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	Provedor de dados Nature Precedings (3) Autor Antonella Mandas (3) Alessandra Pani (2) Claudia Abete (2) Claudia Norfo (2) Fabrizio Angius (2) Sandra Dessì (2) Alessandra Mocali (1) Christina Doriana Orrù (1) Enrico Peiretti (1) Francesco Paoletti (1) Giacomo Diaz (1) Maria F. Mulas (1) Maria Dolores Cannas (1) Mario Pani (1) Maurizio Fossarello (1) Paolo La Colla (1) Pier Luigi Cocco (1) Pierluigi Cocco (1) Rosa Manconi (1) Sandra Dessi (1) Mais... Palavra-chave Molecular Cell Biology (2) Microbiology (1) Neuroscience (1) Pharmacology (1) Tipo do documento Manuscript (3) Ano 2010 (1) 2009 (2) País United Kingdom (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Cholesterol Esterification During Differentiation by Hexamethylene Bisacetamide of Friend Virus-Induced Erythrokeukemia Nature Precedings Maria F. Mulas; Antonella Mandas; Claudia Abete; Sandra Dessi; Mario Pani; Rosa Manconi; Alessandra Mocali; Francesco Paoletti. Cholesterol is an essential constituent of all mammalian cell membranes, and its availability is therefore a prerequisite for cellular growth and other functions. Several lines of evidence are now indicating an association between alterations of cholesterol homeostasis and cell cycle progression in cancer cells. However, the role of cholesterol in cell differentiation is still largely unknown. To begin to address this issue, in this study we examined changes in cholesterol metabolism and in the mRNA levels of proteins involved in cholesterol import and esterification (multi-drug resistance, MDR-3) and acylCoA:cholesterol acyltransferase (ACAT) and cholesterol export (caveolin-1) in Friend virus-induced erythroleukemia cells (MELC), in the absence or in the... Tipo: Manuscript Palavras-chave: Molecular Cell Biology. Ano: 2010 URL: http://precedings.nature.com/documents/5155/version/1 Glucose-6-phosphate-dehydrogenase deficiency as a risk factor in proliferative disorder development Nature Precedings Antonella Mandas; Enrico Peiretti; Pierluigi Cocco; Claudia Norfo; Claudia Abete; Fabrizio Angius; Alessandra Pani; Giacomo Diaz; Sandra Dessì; Maurizio Fossarello. Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway (PPP) which provides reducing power (NADPH) and pentose phosphates. The former is mainly involved in the detoxification of chemical reactive species; the latter in the regulation of cell proliferation. G6PD deficiency is the most common enzymopathy in the human population, characterized by decreased G6PD activity, mainly in red blood cells, but actually also in nucleated cells. This decreased activity is not due to enzyme synthesis impairment, but rather to reduced enzyme stability, which leads to a shortening of its half-life. Therefore, a major problem is to understand the underlying mechanisms linking G6PD deficiency to oxidative stress... Tipo: Manuscript Palavras-chave: Molecular Cell Biology. Ano: 2009 URL: http://precedings.nature.com/documents/3001/version/1 In vitro synergistic anti-prion effect of cholesterol ester modulators Nature Precedings Christina Doriana Orrù; Maria Dolores Cannas; Sarah Vascellari; Fabrizio Angius; Pier Luigi Cocco; Claudia Norfo; Antonella Mandas; Paolo La Colla; Sandra Dessì; Alessandra Pani. Background. Our studies on the role of cholesterol in prion infection/replication showed that brains and peripheral cells of sheep susceptible to or suffering from Scrapie were characterized by an altered cholesterol homeostasis compared to animals with a scrapie-resistant genotype, and that drugs influencing cholesterol esterification were endowed with selective anti-prion activity in N2a cell lines infected with the 22L and RML prion strains. 
Results. In prion-infected N2a cell lines we now report increased anti-prion activity of dual-drug combinations consisting of cholesterol ester modulators associated with prion inhibitors Synergism was obtained with the cholesterol ester modulators everolimus, pioglitazone, progesterone, and... Tipo: Manuscript Palavras-chave: Microbiology; Neuroscience; Pharmacology. Ano: 2009 URL: http://precedings.nature.com/documents/3883/version/1 Registros recuperados: 3 Primeira ... 1 ... Última

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