procedures; Fluoro-Jade B staining was carried out in parallel sections in order to detect neuronal cell death. IL-1β mRNA expression was increased 6 h...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Developing rat; IL-1β; IL-1RI; Hippocampus; Status epilepticus.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000200653
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