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| Pinto,Mônia Aparecida Lemos; Ambrozini,Beatriz; Ferreira,Ana Paula Garcia; Cavalheiro,Éder Tadeu Gomes. |
| Carbamazepine (CBZ), a widely used anticonvulsant drug, can crystallize and exhibits four polymorphic forms and one dihydrate. Anhydrous CBZ can spontaneously absorb water and convert to the hydrate form whose different crystallinity leads to lower biological activity. The present study was concerned to the possibility of recovering the hydrated form by heating. The thermal behavior of spontaneously hydrated carbamazepine was investigated by TG/DTG-DTA and DSC in dynamic atmospheres of air and nitrogen, which revealed that the spontaneous hydration of this pharmaceutical resulted in a Form III hydrate with 1.5 water molecules. After dehydration, this anhydrous Form III converted to Form I, which melted and decomposed in a single event, releasing isocyanic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Carbamazepine/thermal analysis; Polymorphism; Hydrate; Dehydration. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400877 |
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