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	Provedor de dados Biol. Res. (1) Genet. Mol. Biol. (1) Autor Akram,Muhammad (2) Ajmal,Muhammad (1) Bokhari,Habib (1) Daniyal,Muhammad (1) Hussain,Alamdar (1) Idrees,Muhammad (1) Iqbal,Mehwish (1) Khalid,Rana Rehan (1) Khan,Asmat Ullah (1) Qamar,Raheel (1) Siddiqi,Abdul Rauf (1) Mais... Palavra-chave Arylesterase (1) Breast cancer (1) Chemotherapy (1) Gene therapy (1) Hypercholesteremia (1) LDLR mutation (1) Paraoxonase-1 (1) Stem cell therapy (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2018 (1) 2017 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene Genet. Mol. Biol. Idrees,Muhammad; Siddiqi,Abdul Rauf; Ajmal,Muhammad; Akram,Muhammad; Khalid,Rana Rehan; Hussain,Alamdar; Qamar,Raheel; Bokhari,Habib. Abstract Paraoxonase 1 (PON1) is a serum enzyme associated with high density lipoprotein (HDL) regulation through its paraoxonase and arylesterase activity. PON1 inhibits the oxidation of HDL and low density lipoprotein (LDL), and is involved in the pathogenesis of a variety of diseases including atherosclerosis. Conversely, mutations in the low density lipoprotein receptor (LDLR) result in failure of receptor mediated endocytosis of LDL leading to its elevated plasma levels and onset of familial hypercholesterolemia (FH). In the current study we investigated the role of PON1 polymorphisms rs662; c.575A > G (p.Gln192Arg) and rs854560; c.163T > A (p.Leu55Met) in a large family having FH patients harboring a functional mutation in LDLR. Genotypes were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Paraoxonase-1; Hypercholesteremia; Arylesterase; LDLR mutation. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400570 Awareness and current knowledge of breast cancer Biol. Res. Akram,Muhammad; Iqbal,Mehwish; Daniyal,Muhammad; Khan,Asmat Ullah. Abstract Breast cancer remains a worldwide public health dilemma and is currently the most common tumour in the globe. Awareness of breast cancer, public attentiveness, and advancement in breast imaging has made a positive impact on recognition and screening of breast cancer. Breast cancer is life-threatening disease in females and the leading cause of mortality among women population. For the previous two decades, studies related to the breast cancer has guided to astonishing advancement in our understanding of the breast cancer, resulting in further proficient treatments. Amongst all the malignant diseases, breast cancer is considered as one of the leading cause of death in post menopausal women accounting for 23% of all cancer deaths. It is a global... Tipo: Journal article Palavras-chave: Breast cancer; Chemotherapy; Gene therapy; Stem cell therapy. Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100504 Registros recuperados: 2 Primeira ... 1 ... Última

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