|
|
| Omar,Suliman Y. Al; Alkuriji,Afrah; Alwasel,Saleh; Dar,javid Ahmed; Alhammad,Alwaleed; Christmas,Stephen; Mansour,Lamjed. |
| Abstract Killer Cell Immunoglobulin-like Receptors (KIR) have been used as good markers for the study of genetic predisposition in many diseases and in human genetic population dynamics. In this context, we have investigated the genetic diversity of KIR genes and their main HLA class I ligands in Saudi population and compared the data with other studies of neighboring populations. One hundred and fourteen randomly selected healthy Saudi subjects were genotyped for the presence or absence of 16 KIR genes and their HLA-C1, -C2, -Bw4Thr80 and Bw4Ile80 groups, using a PCR-SSP technique. The results show the occurrence of the framework genes (3DL2, 3DL3 and 2DL4) and the pseudogenes (2DP1 and 3DP1) at highest frequencies. All inhibitory KIR (iKIR) genes... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: KIR diversity; Gene polymorphism; Molecular evolution; PCR SSP; Population viability analysis. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000100014 |
| |
