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	Provedor de dados BJMBR (1) Autor Ao,Man (1) Ao,Yazhou (1) Xiao,Xu (1) Palavra-chave Docetaxel (1) Liver cancer (1) Low density lipoprotein (1) Silica nanoparticles (1) Thalidomide (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer BJMBR Ao,Man; Xiao,Xu; Ao,Yazhou. In the present study, we successfully developed a docetaxel (DTX) and thalidomide (TDD) co-delivery system based on low density lipoprotein (LDL) modified silica nanoparticles (LDL/SLN/DTX/TDD). By employing the tumor homing property of LDL and the drug-loading capability of silica nanoparticles, the prepared LDL/SLN/DTX/TDD was expected to locate and specifically deliver the loaded drugs (DTX and TDD) to achieve effective chemotherapy of liver cancer. In vitro analysis revealed that nano-sized LDL/SLN/DTX/TDD with decent drug loading capabilities was able to increase the delivery efficiency by targeting the low density lipoprotein receptors, which were overexpressed on HepG2 human hepatocellular liver carcinoma cell line, which exerted better cytotoxicity... Tipo: Info:eu-repo/semantics/article Palavras-chave: Docetaxel; Thalidomide; Low density lipoprotein; Silica nanoparticles; Liver cancer. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300613 Registros recuperados: 1 Primeira ... 1 ... Última

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