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Tridax procumbens flavonoids: a prospective bioactive compound increased osteoblast differentiation and trabecular bone formation Biol. Res.
Mamun,Md. Abdullah Al; Hosen,Mohammad Jakir; Khatun,Amina; Alam,M. Masihul; Al-Bari,Md. Abdul Alim.
Abstract Background The Tridax procumbens extracts (TPE) are known for their ethno-medicinal properties to increase osteogenic functioning in mesenchymal stem cells. Recently, we found that the T. procumbens flavonoids (TPF) significantly suppressed the RANKL-induced osteoclasts differentiation and bone resorption. The TPF also promoted osteoblasts differentiation and bone formation demonstrated by increasing bone formation markers in cultured mouse primary osteoblasts. However, the effects of the TPF on in vivo bone formation remain unclear. In this study, we investigated the effects of the TPF on in vivo bone formation, injected the TPF (20 mg/kg) twice a day in the low calcium diet mice and killed them after 21 day. Radiographic and histomorphometric...
Tipo: Journal article Palavras-chave: Alkaline phosphatase; Bone formation; Osteoblast differentiation; Tridax procumbens flavonoids; Trabecular bone.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100221
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