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| PIRES,ALANA F.; MARQUES,GABRIELA F.O.; ALENCAR,NYLANE M.N. DE; MARTINS,MARIA G.Q.; SILVA,MAYARA T.L. DA; NASCIMENTO,KYRIA S. DO; CAVADA,BENILDO S.; ASSREUY,ANA MARIA S.. |
| Abstract: Dalbergieae tribe lectins, possessing binding affinity for galactose and mannose, present inflammatory and nociceptive effects, while those for N-acetylglucosamine are anti-inflammatory. Since the anti-inflammatory effect of the seed lectin of L. araripensis (LAL) had been already demonstrated in mice, this effect was presently evaluated in rat models of acute inflammation. LAL (0.01-1 mg/kg) was administered by intravenous (i.v.) route in male Wistar rats 30 min before paw edema induction by dextran or carrageenan, and peritonitis by carrageenan. LAL (1 mg/kg) was incubated with N-acetylglucosamine for allowing lectin-sugar interactions before injection into animals. LAL toxicity was evaluated by the parameters: body mass, organs weight, stomach... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anti-inflammatory effect; Dalbergieae; Lectin domain; Leguminous lectin; Loncocharpus araripensis. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300706 |
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