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| RECH,VIRGINIA C.; MEZZOMO,NATHANA J.; ATHAYDES,GENARO A.; FEKSA,LUCIANE R.; FIGUEIREDO,VANDRÉ C.; KESSLER,ADRIANA; FRANCESCHI,ITIANE D. DE; WANNMACHER,CLOVIS M.D.. |
| ABSTRACT Considering that thiol-containing enzymes like kinases are critical for several metabolic pathways and energy homeostasis, we investigated the effects of cystine dimethyl ester and/or cysteamine administration on kinases crucial for energy metabolism in the kidney of Wistar rats. Animals were injected twice a day with 1.6 µmol/g body weight cystine dimethyl ester and/or 0.26 µmol/g body weight cysteamine from the 16th to the 20th postpartum day and euthanized after 12 hours. Pyruvate kinase, adenylate kinase, creatine kinase activities and thiol/disulfide ratio were determined. Cystine dimethyl ester administration reduced thiol/disulfide ratio and inhibited the kinases activities. Cysteamine administration increased the thiol/disulfide ratio and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cysteamine; Cystine dimethyl ester; Kinases activities; Renal energy metabolism. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000100099 |
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