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	Provedor de dados Arq. Bras. Med. Vet. Zootec. (1) Autor Ahmed,Saeed (1) Li,Xianqiang (1) Liu,Yonghong (1) Wang,Yanping (1) Zhang,Ling (1) Palavra-chave Anesthetic agent (1) Bronchoaveolar lavage (1) Florfenicol (1) Pharmacokinetic (1) Pulmonary (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Pharmacokinetic of florfenicol in pulmonary epithelial lining fluid of swine and effects of anesthetic agent on drug plasma disposition kinetics Arq. Bras. Med. Vet. Zootec. Wang,Yanping; Zhang,Ling; Ahmed,Saeed; Liu,Yonghong; Li,Xianqiang. ABSTRACT The primary objective of the current study was to compare the pharmacokinetic (PK) of florfenicol (FFL) in pulmonary epithelial lining fluid and the plasma in swine. The second objectives were to evaluate the effect of anesthesia with ketamine and propofol on the PK of FFL in plasma. Bronchoaveolar lavage was utilized for quantification of PELF volume and the urea dilution method was used to determine the concentration of FFL in PELF. FFL was administered intramuscularly (IM) to swine in a single dose of 20mg/kg body weight. The main PK parameters of FFL in plasma and PELF were as follows: the area under the concentration-time curve, maximal drug concentration, elimination half-life and mean residence time were 69.45±4.36 vs 85.03±9.26μg·hr/ml,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Anesthetic agent; Bronchoaveolar lavage; Florfenicol; Pharmacokinetic; Pulmonary. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000501497 Registros recuperados: 1 Primeira ... 1 ... Última

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