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Brilhante,Raimunda Sâmia Nogueira; Caetano,Erica Pacheco; Oliveira,Jonathas Sales de; Castelo-Branco,Débora de Souza Collares Maia; Souza,Elizabeth Ribeiro Yokobatake; Alencar,Lucas Pereira de; Cordeiro,Rossana de Aguiar; Bandeira,Tereza de Jesus Pinheiro Gomes; Sidrim,José Júlio Costa; Rocha,Marcos Fábio Gadelha. |
ABSTRACTThe antifungal activity of some statins against different fungal species has been reported. Thus, at the first moment, the in vitro antifungal activity of simvastatin, atorvastatin and pravastatin was tested againstCandida spp. and Cryptococcus spp. Then, in a second approach, considering that the best results were obtained for simvastatin, this drug was evaluated in combination with antifungal drugs against planktonic growth and tested against biofilms ofCandida spp. and Cryptococcus spp. Drug susceptibility testing was performed using the microdilution broth method, as described by the Clinical and Laboratory Standards Institute. The interaction between simvastatin and antifungals against planktonic cells was analyzed by calculating the... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida; Cryptococcus; Simvastatin; Antifungal activity; Biofilm. |
Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500459 |
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Rocha,Marcos Fábio Gadelha; Alencar,Lucas Pereira de; Brilhante,Raimunda Sâmia Nogueira; Sales,Jamille de Alencar; Ponte,Yago Brito de; Rodrigues,Pedro Henrique de Aragão; Sampaio,Célia Maria de Souza; Cordeiro,Rossana de Aguiar; Castelo-Branco,Débora de Souza Collares Maia; Oliveira,Francisco Carlos de; Barbosa,Francisco Geraldo; Teixeira,Carlos Eduardo Cordeiro; Paiva,Manoel de Araújo Neto; Bandeira,Tereza de Jesus Pinheiro Gomes; Moreira,José Luciano Bezerra; Sidrim,José Júlio Costa. |
This study aimed to evaluate the antifungal activity of M. oleifera extracts against fungi isolated from farmed prawns and test the toxicity of the extracts on larvae of Macrobrachium amazonicum. The ethanol extracts of pods, seeds, leaves, stems and flowers and chloroform extract of flowers of M. oleifera were tested against 14 strains of Candida spp. and 10 strains of Hortaea werneckii isolated from farming water and the digestive tract of M. amazonicum. Antifungal activity was determined by microdilution, based on the M27-A3 and M38-A2 CLSI documents. Toxicity was evaluated by exposing larvae of M. amazonicum at concentrations between 10-1000mg mL-1, counting dead larvae (CL50) after 24 hours. The best results were verified with the chloroform extract... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aquaculture; Fungi; Prawn; Moringa oleifera; Antimicrobial. |
Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014001202197 |
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