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Histomorphometric Changes in the Testes and Epididymis of Wistar Strain Albino Rats Following Fourteen Days Oral Administration of Therapeutic Doses of Some Antibiotics International Journal of Morphology
Awobajo,F. O; Raji,Y; Akinloye,A. K.
Studies on testes and epididymis tissue of rats treated orally for fourteen days with therapeutic doses of cloxacillin (6mg/100g/day), ampicillin (4mg/100/day) and tetracycline (12mg/100g/day) separately showed a significant reduction in testicular and epididimis architecture. Microscopic studies of these male reproductive organs further revealed a significant alteration in the epididymis as revealed by a significant reduction (p<0.05) in epididymal ductular diameter (EDD), and epididymal epithelial height (EEH) in treated group of animals. A significant increase (p<0.05) was however recorded in epididymal luminal diameter (ELD) in all the animals after the two and three week's recovery period allowed. This gives another insight into the toxicity...
Tipo: Journal article Palavras-chave: Antibiotics; Testes; Epididymis; Histomorphometry.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400047
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