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	Provedor de dados Anais da ABC (AABC) (1) Autor ANTONIO,CAMILA B. (1) BETTI,ANDRESA H. (1) BORSOI,MILENE (1) NEVES,GILDA (1) PRANKE,MARIANA A. (1) RATES,STELA M.K. (1) Mais... Palavra-chave Antidepressant-like effect (1) Immobility behavior (1) Locomotor activity (1) Memory negative symptoms (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2017 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects Anais da ABC (AABC) NEVES,GILDA; BORSOI,MILENE; ANTONIO,CAMILA B.; PRANKE,MARIANA A.; BETTI,ANDRESA H.; RATES,STELA M.K.. ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there is variability in the experimental design used leading to controversial results. In this study, we evaluated the effects of repeated administration of ketamine sub-anesthetic doses in forced swimming, locomotion in response to novelty and novel object recognition, aiming a broader evaluation of the usefulness of this experimental approach for modeling schizophrenia in mice. Ketamine (30 mg/kg/day i.p.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antidepressant-like effect; Immobility behavior; Locomotor activity; Memory negative symptoms. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401655 Registros recuperados: 1 Primeira ... 1 ... Última

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