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| Sousa,Paulo César P; Brito,Teresinha S; Freire,Daniel S; Ximenes,Rafael M; Magalhães,Pedro Jorge C; Monteiro,Helena SA; Alves,Renata S; Martins,Alice Maria C; Toyama,Daniela O; Toyama,Marcos H. |
| Background : Apis mellifera stings are a problem for public health worldwide, particularly in Latin America due to the aggressiveness of its Africanized honeybees. Massive poisoning by A. mellifera venom (AmV) affects mainly the cardiovascular system, and several works have described its actions on heart muscle. Nevertheless, no work on the pharmacological action mechanisms of the AmV in isolated aorta has been reported. Thus, the present work aimed to investigate the actions of AmV and its main fractions, phospholipase A2 (PLA2) and melittin, on isolated aorta rings and a probable action mechanism. Results : AmV and the complex PLA2 + melittin (0.1-50 μg/mL) caused contraction in endothelium-containing aorta rings, but neither isolated PLA2 nor melittin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Apis mellifera; Venom; Mellitin; Phospholipase A2; Aorta. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100314 |
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