|
|
| Alves,Ricardo; Reis,Thaís Vitória da Silva; Silva,Luis Carlos Cides da; Storpírtis,Silvia; Mercuri,Lucildes Pita; Matos,Jivaldo do Rosário. |
| The thermal behavior of two polymorphic forms of rifampicin was studied by DSC and TG/DTG. The thermoanalytical results clearly showed the differences between the two crystalline forms. Polymorph I was the most thermally stable form, the DSC curve showed no fusion for this species and the thermal decomposition process occurred around 245 ºC. The DSC curve of polymorph II showed two consecutive events, an endothermic event (Tpeak = 193.9 ºC) and one exothermic event (Tpeak = 209.4 ºC), due to a melting process followed by recrystallization, which was attributed to the conversion of form II to form I. Isothermal and non-isothermal thermogravimetric methods were used to determine the kinetic parameters of the thermal decomposition process. For non-isothermal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rifampicin; Tuberculosis; Thermal analysis; Thermal decomposition; Kinetic analysis. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200022 |
| |
