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Star anise extracts modulation of reproductive parameters, fertility potential and DNA fragmentation induced by growth promoter Equigan in rat testes BJPS
Elmasry,Thanaa Ahmed; Al-Shaalan,Nora Hamed; Tousson,Ehab; El-Morshedy,Kadreya; Al-Ghadeer,Areej.
ABSTRACT Equigan is an anabolic steroid that has been developed for veterinary use and derived from endogenous sex hormone testosterone that plays a key role in the development of male reproductive tissue as well as in puberty and spermatogenesis. The current study is aimed to investigate the possible prophylactic effect of star anise extracts (SAE) on the toxicity of rat testes, sexual hormones alternations, sperm count, sperm abnormalities and testicular DNA damage by Equigan. Forty adult male rats were equally divided into four groups (1st Control group, 2nd SAE group, 3rd Equigan and 4th Equigan+SAE group). Food and fluid intakes, relative body weight, potassium, chloride, phosphorous, non-progressive and immotile sperms were significantly increased in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anabolic steroid/Equigan Testis/secretion Spermatogenesis/drug effects Sperm Marphometery Anabolic Agents/pharmacology Star anises/drug effects Illicium verum/drug effects Reproductive Control Agents/pharmacology Fertility Agents; Male/analysis DNA Fragmentation/drug effects..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100621
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Hepatic protective effect of grape seed proanthocyanidin extract against Gleevec-induced apoptosis, liver Injury and Ki67 alterations in rats BJPS
Al-Rasheed,Nawal Mohammed; El-Masry,Thanaa Ahmed; Tousson,Ehab; Hassan,Hanan Mohammad; Al-Ghadeer,Areej.
ABSTRACT Gleevec (imatinib) is an antineoplastic chemotherapeutic agent used in the treatment of many types of cancer. The current study was conducted to examine the possible modifying effects of grape seeds proanthocyandins extract (GSPE) against apoptosis, liver injury and Ki67 alterations induced by Gleevec in male rats. 40 male albino rats were equally divided into four groups (First and second groups were control and GSPE groups; third group was Gleevec group and fourth group was treated with Gleevec and GSPE). Gleevec induced elevations in P53 and depletion of Bcl2 levels in liver tissues were compared with the control group. Liver sections in rats treated with Gleevec exhibited marked cellular infiltrations, vacuolar degeneration hepatocytes,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chemotherapy; Gleevec/effects; Gleevec/Imatinib; Proanthocyandins; Liver; Apoptosis; Proliferation..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200612
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