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Immune factors and immunoregulation in tuberculosis BJMBR
Ferraz,J.C.; Melo,F.B.S.; Albuquerque,M.F.P.M.; Montenegro,S.M.L.; Abath,F.G.C..
Pathogens causing tuberculosis and other chronic infectious diseases of major public health importance commonly have complex mechanisms involved in their persistence in the host despite specific and sometimes strong immune responses. These diseases are also associated with the lack of efficient vaccines, difficult therapeutics and a high mortality rate among susceptible individuals. Here, we will review features of the host immune response that contribute to the occurrence of disease. In addition, we propose that the immune responses observed in tuberculosis cannot be interpreted solely on the basis of a Th1-Th2 counter-regulatory paradigm since there is growing evidence that natural regulatory T cells may play an important role in the regulation of host...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tuberculosis; Mycobacteria; Regulatory T cells; Cytokines.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100002
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Is arterial stiffness in HIV-infected individuals associated with HIV-related factors? BJMBR
Monteiro,P.; Miranda-Filho,D.B.; Bandeira,F.; Lacerda,H.R.; Chaves,H.; Albuquerque,M.F.P.M.; Montarroyos,U.R.; Ximenes,R.A.A..
We investigated the association between pulse wave velocity (PWV) and HIV infection, antiretroviral treatment-related characteristics, viral load, immune status, and metabolic changes in a cross-sectional study nested in a cohort of HIV/AIDS patients who have been followed for metabolic and cardiovascular changes since 2007. The study included patients recruited from the cohort (N = 261) and a comparison group (N = 82) of uninfected individuals, all enrolled from April to November 2009. Aortic stiffness was estimated using the carotid-femoral PWV (Complior-Artech, Paris, France). The groups were similar with respect to age, metabolic syndrome, diabetes mellitus, Framingham score, and use of antihypertensive and hypolipidemic medications. Hypertension was...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; AIDS; Antiretroviral therapy; Arterial stiffness; Pulse wave velocity.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900005
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Exaggerated blood pressure response during the exercise treadmill test as a risk factor for hypertension BJMBR
Lima,S.G.; Albuquerque,M.F.P.M.; Oliveira,J.R.M.; Ayres,C.F.J.; Cunha,J.E.G.; Oliveira,D.F.; Lemos,R.R.; Souza,M.B.R.; Silva,O. Barbosa e.
Exaggerated blood pressure response (EBPR) during the exercise treadmill test (ETT) has been considered to be a risk factor for hypertension. The relationship of polymorphisms of the renin-angiotensin system gene with hypertension has not been established. Our objective was to evaluate whether EBPR during exercise is a clinical marker for hypertension. The study concerned a historical cohort of normotensive individuals. The exposed individuals were those who presented EBPR. At the end of the observation period (41.7 months = 3.5 years), the development of hypertension was analyzed within the two groups. Genetic polymorphisms and blood pressure behavior were assessed as independent variables, together with the classical risk factors for hypertension. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Risk factors; Exaggerated blood pressure response.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400368
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