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	Provedor de dados 17 (2) Autor Alex Odermatt (2) Charlie Chandsawangbhuwana (2) Michael E. Baker (2) Anna A. Dzyakanchuk (1) Christel Gumy (1) Denise V. Kratschmar (1) Lyubomir G. Nashev (1) Zoltán Balázs (1) Mais... Palavra-chave Bioinformatics (2) Pharmacology (2) Immunology (1) Molecular Cell Biology (1) Tipo do documento Manuscript (2) Ano 2008 (2) País United Kingdom (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11[beta]-hydroxysteroid dehydrogenase 1 17 Zoltán Balázs; Lyubomir G. Nashev; Charlie Chandsawangbhuwana; Michael E. Baker; Alex Odermatt. Intracellular glucocorticoid reactivation is catalyzed by 11[beta]-hydroxysteroid dehydrogenase 1 (11[beta]-HSD1), which functions predominantly as a reductase in cells expressing hexose-6-phosphate dehydrogenase (H6PDH). We recently showed that the ratios of cortisone to cortisol and 7-keto- to 7-hydroxy-neurosteroids are regulated by 11[beta]-HSD1 and very much depend on co-expression with H6PDH, providing cosubstrate NADPH. Here, we investigated the impact of H6PDH on the modulation of 11[beta]-HSD1-dependent inter-conversion of cortisone and cortisol by inhibitors and alternative substrates. Using HEK-293 cells expressing 11[beta]-HSD1 or co-expressing 11[beta]-HSD1 and H6PDH, we observed significant differences of 11[beta]-HSD1 inhibition by natural... Tipo: Manuscript Palavras-chave: Molecular Cell Biology; Pharmacology; Bioinformatics. Ano: 2008 URL: http://precedings.nature.com/documents/2430/version/1 Dibutyltin Disrupts Glucocorticoid Receptor Function and Impairs Glucocorticoid-induced Suppression of Cytokine Production 17 Christel Gumy; Charlie Chandsawangbhuwana; Anna A. Dzyakanchuk; Denise V. Kratschmar; Michael E. Baker; Alex Odermatt. _Background_. Organotins are highly toxic and widely distributed environmental chemicals. Dibutyltin (DBT) is used as stabilizer in the production of polyvinyl chloride plastics, and it is also the major metabolite formed from tributyltin (TBT) _in vivo_. DBT is immunotoxic, however, the responsible targets remain to be defined. Due to the importance of glucocorticoids in immune-modulation, we investigated whether DBT could interfere with glucocorticoid receptor (GR) function.
_Methodology_. We used HEK-293 cells transiently transfected with human GR as well as rat H4IIE hepatoma cells and native human macrophages and human THP-1 macrophages expressing endogenous receptor to study organotin effects on GR function. Docking of organotins was... Tipo: Manuscript Palavras-chave: Immunology; Pharmacology; Bioinformatics. Ano: 2008 URL: http://precedings.nature.com/documents/2312/version/1 Registros recuperados: 2 Primeira ... 1 ... Última

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